Details of the Target

General Information of Target

Target ID LDTP19951
Target Name CYFIP-related Rac1 interactor A (CYRIA)
Gene Name CYRIA
Gene ID 81553
Synonyms
FAM49A; CYFIP-related Rac1 interactor A; Protein CYRIA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADTQCCPPPCEFISSAGTDLALGMGWDATLCLLPFTGFGKCAGIWNHMDEEPDNGDDRG
SRRTTGQGRKWAAHGTMAAPRVHTDYHPGGGSACSSVKVRSHVGHTGVFFFVDQDPLAVS
LTSQSLIPPLIKPGLLKAWGFLLLCAQPSANGHSLCCLLYTDLVSSHELSPFRALCLGPS
DAPSACASCNCLASTYYL
Target Bioclass
Other
Family
CYRI family
Subcellular location
Membrane
Function
May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling (Probable). May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions (Probable).
Uniprot ID
Q9H0Q0
Ensemble ID
ENST00000381323.7
HGNC ID
HGNC:25373

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C83(4.29)  LDD3335  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		3.89  LDD0213  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 769-P C83(1.29)  LDD2246  [1]
 LDCM0023  KB03 769-P C83(1.75)  LDD2663  [1]
 LDCM0024  KB05 MONO-MAC-6 C83(4.29)  LDD3335  [1]
 LDCM0090  Rapamycin JHH-7 3.89  LDD0213  [3]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.