General Information of Target

Target ID LDTP05038
Target Name AP-2 complex subunit beta (AP2B1)
Gene Name AP2B1
Gene ID 163
Synonyms
ADTB2; CLAPB1; AP-2 complex subunit beta; AP105B; Adaptor protein complex AP-2 subunit beta; Adaptor-related protein complex 2 subunit beta; Beta-2-adaptin; Beta-adaptin; Clathrin assembly protein complex 2 beta large chain; Plasma membrane adaptor HA2/AP2 adaptin beta subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT
DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE
YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA
VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI
CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY
VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK
YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV
VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST
DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL
DSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKA
KGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQ
SIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLAT
WKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWIL
AELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN
Target Bioclass
Transporter and channel
Family
Adaptor complexes large subunit family
Subcellular location
Cell membrane
Function
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.
Uniprot ID
P63010
Ensemble ID
ENST00000610402.5
HGNC ID
HGNC:563

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
8.77  LDD0402  [1]
A-EBA
 Probe Info 
3.80  LDD0215  [2]
CY-1
 Probe Info 
100.00  LDD0243  [3]
CY4
 Probe Info 
100.00  LDD0244  [3]
N1
 Probe Info 
100.00  LDD0242  [3]
TH211
 Probe Info 
Y121(16.45)  LDD0260  [4]
C-Sul
 Probe Info 
2.72  LDD0066  [5]
TH214
 Probe Info 
Y121(17.16)  LDD0258  [4]
TH216
 Probe Info 
Y121(8.60)  LDD0259  [4]
STPyne
 Probe Info 
K11(5.29); K19(1.62); K31(7.21); K719(10.00)  LDD0277  [6]
Probe 1
 Probe Info 
Y136(91.27); Y333(63.65); Y361(17.40); Y524(16.39)  LDD3495  [7]
DBIA
 Probe Info 
C391(8.01); C241(3.67); C66(3.04); C55(4.63)  LDD3310  [8]
AHL-Pu-1
 Probe Info 
C123(10.39)  LDD0168  [9]
HHS-475
 Probe Info 
Y6(0.61); Y737(0.83); Y136(1.11); Y121(1.26)  LDD0264  [10]
HHS-465
 Probe Info 
Y121(7.66); Y136(10.00)  LDD2237  [11]
5E-2FA
 Probe Info 
H749(0.00); H858(0.00); H773(0.00)  LDD2235  [12]
ATP probe
 Probe Info 
N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info 
C129(0.00); C918(0.00); C391(0.00); C95(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info 
C123(0.00); C57(0.00); C380(0.00); C129(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info 
C433(0.00); C241(0.00)  LDD0030  [16]
IPIAA_L
 Probe Info 
C123(0.00); C241(0.00); C565(0.00); C95(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info 
C380(0.00); C129(0.00); C918(0.00); C391(0.00)  LDD0037  [14]
BTD
 Probe Info 
N.A.  LDD0004  [17]
JW-RF-010
 Probe Info 
C857(0.00); C380(0.00)  LDD0026  [18]
NAIA_4
 Probe Info 
C57(0.00); C95(0.00); C123(0.00); C129(0.00)  LDD2226  [19]
WYneN
 Probe Info 
C857(0.00); C123(0.00); C391(0.00)  LDD0021  [17]
WYneO
 Probe Info 
C857(0.00); C95(0.00); C123(0.00)  LDD0022  [17]
ENE
 Probe Info 
C95(0.00); C241(0.00); C112(0.00)  LDD0006  [17]
IPM
 Probe Info 
C241(0.00); C144(0.00); C95(0.00); C857(0.00)  LDD0147  [18]
PF-06672131
 Probe Info 
N.A.  LDD0017  [20]
TFBX
 Probe Info 
C57(0.00); C380(0.00); C144(0.00); C95(0.00)  LDD0148  [18]
VSF
 Probe Info 
C123(0.00); C95(0.00); C391(0.00); C857(0.00)  LDD0007  [17]
1c-yne
 Probe Info 
N.A.  LDD0228  [21]
Acrolein
 Probe Info 
C857(0.00); C123(0.00); C391(0.00); C144(0.00)  LDD0217  [22]
Cinnamaldehyde
 Probe Info 
C857(0.00); C241(0.00)  LDD0220  [22]
Crotonaldehyde
 Probe Info 
C857(0.00); C241(0.00); C112(0.00); C123(0.00)  LDD0219  [22]
Methacrolein
 Probe Info 
C144(0.00); C123(0.00); C95(0.00); C241(0.00)  LDD0218  [22]
W1
 Probe Info 
C241(0.00); C123(0.00); C857(0.00)  LDD0236  [23]
AOyne
 Probe Info 
7.30  LDD0443  [24]
NAIA_5
 Probe Info 
C380(0.00); C129(0.00); C918(0.00); C391(0.00)  LDD2223  [19]
HHS-482
 Probe Info 
Y121(0.98); Y328(0.79); Y737(1.02)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info 
6.04  LDD0471  [25]
FFF probe13
 Probe Info 
12.53  LDD0475  [25]
FFF probe14
 Probe Info 
12.04  LDD0477  [25]
FFF probe3
 Probe Info 
7.08  LDD0464  [25]
STS-1
 Probe Info 
N.A.  LDD0136  [26]
STS-2
 Probe Info 
N.A.  LDD0138  [26]
Alk-rapa
 Probe Info 
4.33  LDD0213  [27]
DA-2
 Probe Info 
N.A.  LDD0071  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C857(0.53)  LDD2142  [29]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C857(0.86)  LDD2112  [29]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C857(0.91); C123(0.83); C112(0.52)  LDD2095  [29]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C857(0.80)  LDD2130  [29]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C857(1.03); C123(1.35); C112(1.07); C144(0.89)  LDD2117  [29]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C857(2.20); C112(1.42); C241(1.27); C144(0.97)  LDD2152  [29]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C123(0.83); C241(1.31)  LDD2103  [29]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C857(0.98); C112(0.35); C95(0.63); C241(1.01)  LDD2132  [29]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C857(0.45); C112(0.73); C95(0.66)  LDD2131  [29]
 LDCM0025  4SU-RNA HEK-293T C123(10.39)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C123(10.60); C112(3.13)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C57(1.02); C433(1.03); C857(0.98); C225(1.03)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C57(1.07); C433(1.33); C857(1.05); C225(0.97)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C57(1.09); C433(0.85); C857(0.87)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C57(1.01); C433(0.80); C857(1.14)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C57(0.98); C433(0.98); C857(1.12); C225(1.11)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C57(0.95); C433(1.06); C857(1.06)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C57(1.01); C433(0.86); C857(1.01); C225(0.76)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C57(1.03); C433(1.33); C857(1.03); C225(1.02)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C57(1.07); C433(0.74); C857(0.80)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C57(1.13); C433(1.55); C857(1.05); C225(0.99)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C57(1.06); C433(0.96); C857(1.26)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C57(0.99); C433(0.95); C857(1.03)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C57(0.98); C433(0.96); C857(1.07); C225(1.09)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C57(0.89); C433(0.80); C857(1.00)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C57(0.96); C433(0.98); C857(1.09)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C57(1.04); C433(0.87); C857(1.00); C225(0.86)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C57(1.06); C433(1.14); C857(1.08); C225(1.18)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C57(1.00); C433(0.84); C857(0.94)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C57(1.04); C433(1.11); C857(1.18)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C57(1.00); C433(0.99); C857(1.05)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C57(1.03); C433(0.92); C857(1.12)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C57(0.97); C433(0.95); C857(1.11); C225(1.14)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C57(0.92); C433(0.93); C857(1.09)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C57(0.96); C433(0.88); C857(1.03)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C57(1.05); C433(1.01); C857(1.00); C225(1.10)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C57(1.10); C433(1.28); C857(1.00); C225(0.95)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C57(1.03); C433(0.83); C857(0.95)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C57(1.04); C433(0.88); C857(1.07)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C57(1.00); C433(1.02); C857(0.98)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C57(1.05); C433(1.01); C857(1.09); C225(1.23)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C57(0.91); C433(1.18); C857(1.03)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C57(1.10); C433(1.11); C857(1.55)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C57(1.01); C433(0.99); C857(1.07)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C57(1.01); C433(0.88); C857(0.99); C225(1.09)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C57(1.11); C433(1.21); C857(1.04); C225(0.98)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C57(1.04); C433(1.06); C857(0.93)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C57(1.02); C433(0.96); C857(1.00)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C57(0.99); C433(0.97); C857(1.01)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C57(1.00); C433(0.93); C857(1.15); C225(1.17)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C57(0.90); C433(0.95); C857(1.06)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C57(0.97); C433(1.03); C857(1.01)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C57(1.05); C433(0.72); C857(0.96); C225(0.96)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C57(1.06); C433(1.21); C857(1.03)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C57(1.10); C433(1.27); C857(0.98); C225(0.87)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C57(1.12); C433(0.87); C857(0.88)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C57(1.03); C433(0.97); C857(0.85)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C57(1.05); C433(0.95); C857(1.00)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C57(0.99); C433(1.01); C857(1.07); C225(0.88)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C57(0.93); C433(0.96); C857(0.96)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C57(1.01); C433(0.92); C857(1.05)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C57(1.06); C433(0.88); C857(1.05); C225(1.13)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C57(1.17); C433(1.39); C857(1.09); C225(0.93)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C57(1.13); C433(0.76); C857(1.01)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C57(1.00); C433(0.89); C857(1.06); C225(1.00)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C57(1.13); C433(1.04); C857(1.20)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C57(1.03); C433(1.22); C857(1.07)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C57(1.05); C433(0.99); C857(1.07); C225(1.24)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C57(1.02); C433(0.79); C857(1.11)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C57(1.01); C433(0.93); C857(1.14)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C57(1.01); C433(1.08); C857(1.07)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C57(1.04); C433(0.89); C857(1.05)  LDD1569  [30]
 LDCM0545  Acetamide MDA-MB-231 C857(0.55)  LDD2138  [29]
 LDCM0520  AKOS000195272 MDA-MB-231 C857(0.78); C123(0.59); C112(0.89); C95(0.93)  LDD2113  [29]
 LDCM0248  AKOS034007472 HEK-293T C57(1.01); C433(1.04); C857(1.04)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C57(1.01); C433(0.91); C857(0.92); C225(1.10)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C57(1.04); C433(1.00); C857(1.10)  LDD1514  [30]
 LDCM0498  BS-3668 MDA-MB-231 C857(0.64); C123(1.01); C112(0.81); C241(0.66)  LDD2091  [29]
 LDCM0108  Chloroacetamide HeLa C123(0.00); C57(0.00); C144(0.00); C857(0.00)  LDD0222  [22]
 LDCM0367  CL1 HEK-293T C57(1.07); C433(0.93); C857(1.00); C225(0.94)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C57(0.88); C433(0.86); C857(1.06); C225(1.17)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C57(1.11); C433(0.94); C857(0.95); C214(0.75)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C57(1.06); C433(1.27); C857(1.05); C225(0.84)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C57(1.10); C433(0.72); C857(1.05)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C57(0.98); C433(0.90); C857(1.17); C225(0.94)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C57(1.05); C433(1.41); C857(0.99); C214(0.76)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C57(1.00); C433(1.20); C857(0.97); C225(0.80)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C57(0.99); C433(0.98); C857(1.00)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C57(0.97); C433(1.36); C857(1.00); C225(1.02)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C57(1.00); C433(0.97); C857(1.00); C214(0.90)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C57(1.02); C433(1.37); C857(0.94); C225(0.87)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C57(0.73); C433(1.23); C857(1.19)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C57(1.10); C433(1.00); C857(1.00)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C57(0.99); C433(1.01); C857(1.07); C225(0.98)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C57(1.06); C433(0.96); C857(0.99); C214(0.92)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C57(1.00); C433(1.16); C857(1.00); C225(1.05)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C57(1.25); C433(0.87); C857(1.00)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C57(0.93); C433(1.10); C857(1.14); C225(1.04)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C57(1.07); C433(0.96); C857(1.01); C214(0.97)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C57(1.06); C433(1.25); C857(1.01); C225(0.88)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C57(1.07); C433(1.06); C857(1.04)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C57(0.96); C433(0.69); C857(1.05); C225(0.97)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C57(0.89); C433(1.32); C857(1.17)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C57(1.03); C433(0.95); C857(1.01); C214(0.90)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C57(1.08); C433(1.22); C857(1.04); C225(0.84)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C57(1.10); C433(0.87); C857(0.95)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C57(1.05); C433(0.67); C857(1.08); C225(0.91)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C57(1.05); C433(1.01); C857(0.95); C214(0.73)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C57(1.38); C433(1.39); C857(1.04); C225(0.97)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C57(1.34); C433(0.82); C857(1.03)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C57(1.13); C433(0.72); C857(1.05); C225(1.06)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C57(1.18); C433(0.99); C857(1.01); C214(0.96)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C57(1.06); C433(1.42); C857(0.97); C225(0.88)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C57(0.92); C433(0.92); C857(1.02)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C57(1.02); C433(0.55); C857(1.11); C225(1.16)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C57(0.97); C433(1.07); C857(1.07); C214(0.92)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C57(1.02); C433(0.92); C857(0.86); C225(1.16)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C57(0.87); C433(1.52); C857(1.05); C225(1.06)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C57(0.86); C433(0.93); C857(0.79)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C57(1.06); C433(1.12); C857(0.89)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C57(0.81); C433(0.94); C857(1.11)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C57(0.93); C433(0.93); C857(1.05)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C57(0.82); C433(1.13); C857(1.10); C225(1.04)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C57(0.67); C433(1.01); C857(1.13)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C57(0.87); C433(1.16); C857(1.06)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C57(1.21); C433(1.34); C857(0.95); C225(0.90)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C57(0.92); C433(0.89); C857(1.08)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C57(0.94); C433(0.76); C857(1.11); C225(0.93)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C57(0.92); C433(0.80); C857(0.94); C214(0.78)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C57(0.93); C433(0.84); C857(1.02); C225(0.93)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C57(1.03); C433(0.74); C857(1.03); C225(1.08)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C57(0.85); C433(1.33); C857(1.10); C225(1.12)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C57(0.84); C433(0.87); C857(0.86)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C57(0.79); C433(1.03); C857(1.26)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C57(0.87); C433(0.79); C857(1.12)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C57(0.84); C433(1.03); C857(1.06); C225(0.94)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C57(0.66); C433(1.67); C857(1.12)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C57(0.86); C433(1.21); C857(1.15)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C57(1.10); C433(1.37); C857(1.01); C225(1.01)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C57(0.91); C433(0.93); C857(0.96); C225(0.94)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C57(1.10); C433(1.11); C857(0.97); C214(0.94)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C57(0.97); C433(0.82); C857(0.99); C214(0.79)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C57(0.92); C433(0.93); C857(1.03); C225(0.93)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C57(0.77); C433(1.51); C857(1.11); C225(0.85)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C57(0.83); C433(0.95); C857(1.03)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C57(0.81); C433(1.08); C857(1.20)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C57(0.86); C433(1.49); C857(1.07)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C57(0.79); C433(1.08); C857(1.14); C225(0.82)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C57(0.64); C433(1.18); C857(1.16)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C57(0.82); C433(1.01); C857(1.17)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C57(1.23); C433(1.03); C857(1.00); C225(1.01)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C57(1.00); C433(0.84); C857(0.91); C225(1.06)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C57(0.99); C433(1.01); C857(0.99)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C57(0.91); C433(1.12); C857(0.97); C214(0.90)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C57(0.96); C433(1.00); C857(0.93); C225(1.04)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C57(1.00); C433(1.25); C857(0.93); C225(1.13)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C57(0.79); C433(0.94); C857(1.11)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C57(0.77); C433(1.05); C857(1.15)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C57(0.89); C433(1.24); C857(1.08)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C57(0.79); C433(1.09); C857(1.18); C225(1.00)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C57(0.63); C433(1.09); C857(1.15)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C57(1.03); C433(1.40); C857(0.95); C225(0.88)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C57(0.84); C433(1.18); C857(1.13)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C57(1.28); C433(1.27); C857(1.02); C225(0.98)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C57(1.03); C433(0.85); C857(1.01)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C57(0.94); C433(0.96); C857(1.09); C225(1.16)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C57(1.00); C433(1.00); C857(0.94); C214(0.95)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C57(0.94); C433(0.71); C857(0.96); C225(1.04)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C57(0.88); C433(1.38); C857(1.05); C225(1.03)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C57(0.89); C433(0.82); C857(0.98)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C57(0.80); C433(1.09); C857(0.93)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C57(0.85); C433(0.77); C857(1.03)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C57(0.96); C433(1.03); C857(1.14)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C57(0.80); C433(1.13); C857(1.15); C225(1.05)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C57(0.65); C433(1.15); C857(1.08)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C57(0.84); C433(1.21); C857(1.06)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C57(1.21); C433(1.23); C857(1.01); C225(1.09)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C57(1.14); C433(1.20); C857(1.09)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C57(1.01); C433(1.22); C857(1.03); C214(0.79)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C57(0.98); C433(0.69); C857(0.97); C225(1.04)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C57(0.92); C433(1.29); C857(1.00); C225(1.11)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C57(0.90); C433(0.81); C857(0.90)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C57(1.59); C433(1.07); C857(1.64)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C57(0.81); C433(1.02); C857(1.13)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C57(0.91); C433(1.27); C857(1.01)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C57(0.83); C433(1.01); C857(1.14); C225(0.98)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C57(0.71); C433(1.24); C857(1.10)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C57(0.92); C433(1.09); C857(1.12)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C57(1.49); C433(1.96); C857(1.03); C225(0.94)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C57(1.70); C433(0.94); C857(1.04)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C57(1.08); C433(0.84); C857(0.97); C225(0.98)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C57(1.23); C433(1.27); C857(1.02); C214(0.89)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C57(1.09); C433(0.90); C857(0.96); C225(1.09)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C57(0.86); C433(0.96); C857(0.96)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C57(1.37); C433(1.34); C857(1.02); C225(1.18)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C57(0.89); C433(0.92); C857(1.15)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C57(0.96); C433(1.02); C857(1.08)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C57(1.06); C433(1.19); C857(1.00)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C57(0.88); C433(0.91); C857(1.10); C225(1.09)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C57(1.11); C433(1.24); C857(1.07)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C57(1.07); C433(1.14); C857(1.06)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C57(1.19); C433(1.29); C857(0.97); C225(0.86)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C57(1.12); C433(0.85); C857(0.94)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C57(0.98); C433(0.78); C857(1.17); C225(1.01)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C57(0.88); C433(0.69); C857(1.05); C225(1.04)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C123(1.16)  LDD1702  [29]
 LDCM0468  Fragment33 HEK-293T C57(0.99); C433(0.77); C857(1.06); C225(0.96)  LDD1671  [30]
 LDCM0427  Fragment51 HEK-293T C57(0.94); C433(0.87); C857(1.06)  LDD1631  [30]
 LDCM0116  HHS-0101 DM93 Y6(0.61); Y737(0.83); Y136(1.11); Y121(1.26)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y737(0.69); Y6(0.74); Y136(0.85); Y121(1.08)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y6(0.64); Y737(0.71); Y121(0.79); Y136(0.95)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y737(0.81); Y121(0.94); Y136(0.99); Y6(1.05)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y6(0.20); Y121(0.78); Y136(1.06); Y737(1.40)  LDD0268  [10]
 LDCM0107  IAA HeLa C123(0.00); C144(0.00); C112(0.00); H858(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C857(0.96); C57(0.91)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C857(1.02); C57(1.03)  LDD1497  [30]
 LDCM0024  KB05 COLO792 C391(8.01); C241(3.67); C66(3.04); C55(4.63)  LDD3310  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C857(0.70); C123(1.30); C144(0.55)  LDD2121  [29]
 LDCM0109  NEM HeLa H149(0.00); H250(0.00); H858(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C857(0.64)  LDD2089  [29]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C857(0.94); C112(1.33)  LDD2093  [29]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C857(1.49); C123(1.38)  LDD2094  [29]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C857(0.83); C123(0.60); C144(0.13); C129(0.34)  LDD2096  [29]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C112(0.76); C241(0.65); C144(0.79)  LDD2097  [29]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C857(0.76); C123(0.95)  LDD2098  [29]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C857(1.38)  LDD2099  [29]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C857(0.54); C241(0.69)  LDD2100  [29]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C857(0.59); C123(0.88); C112(1.46); C241(1.56)  LDD2101  [29]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C857(0.63); C241(0.97)  LDD2104  [29]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C857(1.07); C123(1.93); C241(1.52)  LDD2105  [29]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C857(0.90); C123(0.99); C112(0.87); C95(1.18)  LDD2107  [29]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C857(0.68); C123(1.04)  LDD2108  [29]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C123(0.86); C112(0.64); C95(0.96); C241(0.93)  LDD2109  [29]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C112(1.04); C241(1.12); C129(1.03)  LDD2111  [29]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C857(0.49); C123(0.33); C112(0.56); C95(0.60)  LDD2115  [29]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C241(3.06); C144(0.52); C129(0.64)  LDD2116  [29]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C857(1.34); C144(0.52); C129(0.55); C380(1.36)  LDD2118  [29]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C857(1.08); C112(1.91); C241(2.23)  LDD2119  [29]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C857(0.80); C123(0.96); C112(0.95); C241(1.05)  LDD2120  [29]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C857(0.82); C144(0.22); C129(0.31)  LDD2122  [29]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C857(1.47); C123(1.26); C112(1.01); C241(0.91)  LDD2123  [29]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C857(0.94); C241(0.93); C144(0.24)  LDD2124  [29]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C857(0.88); C123(1.13); C112(0.93); C241(0.85)  LDD2125  [29]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C857(1.00); C241(1.48); C144(0.15); C129(0.41)  LDD2126  [29]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C857(1.02); C123(1.51); C112(1.13); C241(0.89)  LDD2127  [29]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C857(0.98); C123(0.94)  LDD2128  [29]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C857(0.60); C123(0.40); C112(0.66)  LDD2133  [29]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C857(0.33); C123(0.58); C112(0.46); C95(0.63)  LDD2134  [29]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C857(2.34); C123(1.88); C112(1.66); C95(2.24)  LDD2135  [29]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C857(1.04); C123(1.36); C112(1.29); C95(1.96)  LDD2136  [29]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C857(1.11); C123(1.41); C112(1.05); C241(1.01)  LDD2137  [29]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C857(2.70)  LDD1700  [29]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C857(0.95)  LDD2140  [29]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C857(0.72)  LDD2141  [29]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C857(0.90); C123(0.69); C112(0.85); C144(1.09)  LDD2143  [29]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C857(2.11); C123(1.59); C112(2.19); C95(2.59)  LDD2144  [29]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C123(1.10); C241(0.87); C144(0.85)  LDD2146  [29]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C857(3.56); C112(1.47); C241(3.67)  LDD2147  [29]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C857(0.42); C112(0.40); C144(0.38)  LDD2148  [29]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C857(1.21); C144(0.28); C129(0.55)  LDD2149  [29]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C857(0.54); C112(0.54); C241(1.14); C144(0.34)  LDD2150  [29]
 LDCM0627  NUDT7-COV-1 HEK-293T C144(0.99)  LDD2206  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C380(1.89); C391(0.22)  LDD2207  [31]
 LDCM0090  Rapamycin JHH-7 4.33  LDD0213  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Dopamine beta-hydroxylase (DBH) Copper type II ascorbate-dependent monooxygenase family P09172
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Nitric oxide synthase 3 (NOS3) NOS family P29474
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Peptidase C12 family P09936
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
N-terminal kinase-like protein (SCYL1) Protein kinase superfamily Q96KG9
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) Ser/Thr protein kinase family Q9BXM7
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Transporter and channel
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family Q96CW1
Amyloid-beta precursor protein (APP) APP family P05067
Beta-arrestin-1 (ARRB1) Arrestin family P49407
Clathrin interactor 1 (CLINT1) Epsin family Q14677
Huntingtin (HTT) Huntingtin family P42858
Importin subunit alpha-1 (KPNA2) Importin alpha family P52292
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
ADP/ATP translocase 3 (SLC25A6) Mitochondrial carrier (TC 2.A.29) family P12236
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Peroxisome assembly protein 26 (PEX26) Peroxin-26 family Q7Z412
Peripheral-type benzodiazepine receptor-associated protein 1 (TSPOAP1) RIMBP family O95153
Alpha-synuclein (SNCA) Synuclein family P37840
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AF4/FMR2 family member 4 (AFF4) AF4 family Q9UHB7
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-2 (AP1M2) Adaptor complexes medium subunit family Q9Y6Q5
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Ataxin-1 (ATXN1) ATXN1 family P54253
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Peroxisomal targeting signal 1 receptor (PEX5) Peroxisomal targeting signal receptor family P50542
Alpha-2-macroglobulin (A2M) Protease inhibitor I39 (alpha-2-macroglobulin) family P01023
Splicing factor U2AF 35 kDa subunit (U2AF1) Splicing factor SR family Q01081
Aftiphilin (AFTPH) . Q6ULP2
Arf-GAP domain and FG repeat-containing protein 1 (AGFG1) . P52594
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Epidermal growth factor receptor substrate 15 (EPS15) . P42566
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Intersectin-1 (ITSN1) . Q15811
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Low density lipoprotein receptor adapter protein 1 (LDLRAP1) . Q5SW96
MAGE-like protein 2 (MAGEL2) . Q9UJ55
Male-enhanced antigen 1 (MEA1) . Q16626
Methyl-CpG-binding protein 2 (MECP2) . P51608
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) . Q9UIG4
Small integral membrane protein 34 (SMIM34) . A8MWV9
TAR DNA-binding protein 43 (TARDBP) . Q13148
Testis-expressed protein 12 (TEX12) . Q9BXU0

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.