Details of the Target

General Information of Target

Target ID LDTP06219
Target Name Chromodomain-helicase-DNA-binding protein 4 (CHD4)
Gene Name CHD4
Gene ID 1108
Synonyms
Chromodomain-helicase-DNA-binding protein 4; CHD-4; EC 3.6.4.12; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi2-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKP
RDPKIPKSKRQKKERMLLCRQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKL
GPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKA
FSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESM
VTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGG
FGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVT
AVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQ
WEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPL
PEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPE
RQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKN
KDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVE
IQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLD
ATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLV
SAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKE
ASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLL
TGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKA
DVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCN
HPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLD
LLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADT
VIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVR
PGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDR
NQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRH
HYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRDWQDDQSDNQSDYSVASEEGDEDFDER
SEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFT
TQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMS
LIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPA
EDGIKIEENSLKEEESIEGEKEVKSTAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEK
AEVKERTEEPMETEPKGAADVEKVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETP
KDLNDEKQKKNIKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAG
IINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLR
RAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEEL
LSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRAPEPTPQQVAQQQ
Target Bioclass
Enzyme
Family
SNF2/RAD54 helicase family
Subcellular location
Nucleus
Function
ATP-dependent helicase that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis.
Uniprot ID
Q14839
Ensemble ID
ENST00000544040.7
HGNC ID
HGNC:1919
ChEMBL ID
CHEMBL4105742

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.F1463SfsTer39 DBIA    Probe Info 
CCK81 SNV: p.G1038D DBIA    Probe Info 
EFO27 SNV: p.R538W DBIA    Probe Info 
HCC15 SNV: p.E406Ter DBIA    Probe Info 
HCT116 SNV: p.R1162W .
HEC1 SNV: p.M801T; p.R1300W DBIA    Probe Info 
IM95 SNV: p.Q1186Ter DBIA    Probe Info 
JURKAT SNV: p.C79Y; p.G723S; p.M966I; p.A1747T Compound 10    Probe Info 
KNS81FD SNV: p.R1319Q DBIA    Probe Info 
KPL1 SNV: p.A525V DBIA    Probe Info 
LNCaP clone FGC SNV: p.V872M DBIA    Probe Info 
LOXIMVI SNV: p.L1652M DBIA    Probe Info 
MFE280 SNV: p.R975L DBIA    Probe Info 
MFE319 SNV: p.P1598T DBIA    Probe Info 
MOLT4 SNV: p.S239N; p.Y852H; p.G1272D; p.P1541H IA-alkyne    Probe Info 
P31FUJ SNV: p.R957Q DBIA    Probe Info 
PC9 SNV: p.A935S .
RKO SNV: p.D19G DBIA    Probe Info 
SBC5 Substitution: p.L43Y DBIA    Probe Info 
SUPT1 SNV: p.N528D; p.R1068H DBIA    Probe Info 
SW403 SNV: p.Q1342H .
TCCSUP SNV: p.D1480E DBIA    Probe Info 
WM2664 Insertion: p.W1516CfsTer5; p.N1569KfsTer2 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.65  LDD0215  [2]
TH211
 Probe Info  		Y1040(20.00); Y1804(20.00); Y892(17.50); Y1322(16.76)  LDD0257  [3]
ONAyne
 Probe Info  		K959(10.00)  LDD0275  [4]
Probe 1
 Probe Info  		Y178(117.15); Y1276(13.15); Y1285(20.71); Y1313(26.16)  LDD3495  [5]
DBIA
 Probe Info  		C396(0.91)  LDD3311  [6]
BTD
 Probe Info  		C1594(0.92)  LDD1700  [7]
AHL-Pu-1
 Probe Info  		C1594(2.31)  LDD0168  [8]
HHS-475
 Probe Info  		Y1804(1.02); Y1322(1.10)  LDD0264  [9]
HHS-465
 Probe Info  		Y1322(10.00); Y1804(7.30)  LDD2237  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C396(0.00); C1827(0.00); C1121(0.00); C1468(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C1468(0.00); C1827(0.00); C1121(0.00)  LDD0032  [13]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [14]
IPIAA_L
 Probe Info  		C1121(0.00); C1468(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C396(0.00); C1827(0.00); C1121(0.00); C1468(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_4
 Probe Info  		C1594(0.00); C1827(0.00)  LDD2226  [16]
TFBX
 Probe Info  		C1468(0.00); C1827(0.00)  LDD0027  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
Compound 10
 Probe Info  		C1468(0.00); C1827(0.00)  LDD2216  [18]
Compound 11
 Probe Info  		N.A.  LDD2213  [18]
ENE
 Probe Info  		C1594(0.00); C495(0.00)  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		N.A.  LDD0010  [17]
PPMS
 Probe Info  		N.A.  LDD0008  [17]
SF
 Probe Info  		Y1322(0.00); Y1285(0.00); Y1726(0.00)  LDD0028  [19]
STPyne
 Probe Info  		K1017(0.00); K969(0.00)  LDD0009  [17]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		C1827(0.00); C1594(0.00)  LDD0018  [20]
1c-yne
 Probe Info  		K1212(0.00); K1281(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C1468(0.00); C1594(0.00); C1827(0.00); H1320(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		H1320(0.00); C1468(0.00); C1594(0.00); C1827(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C1827(0.00); C1594(0.00); C1468(0.00); H1321(0.00)  LDD0218  [22]
W1
 Probe Info  		C1594(0.00); C396(0.00); E1323(0.00); Q1324(0.00)  LDD0236  [23]
AOyne
 Probe Info  		5.60  LDD0443  [24]
NAIA_5
 Probe Info  		C1827(0.00); C1594(0.00)  LDD2223  [16]
HHS-482
 Probe Info  		Y1322(0.76); Y1804(0.70)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		13.07  LDD0465  [25]
STS-2
 Probe Info  		3.00  LDD0139  [26]
Alk-rapa
 Probe Info  		7.56  LDD0213  [27]
STS-1
 Probe Info  		N.A.  LDD0068  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1594(0.86); C495(0.90)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1594(0.97)  LDD2112  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1594(0.82)  LDD2130  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1827(1.18)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C495(1.18)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1827(0.70)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C495(0.85)  LDD2131  [7]
 LDCM0025  4SU-RNA HEK-293T C1594(2.31)  LDD0168  [8]
 LDCM0214  AC1 HEK-293T C1468(1.03); C1594(1.01); C1827(1.01); C396(0.95)  LDD1507  [29]
 LDCM0215  AC10 HEK-293T C1468(1.02); C1594(0.94); C1827(1.07); C396(0.90)  LDD1508  [29]
 LDCM0226  AC11 HEK-293T C1468(0.98); C1594(1.01); C1827(0.92); C452(1.17)  LDD1509  [29]
 LDCM0237  AC12 HEK-293T C1468(0.97); C1594(0.96); C1827(0.96); C452(0.98)  LDD1510  [29]
 LDCM0259  AC14 HEK-293T C1468(1.13); C1594(0.98); C1827(1.07); C396(0.95)  LDD1512  [29]
 LDCM0270  AC15 HEK-293T C1468(0.99); C1594(0.99); C1827(1.07); C396(0.99)  LDD1513  [29]
 LDCM0276  AC17 HEK-293T C1468(0.93); C1594(0.99); C1827(1.05); C396(0.99)  LDD1515  [29]
 LDCM0277  AC18 HEK-293T C1468(1.07); C1594(1.05); C1827(1.01); C396(0.96)  LDD1516  [29]
 LDCM0278  AC19 HEK-293T C1468(1.00); C1594(1.02); C1827(0.94); C452(1.33)  LDD1517  [29]
 LDCM0279  AC2 HEK-293T C1468(0.96); C1594(0.93); C1827(0.92); C396(1.01)  LDD1518  [29]
 LDCM0280  AC20 HEK-293T C1468(1.00); C1594(0.91); C1827(1.05); C452(1.00)  LDD1519  [29]
 LDCM0281  AC21 HEK-293T C1468(0.95); C1594(0.94); C1827(0.97); C396(0.90)  LDD1520  [29]
 LDCM0282  AC22 HEK-293T C1468(0.90); C1594(1.00); C1827(1.02); C396(0.88)  LDD1521  [29]
 LDCM0283  AC23 HEK-293T C1468(1.00); C1594(0.96); C1827(1.03); C396(0.90)  LDD1522  [29]
 LDCM0284  AC24 HEK-293T C1468(1.11); C1594(1.00); C1827(1.09); C396(0.99)  LDD1523  [29]
 LDCM0285  AC25 HEK-293T C1468(0.96); C1594(0.98); C1827(1.13); C396(0.93)  LDD1524  [29]
 LDCM0286  AC26 HEK-293T C1468(1.12); C1594(0.98); C1827(0.93); C396(0.89)  LDD1525  [29]
 LDCM0287  AC27 HEK-293T C1468(1.05); C1594(1.05); C1827(0.95); C452(0.93)  LDD1526  [29]
 LDCM0288  AC28 HEK-293T C1468(1.01); C1594(1.00); C1827(1.08); C452(1.24)  LDD1527  [29]
 LDCM0289  AC29 HEK-293T C1468(0.94); C1594(1.01); C1827(0.99); C396(0.92)  LDD1528  [29]
 LDCM0290  AC3 HEK-293T C1468(1.05); C1594(0.98); C1827(0.95); C452(1.17)  LDD1529  [29]
 LDCM0291  AC30 HEK-293T C1468(1.08); C1594(0.99); C1827(1.00); C396(0.99)  LDD1530  [29]
 LDCM0292  AC31 HEK-293T C1468(1.01); C1594(0.99); C1827(1.05); C396(1.02)  LDD1531  [29]
 LDCM0293  AC32 HEK-293T C1468(1.18); C1594(1.09); C1827(1.02); C396(0.93)  LDD1532  [29]
 LDCM0294  AC33 HEK-293T C1468(0.99); C1594(0.97); C1827(0.98); C396(0.91)  LDD1533  [29]
 LDCM0295  AC34 HEK-293T C1468(1.02); C1594(0.91); C1827(0.98); C396(0.92)  LDD1534  [29]
 LDCM0296  AC35 HEK-293T C1468(1.07); C1594(0.92); C1827(1.00); C452(1.00)  LDD1535  [29]
 LDCM0297  AC36 HEK-293T C1468(0.94); C1594(0.88); C1827(1.09); C452(1.10)  LDD1536  [29]
 LDCM0298  AC37 HEK-293T C1468(1.01); C1594(0.93); C1827(1.03); C396(0.93)  LDD1537  [29]
 LDCM0299  AC38 HEK-293T C1468(1.23); C1594(0.91); C1827(0.93); C396(0.96)  LDD1538  [29]
 LDCM0300  AC39 HEK-293T C1468(0.90); C1594(0.86); C1827(1.06); C396(1.02)  LDD1539  [29]
 LDCM0301  AC4 HEK-293T C1468(1.07); C1594(0.94); C1827(1.10); C452(1.01)  LDD1540  [29]
 LDCM0302  AC40 HEK-293T C1468(1.05); C1594(0.91); C1827(1.03); C396(1.04)  LDD1541  [29]
 LDCM0303  AC41 HEK-293T C1468(0.98); C1594(1.00); C1827(0.98); C396(0.88)  LDD1542  [29]
 LDCM0304  AC42 HEK-293T C1468(0.95); C1594(0.97); C1827(0.99); C396(0.85)  LDD1543  [29]
 LDCM0305  AC43 HEK-293T C1468(1.04); C1594(1.05); C1827(0.92); C452(1.24)  LDD1544  [29]
 LDCM0306  AC44 HEK-293T C1468(1.06); C1594(0.92); C1827(0.97); C452(1.08)  LDD1545  [29]
 LDCM0307  AC45 HEK-293T C1468(0.93); C1594(1.05); C1827(1.04); C396(0.99)  LDD1546  [29]
 LDCM0308  AC46 HEK-293T C1468(1.10); C1594(1.10); C1827(1.02); C396(0.89)  LDD1547  [29]
 LDCM0309  AC47 HEK-293T C1468(0.95); C1594(1.02); C1827(0.99); C396(0.97)  LDD1548  [29]
 LDCM0310  AC48 HEK-293T C1468(1.00); C1594(1.00); C1827(1.00); C396(0.92)  LDD1549  [29]
 LDCM0311  AC49 HEK-293T C1468(1.02); C1594(0.92); C1827(0.94); C396(0.97)  LDD1550  [29]
 LDCM0312  AC5 HEK-293T C1468(0.99); C1594(0.94); C1827(0.98); C396(1.10)  LDD1551  [29]
 LDCM0313  AC50 HEK-293T C1468(1.01); C1594(0.95); C1827(0.97); C396(0.97)  LDD1552  [29]
 LDCM0314  AC51 HEK-293T C1468(1.01); C1594(0.94); C1827(0.92); C452(1.19)  LDD1553  [29]
 LDCM0315  AC52 HEK-293T C1468(1.04); C1594(0.91); C1827(1.03); C452(1.25)  LDD1554  [29]
 LDCM0316  AC53 HEK-293T C1468(0.98); C1594(0.96); C1827(0.96); C396(0.95)  LDD1555  [29]
 LDCM0317  AC54 HEK-293T C1468(1.03); C1594(0.88); C1827(0.96); C396(0.97)  LDD1556  [29]
 LDCM0318  AC55 HEK-293T C1468(1.05); C1594(0.87); C1827(0.99); C396(0.87)  LDD1557  [29]
 LDCM0319  AC56 HEK-293T C1468(1.06); C1594(0.90); C1827(0.97); C396(1.00)  LDD1558  [29]
 LDCM0320  AC57 HEK-293T C1468(0.94); C1594(0.93); C1827(0.88); C396(0.84)  LDD1559  [29]
 LDCM0321  AC58 HEK-293T C1468(0.96); C1594(0.99); C1827(0.90); C396(0.92)  LDD1560  [29]
 LDCM0322  AC59 HEK-293T C1468(0.96); C1594(0.96); C1827(0.82); C452(1.03)  LDD1561  [29]
 LDCM0323  AC6 HEK-293T C1468(1.17); C1594(1.04); C1827(0.94); C396(0.90)  LDD1562  [29]
 LDCM0324  AC60 HEK-293T C1468(1.03); C1594(0.84); C1827(1.02); C452(1.04)  LDD1563  [29]
 LDCM0325  AC61 HEK-293T C1468(1.02); C1594(0.93); C1827(0.85); C396(0.84)  LDD1564  [29]
 LDCM0326  AC62 HEK-293T C1468(1.11); C1594(1.09); C1827(0.88); C396(0.90)  LDD1565  [29]
 LDCM0327  AC63 HEK-293T C1468(1.00); C1594(0.89); C1827(0.97); C396(0.90)  LDD1566  [29]
 LDCM0328  AC64 HEK-293T C1468(0.97); C1594(0.94); C1827(0.95); C396(0.98)  LDD1567  [29]
 LDCM0334  AC7 HEK-293T C1468(1.10); C1594(1.02); C1827(1.07); C396(0.96)  LDD1568  [29]
 LDCM0345  AC8 HEK-293T C1468(1.08); C1594(1.00); C1827(1.02); C396(1.03)  LDD1569  [29]
 LDCM0248  AKOS034007472 HEK-293T C1468(0.94); C1594(0.97); C1827(0.96); C396(1.06)  LDD1511  [29]
 LDCM0356  AKOS034007680 HEK-293T C1468(1.03); C1594(0.89); C1827(0.99); C396(0.93)  LDD1570  [29]
 LDCM0275  AKOS034007705 HEK-293T C1468(1.11); C1594(0.92); C1827(0.94); C396(1.05)  LDD1514  [29]
 LDCM0156  Aniline NCI-H1299 11.90  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C869(0.12)  LDD2214  [30]
 LDCM0108  Chloroacetamide HeLa C1594(0.00); C1468(0.00); C1827(0.00); H1320(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C1827(2.01)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C1468(1.09); C1594(0.86); C1827(0.96); C396(1.02)  LDD1571  [29]
 LDCM0368  CL10 HEK-293T C1468(1.20); C1594(0.82); C1827(1.36); C396(0.88)  LDD1572  [29]
 LDCM0369  CL100 HEK-293T C1468(1.08); C1594(1.02); C1827(0.97); C396(1.01)  LDD1573  [29]
 LDCM0370  CL101 HEK-293T C1468(0.97); C1594(1.04); C1827(0.94); C396(0.95)  LDD1574  [29]
 LDCM0371  CL102 HEK-293T C1468(0.88); C1594(0.91); C1827(1.23); C396(0.73)  LDD1575  [29]
 LDCM0372  CL103 HEK-293T C1468(1.30); C1594(0.89); C1827(0.98); C452(0.94)  LDD1576  [29]
 LDCM0373  CL104 HEK-293T C1468(1.04); C1594(0.96); C1827(0.90); C396(1.03)  LDD1577  [29]
 LDCM0374  CL105 HEK-293T C1468(0.99); C1594(0.98); C1827(1.00); C396(0.85)  LDD1578  [29]
 LDCM0375  CL106 HEK-293T C1468(0.87); C1594(0.91); C1827(1.05); C396(0.96)  LDD1579  [29]
 LDCM0376  CL107 HEK-293T C1468(1.07); C1594(0.97); C1827(0.91); C452(0.83)  LDD1580  [29]
 LDCM0377  CL108 HEK-293T C1468(0.96); C1594(1.03); C1827(0.94); C396(0.98)  LDD1581  [29]
 LDCM0378  CL109 HEK-293T C1468(1.01); C1594(0.97); C1827(1.02); C396(0.94)  LDD1582  [29]
 LDCM0379  CL11 HEK-293T C1468(0.99); C1594(0.91); C1827(1.14); C396(0.90)  LDD1583  [29]
 LDCM0380  CL110 HEK-293T C1468(1.02); C1594(0.92); C1827(0.84); C396(0.97)  LDD1584  [29]
 LDCM0381  CL111 HEK-293T C1468(1.08); C1594(1.01); C1827(1.11); C452(0.88)  LDD1585  [29]
 LDCM0382  CL112 HEK-293T C1468(0.96); C1594(0.98); C1827(1.00); C396(0.94)  LDD1586  [29]
 LDCM0383  CL113 HEK-293T C1468(1.08); C1594(0.94); C1827(1.03); C396(0.92)  LDD1587  [29]
 LDCM0384  CL114 HEK-293T C1468(0.89); C1594(0.82); C1827(1.11); C396(0.86)  LDD1588  [29]
 LDCM0385  CL115 HEK-293T C1468(1.27); C1594(0.96); C1827(0.95); C452(0.89)  LDD1589  [29]
 LDCM0386  CL116 HEK-293T C1468(1.10); C1594(0.87); C1827(1.05); C396(1.04)  LDD1590  [29]
 LDCM0387  CL117 HEK-293T C1468(1.01); C1594(0.96); C1827(0.94); C396(0.82)  LDD1591  [29]
 LDCM0388  CL118 HEK-293T C1468(0.90); C1594(0.84); C1827(0.95); C396(0.91)  LDD1592  [29]
 LDCM0389  CL119 HEK-293T C1468(1.13); C1594(0.93); C1827(1.01); C452(0.99)  LDD1593  [29]
 LDCM0390  CL12 HEK-293T C1468(1.18); C1594(1.00); C1827(1.00); C396(0.98)  LDD1594  [29]
 LDCM0391  CL120 HEK-293T C1468(1.08); C1594(0.95); C1827(1.06); C396(1.02)  LDD1595  [29]
 LDCM0392  CL121 HEK-293T C1468(1.05); C1594(1.02); C1827(0.91); C396(1.01)  LDD1596  [29]
 LDCM0393  CL122 HEK-293T C1468(0.97); C1594(0.94); C1827(1.20); C396(1.00)  LDD1597  [29]
 LDCM0394  CL123 HEK-293T C1468(1.19); C1594(0.81); C1827(0.94); C452(0.81)  LDD1598  [29]
 LDCM0395  CL124 HEK-293T C1468(1.11); C1594(0.92); C1827(0.85); C396(0.99)  LDD1599  [29]
 LDCM0396  CL125 HEK-293T C1468(1.08); C1594(0.92); C1827(0.72); C396(1.01)  LDD1600  [29]
 LDCM0397  CL126 HEK-293T C1468(1.01); C1594(0.90); C1827(0.79); C396(0.87)  LDD1601  [29]
 LDCM0398  CL127 HEK-293T C1468(1.08); C1594(0.92); C1827(0.76); C452(0.94)  LDD1602  [29]
 LDCM0399  CL128 HEK-293T C1468(0.98); C1594(0.95); C1827(0.82); C396(1.00)  LDD1603  [29]
 LDCM0400  CL13 HEK-293T C1468(1.07); C1594(0.82); C1827(0.83); C396(0.80)  LDD1604  [29]
 LDCM0401  CL14 HEK-293T C1468(0.95); C1594(0.91); C1827(1.18); C396(1.00)  LDD1605  [29]
 LDCM0402  CL15 HEK-293T C1468(1.05); C1594(0.81); C1827(0.97); C452(0.83)  LDD1606  [29]
 LDCM0403  CL16 HEK-293T C1468(1.21); C1594(0.95); C1827(0.90); C396(1.08)  LDD1607  [29]
 LDCM0404  CL17 HEK-293T C1468(0.95); C1594(0.97); C1827(0.93); C396(0.82)  LDD1608  [29]
 LDCM0405  CL18 HEK-293T C1468(0.96); C1594(1.02); C1827(0.89); C396(0.89)  LDD1609  [29]
 LDCM0406  CL19 HEK-293T C1468(1.12); C1594(1.05); C1827(0.89); C452(1.25)  LDD1610  [29]
 LDCM0407  CL2 HEK-293T C1468(1.01); C1594(1.05); C1827(0.95); C396(1.07)  LDD1611  [29]
 LDCM0408  CL20 HEK-293T C1468(1.20); C1594(0.93); C1827(0.96); C452(1.21)  LDD1612  [29]
 LDCM0409  CL21 HEK-293T C1468(1.09); C1594(0.94); C1827(1.00); C396(0.73)  LDD1613  [29]
 LDCM0410  CL22 HEK-293T C1468(1.15); C1594(1.09); C1827(1.08); C396(0.85)  LDD1614  [29]
 LDCM0411  CL23 HEK-293T C1468(1.04); C1594(1.04); C1827(1.22); C396(0.94)  LDD1615  [29]
 LDCM0412  CL24 HEK-293T C1468(1.25); C1594(0.99); C1827(1.07); C396(1.04)  LDD1616  [29]
 LDCM0413  CL25 HEK-293T C1468(0.92); C1594(0.85); C1827(0.78); C396(0.97)  LDD1617  [29]
 LDCM0414  CL26 HEK-293T C1468(0.90); C1594(0.90); C1827(0.82); C396(1.17)  LDD1618  [29]
 LDCM0415  CL27 HEK-293T C1468(1.14); C1594(1.00); C1827(1.05); C452(0.85)  LDD1619  [29]
 LDCM0416  CL28 HEK-293T C1468(1.04); C1594(0.99); C1827(0.94); C396(1.03)  LDD1620  [29]
 LDCM0417  CL29 HEK-293T C1468(1.01); C1594(1.01); C1827(0.97); C396(0.99)  LDD1621  [29]
 LDCM0418  CL3 HEK-293T C1468(1.20); C1594(0.86); C1827(1.00); C452(1.09)  LDD1622  [29]
 LDCM0419  CL30 HEK-293T C1468(0.98); C1594(0.95); C1827(0.97); C396(1.05)  LDD1623  [29]
 LDCM0420  CL31 HEK-293T C1468(1.10); C1594(1.12); C1827(0.91); C452(0.98)  LDD1624  [29]
 LDCM0421  CL32 HEK-293T C1468(1.04); C1594(0.93); C1827(1.11); C452(1.27)  LDD1625  [29]
 LDCM0422  CL33 HEK-293T C1468(0.96); C1594(0.86); C1827(0.98); C396(0.86)  LDD1626  [29]
 LDCM0423  CL34 HEK-293T C1468(1.16); C1594(1.02); C1827(1.01); C396(0.86)  LDD1627  [29]
 LDCM0424  CL35 HEK-293T C1468(1.19); C1594(1.09); C1827(1.10); C396(0.80)  LDD1628  [29]
 LDCM0425  CL36 HEK-293T C1468(1.10); C1594(1.01); C1827(1.00); C396(0.90)  LDD1629  [29]
 LDCM0426  CL37 HEK-293T C1468(0.99); C1594(0.97); C1827(0.86); C396(1.00)  LDD1630  [29]
 LDCM0428  CL39 HEK-293T C1468(1.05); C1594(1.03); C1827(1.11); C452(0.82)  LDD1632  [29]
 LDCM0429  CL4 HEK-293T C1468(1.15); C1594(0.95); C1827(0.86); C396(1.10)  LDD1633  [29]
 LDCM0430  CL40 HEK-293T C1468(1.16); C1594(1.05); C1827(1.03); C396(1.15)  LDD1634  [29]
 LDCM0431  CL41 HEK-293T C1468(0.97); C1594(0.96); C1827(0.99); C396(0.89)  LDD1635  [29]
 LDCM0432  CL42 HEK-293T C1468(0.99); C1594(1.05); C1827(0.82); C396(0.99)  LDD1636  [29]
 LDCM0433  CL43 HEK-293T C1468(1.12); C1594(1.02); C1827(0.88); C452(1.23)  LDD1637  [29]
 LDCM0434  CL44 HEK-293T C1468(1.04); C1594(0.95); C1827(0.99); C452(1.10)  LDD1638  [29]
 LDCM0435  CL45 HEK-293T C1468(1.00); C1594(1.00); C1827(0.98); C396(0.87)  LDD1639  [29]
 LDCM0436  CL46 HEK-293T C1468(1.18); C1594(0.97); C1827(0.92); C396(0.92)  LDD1640  [29]
 LDCM0437  CL47 HEK-293T C1468(1.09); C1594(0.91); C1827(1.10); C396(0.84)  LDD1641  [29]
 LDCM0438  CL48 HEK-293T C1468(1.06); C1594(1.05); C1827(0.97); C396(0.99)  LDD1642  [29]
 LDCM0439  CL49 HEK-293T C1468(0.96); C1594(0.80); C1827(0.81); C396(0.92)  LDD1643  [29]
 LDCM0440  CL5 HEK-293T C1468(1.04); C1594(0.82); C1827(0.88); C396(0.98)  LDD1644  [29]
 LDCM0441  CL50 HEK-293T C1468(0.99); C1594(0.91); C1827(1.00); C396(1.00)  LDD1645  [29]
 LDCM0443  CL52 HEK-293T C1468(1.07); C1594(0.88); C1827(0.93); C396(1.08)  LDD1646  [29]
 LDCM0444  CL53 HEK-293T C1468(0.98); C1594(0.83); C1827(0.95); C396(0.82)  LDD1647  [29]
 LDCM0445  CL54 HEK-293T C1468(1.07); C1594(0.88); C1827(0.87); C396(0.87)  LDD1648  [29]
 LDCM0446  CL55 HEK-293T C1468(1.00); C1594(0.99); C1827(0.86); C452(1.29)  LDD1649  [29]
 LDCM0447  CL56 HEK-293T C1468(1.19); C1594(0.95); C1827(0.94); C452(1.03)  LDD1650  [29]
 LDCM0448  CL57 HEK-293T C1468(1.06); C1594(0.84); C1827(1.00); C396(0.88)  LDD1651  [29]
 LDCM0449  CL58 HEK-293T C1468(1.12); C1594(0.87); C1827(0.94); C396(0.91)  LDD1652  [29]
 LDCM0450  CL59 HEK-293T C1468(0.89); C1594(0.85); C1827(1.10); C396(0.91)  LDD1653  [29]
 LDCM0451  CL6 HEK-293T C1468(1.07); C1594(1.02); C1827(0.87); C396(0.84)  LDD1654  [29]
 LDCM0452  CL60 HEK-293T C1468(1.12); C1594(0.94); C1827(1.03); C396(1.08)  LDD1655  [29]
 LDCM0453  CL61 HEK-293T C1468(1.00); C1594(0.99); C1827(0.83); C396(0.93)  LDD1656  [29]
 LDCM0454  CL62 HEK-293T C1468(0.98); C1594(0.99); C1827(1.30); C396(1.08)  LDD1657  [29]
 LDCM0455  CL63 HEK-293T C1468(1.21); C1594(1.02); C1827(0.98); C452(0.89)  LDD1658  [29]
 LDCM0456  CL64 HEK-293T C1468(1.03); C1594(0.87); C1827(0.88); C396(0.39)  LDD1659  [29]
 LDCM0457  CL65 HEK-293T C1468(0.97); C1594(0.98); C1827(0.99); C396(0.92)  LDD1660  [29]
 LDCM0458  CL66 HEK-293T C1468(1.08); C1594(1.00); C1827(0.87); C396(0.85)  LDD1661  [29]
 LDCM0459  CL67 HEK-293T C1468(1.06); C1594(1.00); C1827(0.95); C452(1.21)  LDD1662  [29]
 LDCM0460  CL68 HEK-293T C1468(1.09); C1594(0.91); C1827(0.97); C452(1.06)  LDD1663  [29]
 LDCM0461  CL69 HEK-293T C1468(1.07); C1594(1.04); C1827(0.97); C396(0.93)  LDD1664  [29]
 LDCM0462  CL7 HEK-293T C1468(1.12); C1594(1.05); C1827(0.81); C452(1.15)  LDD1665  [29]
 LDCM0463  CL70 HEK-293T C1468(1.24); C1594(0.99); C1827(1.07); C396(0.86)  LDD1666  [29]
 LDCM0464  CL71 HEK-293T C1468(1.06); C1594(0.85); C1827(1.03); C396(0.90)  LDD1667  [29]
 LDCM0465  CL72 HEK-293T C1468(1.04); C1594(1.07); C1827(1.06); C396(1.00)  LDD1668  [29]
 LDCM0466  CL73 HEK-293T C1468(0.98); C1594(0.89); C1827(0.83); C396(1.03)  LDD1669  [29]
 LDCM0467  CL74 HEK-293T C1468(0.87); C1594(0.97); C1827(0.95); C396(0.98)  LDD1670  [29]
 LDCM0469  CL76 HEK-293T C1468(1.14); C1594(0.96); C1827(0.91); C396(1.00)  LDD1672  [29]
 LDCM0470  CL77 HEK-293T C1468(1.08); C1594(0.89); C1827(0.93); C396(0.80)  LDD1673  [29]
 LDCM0471  CL78 HEK-293T C1468(0.97); C1594(0.89); C1827(0.98); C396(0.89)  LDD1674  [29]
 LDCM0472  CL79 HEK-293T C1468(0.93); C1594(0.99); C1827(0.90); C452(1.18)  LDD1675  [29]
 LDCM0473  CL8 HEK-293T C1468(0.92); C1594(0.67); C1827(1.03); C452(1.04)  LDD1676  [29]
 LDCM0474  CL80 HEK-293T C1468(1.03); C1594(0.91); C1827(0.87); C452(1.18)  LDD1677  [29]
 LDCM0475  CL81 HEK-293T C1468(1.14); C1594(0.99); C1827(0.93); C396(0.89)  LDD1678  [29]
 LDCM0476  CL82 HEK-293T C1468(1.11); C1594(0.99); C1827(1.06); C396(0.88)  LDD1679  [29]
 LDCM0477  CL83 HEK-293T C1468(1.09); C1594(0.88); C1827(1.02); C396(0.89)  LDD1680  [29]
 LDCM0478  CL84 HEK-293T C1468(1.05); C1594(0.93); C1827(0.95); C396(1.03)  LDD1681  [29]
 LDCM0479  CL85 HEK-293T C1468(1.11); C1594(0.87); C1827(0.67); C396(0.92)  LDD1682  [29]
 LDCM0480  CL86 HEK-293T C1468(0.94); C1594(0.88); C1827(0.68); C396(1.07)  LDD1683  [29]
 LDCM0481  CL87 HEK-293T C1468(1.10); C1594(0.92); C1827(0.73); C452(0.68)  LDD1684  [29]
 LDCM0482  CL88 HEK-293T C1468(1.14); C1594(0.92); C1827(0.70); C396(1.13)  LDD1685  [29]
 LDCM0483  CL89 HEK-293T C1468(0.99); C1594(0.94); C1827(0.73); C396(0.93)  LDD1686  [29]
 LDCM0484  CL9 HEK-293T C1468(1.19); C1594(0.96); C1827(0.95); C396(0.92)  LDD1687  [29]
 LDCM0485  CL90 HEK-293T C1468(1.03); C1594(0.72); C1827(0.84); C396(0.71)  LDD1688  [29]
 LDCM0486  CL91 HEK-293T C1468(1.15); C1594(0.92); C1827(0.70); C452(0.86)  LDD1689  [29]
 LDCM0487  CL92 HEK-293T C1468(1.02); C1594(0.77); C1827(0.90); C452(1.04)  LDD1690  [29]
 LDCM0488  CL93 HEK-293T C1468(1.07); C1594(0.83); C1827(0.89); C396(0.81)  LDD1691  [29]
 LDCM0489  CL94 HEK-293T C1468(1.14); C1594(0.97); C1827(0.99); C396(0.81)  LDD1692  [29]
 LDCM0490  CL95 HEK-293T C1468(0.96); C1594(0.77); C1827(1.01); C396(0.72)  LDD1693  [29]
 LDCM0491  CL96 HEK-293T C1468(1.05); C1594(0.98); C1827(0.70); C396(0.94)  LDD1694  [29]
 LDCM0492  CL97 HEK-293T C1468(1.09); C1594(0.84); C1827(0.96); C396(0.92)  LDD1695  [29]
 LDCM0493  CL98 HEK-293T C1468(0.91); C1594(0.89); C1827(0.87); C396(1.02)  LDD1696  [29]
 LDCM0494  CL99 HEK-293T C1468(1.16); C1594(1.06); C1827(0.92); C452(0.95)  LDD1697  [29]
 LDCM0634  CY-0357 Hep-G2 C1594(1.06); C1827(0.94)  LDD2228  [16]
 LDCM0495  E2913 HEK-293T C1468(1.05); C1594(0.87); C1827(0.90); C452(1.20)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1018(3.50); C493(1.58); C495(1.43); C1827(1.34)  LDD1702  [7]
 LDCM0625  F8 Ramos C1594(1.35); 0.38; C1827(1.78); C1468(1.38)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C1594(0.68)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C1594(0.39); 0.10; C1468(0.11)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C1594(0.52)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C1594(1.17); C1827(0.55)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C1594(0.61); 0.72; C1827(0.94); C1468(0.90)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C1594(0.38)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C1594(1.14); C1827(0.47)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C1594(1.08)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C1594(1.28)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C1594(0.59); C1827(0.87); C1468(1.05)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C1594(1.08); C1827(0.37)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C1594(1.09); C1827(0.54)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C1594(0.83)  LDD2201  [31]
 LDCM0468  Fragment33 HEK-293T C1468(1.18); C1594(0.86); C1827(0.95); C452(0.65)  LDD1671  [29]
 LDCM0596  Fragment38 Ramos C1594(0.98); C1827(0.45)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C1594(0.66); 0.57; C1827(1.28); C1468(0.90)  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C1468(0.94); C1594(1.00); C1827(1.00); C396(1.04)  LDD1631  [29]
 LDCM0610  Fragment52 Ramos C1594(1.49)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C1594(1.94); C1827(0.32)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C1594(0.67); 0.46; C1827(1.21); C1468(0.86)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C1594(0.52); C1827(0.45)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y1804(1.02); Y1322(1.10)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y1804(0.95); Y1322(0.96)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y1322(0.77); Y1804(0.91)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y1322(0.98); Y1804(1.02)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y1804(0.80); Y1322(1.23)  LDD0268  [9]
 LDCM0107  IAA HeLa H1466(0.00); H1320(0.00); C1827(0.00); H1834(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C1468(0.99); C1594(0.95); C493(1.02); C1827(1.06)  LDD1492  [29]
 LDCM0023  KB03 HEK-293T C1468(1.08); C1594(1.06); C493(1.03); C1827(0.97)  LDD1497  [29]
 LDCM0024  KB05 G361 C396(0.91)  LDD3311  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1594(0.88)  LDD2102  [7]
 LDCM0109  NEM HeLa H1320(0.00); H947(0.00); H630(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C495(1.31)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1594(1.04)  LDD2090  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1594(0.81); C495(1.20); C1827(0.66)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1594(0.81); C1468(0.98)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C495(1.24)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C495(0.94)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C495(1.47); C1827(0.93)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1594(1.01); C1827(1.16)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1594(0.80); C495(1.12)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1827(1.13); C1468(0.40)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1594(1.70); C1827(0.83)  LDD2110  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1594(0.71); C1827(0.68)  LDD2114  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1827(0.31)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1594(0.44)  LDD2118  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C495(1.09)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1594(1.24)  LDD2122  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C495(0.98); C1827(1.28)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1594(0.52)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1827(1.27)  LDD2127  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1827(1.28)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C495(1.51)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1827(1.00)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1594(0.92)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1594(0.85)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1594(0.95); C495(0.89)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C495(1.20)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1594(2.67)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C495(1.21)  LDD2146  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1594(1.82); C1827(1.58)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C1827(0.84)  LDD2206  [32]
 LDCM0131  RA190 MM1.R C1594(1.22)  LDD0304  [33]
 LDCM0090  Rapamycin JHH-7 7.56  LDD0213  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 827 (ZNF827) Krueppel C2H2-type zinc-finger protein family Q17R98
Myc proto-oncogene protein (MYC) . P01106

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
28 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.