Details of the Target

General Information of Target

Target ID LDTP08842
Target Name Cohesin subunit SA-2 (STAG2)
Gene Name STAG2
Gene ID 10735
Synonyms
SA2; Cohesin subunit SA-2; SCC3 homolog 2; Stromal antigen 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIAAPEIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCKKGKKGPAEKGKGGNGG
GKPPSGPNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINF
FIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIG
VLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIN
MDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDA
IAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKEL
NSKLELFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSA
HRPVAVAAGEFLYKKLFSRRDPEEDGMMKRRGRQGPNANLVKTLVFFFLESELHEHAAYL
VDSMWDCATELLKDWECMNSLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVG
RGTGKRVLTAKEKKTQLDDRTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIY
TTGRLEKHLDALLRQIRNIVEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDE
LADKFNRLLEDFLQEGEEPDEDDAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGI
ENGDMPEQIVIHALQCTHYVILWQLAKITESSSTKEDLLRLKKQMRVFCQICQHYLTNVN
TTVKEQAFTILCDILMIFSHQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDD
NNSADGQQEDEASKIEALHKRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDII
KETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFG
LDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYV
YLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGSTVRSKKSKPSTG
KRKVVEGMQLSLTEESSSSDSMWLSREQTLHTPVMMQTPQLTSTIMREPKRLRPEDSFMS
VYPMQTEHHQTPLDYNRRGTSLMEDDEEPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPP
SKNRRERTELKPDFFDPASIMDESVLGVSMF
Target Bioclass
Other
Family
SCC3 family
Subcellular location
Nucleus
Function
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Uniprot ID
Q8N3U4
Ensemble ID
ENST00000218089.13
HGNC ID
HGNC:11355

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.07  LDD0402  [1]
C-Sul
 Probe Info  		4.05  LDD0066  [2]
Probe 1
 Probe Info  		Y384(15.04); Y893(30.53); Y896(16.67)  LDD3495  [3]
DBIA
 Probe Info  		C347(4.80); C535(2.00); C640(2.03)  LDD3311  [4]
BTD
 Probe Info  		C632(0.76)  LDD2104  [5]
IPM
 Probe Info  		C535(5.31)  LDD1701  [5]
CY-1
 Probe Info  		E249(0.00); E251(0.00)  LDD0246  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C308(0.00); C347(0.00); C632(0.00); C869(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C632(0.00); C915(0.00)  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C308(0.00); C347(0.00); C632(0.00); C410(0.00)  LDD0037  [7]
TFBX
 Probe Info  		C632(0.00); C915(0.00)  LDD0027  [9]
NHS
 Probe Info  		K949(0.00); K270(0.00)  LDD0010  [10]
OSF
 Probe Info  		Y893(0.00); Y892(0.00)  LDD0029  [11]
STPyne
 Probe Info  		K607(0.00); K622(0.00)  LDD0009  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		C632(0.00); C711(0.00); H138(0.00); H217(0.00)  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
Methacrolein
 Probe Info  		C632(0.00); C535(0.00); C869(0.00); C711(0.00)  LDD0218  [13]
NAIA_5
 Probe Info  		C632(0.00); C186(0.00); C915(0.00); C176(0.00)  LDD2223  [14]
HHS-465
 Probe Info  		N.A.  LDD2240  [15]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		6.36  LDD0471  [16]
FFF probe13
 Probe Info  		13.53  LDD0475  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe2
 Probe Info  		20.00  LDD0463  [16]
FFF probe3
 Probe Info  		20.00  LDD0464  [16]
STS-2
 Probe Info  		N.A.  LDD0139  [17]
Alk-rapa
 Probe Info  		3.91  LDD0213  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C632(0.57)  LDD2112  [5]
 LDCM0214  AC1 HEK-293T C535(1.04); C632(0.94); C640(1.00); C347(0.97)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C632(0.97); C640(1.01); C347(0.99); C869(0.97)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C632(1.03); C640(0.96); C347(0.91); C869(0.93)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C535(1.01); C632(1.02); C640(1.02); C347(0.96)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C535(1.02); C632(1.01); C640(0.99); C347(0.94)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C535(1.09); C632(1.00); C640(1.00); C347(0.95)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C535(1.03); C632(0.96); C640(0.95); C347(1.02)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C632(0.94); C640(1.03); C347(0.99); C869(1.02)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C632(0.88); C640(0.95); C347(0.95); C869(0.89)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C632(0.98); C640(1.04); C347(0.98); C869(1.04)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C535(0.92); C632(0.99); C640(1.06); C347(0.94)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C535(1.08); C632(0.96); C640(1.00); C347(0.97)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C535(1.04); C632(0.98); C640(0.96); C347(0.91)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C535(1.04); C632(1.06); C640(1.01); C347(0.96)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C535(1.00); C632(1.04); C640(0.97); C347(0.99)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C535(1.03); C632(0.95); C640(0.97); C347(0.95)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C632(0.92); C640(1.00); C347(0.98); C869(1.01)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C632(0.97); C640(0.87); C347(0.95); C869(0.96)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C535(0.89); C632(0.95); C640(1.03); C347(0.97)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C535(1.17); C632(0.96); C640(0.98); C347(1.01)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C632(0.95); C640(0.99); C347(0.93); C869(0.99)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C535(1.03); C632(1.10); C640(0.96); C347(0.90)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C535(1.01); C632(1.00); C640(0.95); C347(0.98)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C535(0.99); C632(0.94); C640(0.97); C347(1.03)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C535(0.99); C632(0.96); C640(0.99); C347(0.87)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C632(0.89); C640(1.05); C347(0.97); C869(0.92)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C632(0.88); C640(0.95); C347(0.87); C869(0.86)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C535(0.89); C632(0.98); C640(1.10); C347(0.91)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C535(0.90); C632(1.02); C640(1.02); C347(0.98)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C535(1.04); C632(1.08); C640(0.92); C347(0.87)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C535(1.03); C632(1.03); C640(0.97); C347(0.91)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C535(0.91); C632(1.03); C640(1.06); C347(0.94)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C535(1.10); C632(1.00); C640(0.98); C347(1.01)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C535(1.13); C632(0.94); C640(0.92); C347(0.96)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C632(0.86); C640(1.01); C347(0.97); C869(0.90)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C632(1.01); C640(0.90); C347(0.92); C869(0.84)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C535(0.89); C632(1.12); C640(1.01); C347(0.93)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C535(1.07); C632(1.06); C640(1.00); C347(0.91)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C535(1.04); C632(0.99); C640(0.96); C347(0.91)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C535(1.12); C632(1.04); C640(0.96); C347(0.97)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C535(1.19); C632(1.03); C640(1.00); C347(0.96)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C535(1.06); C632(1.05); C640(0.94); C347(1.01)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C535(1.02); C632(1.06); C640(1.00); C347(0.99)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C632(0.93); C640(1.08); C347(0.92); C869(1.02)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C632(0.96); C640(0.94); C347(0.95); C869(1.03)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C535(0.92); C632(1.05); C640(1.02); C347(0.92)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C535(1.04); C632(1.06); C640(1.05); C347(0.92)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C535(1.07); C632(1.03); C640(0.91); C347(0.90)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C535(1.05); C632(1.02); C640(0.96); C347(1.00)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C535(1.18); C632(1.03); C640(0.91); C347(1.03)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C535(1.05); C632(0.98); C640(0.99); C347(0.94)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C632(0.94); C640(1.11); C347(0.97); C869(0.96)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C632(0.94); C640(0.89); C347(0.95); C869(1.02)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C535(1.05); C632(1.02); C640(1.03); C347(0.91)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C535(0.96); C632(1.02); C640(1.02); C347(0.95)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C535(1.01); C632(0.95); C640(0.95); C347(0.98)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C535(1.04); C632(1.00); C640(0.91); C347(0.92)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C535(1.10); C632(1.04); C640(0.99); C347(0.93)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C535(1.04); C632(1.03); C640(0.97); C347(0.97)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C535(1.02); C632(1.13); C640(1.11); C347(0.94)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C535(1.04); C632(1.00); C640(0.98); C347(0.98)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C535(1.07); C632(1.05); C640(1.05); C347(0.99)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C535(1.06); C632(0.99); C640(0.93); C347(1.01)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C535(1.13); C632(1.02); C640(0.97); C347(1.04)  LDD1514  [19]
 LDCM0108  Chloroacetamide HeLa C632(0.00); C869(0.00); H623(0.00); C711(0.00)  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C915(0.64)  LDD2227  [14]
 LDCM0367  CL1 HEK-293T C535(1.04); C632(1.13); C640(1.13); C347(1.07)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C535(1.31); C632(1.02); C640(0.90); C347(0.97)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C535(1.03); C632(0.99); C640(0.95); C347(1.06)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C535(1.08); C632(1.06); C640(0.99); C347(0.99)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C535(1.16); C632(0.95); C640(0.93); C347(1.20)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C632(1.00); C640(0.95); C347(1.04); C869(0.95)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C535(1.06); C632(1.01); C640(0.93); C347(0.98)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C535(1.00); C632(1.01); C640(0.94); C347(1.09)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C535(1.07); C632(0.93); C640(0.96); C347(1.08)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C632(1.02); C640(0.98); C347(1.03); C869(1.04)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C535(0.98); C632(0.97); C640(0.91); C347(1.02)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C535(0.99); C632(1.00); C640(0.97); C347(1.13)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C535(1.10); C632(1.16); C640(1.10); C347(1.05)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C535(0.95); C632(0.92); C640(0.92); C347(1.56)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C632(0.95); C640(1.00); C347(1.14); C869(0.96)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C535(1.05); C632(0.92); C640(1.02); C347(0.97)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C535(1.02); C632(1.03); C640(1.05); C347(0.86)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C535(1.01); C632(0.92); C640(0.97); C347(1.24)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C632(0.92); C640(1.00); C347(0.95); C869(1.00)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C535(1.07); C632(1.00); C640(1.00); C347(0.92)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C535(1.00); C632(1.05); C640(0.96); C347(0.96)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C535(1.02); C632(1.03); C640(0.96); C347(0.96)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C632(0.92); C640(1.01); C347(0.97); C869(1.03)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C535(1.09); C632(1.12); C640(0.90); C347(1.24)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C535(1.03); C632(0.98); C640(1.03); C347(0.92)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C535(1.09); C632(1.06); C640(1.04); C347(0.96)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C535(1.10); C632(0.98); C640(1.04); C347(1.00)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C632(0.86); C640(1.05); C347(1.49); C869(1.00)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C535(1.02); C632(0.96); C640(1.03); C347(1.12)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C535(1.09); C632(1.05); C640(1.14); C347(0.95)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C535(1.05); C632(1.02); C640(0.92); C347(0.94)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C632(0.97); C640(1.00); C347(0.98); C869(1.05)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C535(1.08); C632(0.97); C640(0.96); C347(0.94)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C535(1.05); C632(1.10); C640(0.91); C347(0.93)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C535(1.05); C632(1.06); C640(1.03); C347(0.95)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C632(0.96); C640(1.05); C347(1.68); C869(0.78)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C535(0.94); C632(1.08); C640(1.01); C347(0.95)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C535(1.08); C632(1.00); C640(1.00); C347(1.24)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C632(0.95); C640(1.05); C347(1.03); C869(0.71)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C632(1.01); C640(0.99); C347(1.00); C869(0.68)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C535(0.94); C632(1.03); C640(0.98); C347(0.96)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C535(0.92); C632(1.23); C640(1.08); C347(1.11)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C535(0.86); C632(1.07); C640(0.98); C347(1.91)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C535(1.13); C632(1.14); C640(0.96); C347(0.99)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C535(1.02); C632(1.14); C640(1.04); C347(1.09)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C535(1.08); C632(1.07); C640(0.99); C347(1.21)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C535(1.32); C632(1.06); C640(1.03); C347(1.22)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C535(1.06); C632(0.99); C640(0.95); C347(1.02)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C632(1.01); C640(1.01); C347(1.04); C869(0.87)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C535(1.03); C632(1.00); C640(1.01); C347(1.15)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C535(1.04); C632(1.01); C640(0.97); C347(1.05)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C632(0.96); C640(1.03); C347(1.17); C869(0.91)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C632(1.02); C640(1.07); C347(1.02); C869(0.83)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C632(1.07); C640(0.96); C347(1.04); C869(0.68)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C535(0.97); C632(1.00); C640(1.03); C347(1.10)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C535(1.11); C632(1.10); C640(1.00); C347(1.78)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C535(0.98); C632(1.08); C640(0.96); C347(1.15)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C535(1.15); C632(1.12); C640(1.03); C347(1.10)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C535(1.05); C632(1.09); C640(0.89); C347(1.25)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C535(1.09); C632(1.07); C640(1.04); C347(1.13)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C632(0.94); C640(0.89); C347(0.96); C869(0.86)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C535(1.10); C632(1.05); C640(1.02); C347(1.09)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C535(1.03); C632(0.99); C640(1.03); C347(0.96)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C535(1.04); C632(1.07); C640(0.93); C347(1.02)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C632(1.04); C640(1.05); C347(0.98); C869(0.77)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C632(1.07); C640(0.92); C347(1.01); C869(0.73)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C535(0.93); C632(0.98); C640(1.09); C347(1.04)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C535(1.08); C632(0.98); C640(0.94); C347(1.17)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C535(1.05); C632(1.02); C640(0.89); C347(1.12)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C535(1.14); C632(1.07); C640(1.07); C347(1.08)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C535(0.97); C632(1.10); C640(0.80); C347(1.18)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C535(1.11); C632(1.11); C640(0.94); C347(1.03)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C535(1.12); C632(1.15); C640(0.97); C347(0.99)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C535(1.00); C632(0.98); C640(0.97); C347(1.06)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C535(1.08); C632(1.06); C640(1.00); C347(0.93)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C535(1.15); C632(1.02); C640(0.94); C347(1.22)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C632(0.90); C640(1.01); C347(1.69); C869(0.71)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C632(0.96); C640(0.95); C347(0.95); C869(0.64)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C535(1.07); C632(1.07); C640(0.99); C347(0.95)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C535(1.07); C632(1.03); C640(0.94); C347(1.20)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C535(1.05); C632(1.04); C640(0.91); C347(1.06)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C535(1.09); C632(1.05); C640(0.99); C347(1.08)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C632(0.97); C640(1.05); C347(1.45); C869(0.63)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C535(1.08); C632(1.08); C640(0.84); C347(1.16)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C535(1.11); C632(1.12); C640(1.02); C347(0.91)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C535(0.91); C632(1.02); C640(0.95); C347(0.93)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C632(1.04); C640(1.02); C347(0.96); C869(0.92)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C535(1.03); C632(0.91); C640(0.94); C347(1.30)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C535(1.14); C632(1.10); C640(0.96); C347(0.92)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C632(0.94); C640(1.09); C347(1.00); C869(0.72)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C632(1.00); C640(1.00); C347(0.98); C869(0.73)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C535(0.95); C632(1.15); C640(1.05); C347(1.02)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C535(1.14); C632(1.05); C640(0.91); C347(1.14)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C632(1.05); C640(1.05); C347(1.04); C869(0.67)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C535(1.09); C632(1.08); C640(0.99); C347(1.02)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C535(1.02); C632(1.11); C640(1.03); C347(1.07)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C535(1.16); C632(1.09); C640(0.88); C347(1.13)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C535(1.11); C632(1.05); C640(1.10); C347(1.03)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C535(1.02); C632(1.00); C640(1.00); C347(0.91)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C535(1.08); C632(1.01); C640(1.09); C347(1.01)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C535(1.10); C632(0.94); C640(0.88); C347(1.19)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C632(1.00); C640(1.08); C347(1.02); C869(0.76)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C632(0.98); C640(0.97); C347(0.98); C869(0.78)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C535(0.96); C632(1.06); C640(0.91); C347(8.85)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C535(0.96); C632(1.05); C640(1.05); C347(0.98)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C535(1.06); C632(1.09); C640(1.00); C347(1.07)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C535(1.05); C632(1.03); C640(0.95); C347(0.96)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C535(1.09); C632(1.02); C640(1.06); C347(1.15)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C535(1.12); C632(1.05); C640(0.95); C347(1.29)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C535(1.20); C632(1.11); C640(1.00); C347(0.94)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C535(0.99); C632(0.98); C640(0.91); C347(0.94)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C632(0.96); C640(1.01); C347(1.04); C869(1.02)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C535(1.11); C632(1.01); C640(1.06); C347(0.95)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C535(1.08); C632(1.06); C640(0.99); C347(1.06)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C535(1.12); C632(1.10); C640(1.05); C347(1.14)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C632(0.90); C640(0.97); C347(1.86); C869(0.63)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C632(0.93); C640(0.95); C347(1.03); C869(0.79)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C535(0.80); C632(1.00); C640(1.00); C347(1.09)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C535(1.02); C632(1.05); C640(1.03); C347(1.23)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C535(1.07); C632(1.05); C640(0.92); C347(0.95)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C535(1.22); C632(0.98); C640(0.90); C347(1.86)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C535(1.27); C632(0.95); C640(0.94); C347(1.40)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C535(1.10); C632(1.01); C640(0.95); C347(1.27)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C535(1.10); C632(1.02); C640(0.94); C347(1.00)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C632(0.94); C640(1.00); C347(0.98); C869(1.02)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C632(0.99); C640(0.94); C347(0.95); C869(0.75)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C632(2.84)  LDD1702  [5]
 LDCM0575  Fragment13 Ramos C347(1.04)  LDD2192  [20]
 LDCM0580  Fragment21 Ramos C347(0.52)  LDD2195  [20]
 LDCM0578  Fragment27 Ramos C347(0.89)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C347(0.80)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C347(0.59)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C347(1.34)  LDD2200  [20]
 LDCM0468  Fragment33 HEK-293T C632(0.99); C640(1.04); C347(1.03); C869(0.91)  LDD1671  [19]
 LDCM0596  Fragment38 Ramos C347(1.19)  LDD2203  [20]
 LDCM0427  Fragment51 HEK-293T C535(0.96); C632(1.00); C640(0.96); C347(0.94)  LDD1631  [19]
 LDCM0614  Fragment56 Ramos C347(0.39)  LDD2205  [20]
 LDCM0107  IAA HeLa H623(0.00); H138(0.00); H608(0.00)  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C535(0.94); C632(0.80); C640(0.95); C769(0.89)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C535(0.91); C632(0.81); C640(0.95); C769(0.92)  LDD1497  [19]
 LDCM0024  KB05 G361 C347(4.80); C535(2.00); C640(2.03)  LDD3311  [4]
 LDCM0109  NEM HeLa H138(0.00); H608(0.00)  LDD0223  [13]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C632(0.76)  LDD2104  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C632(0.80)  LDD2108  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C535(0.89)  LDD2122  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C535(0.97)  LDD2129  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C632(1.90)  LDD2136  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C535(0.65)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C632(1.13)  LDD2141  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C915(0.80); C176(0.55)  LDD2207  [21]
 LDCM0090  Rapamycin JHH-7 3.91  LDD0213  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SSU72) SSU72 phosphatase family Q9NP77
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sister chromatid cohesion protein PDS5 homolog A (PDS5A) PDS5 family Q29RF7
Sister chromatid cohesion protein PDS5 homolog B (PDS5B) PDS5 family Q9NTI5
Double-strand-break repair protein rad21 homolog (RAD21) Rad21 family O60216
Cohesin subunit SA-1 (STAG1) SCC3 family Q8WVM7
Shugoshin 1 (SGO1) Shugoshin family Q5FBB7
Structural maintenance of chromosomes protein 1A (SMC1A) SMC family Q14683
Structural maintenance of chromosomes protein 3 (SMC3) SMC family Q9UQE7
Wings apart-like protein homolog (WAPL) WAPL family Q7Z5K2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.