Details of the Target

General Information of Target

Target ID LDTP15012
Target Name RNA-binding protein 26 (RBM26)
Gene Name RBM26
Gene ID 64062
Synonyms
C13orf10; RNA-binding protein 26; CTCL tumor antigen se70-2; RNA-binding motif protein 26
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSDDKSKSNDPKTEPKNCDPKCEQKCESKCQPSCLKKLLQRCFEKCPWEKCPAPPKCLP
CPSQSPSSCPPQPCTKPCPPKCPSSCPHACPPPCPPPE
Target Bioclass
Other
Function May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Uniprot ID
Q5T8P6
Ensemble ID
ENST00000267229.11
HGNC ID
HGNC:20327

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.V698M DBIA    Probe Info 
HCT15 SNV: p.A12T; p.S315N; p.P335H DBIA    Probe Info 
IM95 Deletion: p.E998del DBIA    Probe Info 
LN18 SNV: p.C53S DBIA    Probe Info 
MEWO Substitution: p.P310F DBIA    Probe Info 
MFE319 SNV: p.G879C DBIA    Probe Info 
NALM6 SNV: p.R177H DBIA    Probe Info 
SUPT1 SNV: p.R141H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y35(20.00); Y822(5.39)  LDD0257  [2]
TH216
 Probe Info  		Y35(20.00)  LDD0259  [2]
STPyne
 Probe Info  		K510(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y822(25.37)  LDD3495  [4]
HHS-465
 Probe Info  		Y699(4.85)  LDD2237  [5]
DBIA
 Probe Info  		C25(1.09)  LDD0080  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		K103(0.00); K533(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C53(0.00); C25(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C25(0.00); C53(0.00)  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C53(0.00); C25(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		N.A.  LDD0005  [12]
NHS
 Probe Info  		K533(0.00); K823(0.00); K585(0.00)  LDD0010  [12]
PPMS
 Probe Info  		N.A.  LDD0008  [12]
SF
 Probe Info  		Y699(0.00); Y822(0.00)  LDD0028  [14]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		C25(0.00); C53(0.00); C799(0.00)  LDD0018  [15]
Acrolein
 Probe Info  		C53(0.00); C25(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		5.97  LDD0213  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C25(0.78)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C25(0.89); C53(1.32)  LDD0532  [6]
 LDCM0226  AC11 HCT 116 C25(0.89); C53(1.17)  LDD0543  [6]
 LDCM0230  AC113 HCT 116 C25(1.01)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C25(0.86)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C25(0.95)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C25(0.95)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C25(0.91)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C25(0.89)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C25(1.02)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C25(0.91); C53(1.11)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C25(0.96)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C25(0.78)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C25(0.90)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C25(0.76)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C25(0.84)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C25(1.01)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C25(0.80)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C25(0.94)  LDD0562  [6]
 LDCM0259  AC14 HCT 116 C25(0.80); C53(1.19)  LDD0576  [6]
 LDCM0263  AC143 HCT 116 C53(0.91)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C53(0.88)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C53(0.86)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C53(0.87)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C53(0.82)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C53(0.94)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C53(0.92)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C25(0.83); C53(1.09)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C53(0.87)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C53(0.93)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C53(0.93)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C53(0.98)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C53(0.94)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C53(0.84)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C53(0.80)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C53(0.98)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C53(1.19)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C53(0.83)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C53(1.10)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C25(0.94)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C53(1.22)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C53(1.05)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C53(0.98)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C53(1.14)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C53(1.28)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C53(0.89)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C53(0.87)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C53(1.14)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C53(0.90)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C53(0.90)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C25(0.85)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C53(0.84)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C53(0.99)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C53(0.98)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C53(0.80)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C53(0.81)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C25(0.84); C53(1.01)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C53(0.87); C25(0.90)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C25(0.62); C53(1.16)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C25(1.02); C53(1.16)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C25(0.86); C53(1.08)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C25(0.84)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C25(0.83); C53(1.04)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C25(0.79); C53(0.97)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C25(0.85); C53(0.95)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C53(0.90); C25(0.92)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C25(0.67); C53(0.90)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C25(0.64); C53(1.13)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C25(1.56)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C25(1.07)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C25(1.28)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C25(1.48)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C25(0.79)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C25(1.57)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C25(1.31)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C25(1.28)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C25(1.07)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C25(1.36)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C25(1.04)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C25(1.23)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C53(0.91); C25(0.95)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C53(1.00); C25(1.07)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C53(1.03); C25(1.01)  LDD1561  [21]
 LDCM0323  AC6 HCT 116 C25(1.05); C53(1.26)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C53(1.00); C25(0.90)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C53(0.93); C25(0.89)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C53(0.90); C25(0.98)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C53(1.01); C25(1.05)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C53(0.93); C25(0.94)  LDD1567  [21]
 LDCM0334  AC7 HCT 116 C25(1.01); C53(1.10)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C53(0.94); C25(0.98)  LDD0662  [6]
 LDCM0349  AC83 HCT 116 C25(1.36)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C25(1.31)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C25(1.34)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C25(1.07)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C25(1.03)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C25(1.16)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C25(1.30)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C25(1.08)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C25(1.42)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C25(1.17)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C25(1.29)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C25(1.47)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C25(1.13)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C25(1.26)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C25(1.29)  LDD0681  [6]
 LDCM0248  AKOS034007472 HCT 116 C25(0.90); C53(1.49)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C25(0.79); C53(1.17)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C25(1.04); C53(1.41)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.36  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C53(0.00); H944(0.00); C25(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C25(1.01)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C25(0.96)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C25(0.83)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C25(0.88)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C25(0.95); C53(1.35)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C25(0.79); C53(1.28)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C25(0.92); C53(1.15)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C25(0.94); C53(1.11)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C53(1.19)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C53(1.29)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C53(1.07)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C53(1.32)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C53(1.11)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C25(0.56)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C53(1.21)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C53(1.19)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C53(0.89)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C53(0.74)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C53(0.86)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C53(0.96)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C53(0.92)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C25(1.05); C53(1.13)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C25(0.85); C53(1.18)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C25(0.81); C53(0.96)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C25(0.58)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C53(0.87); C25(0.98)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C25(1.11)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C25(1.09)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C25(0.99)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C25(1.40)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C53(0.98); C25(0.90)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C53(0.94); C25(0.95)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C53(0.95); C25(0.90)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C53(0.95); C25(0.98)  LDD1603  [21]
 LDCM0400  CL13 HCT 116 C25(0.87)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C25(0.83)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C25(0.94)  LDD0719  [6]
 LDCM0403  CL16 PaTu 8988t C25(1.30)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C25(1.09)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C25(1.31)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C25(1.33)  LDD1285  [6]
 LDCM0407  CL2 HCT 116 C25(0.98)  LDD0724  [6]
 LDCM0408  CL20 PaTu 8988t C25(1.26)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C25(1.30)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C25(1.34)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C25(1.53)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C25(1.34)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C25(1.43)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C25(1.25)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C25(1.45)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C25(1.40)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C25(1.36)  LDD1296  [6]
 LDCM0418  CL3 HCT 116 C25(0.62)  LDD0735  [6]
 LDCM0419  CL30 PaTu 8988t C25(1.46)  LDD1298  [6]
 LDCM0420  CL31 HEK-293T C53(0.94); C25(0.97)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C53(0.97); C25(0.99)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C53(0.89); C25(0.92)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C53(1.01); C25(0.93)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C53(0.89); C25(1.03)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C53(0.94); C25(0.99)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C53(0.97); C25(0.90)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C53(0.95); C25(0.90)  LDD1632  [21]
 LDCM0429  CL4 HCT 116 C25(0.76)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C53(1.04); C25(1.07)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C53(0.97); C25(0.90)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C53(1.01); C25(1.06)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C53(1.00); C25(1.01)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C53(0.98); C25(0.96)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C53(0.98); C25(0.91)  LDD1639  [21]
 LDCM0436  CL46 PaTu 8988t C25(1.10)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C25(1.23)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C25(1.27)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C25(1.24)  LDD1318  [6]
 LDCM0440  CL5 HCT 116 C25(0.99)  LDD0757  [6]
 LDCM0441  CL50 PaTu 8988t C25(1.34)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C25(1.25)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C25(1.33)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C25(1.53)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C25(1.37)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C25(1.15)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C25(0.34)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C25(2.37)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C25(1.47)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C25(2.68)  LDD1329  [6]
 LDCM0451  CL6 HCT 116 C25(0.94)  LDD0768  [6]
 LDCM0452  CL60 PaTu 8988t C25(2.01)  LDD1331  [6]
 LDCM0453  CL61 HCT 116 C53(0.91)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C53(0.97)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C53(1.03)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C53(0.99)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C53(1.07)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C53(1.16)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C53(1.08)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C53(0.98)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C53(0.94)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C25(0.99)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C53(0.90)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C53(0.95)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C53(1.05)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C53(0.95)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C53(0.99)  LDD0784  [6]
 LDCM0469  CL76 PaTu 8988t C25(1.11)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C25(0.93)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C25(0.87)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C25(1.19)  LDD1351  [6]
 LDCM0473  CL8 HCT 116 C25(0.98)  LDD0790  [6]
 LDCM0474  CL80 PaTu 8988t C25(1.21)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C25(1.12)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C25(1.41)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C25(1.05)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C25(1.19)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C25(0.98)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C25(1.63)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C25(1.78)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C25(1.45)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C25(1.11)  LDD1362  [6]
 LDCM0484  CL9 HCT 116 C25(1.04)  LDD0801  [6]
 LDCM0485  CL90 PaTu 8988t C25(1.27)  LDD1364  [6]
 LDCM0486  CL91 HCT 116 C25(1.02)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C25(0.94)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C25(0.84)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C25(0.80)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C25(0.88)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C25(0.84)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C25(0.95)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C25(0.90)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C25(0.91)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C53(0.92); C25(0.95)  LDD1698  [21]
 LDCM0625  F8 Ramos C25(1.15); C53(0.41)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C25(1.51); C53(0.95)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C25(0.02); C53(0.72)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C25(1.95)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C25(0.96); C53(1.11)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C25(3.30); C53(3.96)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C25(5.66)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C25(0.96); C53(0.23)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C25(4.41); C53(1.41)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C25(0.83); C53(1.17)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C25(1.29); C53(0.50)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C25(1.25); C53(0.41)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C25(1.06); C53(1.44)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C25(1.42); C53(1.44)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C53(0.96)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C25(1.31); C53(0.66)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C25(1.54); C53(0.78)  LDD2184  [22]
 LDCM0427  Fragment51 HEK-293T C53(0.97); C25(0.92)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C25(1.27); C53(0.51)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C25(1.26); C53(0.57)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C25(1.55); C53(0.61)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C25(5.13)  LDD2188  [22]
 LDCM0107  IAA HeLa H944(0.00); C25(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C25(1.09)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C25(1.42)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C25(1.37)  LDD0082  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0627  NUDT7-COV-1 HEK-293T C25(1.00)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C53(0.94); C25(0.72)  LDD2207  [23]
 LDCM0090  Rapamycin JHH-7 5.97  LDD0213  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic protein NCK2 (NCK2) . O43639

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.