Details of the Target

General Information of Target

Target ID LDTP16040
Target Name Glyoxalase domain-containing protein 4 (GLOD4)
Gene Name GLOD4
Gene ID 51031
Synonyms
C17orf25; Glyoxalase domain-containing protein 4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MERNSSLWKNLIDEHPVCTTWKQEAEGAIYHLASILFVVGFMGGSGFFGLLYVFSLLGLG
FLCSAVWAWVDVCAADIFSWNFVLFVICFMQFVHIAYQVRSITFAREFQVLYSSLFQPLG
ISLPVFRTIALSSEVVTLEKEHCYAMQGKTSIDKLSLLVSGRIRVTVDGEFLHYIFPLQF
LDSPEWDSLRPTEEGIFQVTLTAETDCRYVSWRRKKLYLLFAQHRYISRLFSVLIGSDIA
DKLYALNDRVYIGKRYHYDIRLPNFYQMSTPEIRRSPLTQHFQNSRRYCDK
Target Bioclass
Enzyme
Family
Glyoxalase I family
Subcellular location
Mitochondrion
Uniprot ID
Q9HC38
Ensemble ID
ENST00000301328.9
HGNC ID
HGNC:14111
ChEMBL ID
CHEMBL4295951

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K181(10.00); K198(4.71); K305(5.54); K308(10.00)  LDD0277  [4]
DBIA
 Probe Info  		C197(1.13)  LDD3311  [5]
BTD
 Probe Info  		C197(2.26); C221(1.70)  LDD1700  [6]
DA-P3
 Probe Info  		6.47  LDD0179  [7]
AHL-Pu-1
 Probe Info  		C197(2.15)  LDD0169  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
Acrolein
 Probe Info  		H8(0.00); C221(0.00)  LDD0221  [10]
ATP probe
 Probe Info  		K224(0.00); K298(0.00); K305(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C197(0.00); C269(0.00); C221(0.00); C171(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C221(0.00); C171(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C197(0.00); C269(0.00); C221(0.00); C171(0.00)  LDD0037  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
Compound 10
 Probe Info  		C197(0.00); C221(0.00)  LDD2216  [15]
IPM
 Probe Info  		N.A.  LDD0147  [16]
NHS
 Probe Info  		K305(0.00); K205(0.00)  LDD0010  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Ox-W18
 Probe Info  		N.A.  LDD2175  [17]
1c-yne
 Probe Info  		K239(0.00); K298(0.00)  LDD0228  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C197(0.00); C221(0.00); C171(0.00)  LDD2223  [20]
HHS-465
 Probe Info  		N.A.  LDD2240  [21]
PAL-AfBPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C011
 Probe Info  		5.70  LDD1720  [22]
C055
 Probe Info  		47.50  LDD1752  [22]
C064
 Probe Info  		9.45  LDD1761  [22]
C071
 Probe Info  		20.25  LDD1767  [22]
C072
 Probe Info  		7.31  LDD1768  [22]
C129
 Probe Info  		10.93  LDD1811  [22]
C130
 Probe Info  		7.57  LDD1812  [22]
C133
 Probe Info  		7.16  LDD1815  [22]
C134
 Probe Info  		25.81  LDD1816  [22]
C147
 Probe Info  		8.51  LDD1829  [22]
C161
 Probe Info  		13.09  LDD1841  [22]
C178
 Probe Info  		25.28  LDD1857  [22]
C193
 Probe Info  		5.06  LDD1869  [22]
C196
 Probe Info  		13.09  LDD1872  [22]
C229
 Probe Info  		8.00  LDD1902  [22]
C233
 Probe Info  		12.55  LDD1906  [22]
C234
 Probe Info  		8.06  LDD1907  [22]
C235
 Probe Info  		20.39  LDD1908  [22]
C238
 Probe Info  		13.00  LDD1911  [22]
C243
 Probe Info  		36.50  LDD1916  [22]
C249
 Probe Info  		17.15  LDD1922  [22]
C255
 Probe Info  		7.57  LDD1928  [22]
C260
 Probe Info  		26.72  LDD1932  [22]
C287
 Probe Info  		12.91  LDD1957  [22]
C300
 Probe Info  		5.74  LDD1969  [22]
C322
 Probe Info  		21.26  LDD1988  [22]
C353
 Probe Info  		7.01  LDD2014  [22]
C367
 Probe Info  		6.32  LDD2028  [22]
C388
 Probe Info  		39.40  LDD2047  [22]
C390
 Probe Info  		46.85  LDD2049  [22]
C392
 Probe Info  		6.11  LDD2051  [22]
C399
 Probe Info  		8.94  LDD2058  [22]
C408
 Probe Info  		5.24  LDD2065  [22]
C419
 Probe Info  		12.04  LDD2074  [22]
C424
 Probe Info  		7.73  LDD2079  [22]
C429
 Probe Info  		41.93  LDD2084  [22]
C431
 Probe Info  		25.11  LDD2086  [22]
FFF probe11
 Probe Info  		5.50  LDD0472  [23]
FFF probe13
 Probe Info  		14.18  LDD0475  [23]
FFF probe2
 Probe Info  		6.22  LDD0463  [23]
FFF probe3
 Probe Info  		5.77  LDD0465  [23]
FFF probe4
 Probe Info  		6.13  LDD0466  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C221(0.44)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C221(0.95)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C221(0.98); C197(1.07)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C221(1.17)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C221(0.43)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C221(0.74)  LDD2131  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C197(2.15)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C221(0.88); C197(0.88); C269(0.88); C171(0.95)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C221(0.88); C197(1.13); C269(1.03); C171(0.99)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C221(0.85); C197(0.98); C269(1.03); C171(0.93)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C221(0.79); C197(0.94); C269(0.96); C171(0.93)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C221(0.90); C197(0.95); C269(0.96); C171(1.06)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C221(0.82); C197(0.97); C269(0.94); C171(1.04)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C221(0.79); C197(0.83); C269(0.94); C171(0.98)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C221(0.88); C197(1.15); C269(1.02); C171(0.95)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C221(0.74); C197(0.87); C269(0.97); C171(0.82)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C221(0.88); C197(1.23); C269(0.96); C171(0.97)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C221(0.88); C197(0.92); C269(1.06); C171(1.19)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C221(0.99); C197(1.00); C269(1.08); C171(1.04)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C221(0.91); C197(0.95); C269(1.02); C171(0.98)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C221(0.80); C197(0.94); C269(0.96); C171(1.28)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C221(0.89); C197(0.91); C269(0.98); C171(0.95)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C221(0.88); C197(0.88); C269(0.92); C171(0.95)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C221(0.90); C197(1.15); C269(0.93); C171(0.98)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C221(0.86); C197(1.00); C269(0.98); C171(0.94)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C221(0.92); C197(1.00); C269(1.08); C171(0.96)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C221(1.03); C197(1.02); C269(1.06); C171(0.99)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C221(0.88); C197(1.00); C269(1.12); C171(0.94)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C221(0.95); C197(1.00); C269(0.98); C171(1.12)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C221(0.92); C197(1.06); C269(1.02); C171(1.04)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C221(0.87); C197(0.91); C269(1.13); C171(0.96)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C221(0.76); C197(0.77); C269(0.83); C171(0.99)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C221(0.88); C197(1.00); C269(0.99); C171(0.90)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C221(0.79); C197(0.85); C269(1.03); C171(0.90)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C221(0.79); C197(0.98); C269(1.00); C171(1.05)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C221(0.98); C197(1.08); C269(1.09); C171(0.99)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C221(0.87); C197(0.96); C269(1.03); C171(1.12)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C221(0.74); C197(1.02); C269(0.91); C171(1.06)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C221(0.91); C197(1.08); C269(0.92); C171(0.94)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C221(0.82); C197(0.98); C269(0.87); C171(1.02)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C221(0.77); C197(0.80); C269(1.01); C171(0.96)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C221(0.89); C197(1.10); C269(1.04); C171(0.94)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C221(0.84); C197(0.90); C269(1.00); C171(0.99)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C221(0.80); C197(0.99); C269(0.98); C171(1.30)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C221(0.88); C197(1.06); C269(1.03); C171(1.05)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C221(0.85); C197(0.94); C269(0.91); C171(0.92)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C221(0.79); C197(1.00); C269(0.98); C171(1.21)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C221(0.82); C197(0.93); C269(0.91); C171(0.96)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C221(0.77); C197(0.82); C269(0.92); C171(1.01)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C221(0.91); C197(1.03); C269(1.05); C171(0.97)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C221(0.91); C197(1.15); C269(1.02); C171(0.95)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C221(0.89); C197(0.99); C269(1.03); C171(1.06)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C221(0.79); C197(0.93); C269(0.99); C171(1.04)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C221(0.88); C197(0.98); C269(0.98); C171(1.07)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C221(0.81); C197(0.90); C269(0.96); C171(1.10)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C221(0.74); C197(1.01); C269(1.02); C171(1.09)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C221(0.82); C197(0.95); C269(1.10); C171(1.03)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C221(0.78); C197(0.86); C269(0.95); C171(0.99)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C221(0.88); C197(0.99); C269(1.00); C171(1.02)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C221(0.88); C197(0.99); C269(1.03); C171(1.00)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C221(0.88); C197(0.99); C269(1.03); C171(1.03)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C221(0.81); C197(0.93); C269(1.00); C171(0.88)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C221(0.91); C197(0.97); C269(1.03); C171(0.94)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C221(0.83); C197(0.78); C269(0.87); C171(0.94)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C221(0.78); C197(0.98); C269(0.97); C171(0.93)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C221(0.86); C197(1.04); C269(1.03); C171(1.07)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C221(0.82); C197(1.08); C269(0.90); C171(1.18)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C221(0.92); C197(1.09); C269(0.96); C171(1.12)  LDD1569  [24]
 LDCM0248  AKOS034007472 HEK-293T C221(0.93); C197(1.01); C269(1.08); C171(1.03)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C221(0.79); C197(0.88); C269(0.98); C171(1.01)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C221(0.84); C197(0.99); C269(0.91); C171(1.04)  LDD1514  [24]
 LDCM0156  Aniline NCI-H1299 12.58  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C221(0.60)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C197(0.00); C221(0.00)  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C221(0.70); C197(0.70); C269(1.02); C171(0.94)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C221(0.67); C197(0.76); C269(0.96); C171(0.89)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C221(0.86); C197(0.86); C269(0.93); C171(1.12)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C221(0.86); C197(0.89); C269(1.07); C171(1.08)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C221(0.87); C197(0.99); C269(0.94); C171(1.01)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C221(0.79); C197(0.88); C269(0.86); C171(1.04)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C221(0.87); C197(0.92); C269(1.06); C171(1.08)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C221(0.86); C197(0.93); C269(1.02); C171(0.98)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C221(0.99); C197(0.93); C269(0.88); C171(0.88)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C221(0.85); C197(0.95); C269(0.97); C171(1.02)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C221(0.93); C197(0.89); C269(1.09); C171(0.97)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C221(0.88); C197(0.97); C269(0.95); C171(0.92)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C221(0.75); C197(1.11); C269(0.94); C171(1.05)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C221(0.87); C197(0.98); C269(0.88); C171(0.93)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C221(0.95); C197(0.94); C269(0.97); C171(1.05)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C221(0.91); C197(0.93); C269(0.92); C171(0.89)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C221(0.82); C197(0.91); C269(1.06); C171(0.92)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C221(0.79); C197(0.90); C269(0.99); C171(0.96)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C221(0.85); C197(1.07); C269(0.93); C171(1.08)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C221(0.85); C197(0.88); C269(1.10); C171(1.12)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C221(0.89); C197(0.89); C269(1.28); C171(0.87)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C221(0.91); C197(0.95); C269(1.12); C171(1.00)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C221(0.88); C197(1.11); C269(1.00); C171(1.09)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C221(0.64); C197(0.88); C269(0.89); C171(1.02)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C221(0.89); C197(0.91); C269(1.02); C171(1.01)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C221(0.84); C197(0.89); C269(1.11); C171(0.94)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C221(0.84); C197(0.86); C269(1.12); C171(0.95)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C221(0.80); C197(0.90); C269(0.91); C171(0.92)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C221(0.80); C197(0.94); C269(1.05); C171(0.95)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C221(0.89); C197(0.88); C269(1.08); C171(1.07)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C221(0.87); C197(0.99); C269(1.05); C171(0.99)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C221(0.92); C197(0.94); C269(0.96); C171(1.08)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C221(0.89); C197(0.84); C269(0.98); C171(1.07)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C221(0.73); C197(0.79); C269(1.06); C171(0.96)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C221(0.79); C197(0.84); C269(1.29); C171(0.96)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C221(0.71); C197(0.76); C269(0.81); C171(0.99)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C221(0.74); C197(0.84); C269(0.96); C171(1.02)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C221(0.65); C197(0.73); C269(0.93); C171(0.94)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C221(0.81); C197(1.00); C269(1.05); C171(0.86)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C221(0.81); C197(0.94); C269(1.00); C171(0.96)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C221(0.97); C197(0.88); C269(0.92); C171(1.01)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C221(0.82); C197(1.09); C269(0.96); C171(0.95)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C221(0.66); C197(0.77); C269(0.94); C171(0.82)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C221(0.84); C197(0.95); C269(1.08); C171(1.08)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C221(0.74); C197(1.15); C269(0.94); C171(1.30)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C221(0.82); C197(0.97); C269(0.97); C171(1.02)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C221(0.78); C197(0.81); C269(0.99); C171(0.90)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C221(0.97); C197(0.91); C269(1.07); C171(0.97)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C221(0.86); C197(1.04); C269(0.97); C171(1.09)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C221(0.83); C197(1.02); C269(1.02); C171(0.96)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C221(0.84); C197(0.84); C269(0.87); C171(1.01)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C221(0.80); C197(0.97); C269(0.97); C171(1.16)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C221(0.89); C197(1.21); C269(0.97); C171(1.00)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C221(0.80); C197(0.98); C269(0.95); C171(0.91)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C221(0.84); C197(0.98); C269(0.91); C171(0.98)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C221(0.74); C197(0.94); C269(0.92); C171(0.78)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C221(0.85); C197(0.95); C269(0.98); C171(1.15)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C221(0.77); C197(1.11); C269(0.92); C171(0.91)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C221(0.79); C197(1.02); C269(0.87); C171(1.04)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C221(0.88); C197(0.83); C269(1.04); C171(1.00)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C221(0.80); C197(0.80); C269(0.87); C171(1.10)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C221(0.74); C197(0.80); C269(1.06); C171(0.97)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C221(0.82); C197(0.93); C269(1.00); C171(1.05)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C221(0.77); C197(0.85); C269(0.96); C171(0.90)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C221(0.96); C197(1.23); C269(1.01); C171(0.97)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C221(0.93); C197(0.98); C269(1.00); C171(0.96)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C221(0.82); C197(1.07); C269(0.90); C171(1.08)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C221(0.82); C197(0.97); C269(0.96); C171(0.84)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C221(0.76); C197(0.96); C269(1.09); C171(0.95)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C221(0.79); C197(1.03); C269(0.90); C171(0.97)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C221(0.80); C197(0.94); C269(1.07); C171(1.03)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C221(0.89); C197(0.97); C269(1.02); C171(1.08)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C221(0.80); C197(0.96); C269(1.13); C171(1.13)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C221(0.86); C197(0.92); C269(0.97); C171(0.93)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C221(0.80); C197(0.93); C269(0.98); C171(1.04)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C221(0.75); C197(0.81); C269(0.93); C171(0.94)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C221(0.81); C197(1.00); C269(1.03); C171(0.92)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C221(0.79); C197(1.01); C269(0.97); C171(1.01)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C221(0.78); C197(1.05); C269(0.92); C171(0.88)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C221(0.80); C197(0.97); C269(1.05); C171(0.89)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C221(0.82); C197(0.91); C269(0.94); C171(1.03)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C221(0.71); C197(1.07); C269(0.95); C171(1.02)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C221(0.77); C197(1.02); C269(1.04); C171(0.81)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C221(0.73); C197(0.95); C269(0.98); C171(0.96)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C221(0.86); C197(0.84); C269(1.07); C171(0.98)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C221(0.90); C197(0.91); C269(1.06); C171(1.06)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C221(0.79); C197(0.98); C269(1.13); C171(1.11)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C221(0.73); C197(0.79); C269(0.92); C171(0.94)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C221(0.73); C197(0.77); C269(0.83); C171(0.94)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C221(0.80); C197(1.20); C269(1.03); C171(0.92)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C221(0.83); C197(0.98); C269(1.10); C171(0.96)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C221(0.80); C197(1.08); C269(0.96); C171(0.95)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C221(0.86); C197(0.96); C269(1.04); C171(0.98)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C221(0.78); C197(0.91); C269(1.00); C171(1.09)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C221(0.81); C197(0.95); C269(1.17); C171(0.98)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C221(0.78); C197(1.11); C269(1.01); C171(1.15)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C221(0.72); C197(0.85); C269(0.90); C171(0.96)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C221(0.91); C197(0.89); C269(0.98); C171(0.93)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C221(1.00); C197(0.95); C269(1.13); C171(1.03)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C221(0.84); C197(0.97); C269(0.99); C171(1.13)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C221(0.74); C197(0.84); C269(0.99); C171(0.93)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C221(0.85); C197(1.38); C269(1.03); C171(0.98)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C221(0.91); C197(1.07); C269(1.00); C171(1.02)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C221(0.55); C197(0.76); C269(0.73); C171(0.74)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C221(0.94); C197(1.26); C269(1.02); C171(1.13)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C221(0.85); C197(1.07); C269(1.07); C171(1.03)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C221(0.97); C197(1.07); C269(1.14); C171(1.12)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C221(0.81); C197(1.13); C269(0.97); C171(1.10)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C221(0.87); C197(1.02); C269(1.00); C171(1.02)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C221(0.82); C197(0.83); C269(1.13); C171(1.00)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C221(0.92); C197(0.88); C269(1.07); C171(0.87)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C221(0.84); C197(0.95); C269(1.02); C171(1.06)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C221(0.79); C197(0.89); C269(1.15); C171(1.09)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C221(0.80); C197(0.79); C269(1.12); C171(1.05)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C221(0.89); C197(1.02); C269(1.09); C171(1.05)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C221(0.72); C197(0.91); C269(0.92); C171(0.79)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C221(0.92); C197(1.03); C269(1.01); C171(0.99)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C221(0.73); C197(0.93); C269(0.76); C171(0.98)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C221(0.84); C197(1.03); C269(1.02); C171(0.88)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C221(0.81); C197(0.91); C269(1.10); C171(0.95)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C221(0.65); C197(0.91); C269(0.82); C171(1.09)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C221(0.75); C197(0.94); C269(0.91); C171(0.98)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C221(0.82); C197(0.87); C269(0.94); C171(0.96)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C221(0.91); C197(0.99); C269(1.10); C171(1.18)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C221(0.91); C197(1.09); C269(1.07); C171(1.03)  LDD1697  [24]
 LDCM0028  Dobutamine HEK-293T 9.18  LDD0180  [7]
 LDCM0027  Dopamine HEK-293T 6.47  LDD0179  [7]
 LDCM0495  E2913 HEK-293T C221(0.71); C197(0.95); C269(0.94); C171(1.00)  LDD1698  [24]
 LDCM0031  Epigallocatechin gallate HEK-293T 39.75  LDD0183  [7]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0625  F8 Ramos C171(1.30)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C171(0.63)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C171(20.00)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C171(0.74)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C171(0.85)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C171(1.08)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C171(0.48)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C171(1.24)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C171(1.16)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C171(0.72)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C171(0.48)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C171(0.93)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C171(1.12)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C171(1.29)  LDD2201  [25]
 LDCM0468  Fragment33 HEK-293T C221(0.82); C197(1.11); C269(1.06); C171(1.17)  LDD1671  [24]
 LDCM0596  Fragment38 Ramos C171(1.43)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C171(0.64)  LDD2184  [25]
 LDCM0427  Fragment51 HEK-293T C221(0.91); C197(0.92); C269(1.04); C171(0.99)  LDD1631  [24]
 LDCM0610  Fragment52 Ramos C171(0.67)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C171(2.06)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C171(0.77)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C171(0.42)  LDD2188  [25]
 LDCM0107  IAA HeLa H8(0.00); C221(0.00)  LDD0221  [10]
 LDCM0022  KB02 Ramos C171(0.49)  LDD2182  [25]
 LDCM0023  KB03 Ramos C171(0.72)  LDD2183  [25]
 LDCM0024  KB05 G361 C197(1.13)  LDD3311  [5]
 LDCM0030  Luteolin HEK-293T 26.10  LDD0182  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C221(0.53)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C221(0.72)  LDD2089  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C221(1.16)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C221(0.23)  LDD2096  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C221(0.95); C197(1.31)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C221(0.81); C197(0.92)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C221(0.53); C197(0.71)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C221(0.93)  LDD2111  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C221(0.65)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C221(2.57); C197(2.48)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C221(1.05)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C221(0.36)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C221(0.92); C197(0.91)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C221(0.34)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C221(0.82)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C221(0.92)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C221(1.02)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C221(1.21); C197(1.18)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C221(1.05)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C221(0.48); C197(0.36)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C221(1.38)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C221(1.04)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C221(0.83); C197(1.02)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C197(2.26); C221(1.70)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C221(0.70)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C221(1.23)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C221(3.15); C197(2.20)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C221(0.91); C197(0.97)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C221(2.63)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C197(0.58)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C221(0.60)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C221(0.37)  LDD2151  [6]
 LDCM0029  Quercetin HEK-293T 12.00  LDD0181  [7]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578