Details of the Target

General Information of Target

Target ID LDTP04679
Target Name Afadin (AFDN)
Gene Name AFDN
Gene ID 4301
Synonyms
AF6; MLLT4; Afadin; ALL1-fused gene from chromosome 6 protein; Protein AF-6; Afadin adherens junction formation factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
DREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQA
SDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSS
DGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARV
MLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLE
GKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLYR
LQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISET
TMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDI
HSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELI
LPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERT
HKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLA
HLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNA
ALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAAD
CHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIE
NVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLC
QRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGL
SIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTR
TSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGS
PESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSV
STGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHT
DSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQE
HLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFD
GMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERK
LGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITV
SKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKL
MLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMR
KREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEA
PGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEE
DCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQ
GQDVSNKVKASRKLTELENELNTK
Target Bioclass
Other
Subcellular location
Cell junction, adherens junction
Function
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions.
Uniprot ID
P55196
Ensemble ID
ENST00000392108.7
HGNC ID
HGNC:7137

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K258(10.00); K362(1.56); K510(2.92); K520(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y203(2.21); Y253(21.91); Y471(12.13); Y584(19.23)  LDD3495  [3]
DBIA
 Probe Info  		C324(1.66); C1206(1.54)  LDD3312  [4]
BTD
 Probe Info  		C1684(1.27)  LDD2090  [5]
AHL-Pu-1
 Probe Info  		C841(3.21); C1742(2.17); C1684(2.57); C1206(3.43)  LDD0168  [6]
ATP probe
 Probe Info  		K510(0.00); K1807(0.00); K1809(0.00)  LDD0199  [7]
IA-alkyne
 Probe Info  		C1206(0.00); C1684(0.00); C960(0.00); C942(0.00)  LDD0032  [8]
1d-yne
 Probe Info  		N.A.  LDD0356  [9]
IPM
 Probe Info  		C1684(0.00); C841(0.00)  LDD0005  [10]
PF-06672131
 Probe Info  		N.A.  LDD0017  [11]
VSF
 Probe Info  		C870(0.00); C1684(0.00); C1206(0.00)  LDD0007  [10]
Phosphinate-6
 Probe Info  		C1684(0.00); C1764(0.00); C59(0.00)  LDD0018  [12]
W1
 Probe Info  		C960(0.00); C324(0.00); C1684(0.00)  LDD0236  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
HHS-465
 Probe Info  		Y1189(0.00); Y253(0.00)  LDD2240  [15]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [16]
FFF probe13
 Probe Info  		20.00  LDD0475  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe3
 Probe Info  		8.89  LDD0465  [16]
FFF probe6
 Probe Info  		12.48  LDD0467  [16]
Alk-rapa
 Probe Info  		2.91  LDD0213  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C841(0.93)  LDD2117  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1684(0.96)  LDD2103  [5]
 LDCM0025  4SU-RNA HEK-293T C841(3.21); C1742(2.17); C1684(2.57); C1206(3.43)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C841(2.97); C1742(3.39); C1684(2.97); C1206(2.79)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C841(1.14); C1206(0.96); C870(1.05); C811(0.94)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C841(1.05); C1206(1.10); C870(1.07); C811(0.98)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C841(0.85); C1206(0.96); C870(0.95); C811(1.02)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C841(0.98); C1206(1.02); C870(0.93); C811(0.98)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C841(1.05); C1206(1.07); C870(0.94); C811(0.90)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C841(1.01); C1206(0.73); C870(1.07); C811(0.99)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C841(1.10); C1206(0.91); C870(1.05); C811(0.89)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C841(1.00); C1206(1.01); C870(1.08); C811(0.90)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C841(0.87); C1206(1.01); C870(1.03); C811(1.01)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C841(0.94); C1206(1.00); C870(1.05); C811(0.94)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C841(1.00); C1206(0.93); C870(1.01); C811(0.88)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C841(1.02); C1206(0.96); C870(1.00); C811(0.98)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C841(1.02); C1206(1.12); C870(0.95); C811(0.93)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C841(1.00); C1206(0.98); C870(1.06); C811(0.93)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C841(1.00); C1206(1.15); C870(1.00); C811(0.98)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C841(1.04); C1206(1.06); C870(1.04); C811(0.93)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C841(0.92); C1206(1.02); C870(1.04); C811(0.94)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C841(0.94); C1206(0.94); C870(1.01); C811(0.96)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C841(1.01); C1206(0.94); C870(0.96); C811(0.97)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C841(0.98); C1206(0.99); C870(0.97); C811(0.98)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C841(1.08); C1206(1.11); C870(0.98); C811(0.97)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C841(1.09); C1206(1.12); C870(0.98); C811(0.92)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C841(0.95); C1206(0.77); C870(1.06); C811(0.97)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C841(0.95); C1206(1.17); C870(0.99); C811(0.86)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C841(0.93); C1206(1.06); C870(1.07); C811(0.96)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C841(0.96); C1206(1.11); C870(0.99); C811(0.98)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C841(0.88); C1206(1.04); C870(0.93); C811(1.01)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C841(1.00); C1206(0.86); C870(0.99); C811(0.89)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C841(0.99); C1206(1.13); C870(0.96); C811(1.04)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C841(1.06); C1206(0.90); C870(0.89); C811(0.91)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C841(0.94); C1206(0.98); C870(1.00); C811(0.97)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C841(1.05); C1206(0.96); C870(0.99); C811(0.96)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C841(1.04); C1206(1.22); C870(1.02); C811(0.98)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C841(1.04); C1206(1.02); C870(1.06); C811(0.92)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C841(0.99); C1206(1.11); C870(1.05); C811(1.01)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C841(0.95); C1206(1.18); C870(0.96); C811(0.99)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C841(0.94); C1206(0.96); C870(0.95); C811(0.88)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C841(1.02); C1206(1.01); C870(0.96); C811(1.01)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C841(1.03); C1206(1.11); C870(0.89); C811(0.94)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C841(0.96); C1206(0.85); C870(0.99); C811(0.97)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C841(0.99); C1206(1.15); C870(0.97); C811(0.94)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C841(1.04); C1206(0.96); C870(0.98); C811(0.98)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C841(0.96); C1206(1.05); C870(1.01); C811(0.98)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C841(0.98); C1206(1.07); C870(1.04); C811(0.92)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C841(0.94); C1206(1.15); C870(0.98); C811(0.92)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C841(0.95); C1206(0.88); C870(0.97); C811(0.91)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C841(0.95); C1206(1.04); C870(0.95); C811(0.96)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C841(0.96); C1206(1.03); C870(0.90); C811(0.88)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C841(0.92); C1206(0.92); C870(1.03); C811(0.91)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C841(0.80); C1206(1.11); C870(0.91); C811(1.03)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C841(1.01); C1206(1.02); C870(1.06); C811(1.06)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C841(0.93); C1206(1.03); C870(1.06); C811(1.03)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C841(0.81); C1206(0.93); C870(0.96); C811(1.01)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C841(1.04); C1206(0.97); C870(0.98); C811(0.95)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C841(0.98); C1206(0.89); C870(1.08); C811(1.04)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C841(0.92); C1206(0.98); C870(1.00); C811(1.02)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C841(0.94); C1206(0.96); C870(0.99); C811(0.97)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C841(0.97); C1206(0.85); C870(1.08); C811(1.01)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C841(0.95); C1206(1.10); C870(0.93); C811(1.01)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C841(0.98); C1206(0.97); C870(1.04); C811(1.02)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C841(0.95); C1206(1.07); C870(0.94); C811(0.99)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C841(0.99); C1206(1.01); C870(0.98); C811(1.01)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C841(1.08); C1206(1.01); C870(0.97); C811(1.01)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C841(0.94); C1206(1.14); C870(0.97); C811(0.99)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 11.47  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C841(1.12); C1206(0.86); C870(1.00); C811(1.41)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C841(1.72); C1206(0.89); C870(1.63); C811(2.49)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C841(1.17); C1206(0.92); C870(1.01); C811(1.06)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C841(0.93); C1206(0.95); C870(0.92); C811(0.98)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C841(1.22); C1206(0.95); C870(1.10); C811(1.18)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C841(0.89); C1206(1.04); C870(0.94); C811(1.03)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C841(1.08); C1206(1.16); C870(1.05); C811(0.98)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C841(1.10); C1206(0.91); C870(0.94); C811(1.07)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C841(1.45); C1206(1.00); C870(1.02); C811(1.13)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C841(0.85); C1206(1.02); C870(0.97); C811(0.86)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C841(1.11); C1206(0.96); C870(0.97); C811(0.92)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C841(1.23); C1206(0.93); C870(1.03); C811(1.12)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C841(1.25); C1206(0.92); C870(1.10); C811(1.63)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C841(1.68); C1206(0.90); C870(1.17); C811(1.27)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C841(1.04); C1206(0.97); C870(1.02); C811(1.05)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C841(1.06); C1206(0.94); C870(0.99); C811(0.96)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C841(0.95); C1206(0.90); C870(0.93); C811(0.96)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C841(1.28); C1206(1.14); C870(1.05); C811(1.53)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C841(0.90); C1206(1.00); C870(0.93); C811(0.86)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C841(1.05); C1206(1.05); C870(1.02); C811(0.88)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C841(0.88); C1206(0.97); C870(0.90); C811(0.96)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C841(1.36); C1206(0.91); C870(0.98); C811(1.01)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C841(0.85); C1206(1.08); C870(0.89); C811(0.96)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C841(1.24); C1206(1.04); C870(1.09); C811(1.57)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C841(1.06); C1206(0.99); C870(0.99); C811(0.96)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C841(0.99); C1206(0.90); C870(0.95); C811(1.02)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C841(1.10); C1206(0.89); C870(1.02); C811(1.06)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C841(1.11); C1206(0.91); C870(1.07); C811(1.28)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C841(1.22); C1206(1.04); C870(1.01); C811(1.10)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C841(0.76); C1206(0.93); C870(0.98); C811(1.15)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C841(0.89); C1206(0.92); C870(1.06); C811(1.31)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C841(0.79); C1206(1.02); C870(1.00); C811(0.91)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C841(0.94); C1206(1.08); C870(1.06); C811(1.01)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C841(1.01); C1206(0.90); C870(1.04); C811(1.24)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C841(1.03); C1206(0.90); C870(0.97); C811(0.97)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C841(1.09); C1206(0.96); C870(1.25); C811(1.56)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C841(1.11); C1206(0.99); C870(1.03); C811(0.95)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C841(1.39); C1206(0.95); C870(1.16); C811(1.46)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C841(1.00); C1206(1.04); C870(1.06); C811(0.95)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C841(0.83); C1206(1.06); C870(0.99); C811(1.13)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C841(0.85); C1206(0.97); C870(0.95); C811(1.16)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C841(1.05); C1206(1.09); C870(0.99); C811(1.25)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C841(1.23); C1206(0.93); C870(1.18); C811(1.89)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C841(1.13); C1206(1.10); C870(1.05); C811(1.39)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C841(1.02); C1206(0.99); C870(1.11); C811(1.27)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C841(0.98); C1206(1.10); C870(1.02); C811(1.27)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C841(1.21); C1206(0.77); C870(1.18); C811(1.94)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C841(0.87); C1206(0.97); C870(1.00); C811(1.00)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C841(1.02); C1206(1.01); C870(0.98); C811(0.91)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C841(1.27); C1206(0.98); C870(1.03); C811(1.00)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C841(1.07); C1206(1.01); C870(1.01); C811(0.94)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C841(0.97); C1206(1.01); C870(1.06); C811(1.19)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C841(0.95); C1206(1.04); C870(1.04); C811(0.98)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C841(1.05); C1206(1.26); C870(0.93); C811(1.10)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C841(1.17); C1206(1.03); C870(0.98); C811(1.12)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C841(1.35); C1206(0.77); C870(1.39); C811(2.96)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C841(1.42); C1206(0.97); C870(1.13); C811(1.37)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C841(1.11); C1206(0.87); C870(1.08); C811(1.22)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C841(1.28); C1206(1.12); C870(1.08); C811(1.42)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C841(1.01); C1206(0.99); C870(0.94); C811(1.14)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C841(1.19); C1206(0.96); C870(0.92); C811(1.15)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C841(1.27); C1206(1.04); C870(1.12); C811(1.23)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C841(1.04); C1206(1.11); C870(1.04); C811(0.91)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C841(1.45); C1206(0.96); C870(1.17); C811(1.14)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C841(0.99); C1206(1.12); C870(1.03); C811(0.99)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C841(1.00); C1206(1.01); C870(0.90); C811(1.11)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C841(1.02); C1206(1.01); C870(1.01); C811(1.06)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C841(1.40); C1206(0.96); C870(1.05); C811(1.53)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C841(1.38); C1206(0.97); C870(1.09); C811(1.20)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C841(1.09); C1206(0.96); C870(1.09); C811(1.15)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C841(1.11); C1206(1.10); C870(1.13); C811(1.39)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C841(0.93); C1206(0.88); C870(0.96); C811(1.19)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C841(0.92); C1206(1.09); C870(1.07); C811(1.16)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C841(1.08); C1206(1.01); C870(1.00); C811(1.04)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C841(1.07); C1206(0.97); C870(0.93); C811(0.97)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C841(1.50); C1206(0.99); C870(1.20); C811(1.47)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C841(1.66); C1206(0.91); C870(1.22); C811(1.50)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C841(1.13); C1206(1.26); C870(0.95); C811(1.15)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C841(1.17); C1206(1.06); C870(0.99); C811(1.18)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C841(1.15); C1206(0.98); C870(1.17); C811(1.64)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C841(1.09); C1206(0.99); C870(1.03); C811(1.31)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C841(1.15); C1206(0.81); C870(1.05); C811(1.21)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C841(1.21); C1206(0.95); C870(1.15); C811(1.75)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C841(1.21); C1206(1.16); C870(1.03); C811(1.34)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C841(0.93); C1206(0.68); C870(0.94); C811(1.03)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C841(1.21); C1206(0.98); C870(0.98); C811(0.95)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C841(0.87); C1206(1.09); C870(0.99); C811(0.84)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C841(1.45); C1206(0.99); C870(1.04); C811(1.34)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C841(1.05); C1206(1.03); C870(1.07); C811(0.93)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C841(1.22); C1206(1.02); C870(1.07); C811(1.01)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C841(1.00); C1206(1.37); C870(0.91); C811(0.96)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C841(1.33); C1206(1.03); C870(1.03); C811(1.20)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C841(1.35); C1206(0.92); C870(1.04); C811(1.29)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C841(0.90); C1206(1.18); C870(0.99); C811(1.38)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C841(1.05); C1206(1.00); C870(1.03); C811(1.19)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C841(1.05); C1206(1.01); C870(1.08); C811(1.21)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C841(1.07); C1206(1.09); C870(1.03); C811(1.26)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C841(1.26); C1206(0.90); C870(1.01); C811(1.14)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C841(0.75); C1206(1.03); C870(0.99); C811(0.99)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C841(0.99); C1206(1.04); C870(0.94); C811(0.87)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C841(1.37); C1206(0.94); C870(1.14); C811(1.18)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C841(1.07); C1206(1.11); C870(0.98); C811(0.99)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C841(0.96); C1206(0.92); C870(0.95); C811(1.05)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C841(1.33); C1206(0.78); C870(2.36); C811(2.73)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C841(1.00); C1206(1.05); C870(0.96); C811(0.92)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C841(0.98); C1206(0.98); C870(1.02); C811(1.06)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C841(1.08); C1206(1.03); C870(0.97); C811(1.06)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C841(1.07); C1206(0.77); C870(1.13); C811(1.25)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C841(1.14); C1206(1.18); C870(1.12); C811(1.48)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C841(0.79); C1206(0.84); C870(0.91); C811(1.17)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C841(0.87); C1206(0.96); C870(1.02); C811(1.13)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C841(0.84); C1206(0.97); C870(0.90); C811(1.12)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C841(0.88); C1206(1.06); C870(1.03); C811(1.07)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C841(0.90); C1206(1.05); C870(1.01); C811(0.95)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C841(1.11); C1206(0.99); C870(1.06); C811(1.62)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C841(1.11); C1206(0.87); C870(1.58); C811(2.89)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C841(0.82); C1206(1.04); C870(0.93); C811(1.10)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C841(1.36); C1206(1.04); C870(1.08); C811(1.12)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C841(1.27); C1206(0.94); C870(1.06); C811(1.49)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C841(1.00); C1206(1.15); C870(1.02); C811(1.16)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C841(1.41); C1206(0.88); C870(1.90); C811(2.09)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C841(1.02); C1206(1.15); C870(1.11); C811(1.57)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C841(1.40); C1206(0.84); C870(0.98); C811(1.34)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C841(1.25); C1206(0.98); C870(1.02); C811(1.06)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C841(1.04); C1206(0.98); C870(0.95); C811(0.96)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C841(0.98); C1206(1.04); C870(0.87); C811(0.96)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C811(1.70); C1684(1.12)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C841(1.04); C1206(1.03); C870(0.92); C811(0.92)  LDD1671  [18]
 LDCM0427  Fragment51 HEK-293T C841(0.96); C1206(0.92); C870(1.00); C811(0.96)  LDD1631  [18]
 LDCM0022  KB02 HEK-293T C841(0.88); C1206(1.26); C1684(1.05); C870(0.93)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C841(0.72); C1206(1.11); C1684(0.91); C870(0.95)  LDD1497  [18]
 LDCM0024  KB05 HMCB C324(1.66); C1206(1.54)  LDD3312  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1684(0.98)  LDD2102  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1684(1.27)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1684(0.94)  LDD2092  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1684(1.22)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1684(0.39)  LDD2096  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1684(0.87)  LDD2098  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1684(1.53)  LDD2105  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1684(0.33)  LDD2118  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1684(0.96)  LDD2143  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1684(1.99)  LDD2153  [5]
 LDCM0090  Rapamycin JHH-7 2.91  LDD0213  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nectin-2 (NECTIN2) Nectin family Q92692
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Drebrin (DBN1) . Q16643

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(5r)-2-sulfanyl-5-[4-(Trifluoromethyl)Benzyl]-13-thiazol-4(5h)-one . DB08574

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402