Details of the Target

General Information of Target

Target ID LDTP05101
Target Name General transcription factor II-I (GTF2I)
Gene Name GTF2I
Gene ID 2969
Synonyms
BAP135; WBSCR6; General transcription factor II-I; GTFII-I; TFII-I; Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; SPIN; Williams-Beuren syndrome chromosomal region 6 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTE
RGRAFVNTRKDFQKDFVKYCVEEEEKAAEMHKMKSTTQANRMSVDAVEIETLRKTVEDYF
CFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVK
EESEDPDYYQYNIQAGPSETDDVDEKQPLSKPLQGSHHSSEGNEGTEMEVPAEDSTQHVP
SETSEDPEVEVTIEDDDYSPPSKRPKANELPQPPVPEPANAGKRKVREFNFEKWNARITD
LRKQVEELFERKYAQAIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLE
RILLAKERIRFVIKKHELLNSTREDLQLDKPASGVKEEWYARITKLRKMVDQLFCKKFAE
ALGSTEAKAVPYQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKR
PELLTHSTTEVTQPRTNTPVKEDWNVRITKLRKQVEEIFNLKFAQALGLTEAVKVPYPVF
ESNPEFLYVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVVKKPELVISYLPPGMASK
INTKALQSPKRPRSPGSNSKVPEIEVTVEGPNNNNPQTSAVRTPTQTNGSNVPFKPRGRE
FSFEAWNAKITDLKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPF
RRPSTFGIPRLEKILRNKAKIKFIIKKPEMFETAIKESTSSKSPPRKINSSPNVNTTASG
VEDLNIIQVTIPDDDNERLSKVEKARQLREQVNDLFSRKFGEAIGMGFPVKVPYRKITIN
PGCVVVDGMPPGVSFKAPSYLEISSMRRILDSAEFIKFTVIRPFPGLVINNQLVDQSESE
GPVIQESAEPSQLEVPATEEIKETDGSSQIKQEPDPTW
Target Bioclass
Transcription factor
Family
TFII-I family
Subcellular location
Cytoplasm
Function
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.
Uniprot ID
P78347
Ensemble ID
ENST00000443166.5
HGNC ID
HGNC:4659

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.R101W DBIA    Probe Info 
KPL1 Insertion: p.V309IfsTer18
SNV: .		 DBIA    Probe Info 
PANC0403 SNV: p.E84Ter DBIA    Probe Info 
RKO SNV: p.L142V DBIA    Probe Info 
TE1 SNV: p.T238I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.81  LDD0402  [1]
A-EBA
 Probe Info  		3.31  LDD0215  [2]
TH211
 Probe Info  		Y460(20.00); Y492(20.00); Y894(20.00); Y124(19.69)  LDD0257  [3]
TH216
 Probe Info  		Y138(20.00); Y503(20.00); Y79(10.97); Y920(10.85)  LDD0259  [3]
Probe 1
 Probe Info  		Y79(17.65); Y138(18.57); Y165(12.23); Y460(21.13)  LDD3495  [4]
BTD
 Probe Info  		C215(1.16)  LDD1700  [5]
AHL-Pu-1
 Probe Info  		C215(3.95)  LDD0169  [6]
HHS-475
 Probe Info  		Y920(0.95)  LDD0264  [7]
HHS-465
 Probe Info  		Y920(10.00)  LDD2237  [8]
DBIA
 Probe Info  		C215(0.99); C80(0.90)  LDD0078  [9]
5E-2FA
 Probe Info  		H161(0.00); H546(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K494(0.00); K526(0.00); K343(0.00); K806(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C745(0.00); C903(0.00); C475(0.00); C34(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C475(0.00); C745(0.00); C80(0.00); C215(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C745(0.00); C475(0.00); C34(0.00); C215(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		C215(0.00); C903(0.00)  LDD0026  [14]
NAIA_4
 Probe Info  		C80(0.00); C215(0.00)  LDD2226  [15]
TFBX
 Probe Info  		C215(0.00); C745(0.00); C475(0.00); C903(0.00)  LDD0027  [14]
WYneN
 Probe Info  		C475(0.00); C745(0.00); C215(0.00)  LDD0021  [16]
WYneO
 Probe Info  		C475(0.00); C745(0.00); C215(0.00)  LDD0022  [16]
DA-P3
 Probe Info  		N.A.  LDD0178  [17]
1d-yne
 Probe Info  		N.A.  LDD0356  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
Compound 11
 Probe Info  		N.A.  LDD2213  [19]
IPM
 Probe Info  		N.A.  LDD0005  [16]
NHS
 Probe Info  		K130(0.00); K160(0.00); K456(0.00); K561(0.00)  LDD0010  [16]
NPM
 Probe Info  		N.A.  LDD0016  [16]
PF-06672131
 Probe Info  		C215(0.00); C475(0.00)  LDD0017  [20]
SF
 Probe Info  		K130(0.00); Y503(0.00); Y652(0.00); K645(0.00)  LDD0028  [21]
STPyne
 Probe Info  		K130(0.00); K488(0.00)  LDD0009  [16]
VSF
 Probe Info  		N.A.  LDD0007  [16]
Phosphinate-6
 Probe Info  		C215(0.00); C34(0.00); C903(0.00)  LDD0018  [22]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1c-yne
 Probe Info  		K488(0.00); K456(0.00); K221(0.00); K891(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		H546(0.00); H498(0.00); C215(0.00); C34(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		H546(0.00); C215(0.00); C80(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C215(0.00); C80(0.00); C34(0.00)  LDD0218  [24]
W1
 Probe Info  		C215(0.00); C475(0.00); C903(0.00)  LDD0236  [25]
AOyne
 Probe Info  		4.90  LDD0443  [26]
NAIA_5
 Probe Info  		C745(0.00); C475(0.00); C34(0.00); C215(0.00)  LDD2223  [15]
HHS-482
 Probe Info  		Y460(0.60); Y920(0.84)  LDD2239  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		5.55  LDD0464  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]
Alk-rapa
 Probe Info  		6.47  LDD0213  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C745(0.48)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C745(0.94)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C475(1.10); C215(0.88)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C475(0.97); C215(1.04)  LDD2152  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C215(3.95)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C121(0.72); C123(0.78); C215(1.39); C475(1.24)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C121(0.94); C123(1.00); C215(1.15); C34(0.96)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C121(0.54); C123(0.50); C215(1.11); C34(0.81)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C121(0.61); C123(0.55); C215(1.04); C34(0.97)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C121(0.62); C123(0.61); C215(1.14); C34(1.38)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C121(0.53); C123(0.44); C215(1.37); C34(1.26)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C121(0.52); C123(0.51); C215(1.25); C34(1.53)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C121(0.53); C123(0.46); C215(1.32); C34(1.06)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C121(0.47); C123(0.44); C215(1.31); C34(0.80)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C121(0.52); C123(0.55); C215(1.42); C34(1.34)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C121(0.56); C123(0.50); C215(1.05); C34(1.86)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C121(0.65); C123(0.61); C215(0.90); C34(0.93)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C121(0.95); C123(1.06); C215(1.23); C34(0.89)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C121(0.63); C123(0.52); C215(1.00); C34(0.61)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C121(0.64); C123(0.55); C215(0.99); C34(0.59)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C121(0.55); C123(0.49); C215(1.27); C34(0.97)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C121(0.88); C123(0.79); C215(1.09); C475(1.06)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C121(0.80); C123(0.53); C215(1.19); C475(1.12)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C121(0.74); C123(0.52); C215(1.20); C475(0.98)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C121(0.72); C123(0.50); C215(1.22); C475(1.02)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C121(0.81); C123(0.59); C215(1.15); C475(1.10)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C121(0.85); C123(0.74); C215(1.07); C475(1.10)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C121(0.87); C123(0.59); C215(1.13); C475(1.02)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C121(0.91); C123(0.86); C215(1.15); C34(0.97)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C121(1.16); C123(0.65); C215(1.23); C475(0.94)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C121(1.00); C123(0.74); C215(1.05); C475(1.19)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C121(0.89); C123(0.75); C215(1.08); C475(0.92)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C121(1.00); C123(0.83); C215(1.05); C475(1.13)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C121(0.97); C123(0.71); C215(1.07); C475(1.25)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C121(0.91); C123(0.71); C215(1.08); C475(1.13)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C121(0.68); C123(0.46); C215(1.14); C475(1.18)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C121(0.77); C123(0.52); C215(1.12); C475(1.23)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C121(0.96); C123(0.75); C215(1.25); C475(1.16)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C121(1.02); C123(1.08); C215(0.85); C475(0.99)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C121(0.88); C123(0.80); C215(1.04); C475(1.04)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C121(1.07); C123(1.09); C215(0.84); C475(0.74)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C121(0.94); C123(0.97); C215(0.92); C475(1.01)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C121(0.90); C123(0.80); C215(0.99); C475(1.04)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C121(0.92); C123(0.75); C215(1.06); C475(0.98)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C121(0.93); C123(0.72); C215(1.01); C475(1.05)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C121(0.95); C123(0.79); C215(1.03); C475(1.10)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C121(0.95); C123(0.83); C215(1.01); C475(1.04)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C121(1.08); C123(0.81); C215(1.10); C475(1.12)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C121(0.93); C123(0.81); C215(1.06); C475(1.10)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C121(1.13); C123(1.10); C215(1.09); C34(0.92)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C121(0.99); C123(0.71); C215(1.08); C475(1.07)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C121(0.94); C123(0.82); C215(1.15); C475(1.05)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C121(1.11); C123(1.34); C215(0.97); C475(1.11)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C121(0.80); C123(0.82); C215(1.07); C34(1.02)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C121(0.67); C123(0.76); C903(0.93); C475(0.96)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C121(0.73); C123(0.84); C903(0.91); C80(0.97)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C121(0.76); C123(0.82); C80(0.92); C903(0.98)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C123(0.67); C121(0.71); C475(0.94); C903(0.95)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C121(0.69); C123(0.73); C80(1.08); C903(1.10)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C123(0.67); C121(0.73); C80(0.95); C475(0.99)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C34(0.87); C80(0.94); C475(0.97); C903(1.02)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C123(0.77); C121(0.81); C903(0.86); C80(0.98)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C121(0.77); C123(0.82); C34(0.87); C475(0.92)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C123(0.78); C121(0.78); C903(0.92); C475(1.02)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C121(0.72); C123(0.76); C80(1.11); C903(1.20)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C121(0.78); C123(0.79); C215(1.52); C34(1.67)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C121(0.70); C123(0.70); C215(1.58); C34(1.87)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C121(0.90); C123(0.86); C215(1.19); C34(0.94)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C121(0.99); C123(0.97); C215(1.14); C34(0.93)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C903(0.77); C475(0.92); C80(0.94); C121(0.96)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C903(0.73); C121(0.85); C475(0.97); C34(1.03)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C903(0.80); C475(0.83); C80(0.89); C121(0.89)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C123(0.75); C121(0.78); C903(0.97); C745(1.00)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C903(0.71); C34(0.74); C80(0.87); C475(0.92)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C903(0.85); C34(0.87); C121(0.92); C475(0.95)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C903(0.79); C80(0.89); C475(1.02); C215(1.06)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C903(0.73); C34(0.74); C80(0.84); C475(1.03)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C903(0.74); C80(0.84); C475(0.94); C34(0.99)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C121(0.77); C123(0.77); C215(0.99); C475(1.04)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C121(0.54); C123(0.54); C34(0.90); C475(0.94)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C121(0.46); C123(0.46); C475(0.82); C903(1.04)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C121(0.48); C123(0.48); C475(0.90); C903(0.99)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C121(0.59); C123(0.59); C475(0.79); C903(1.06)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C121(0.64); C123(0.66); C745(0.96); C903(1.04)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C121(0.53); C123(0.53); C475(0.77); C903(0.99)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C121(0.53); C123(0.53); C475(0.84); C903(0.96)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C121(0.35); C123(0.35); C475(0.81); C903(1.01)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C121(0.40); C123(0.40); C475(0.86); C903(0.96)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C121(0.35); C123(0.35); C475(0.90); C903(1.04)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C903(0.89); C215(0.92); C80(0.94); C475(1.09)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C903(0.85); C215(1.02); C80(1.04); C475(1.08)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C215(0.95); C121(1.06); C475(1.12); C903(1.18)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C215(0.93); C80(0.96); C903(0.96); C121(0.97)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C121(0.88); C123(0.94); C475(0.98); C903(1.05)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C121(0.54); C123(0.56); C745(0.92); C903(1.07)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C123(0.76); C121(0.83); C80(0.99); C475(1.02)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C475(0.90); C903(0.90); C123(1.02); C121(1.03)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C123(0.82); C475(0.84); C121(0.87); C215(0.96)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C475(0.83); C903(0.86); C123(1.05); C215(1.07)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C123(0.85); C121(0.90); C903(0.98); C475(1.00)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C123(0.83); C121(0.84); C475(0.95); C903(1.02)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C475(0.97); C121(1.06); C80(1.09); C215(1.12)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C121(0.85); C123(0.85); C475(1.03); C215(1.05)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C121(1.07); C215(1.15); C475(1.15); C80(1.26)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C123(0.75); C121(0.90); C475(0.95); C80(1.18)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C123(0.50); C121(0.51); C745(0.98); C903(1.09)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C123(0.75); C121(0.87); C475(0.94); C80(1.21)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C215(0.95); C475(1.07); C80(1.24); C121(1.38)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C121(0.96); C123(0.97); C475(0.98); C215(1.04)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C123(0.78); C121(0.90); C475(0.94); C80(1.06)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C123(0.81); C121(0.89); C475(0.97); C80(1.04)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C123(0.76); C121(0.78); C475(0.99); C215(1.24)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C123(0.82); C121(0.91); C475(1.10); C80(1.54)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C123(0.47); C121(0.56); C475(0.84); C80(0.98)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C123(0.51); C121(0.67); C475(0.84); C903(0.94)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C123(0.44); C121(0.57); C475(0.84); C80(0.90)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C80(0.88); C903(0.93); C123(0.94); C475(0.94)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C123(0.53); C121(0.66); C475(0.82); C745(0.97)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C123(0.63); C121(0.73); C475(0.90); C80(0.90)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C123(0.39); C121(0.50); C475(0.87); C745(1.00)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C123(0.50); C121(0.60); C475(0.86); C903(0.90)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C123(0.42); C121(0.53); C475(0.86); C80(0.91)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C123(0.41); C121(0.52); C475(0.92); C215(0.99)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C123(0.43); C121(0.59); C475(0.93); C215(0.95)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C123(0.31); C121(0.50); C475(0.93); C80(1.03)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C123(0.87); C121(0.92); C745(0.96); C475(1.04)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C123(0.79); C121(0.85); C745(1.00); C475(1.10)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C34(0.86); C123(0.88); C80(0.91); C903(0.93)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C123(0.60); C121(0.72); C745(0.93); C475(1.03)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C123(0.79); C121(0.83); C745(0.99); C215(1.01)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C123(0.79); C121(0.81); C745(0.95); C475(1.02)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C123(0.68); C121(0.73); C745(1.05); C475(1.21)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C123(0.71); C121(0.75); C745(1.00); C475(1.22)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C123(0.68); C121(0.74); C745(1.02); C475(1.25)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C123(0.70); C121(0.70); C745(0.95); C475(1.08)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C123(0.71); C121(0.86); C745(1.00); C475(1.05)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C121(0.95); C215(1.08); C475(1.11); C745(1.13)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C121(0.79); C123(0.83); C745(1.00); C475(1.08)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C34(0.75); C80(0.87); C123(0.95); C903(0.99)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C121(0.80); C123(0.84); C745(0.92); C475(1.03)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C215(1.00); C745(1.07); C475(1.21); C80(1.23)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C123(0.73); C121(0.84); C745(0.97); C475(1.39)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C123(0.34); C121(0.55); C475(0.94); C903(1.20)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C123(0.37); C121(0.56); C475(0.93); C80(1.08)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C123(0.44); C121(0.57); C475(0.86); C80(0.88)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C123(0.41); C121(0.52); C475(0.84); C903(0.91)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C123(0.82); C121(0.83); C475(0.94); C903(0.94)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C123(0.49); C121(0.59); C475(0.86); C80(0.97)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C123(0.44); C121(0.58); C475(0.83); C903(0.99)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C121(0.76); C123(0.85); C80(0.90); C475(0.98)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C123(0.32); C121(0.45); C475(0.87); C80(1.16)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C123(0.34); C121(0.44); C475(0.88); C903(1.08)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C123(0.42); C121(0.53); C475(0.89); C903(0.94)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C121(0.58); C123(0.61); C475(0.87); C80(0.93)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C121(0.85); C123(0.86); C475(0.96); C903(1.05)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C123(0.42); C121(0.47); C475(0.86); C903(0.87)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C123(0.35); C121(0.47); C475(0.84); C903(0.89)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C123(0.40); C121(0.44); C903(0.59); C475(0.92)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C123(0.62); C903(0.65); C121(0.65); C34(0.73)  LDD0683  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C215(0.75)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C121(0.98); C123(0.92); C215(1.06); C34(0.93)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C34(0.89); C123(0.94); C903(1.04); C121(1.04)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C121(0.86); C80(1.02); C475(1.03); C123(1.04)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C215(0.99); C80(0.90)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa H546(0.00); C215(0.00); C34(0.00); C80(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C215(20.00); C215(5.42); C903(1.96); C475(1.74)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C215(0.96); C475(0.97); C121(1.00); C745(1.01)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C745(0.92); C121(0.93); C475(0.93); C123(1.00)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C123(0.61); C121(0.67); C745(0.83); C903(0.89)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C80(0.85); C34(0.88); C475(0.91); C903(1.01)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C80(0.87); C123(0.98); C475(0.98); C215(0.99)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C34(0.85); C80(0.95); C215(0.99); C475(1.06)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C80(0.87); C215(0.98); C903(1.04); C475(1.04)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C121(0.72); C903(0.79); C34(0.86); C80(0.89)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C903(0.76); C121(0.79); C475(1.04); C80(1.11)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C903(0.79); C121(0.80); C475(1.04); C34(1.08)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C121(0.71); C903(0.78); C475(0.90); C80(0.97)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C903(0.74); C475(0.84); C121(0.88); C34(0.96)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C123(0.76); C121(0.78); C745(0.90); C475(1.01)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C903(0.69); C121(0.86); C475(0.86); C80(0.89)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C903(0.71); C80(0.75); C475(0.91); C121(0.95)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C475(0.95); C121(0.97); C123(0.97); C903(1.03)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C121(0.38); C123(0.38); C475(0.87); C903(1.00)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C121(0.68); C123(0.68); C34(0.82); C475(0.91)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C121(0.55); C123(0.55); C475(0.83); C903(1.03)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C121(0.50); C123(0.50); C475(0.92); C903(1.00)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C123(0.80); C475(0.85); C121(0.88); C903(1.02)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C121(0.83); C123(0.87); C215(1.00); C903(1.03)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C121(0.88); C903(0.91); C475(0.97); C123(1.00)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C123(0.67); C121(0.71); C475(0.98); C745(0.98)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C903(0.90); C475(0.91); C121(0.95); C123(1.04)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C475(0.85); C80(1.00); C215(1.17); C121(1.33)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C123(0.97); C475(1.05); C121(1.13); C215(1.14)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C123(0.81); C121(0.84); C475(0.98); C80(1.08)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C123(0.75); C121(0.81); C475(0.94); C215(1.27)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C123(0.74); C80(0.79); C121(0.79); C475(0.90)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C123(0.65); C121(0.82); C475(0.85); C903(0.92)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C123(0.64); C121(0.78); C80(0.82); C903(0.90)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C123(0.46); C121(0.54); C475(0.82); C745(0.93)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C121(0.81); C123(0.87); C475(0.98); C745(1.01)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C121(0.79); C123(0.87); C475(0.93); C903(0.94)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C121(0.90); C475(0.96); C123(0.98); C745(1.13)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C745(0.98); C903(1.02); C121(1.09); C80(1.10)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C475(0.85); C903(0.89); C745(0.93); C80(0.99)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C903(0.93); C745(0.98); C475(1.01); C215(1.22)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C475(0.86); C745(1.02); C903(1.05); C123(1.10)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C121(0.97); C215(1.01); C475(1.03); C123(1.03)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C123(0.82); C475(0.85); C121(0.90); C745(0.93)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C123(0.63); C121(0.77); C475(0.85); C745(0.89)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C123(0.61); C475(0.84); C745(0.94); C121(1.06)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C903(0.90); C745(0.94); C123(0.96); C121(0.96)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C123(0.74); C121(0.75); C745(0.95); C903(1.01)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C121(0.75); C123(0.68); C215(1.43); C475(1.21)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C121(1.03); C123(0.88); C215(1.22); C475(1.03)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C121(0.74); C123(0.75); C215(1.11); C475(1.01)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C121(0.88); C123(0.82); C215(1.45); C475(0.99)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C121(0.78); C123(0.69); C215(1.22); C475(0.95)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C121(0.87); C123(0.82); C215(0.99); C475(0.93)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C121(0.91); C123(1.02); C215(1.06); C475(1.53)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C121(1.04); C215(0.99); C475(0.89); C745(0.86)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C121(1.44); C215(1.10); C475(0.97); C745(0.91)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C121(1.38); C215(1.12); C475(0.91); C745(0.81)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C121(0.96); C215(1.10); C475(0.86); C745(0.72)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C121(1.10); C215(1.11); C475(0.82); C745(0.79)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C121(1.06); C215(1.04); C475(0.80); C745(0.78)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C121(0.86); C215(1.20); C475(0.85); C745(0.85)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C121(0.82); C215(1.22); C475(0.90); C745(0.78)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C121(0.98); C123(1.01); C215(0.95); C475(0.92)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C121(0.99); C215(1.14); C475(0.83); C745(0.75)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C121(0.94); C215(1.05); C475(0.81); C745(0.85)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C121(1.03); C215(1.54); C475(0.99); C745(0.77)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C121(0.88); C215(1.19); C475(0.87); C745(0.79)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C121(0.83); C215(1.14); C475(0.90); C745(0.89)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C121(0.79); C215(1.27); C475(0.91); C745(0.82)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C121(0.87); C123(1.49); C215(0.90); C475(0.94)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C121(1.17); C123(1.46); C215(0.88); C475(0.93)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C121(1.21); C123(1.65); C215(0.86); C475(0.96)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C121(1.19); C123(1.10); C215(0.82); C475(0.88)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C121(0.93); C123(0.97); C215(1.03); C475(0.98)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C121(1.06); C123(1.18); C215(0.93); C475(0.98)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C121(1.03); C123(1.20); C215(0.95); C475(0.95)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C121(1.03); C123(1.25); C215(0.92); C475(0.89)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C121(1.44); C123(1.24); C215(0.89); C475(0.87)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C121(1.03); C123(1.37); C215(0.90); C475(0.90)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C121(1.02); C123(1.30); C215(0.89); C475(0.99)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C121(1.11); C123(0.97); C215(0.97); C475(0.97)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C121(1.26); C123(1.22); C215(0.86); C475(0.85)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C121(1.23); C123(1.53); C215(0.90); C475(0.92)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C121(1.05); C123(1.13); C215(0.96); C475(0.94)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C121(0.86); C123(0.98); C215(1.12); C475(1.01)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C121(1.12); C123(1.25); C215(0.99); C475(0.98)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C121(0.71); C215(1.00); C475(0.94); C745(1.03)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C121(0.45); C215(1.00); C475(1.03); C745(1.04)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C121(0.42); C215(0.99); C475(0.98); C745(1.10)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C121(0.44); C215(0.97); C475(0.90); C745(1.00)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C121(0.68); C215(0.90); C475(0.97); C745(1.10)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C121(0.39); C215(0.98); C475(0.93); C745(1.02)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C121(0.56); C215(0.87); C475(0.91); C745(1.00)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C121(0.63); C215(0.88); C475(0.94); C745(1.11)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C121(1.07); C215(1.00); C475(0.97); C745(1.11)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C121(0.74); C123(0.77); C215(1.20); C475(1.02)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C121(0.74); C215(0.95); C475(0.99); C745(1.10)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C121(0.55); C215(0.99); C475(0.98); C745(1.05)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C121(0.63); C215(0.96); C475(1.00); C745(1.10)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C121(0.68); C215(0.95); C475(0.90); C745(0.98)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C121(0.60); C215(0.93); C475(0.92); C745(1.00)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C121(0.92); C123(0.84); C215(1.14); C34(1.26)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C121(1.07); C123(0.95); C215(0.99); C34(1.47)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C121(0.77); C123(0.76); C215(1.23); C34(0.99)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C121(0.81); C123(0.67); C215(1.28); C34(1.56)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C121(0.68); C123(0.68); C215(1.30); C475(1.02)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C121(1.10); C123(1.10); C215(1.07); C34(1.38)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C121(0.85); C123(0.77); C215(1.17); C34(1.02)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C121(0.80); C123(0.73); C215(1.41); C34(1.32)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C121(0.68); C123(0.63); C215(1.31); C34(1.38)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C121(0.74); C123(0.68); C215(1.44); C34(1.55)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C121(0.72); C123(0.73); C215(1.21); C34(1.23)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C121(0.81); C123(0.76); C215(1.04); C34(1.21)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C121(0.77); C123(0.71); C215(1.14); C34(1.30)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C121(0.75); C123(0.66); C215(1.32); C34(1.36)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C121(0.85); C123(0.75); C215(1.52); C34(1.96)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C121(0.88); C123(0.99); C215(1.16); C475(0.98)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C121(0.96); C123(0.86); C215(1.34); C34(1.13)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C121(0.86); C123(0.72); C215(1.42); C475(1.06)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C121(1.13); C123(0.76); C215(1.35); C475(1.03)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C121(0.98); C123(0.77); C215(1.19); C475(1.10)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C121(1.10); C123(0.60); C215(1.28); C475(0.99)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C121(0.88); C123(0.59); C215(1.42); C475(0.97)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C121(0.77); C123(0.70); C215(1.31); C475(1.07)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C121(0.81); C123(0.67); C215(1.18); C475(0.98)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C121(0.58); C123(0.53); C215(1.38); C475(1.08)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C121(0.63); C123(0.60); C215(1.34); C475(1.13)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C80(0.84); C745(0.91); C475(1.03); C903(0.98)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C475(2.27); C215(1.19)  LDD1702  [5]
 LDCM0625  F8 Ramos C475(0.74); C215(0.94); C903(0.89)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C475(0.68); C215(1.21); C903(0.45)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C475(0.60); C215(0.03); C903(1.37)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C475(0.72); C215(0.69); C903(0.46)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C475(0.93); C215(0.95); C903(0.71)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C475(1.22); C215(0.65); C903(0.87)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C475(0.63); C215(0.65); C903(0.40)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C475(0.77); C215(0.80); C903(0.61)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C475(0.89); C215(0.95); C903(0.61)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C475(0.81); C215(0.79); C903(0.89)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C475(0.92); C215(0.99); C903(0.69)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C475(1.09); C215(1.07); C903(0.73)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C475(1.13); C215(0.91); C903(0.59)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C475(0.67); C215(0.94); C903(0.51)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C121(0.69); C215(0.86); C475(0.93); C745(1.03)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C475(1.07); C215(0.83); C903(0.67)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C475(0.91); C215(1.06); C903(1.12)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C121(0.79); C215(1.39); C475(0.86); C745(0.70)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C475(1.08); C215(1.03); C903(0.81)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C475(0.99); C215(1.24); C903(0.88)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C475(0.68); C215(0.82); C903(0.59)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C475(0.64); C215(0.96); C903(0.37)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y920(0.95)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y920(0.52)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y920(0.35)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y920(0.76)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y920(0.81)  LDD0268  [7]
 LDCM0107  IAA HeLa H546(0.00); H498(0.00); H436(0.00); C34(0.00)  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C745(2.26); C80(1.56); C121(2.24); C123(2.24)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C745(1.68); C80(1.53); C121(2.04); C123(2.04)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C745(3.12); C80(2.04); C121(1.99); C123(1.99)  LDD0082  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C745(0.98)  LDD2102  [5]
 LDCM0109  NEM HeLa H546(0.00); H498(0.00); H436(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C745(0.55)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C745(1.04)  LDD2090  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C215(1.00)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C745(1.23)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C215(0.44)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C215(0.84)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C745(0.74); C215(0.70)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C745(1.12); C215(0.77)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C745(1.19)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C215(0.77)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C745(1.16)  LDD2104  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C745(1.08); C475(0.75); C215(1.07)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C745(0.62); C215(1.19)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C745(0.69); C475(0.90); C215(0.75)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C745(0.73)  LDD2110  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C215(1.00)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C745(0.64)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C215(0.61)  LDD2115  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C745(0.76); C215(0.57)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C745(1.78); C475(1.59); C215(2.07)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C215(0.82)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C745(0.75); C215(0.59)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C475(0.99); C215(0.93)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C215(0.47)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C745(0.86); C475(0.80); C215(0.74)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C215(0.47)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C475(1.16); C215(0.69)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C745(1.01); C475(0.99); C215(0.84)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C215(0.53)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C215(0.51)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C745(0.70); C475(1.94); C215(0.87)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C745(1.11); C475(1.22); C215(1.26)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C745(0.98); C475(1.00); C215(0.89)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C215(1.16)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C745(1.27); C475(1.00); C215(0.93)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C745(0.65)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C745(1.04); C215(0.94)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C745(1.78); C475(1.59); C215(2.60)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C745(3.70)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C745(0.93); C475(0.94); C215(1.08)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C215(1.54)  LDD2147  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C215(0.51)  LDD2148  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C215(0.61)  LDD2149  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C215(0.36)  LDD2150  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C215(1.00)  LDD2151  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C745(1.53)  LDD2153  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C215(1.19); C215(0.77)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C215(0.50); C215(0.43); C215(0.18)  LDD2207  [32]
 LDCM0131  RA190 MM1.R C215(1.28)  LDD0304  [33]
 LDCM0090  Rapamycin JHH-7 6.47  LDD0213  [29]
 LDCM0021  THZ1 HCT 116 C475(1.08); C215(1.08); C903(1.03); C121(1.09)  LDD2173  [9]
 LDCM0113  W17 Hep-G2 C215(6.36)  LDD0240  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase BTK (BTK) Tyr protein kinase family Q06187
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Protein dpy-30 homolog (DPY30) Dpy-30 family Q9C005

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.