General Information of Experiment

Probe Name C392  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01769  Dihydrofolate reductase (DHFR) 26.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 23.3
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 11.9
 LDTP03787  Choline kinase alpha (CHKA) 11.6
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 11.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.1
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 7.8
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.0
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 6.1
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 6.1
 LDTP06501  Ras-related protein Rab-11B (RAB11B) 5.7
 LDTP00988  Protein O-GlcNAcase (OGA) 5.5
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 5.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 5.1
Transporter and channel
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 6.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 6.5
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 6.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.6
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 5.1
 LDTP15481  Transmembrane protein 87A (TMEM87A) 4.9
Other
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 18.6
 LDTP02053  Heat shock protein beta-1 (HSPB1) 9.1
 LDTP05160  Nucleobindin-2 (NUCB2) 8.5
 LDTP13630  Neudesin (NENF) 7.6
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 6.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 6.9
 LDTP05226  RNA-binding protein 3 (RBM3) 6.3
 LDTP05375  Nucleobindin-1 (NUCB1) 5.3

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587