Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C071  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 20.8
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 20.3
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 18.1
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 17.5
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 15.6
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 15.1
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 14.2
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 13.8
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 13.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 13.0
 LDTP09955  Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1) 12.6
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 12.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 12.2
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 11.2
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 11.2
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 11.0
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 10.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 10.2
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 9.9
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 9.8
 LDTP04581  Holocytochrome c-type synthase (HCCS) 9.7
 LDTP02359  Heme oxygenase 1 (HMOX1) 9.6
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 9.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 9.4
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 9.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 9.3
 LDTP00462  Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDK) 9.2
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 9.2
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 9.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 9.0
 LDTP03822  Activin receptor type-1B (ACVR1B) 8.9
 LDTP11268  Acireductone dioxygenase (ADI1) 8.9
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 8.8
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 8.8
 LDTP02505  Lysosomal protective protein (CTSA) 8.7
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 8.6
 LDTP02837  Beta-galactosidase (GLB1) 8.5
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 8.5
 LDTP13352  GTP:AMP phosphotransferase AK3, mitochondrial (AK3) 8.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 8.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 8.3
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 8.2
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) 8.1
 LDTP10329  Ceramide synthase 2 (CERS2) 8.1
 LDTP11090  Mitochondrial genome maintenance exonuclease 1 (MGME1) 8.1
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 8.1
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 8.1
Transporter and channel
Click to Show/Hide to Show 31 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 22.6
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 15.5
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 14.2
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 14.2
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 14.2
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 13.6
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 13.1
 LDTP07667  Transmembrane protein 205 (TMEM205) 12.3
 LDTP01631  Mitochondrial pyruvate carrier 2 (MPC2) 11.6
 LDTP15948  Transmembrane protein 126A (TMEM126A) 11.2
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 11.2
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 10.9
 LDTP05900  Metaxin-1 (MTX1) 10.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 10.7
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 10.6
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 10.6
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 10.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 10.3
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 10.2
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 10.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 9.4
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 9.4
 LDTP07236  Protein GPR107 (GPR107) 9.1
 LDTP08881  Transmembrane protein 199 (TMEM199) 9.0
 LDTP12383  Protein GPR108 (GPR108) 8.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 8.9
 LDTP20002  Transmembrane protein 160 (TMEM160) 8.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 8.8
 LDTP16813  Tetraspanin-3 (TSPAN3) 8.4
 LDTP15648  BRI3-binding protein (BRI3BP) 8.1
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 8.1
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 31.3
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 8.9
 LDTP01913  HLA class I histocompatibility antigen, B alpha chain (HLA-B) 8.8
Other
Click to Show/Hide to Show 19 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01358  Pre-mRNA-splicing factor SPF27 (BCAS2) 23.8
 LDTP11076  Apolipoprotein L2 (APOL2) 19.3
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 15.5
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 13.9
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 12.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.1
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 12.0
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 11.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 11.8
 LDTP05922  Dynactin subunit 2 (DCTN2) 10.1
 LDTP05868  Protein unc-119 homolog A (UNC119) 10.1
 LDTP05160  Nucleobindin-2 (NUCB2) 10.1
 LDTP12476  Translation initiation factor eIF2B subunit gamma (EIF2B3) 9.0
 LDTP03175  Galanin peptides (GAL) 8.9
 LDTP05277  Protein SET (SET) 8.9
 LDTP01522  Reticulon-3 (RTN3) 8.6
 LDTP18883  Protein CEBPZOS (CEBPZOS) 8.5
 LDTP01652  Centrosomal protein 43 (CEP43) 8.3
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 8.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587