Details of the Target

General Information of Target

Target ID LDTP01358
Target Name Pre-mRNA-splicing factor SPF27 (BCAS2)
Gene Name BCAS2
Gene ID 10286
Synonyms
DAM1; Pre-mRNA-splicing factor SPF27; Breast carcinoma-amplified sequence 2; DNA amplified in mammary carcinoma 1 protein; Spliceosome-associated protein SPF 27
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSA
FETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVR
IENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLRE
MESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF
Target Bioclass
Other
Family
SPF27 family
Subcellular location
Nucleus
Function
Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
Uniprot ID
O75934
Ensemble ID
ENST00000369541.4
HGNC ID
HGNC:975

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		5.63  LDD0393  [2]
STPyne
 Probe Info  		K158(2.91); K168(8.33); K177(9.21); K85(6.14)  LDD0277  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [3]
Probe 1
 Probe Info  		Y87(32.12)  LDD3495  [4]
BTD
 Probe Info  		C132(1.07)  LDD2092  [5]
AHL-Pu-1
 Probe Info  		C106(2.24)  LDD0169  [6]
HHS-475
 Probe Info  		Y207(0.86)  LDD0264  [7]
DBIA
 Probe Info  		C106(2.14); C132(1.35)  LDD0080  [8]
5E-2FA
 Probe Info  		H213(0.00); H144(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		K168(0.00); K177(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C132(0.00); C106(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C132(0.00); C106(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		C106(0.00); C132(0.00)  LDD2226  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
IPM
 Probe Info  		N.A.  LDD0005  [16]
Phosphinate-6
 Probe Info  		C106(0.00); C132(0.00)  LDD0018  [17]
1c-yne
 Probe Info  		K47(0.00); K97(0.00)  LDD0228  [18]
1d-yne
 Probe Info  		N.A.  LDD0357  [18]
Acrolein
 Probe Info  		C132(0.00); H213(0.00); C106(0.00)  LDD0217  [19]
Methacrolein
 Probe Info  		C132(0.00); C106(0.00)  LDD0218  [19]
W1
 Probe Info  		C106(0.00); C132(0.00)  LDD0236  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		C132(0.00); C106(0.00)  LDD2223  [14]
TER-AC
 Probe Info  		N.A.  LDD0426  [22]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C064
 Probe Info  		6.96  LDD1761  [23]
C071
 Probe Info  		23.75  LDD1767  [23]
C134
 Probe Info  		28.05  LDD1816  [23]
C147
 Probe Info  		7.01  LDD1829  [23]
C169
 Probe Info  		25.11  LDD1849  [23]
C265
 Probe Info  		13.36  LDD1936  [23]
C347
 Probe Info  		8.40  LDD2008  [23]
C380
 Probe Info  		5.46  LDD2039  [23]
C397
 Probe Info  		9.51  LDD2056  [23]
FFF probe11
 Probe Info  		12.42  LDD0471  [24]
FFF probe13
 Probe Info  		20.00  LDD0475  [24]
FFF probe14
 Probe Info  		17.43  LDD0477  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe3
 Probe Info  		17.14  LDD0464  [24]
FFF probe4
 Probe Info  		20.00  LDD0466  [24]
Alk-rapa
 Probe Info  		3.95  LDD0213  [25]
OEA-DA
 Probe Info  		9.33  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C106(2.93); C132(3.32)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C106(2.24)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C106(1.10); C132(1.25)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C106(0.93); C132(1.09)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C106(1.28); C132(0.82)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C106(1.50); C132(0.90)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C106(1.56); C132(0.94)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C106(1.57); C132(1.01)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C106(2.26); C132(0.94)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C106(1.67); C132(0.80)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C106(2.53); C132(0.97)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C106(1.33); C132(0.94)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C106(1.50); C132(0.80)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C106(1.70); C132(0.83)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C106(0.89); C132(1.04)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C106(2.12); C132(0.86)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C106(2.40); C132(0.90)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C106(1.74); C132(0.97)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C106(0.83); C132(0.98)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C106(0.94); C132(0.98)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C106(1.09); C132(0.96)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C106(0.94); C132(1.13)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C106(0.85); C132(0.99)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C106(0.76); C132(1.07)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C106(0.95); C132(1.01)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C106(0.75); C132(1.06)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C106(0.90); C132(1.34)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C106(0.87); C132(1.14)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C106(0.94); C132(1.00)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C106(0.73); C132(1.40)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C106(0.77); C132(1.08)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C106(0.97); C132(0.98)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C106(0.90); C132(1.03)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C106(0.77); C132(1.21)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C106(1.25); C132(1.01)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C106(1.40); C132(0.85)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C106(1.31); C132(0.87)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C106(1.23); C132(0.96)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C106(1.11); C132(0.93)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C106(1.52); C132(1.01)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C106(1.31); C132(1.16)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C106(1.20); C132(1.01)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C106(1.35); C132(1.11)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C106(1.26); C132(1.07)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C106(1.11); C132(1.39)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C106(1.36); C132(1.04)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C106(1.04); C132(1.04)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C106(1.31); C132(1.16)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C106(1.51); C132(1.12)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C106(1.50); C132(1.11)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C132(1.36)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C132(1.04)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C132(0.90)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C132(1.18)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C132(1.16)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C132(1.29)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C132(1.22)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C106(0.91); C132(1.06)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C132(1.16)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C132(1.23)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C132(1.18)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C132(1.27)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C132(1.08)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C132(1.19)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C132(1.15)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C132(1.10)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C132(0.90); C106(1.13)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C132(0.94); C106(1.23)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C132(0.85); C106(1.22)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C132(1.22); C106(1.27)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C132(0.98); C106(1.04)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C132(0.80); C106(0.84)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C132(0.75); C106(1.10)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C106(0.90); C132(0.92)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C132(0.85); C106(1.00)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C132(0.76); C106(0.96)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C132(1.04); C106(1.14)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C132(0.97); C106(1.09)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C106(0.86); C132(0.92)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C132(0.98); C106(1.14)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C106(1.08); C132(1.11)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C106(0.80); C132(1.06)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C132(0.84); C106(1.02)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C132(0.89); C106(1.16)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C132(0.97); C106(1.01)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C106(0.83); C132(1.39)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C132(0.89)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C132(0.79)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C132(0.76)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C132(1.01)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C132(0.99)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C106(1.32); C132(1.39)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C132(0.99)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C132(0.88)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C132(0.88)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C132(0.79)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C132(0.86)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C132(0.90)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C132(0.85); C106(1.02)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C132(0.84); C106(0.99)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C132(0.75); C106(0.92)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C132(1.05); C106(1.25)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C106(1.35); C132(1.50)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C132(0.95); C106(1.02)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C132(0.68); C106(0.93)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C132(0.82); C106(0.85)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C132(0.76); C106(0.78)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C132(0.98); C106(1.21)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C132(0.83); C106(0.97)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C106(0.93); C132(1.07)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C132(1.00); C106(1.26)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C106(1.09); C132(1.29)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C106(1.05); C132(1.21)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C106(1.07); C132(1.11)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C106(1.08); C132(1.15)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C106(1.07); C132(1.15)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C132(1.19); C106(1.19)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C106(1.05); C132(1.30)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C106(1.00); C132(1.21)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C106(1.11); C132(1.18)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C106(0.91); C132(1.19)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C106(0.90); C132(1.26)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C132(0.91); C106(1.01)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C132(0.94); C106(0.96)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C106(0.98); C132(1.13)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C132(0.83); C106(0.84)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C132(1.05); C106(1.06)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C132(0.93); C106(0.99)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C106(0.90); C132(1.08)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C106(1.02); C132(1.12)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C106(0.76); C132(1.14)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C132(1.01); C106(1.01)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C132(0.95); C106(0.98)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C106(0.95); C132(1.06)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C106(1.02); C132(1.11)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C106(0.79); C132(1.21)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C106(0.90); C132(1.03)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C106(0.91); C132(1.13)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C106(0.93); C132(1.29)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C132(1.18); C106(1.58)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C132(1.13); C106(2.02)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C106(1.04); C132(1.08)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C132(0.97); C106(1.23)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C132(1.03); C106(1.08)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C132(0.92); C106(1.08)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C132(0.96); C106(1.31)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C132(0.85); C106(0.88)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C106(0.90); C132(0.99)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C132(1.02); C106(1.15)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C132(1.25); C106(1.27)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C106(0.94); C132(1.06)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C132(0.90); C106(1.00)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C132(0.93); C106(1.35)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C106(0.89); C132(1.10)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C132(1.04); C106(1.60)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C132(0.82); C106(2.56)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C106(1.03); C132(0.99)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C106(0.96); C132(1.20)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C106(0.93); C132(1.26)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 14.90  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C132(1.21)  LDD2171  [8]
 LDCM0630  CCW28-3 231MFP C106(1.36); C132(1.32)  LDD2214  [27]
 LDCM0108  Chloroacetamide HeLa C106(0.00); C132(0.00); H159(0.00)  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C106(2.15); C132(1.06)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C132(0.99)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C132(1.04)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C106(1.18); C132(1.33)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C106(1.08); C132(1.22)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C106(1.19); C132(1.22)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C106(0.80); C132(0.94)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C106(0.89); C132(1.08)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C106(0.84); C132(0.93)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C106(1.00); C132(1.19)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C106(1.04); C132(1.06)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C106(1.03); C132(1.15)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C106(0.95); C132(1.01)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C132(0.98)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C106(0.99); C132(1.02)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C132(0.99); C106(1.14)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C132(0.76); C106(0.85)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C106(0.94); C132(1.16)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C106(0.88); C132(1.14)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C106(0.98); C132(1.59)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C132(1.03); C106(1.14)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C132(1.02)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C132(0.94)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C132(0.75)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C132(0.96)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C132(0.72)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C132(0.71); C106(1.16)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C132(1.07); C106(1.27)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C132(0.89); C106(0.90)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C132(0.95); C106(1.09)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C106(0.93); C132(0.93)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C106(0.88); C132(1.32)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C106(1.05); C132(1.17)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C132(0.96); C106(1.08)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C132(1.05)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C132(0.98)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C132(1.01)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C132(1.14)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C132(1.33)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C132(0.99)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C132(0.88)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C132(0.85)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C132(1.50)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C132(1.08)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C132(1.53)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C132(1.41)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C132(0.91)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C132(1.10)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C132(1.24)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C132(1.10)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C132(1.07)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C132(1.19)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C132(1.19)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C132(1.24)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C132(0.98)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C132(0.79)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C132(0.82)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C132(0.72)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C132(1.09)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C132(0.92)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C132(1.17)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C132(0.98)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C132(1.05)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C132(1.04)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C132(0.84)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C132(1.04)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C132(0.73)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C132(0.82)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C132(0.71)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C106(0.92); C132(0.74)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C106(0.80); C132(0.70)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C106(0.93); C132(0.66)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C106(1.04); C132(0.76)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C132(0.82)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C106(0.95); C132(0.74)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C106(1.09); C132(0.71)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C106(1.04); C132(0.80)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C106(0.93); C132(0.88)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C106(0.83); C132(0.70)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C106(0.96); C132(0.69)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C106(1.07); C132(0.88)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C106(0.92); C132(0.94)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C106(0.92); C132(0.79)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C106(0.88); C132(0.90)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C132(0.87)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C106(0.88); C132(0.81)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C106(1.02); C132(0.90)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C106(0.93); C132(0.81)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C106(1.00); C132(1.06)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C106(0.99); C132(0.88)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C106(1.12); C132(1.02)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C106(0.96); C132(0.84)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C106(1.27); C132(1.02)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C106(1.07); C132(1.78)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C106(0.99); C132(0.98)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C132(0.83)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C106(1.09); C132(1.01)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C106(0.93); C132(0.99)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C106(1.03); C132(1.04)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C106(1.00); C132(1.09)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C106(1.13); C132(1.12)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C106(1.26); C132(1.48)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C106(1.18); C132(1.63)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C106(1.42); C132(1.14)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C106(1.33); C132(1.32)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C132(0.94)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C106(1.08); C132(1.01)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C106(1.35); C132(1.00)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C106(1.68); C132(1.01)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C106(1.28); C132(1.09)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C106(1.39); C132(1.22)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C106(1.57); C132(1.22)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C106(1.14); C132(1.35)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C106(1.37); C132(1.47)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C106(1.43); C132(1.64)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C106(1.70); C132(1.34)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C132(0.89)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C106(1.44); C132(1.31)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C106(0.97); C132(1.02)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C106(0.95); C132(1.09)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C106(0.80); C132(1.11)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C106(0.98); C132(1.12)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C106(0.89); C132(1.30)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C106(0.92); C132(1.24)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C106(0.93); C132(1.05)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C106(1.24); C132(1.43)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C106(1.14); C132(1.32)  LDD0811  [8]
 LDCM0634  CY-0357 Hep-G2 C132(0.54)  LDD2228  [14]
 LDCM0495  E2913 HEK-293T C132(1.55); C106(1.24)  LDD1698  [28]
 LDCM0625  F8 Ramos C132(0.77); C106(0.59)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C132(0.90)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C132(2.33); C106(0.56)  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C132(1.00)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C132(0.91)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C132(0.87); C106(1.08)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C132(0.89)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C132(0.94)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C132(0.85)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C132(1.31)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C132(0.86); C106(0.55)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C132(1.26)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C132(1.02)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C132(0.92)  LDD2201  [29]
 LDCM0468  Fragment33 HCT 116 C106(1.08); C132(0.93)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C132(0.90)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C132(0.85)  LDD2184  [29]
 LDCM0427  Fragment51 HCT 116 C132(1.02)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C132(1.04)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C132(1.11)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C132(0.59)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C132(0.80)  LDD2188  [29]
 LDCM0116  HHS-0101 DM93 Y207(0.86)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y207(0.75)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y207(0.40)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y207(1.79)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y207(0.67)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [19]
 LDCM0022  KB02 HCT 116 C106(2.14); C132(1.35)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C106(1.80); C132(1.35)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C106(2.73); C132(1.54)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [19]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C132(1.07)  LDD2092  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C132(0.65); C106(0.33)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C132(1.03); C106(0.19)  LDD2207  [30]
 LDCM0131  RA190 MM1.R C106(1.81); C132(1.45)  LDD0304  [31]
 LDCM0090  Rapamycin JHH-7 3.95  LDD0213  [25]
 LDCM0021  THZ1 HCT 116 C132(1.21)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aminoacylase-1 (ACY1) Peptidase M20A family Q03154
Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2) Pterin-4-alpha-carbinolamine dehydratase family Q9H0N5
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
Pre-mRNA-processing factor 19 (PRPF19) WD repeat PRP19 family Q9UMS4
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Paired box protein Pax-5 (PAX5) . Q02548
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 36 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cuticular Ha7 (KRT37) Intermediate filament family O76014
Keratin, type I cytoskeletal 20 (KRT20) Intermediate filament family P35900
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 29 (MED29) Mediator complex subunit 29 family Q9NX70
Protein Mis18-beta (OIP5) Mis18 family O43482
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Sperm microtubule inner protein 6 (SPMIP6) SMRP1 family Q8NCR6
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
Pleiotropic regulator 1 (PLRG1) WD repeat PRL1/PRL2 family O43660
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
EMILIN-3 (EMILIN3) . Q9NT22
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Extracellular matrix protein 1 (ECM1) . Q16610
Heat shock factor 2-binding protein (HSF2BP) . O75031
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
LIM domain transcription factor LMO4 (LMO4) . P61968
Migration and invasion-inhibitory protein (MIIP) . Q5JXC2
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Pre-mRNA-processing-splicing factor 8 (PRPF8) . Q6P2Q9
Rhombotin-1 (LMO1) . P25800
ZW10 interactor (ZWINT) . O95229

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
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Mass spectrometry data entry: PXD007570
27 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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