Details of the Target

General Information of Target

Target ID LDTP03628
Target Name Glycerol kinase (GK)
Gene Name GK
Gene ID 2710
Synonyms
Glycerol kinase; Glycerokinase; EC 2.7.1.30; ATP:glycerol 3-phosphotransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEI
LHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQ
STVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIY
GLMKISHSVKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCV
FSDHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGT
SYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRD
CGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSL
EPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGDPSIFCSLPLGF
FIVSSMVMLIGARYISGIP
Target Bioclass
Enzyme
Family
FGGY kinase family
Subcellular location
Mitochondrion outer membrane
Function
Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis.
Uniprot ID
P32189
Ensemble ID
ENST00000378943.7
HGNC ID
HGNC:4289
ChEMBL ID
CHEMBL2300

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-4
 Probe Info  		100.00  LDD0445  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C387(0.88)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
IPM
 Probe Info  		C421(0.00); C299(0.00); C289(0.00); C387(0.00)  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
Alk-rapa
 Probe Info  		5.73  LDD0213  [8]
DA-2
 Probe Info  		N.A.  LDD0070  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C421(1.09); C67(1.01); C387(1.02); C364(1.03)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C421(1.01); C67(0.94); C387(0.96); C364(0.94)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C421(1.06); C67(0.96); C387(0.95); C364(0.97)  LDD1509  [10]
 LDCM0230  AC113 HEK-293T C387(0.85)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C387(0.89)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C387(0.98)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C387(0.90)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C387(0.81)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C387(0.93)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C387(0.91)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C421(1.09); C67(0.84); C387(0.98); C364(1.03)  LDD1510  [10]
 LDCM0238  AC120 HEK-293T C387(0.83)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C387(0.81)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C387(0.78)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C387(0.75)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C387(0.85)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C387(0.85)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C387(0.76)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C387(0.70)  LDD0843  [3]
 LDCM0259  AC14 HEK-293T C421(1.17); C67(0.88); C387(1.01); C364(0.85)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C421(1.08); C67(0.93); C387(0.96); C364(0.99)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C421(1.04); C67(0.93); C387(1.00); C364(1.20)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C421(1.02); C67(1.06); C387(1.07); C364(1.11)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C421(1.08); C67(0.96); C387(0.98); C364(0.99)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C421(0.98); C67(1.03); C387(0.93); C364(1.01)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C421(1.02); C67(0.98); C387(0.98); C364(1.01)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C421(1.00); C67(1.10); C387(0.95); C364(0.94)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C421(1.03); C67(1.01); C387(0.95); C364(0.90)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C421(1.06); C67(1.00); C387(0.95); C364(0.98)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C421(0.95); C67(0.96); C387(0.95); C364(0.98)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C421(1.02); C67(0.87); C387(1.03); C364(1.02)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C421(1.05); C67(0.98); C387(0.99); C364(1.10)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C421(0.97); C67(0.95); C387(0.95); C364(1.22)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C421(1.09); C67(0.85); C387(1.02); C364(1.12)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C421(0.95); C67(0.97); C387(1.01); C364(1.16)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C421(1.01); C67(1.09); C387(1.00); C364(1.06)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C421(0.95); C67(0.95); C387(0.93); C364(1.08)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C421(0.97); C67(0.93); C387(0.98); C364(1.05)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C421(1.02); C67(1.00); C387(0.97); C364(1.22)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C421(1.05); C67(0.89); C387(0.97); C364(0.96)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C421(1.01); C67(0.99); C387(0.93); C364(1.15)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C421(0.94); C67(1.00); C387(0.95); C364(0.99)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C421(0.90); C67(0.86); C387(1.00); C364(1.11)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C421(0.98); C67(1.01); C387(0.90); C364(0.95)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C421(0.95); C67(0.97); C387(0.99); C364(1.00)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C421(1.02); C67(0.97); C387(0.98); C364(1.05)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C421(0.99); C67(0.92); C387(1.03); C364(1.09)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C421(0.96); C67(1.03); C387(1.03); C364(0.99)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C421(1.07); C67(0.93); C387(0.99); C364(1.41)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C421(1.06); C67(0.92); C387(1.01); C364(1.15)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C421(0.97); C67(0.99); C387(0.97); C364(1.09)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C421(0.98); C67(0.83); C387(1.01); C364(1.07)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C421(1.01); C67(0.88); C387(0.94); C364(1.14)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C421(0.99); C67(0.98); C387(1.01); C364(0.92)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C421(1.01); C67(0.89); C387(1.00); C364(1.16)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C421(0.96); C67(0.91); C387(0.93); C364(0.94)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C421(1.00); C67(0.96); C387(1.00); C364(1.18)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C421(1.07); C67(1.06); C387(0.95); C364(1.16)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C421(1.06); C67(1.05); C387(0.94); C364(0.97)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C421(0.97); C67(0.95); C387(0.93); C364(0.99)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C421(0.97); C67(0.92); C387(1.04); C364(1.07)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C421(0.96); C67(0.94); C387(0.91); C364(1.03)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C421(1.00); C67(0.95); C387(1.01); C364(0.90)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C421(0.97); C67(0.98); C387(0.99); C364(0.93)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C421(1.03); C67(0.99); C387(0.98); C364(0.97)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C421(1.06); C67(0.91); C387(1.01); C364(1.11)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C421(1.03); C67(1.01); C387(1.00); C364(1.02)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C421(1.01); C67(1.01); C387(0.93); C364(0.98)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C421(0.98); C67(1.03); C387(1.06); C364(1.01)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C421(0.99); C67(0.91); C387(1.05); C364(1.15)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C421(0.99); C67(0.98); C387(0.96); C364(1.20)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C421(0.98); C67(0.92); C387(1.03); C364(1.04)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C421(0.98); C67(0.95); C387(1.00); C364(1.11)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C421(0.97); C67(0.98); C387(0.98); C364(0.86)  LDD1567  [10]
 LDCM0332  AC68 HEK-293T C387(0.91)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C387(0.92)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C421(1.00); C67(1.01); C387(0.97); C364(1.35)  LDD1568  [10]
 LDCM0335  AC70 HEK-293T C387(0.97)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C387(1.04)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C387(0.86)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C387(0.99)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C387(0.90)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C387(1.04)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C387(0.89)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C387(0.87)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C387(0.85)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C387(0.89)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C421(1.06); C67(0.98); C387(1.02); C364(0.90)  LDD1569  [10]
 LDCM0346  AC80 HEK-293T C387(0.96)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C387(0.91)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C387(0.86)  LDD0946  [3]
 LDCM0248  AKOS034007472 HEK-293T C421(1.05); C67(0.97); C387(0.95); C364(0.99)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C421(1.05); C67(0.91); C387(0.98); C364(1.11)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C421(1.01); C67(0.98); C387(0.96); C364(0.86)  LDD1514  [10]
 LDCM0020  ARS-1620 HCC44 C387(0.88)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C387(0.86)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C387(0.54)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C421(0.99); C67(1.03); C387(1.08); C364(1.24)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C421(1.01); C67(0.92); C387(1.02); C364(1.18)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C421(1.11); C67(1.06); C387(1.15); C364(0.91)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C421(1.00); C67(0.95); C387(0.95); C364(1.04)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C421(0.98); C67(1.00); C387(1.00); C364(1.02)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C421(0.98); C67(0.94); C387(1.01); C364(1.11)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C421(1.02); C67(1.11); C387(1.02); C364(1.09)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C421(0.98); C67(0.98); C387(1.01); C364(0.89)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C421(0.88); C67(1.02); C387(0.97); C364(0.89)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C421(1.02); C67(0.96); C387(1.14); C364(1.17)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C387(0.55)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C421(1.22); C67(1.21); C387(1.18); C364(1.31)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C421(1.00); C67(0.98); C387(1.20); C364(0.87)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C421(0.90); C67(1.00); C387(1.05); C364(1.14)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C421(0.94); C67(0.91); C387(0.93); C364(1.02)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C421(1.12); C67(1.10); C387(1.21); C364(1.03)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C421(1.01); C67(0.94); C387(0.99); C364(0.80)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C421(0.99); C67(1.03); C387(0.98); C364(1.22)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C421(0.98); C67(0.91); C387(1.00); C364(1.23)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C421(1.00); C67(0.92); C387(0.93); C364(1.02)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C421(1.01); C67(0.93); C387(0.97); C364(0.92)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C387(0.73)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C421(0.92); C67(0.95); C387(0.96); C364(0.99)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C421(1.01); C67(0.97); C387(0.93); C364(1.29)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C421(1.02); C67(0.99); C387(1.06); C364(1.08)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C421(1.04); C67(1.01); C387(1.59); C364(0.90)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C421(0.97); C67(1.06); C387(1.07); C364(1.13)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C421(1.01); C67(0.89); C387(1.05); C364(1.09)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C421(1.02); C67(1.04); C387(1.05); C364(1.13)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C421(0.97); C67(1.01); C387(1.08); C364(0.97)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C421(0.98); C67(0.98); C387(0.97); C364(1.03)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C387(0.75)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C387(0.72)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C387(0.64)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C421(0.98); C67(1.00); C387(0.95); C364(1.37)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C421(1.24); C67(0.87); C387(2.04); C364(1.06)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C421(1.15); C67(0.99); C387(0.91); C364(1.02)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C421(1.01); C67(0.95); C387(0.95); C364(0.94)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C387(0.81)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C421(1.17); C67(0.81); C387(1.13); C364(1.17)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C421(1.10); C67(1.05); C387(1.38); C364(0.80)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C421(1.18); C67(1.01); C387(1.15); C364(0.80)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C421(1.25); C67(0.95); C387(1.06); C364(0.89)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C421(1.15); C67(1.01); C387(1.14); C364(1.07)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C421(1.08); C67(1.12); C387(1.26); C364(0.99)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C421(1.12); C67(1.01); C387(0.98); C364(0.87)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C421(1.01); C67(0.99); C387(0.99); C364(1.00)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C421(0.97); C67(1.09); C387(0.98); C364(0.95)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C421(1.13); C67(0.94); C387(0.94); C364(1.12)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C387(0.83)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C421(1.09); C67(1.10); C387(0.90); C364(1.15)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C387(0.94)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C387(0.74)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C387(0.79)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C387(0.80)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C387(0.79)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C387(0.86)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C387(0.83)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C387(0.69)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C387(0.76)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C387(0.67)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C387(0.68)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C387(0.74)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C387(0.73)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C387(0.80)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C387(0.75)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C421(1.23); C67(1.06); C387(1.12); C364(0.77)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C421(1.30); C67(1.04); C387(1.07); C364(0.97)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C421(1.17); C67(1.08); C387(1.14); C364(0.97)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C421(0.99); C67(0.93); C387(1.02); C364(1.31)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C387(0.68)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C421(1.10); C67(0.95); C387(1.00); C364(1.26)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C421(0.94); C67(1.04); C387(0.96); C364(1.39)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C421(1.11); C67(1.07); C387(1.39); C364(1.04)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C421(1.18); C67(0.98); C387(1.54); C364(1.35)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C421(0.93); C67(1.05); C387(0.98); C364(0.99)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C421(1.07); C67(0.90); C387(1.06); C364(1.12)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C421(1.02); C67(1.06); C387(1.50); C364(1.10)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C421(1.12); C67(1.00); C387(1.18); C364(0.92)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C421(1.17); C67(1.10); C387(1.06); C364(1.10)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C387(0.72)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C421(1.04); C67(1.05); C387(1.12); C364(1.14)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C387(1.12)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C387(0.92)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C387(1.05)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C387(1.12)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C387(1.06)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C387(0.93)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C387(0.93)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C387(0.86)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C387(0.97)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C387(0.68)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C387(0.93)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C387(0.81)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C387(0.89)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C387(0.79)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C387(0.70)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C421(0.99); C67(1.03); C387(0.94); C364(0.89)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C421(1.13); C67(1.00); C387(1.32); C364(1.26)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C421(1.02); C67(1.09); C387(0.95); C364(0.93)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C421(0.97); C67(1.00); C387(0.93); C364(0.92)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C387(1.40)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C421(1.00); C67(1.02); C387(1.01); C364(0.99)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C421(1.01); C67(1.08); C387(1.00); C364(1.02)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C421(0.99); C67(1.05); C387(1.03); C364(0.91)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C421(1.34); C67(1.10); C387(1.16); C364(0.97)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C421(1.11); C67(1.18); C387(1.23); C364(0.85)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C421(0.98); C67(0.89); C387(1.00); C364(0.86)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C421(0.99); C67(0.98); C387(1.03); C364(1.12)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C421(1.02); C67(1.01); C387(1.14); C364(0.82)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C421(1.00); C67(0.92); C387(1.00); C364(0.88)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C421(1.00); C67(0.86); C387(1.03); C364(1.15)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C387(1.27)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C421(1.56); C67(1.05); C387(2.23); C364(1.06)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C421(0.97); C67(1.03); C387(0.98); C364(1.00)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C421(1.05); C67(0.83); C387(1.33); C364(1.11)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C421(1.10); C67(0.96); C387(1.24); C364(0.91)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C421(1.15); C67(0.98); C387(1.05); C364(0.82)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C421(1.79); C67(1.13); C387(1.94); C364(1.02)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C421(1.18); C67(1.08); C387(1.23); C364(0.27)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C421(1.07); C67(1.03); C387(1.13); C364(1.04)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C421(1.03); C67(1.08); C387(1.06); C364(0.99)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C421(1.05); C67(1.01); C387(1.04); C364(0.91)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C421(0.92); C67(0.98); C387(0.94); C364(0.80)  LDD1698  [10]
 LDCM0572  Fragment10 Ramos C421(0.50)  LDD2189  [11]
 LDCM0576  Fragment14 Ramos C421(1.85)  LDD2193  [11]
 LDCM0588  Fragment30 Ramos C421(0.90)  LDD2199  [11]
 LDCM0590  Fragment32 Ramos C421(0.55)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C387(0.70)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos C421(0.98)  LDD2203  [11]
 LDCM0427  Fragment51 HEK-293T C387(0.91)  LDD1025  [3]
 LDCM0614  Fragment56 Ramos C421(1.37)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C421(1.17)  LDD2186  [11]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HEK-293T C421(0.96); C67(0.95); C299(0.85); C387(0.91)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C421(0.95); C67(0.92); C299(0.89); C387(0.92)  LDD1497  [10]
 LDCM0024  KB05 MOLM-13 C220(2.24)  LDD3333  [12]
 LDCM0109  NEM HeLa N.A.  LDD0225  [2]
 LDCM0090  Rapamycin JHH-7 5.73  LDD0213  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) Nuclear hormone receptor family P22736

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
9 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840