Details of the Target

General Information of Target

Target ID LDTP13902
Target Name Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3)
Gene Name COA3
Gene ID 28958
Synonyms
CCDC56; MITRAC12; Cytochrome c oxidase assembly factor 3 homolog, mitochondrial; Coiled-coil domain-containing protein 56; Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNG
NQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLT
QVAAS
Target Bioclass
Other
Family
COA3 family
Subcellular location
Mitochondrion inner membrane
Function
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
Uniprot ID
Q9Y2R0
Ensemble ID
ENST00000328434.8
HGNC ID
HGNC:24990

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K48(6.75)  LDD0277  [1]
AZ-9
 Probe Info  		D86(10.00)  LDD2209  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
NHS
 Probe Info  		N.A.  LDD0010  [5]
PAL-AfBPP Probe
Click To Hide/Show 145 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.13  LDD1711  [6]
C003
 Probe Info  		13.83  LDD1713  [6]
C004
 Probe Info  		17.63  LDD1714  [6]
C007
 Probe Info  		5.62  LDD1716  [6]
C010
 Probe Info  		9.06  LDD1719  [6]
C011
 Probe Info  		5.78  LDD1720  [6]
C022
 Probe Info  		71.51  LDD1728  [6]
C026
 Probe Info  		9.99  LDD1732  [6]
C040
 Probe Info  		38.32  LDD1740  [6]
C041
 Probe Info  		21.86  LDD1741  [6]
C044
 Probe Info  		6.54  LDD1743  [6]
C049
 Probe Info  		15.14  LDD1747  [6]
C052
 Probe Info  		6.87  LDD1750  [6]
C053
 Probe Info  		15.45  LDD1751  [6]
C055
 Probe Info  		67.65  LDD1752  [6]
C056
 Probe Info  		99.73  LDD1753  [6]
C059
 Probe Info  		5.10  LDD1756  [6]
C063
 Probe Info  		42.81  LDD1760  [6]
C064
 Probe Info  		11.79  LDD1761  [6]
C067
 Probe Info  		5.50  LDD1763  [6]
C070
 Probe Info  		26.35  LDD1766  [6]
C072
 Probe Info  		13.00  LDD1768  [6]
C082
 Probe Info  		11.63  LDD1774  [6]
C087
 Probe Info  		27.28  LDD1779  [6]
C091
 Probe Info  		95.01  LDD1782  [6]
C092
 Probe Info  		99.73  LDD1783  [6]
C093
 Probe Info  		9.85  LDD1784  [6]
C094
 Probe Info  		99.73  LDD1785  [6]
C100
 Probe Info  		7.57  LDD1789  [6]
C102
 Probe Info  		4.96  LDD1790  [6]
C106
 Probe Info  		99.73  LDD1793  [6]
C107
 Probe Info  		29.65  LDD1794  [6]
C108
 Probe Info  		40.22  LDD1795  [6]
C112
 Probe Info  		99.73  LDD1799  [6]
C130
 Probe Info  		10.20  LDD1812  [6]
C134
 Probe Info  		86.22  LDD1816  [6]
C135
 Probe Info  		19.43  LDD1817  [6]
C139
 Probe Info  		15.03  LDD1821  [6]
C140
 Probe Info  		8.57  LDD1822  [6]
C141
 Probe Info  		17.39  LDD1823  [6]
C143
 Probe Info  		59.30  LDD1825  [6]
C147
 Probe Info  		7.01  LDD1829  [6]
C153
 Probe Info  		74.54  LDD1834  [6]
C159
 Probe Info  		45.57  LDD1839  [6]
C160
 Probe Info  		25.11  LDD1840  [6]
C161
 Probe Info  		60.97  LDD1841  [6]
C163
 Probe Info  		9.19  LDD1843  [6]
C165
 Probe Info  		15.14  LDD1845  [6]
C166
 Probe Info  		7.67  LDD1846  [6]
C169
 Probe Info  		99.73  LDD1849  [6]
C170
 Probe Info  		20.25  LDD1850  [6]
C172
 Probe Info  		9.13  LDD1852  [6]
C173
 Probe Info  		11.96  LDD1853  [6]
C174
 Probe Info  		8.40  LDD1854  [6]
C177
 Probe Info  		7.46  LDD1856  [6]
C178
 Probe Info  		38.32  LDD1857  [6]
C183
 Probe Info  		5.31  LDD1861  [6]
C186
 Probe Info  		15.45  LDD1864  [6]
C201
 Probe Info  		99.73  LDD1877  [6]
C206
 Probe Info  		29.04  LDD1881  [6]
C210
 Probe Info  		73.01  LDD1884  [6]
C216
 Probe Info  		9.85  LDD1890  [6]
C217
 Probe Info  		5.58  LDD1891  [6]
C218
 Probe Info  		77.17  LDD1892  [6]
C219
 Probe Info  		15.89  LDD1893  [6]
C220
 Probe Info  		99.73  LDD1894  [6]
C225
 Probe Info  		9.71  LDD1898  [6]
C226
 Probe Info  		9.78  LDD1899  [6]
C228
 Probe Info  		65.34  LDD1901  [6]
C229
 Probe Info  		11.55  LDD1902  [6]
C231
 Probe Info  		85.04  LDD1904  [6]
C232
 Probe Info  		99.73  LDD1905  [6]
C233
 Probe Info  		17.15  LDD1906  [6]
C234
 Probe Info  		8.94  LDD1907  [6]
C235
 Probe Info  		72.50  LDD1908  [6]
C238
 Probe Info  		36.25  LDD1911  [6]
C240
 Probe Info  		18.25  LDD1913  [6]
C243
 Probe Info  		64.45  LDD1916  [6]
C246
 Probe Info  		76.64  LDD1919  [6]
C249
 Probe Info  		38.05  LDD1922  [6]
C252
 Probe Info  		10.85  LDD1925  [6]
C264
 Probe Info  		72.50  LDD1935  [6]
C265
 Probe Info  		28.64  LDD1936  [6]
C266
 Probe Info  		7.89  LDD1937  [6]
C270
 Probe Info  		11.47  LDD1940  [6]
C285
 Probe Info  		27.47  LDD1955  [6]
C287
 Probe Info  		14.22  LDD1957  [6]
C288
 Probe Info  		10.34  LDD1958  [6]
C289
 Probe Info  		78.79  LDD1959  [6]
C293
 Probe Info  		88.03  LDD1963  [6]
C296
 Probe Info  		49.18  LDD1966  [6]
C307
 Probe Info  		7.26  LDD1975  [6]
C310
 Probe Info  		20.53  LDD1977  [6]
C313
 Probe Info  		22.16  LDD1980  [6]
C314
 Probe Info  		53.82  LDD1981  [6]
C317
 Probe Info  		6.50  LDD1983  [6]
C322
 Probe Info  		14.32  LDD1988  [6]
C326
 Probe Info  		9.45  LDD1990  [6]
C338
 Probe Info  		22.94  LDD2001  [6]
C339
 Probe Info  		22.47  LDD2002  [6]
C343
 Probe Info  		36.50  LDD2005  [6]
C346
 Probe Info  		10.34  LDD2007  [6]
C348
 Probe Info  		30.70  LDD2009  [6]
C349
 Probe Info  		34.78  LDD2010  [6]
C350
 Probe Info  		99.73  LDD2011  [6]
C354
 Probe Info  		8.88  LDD2015  [6]
C355
 Probe Info  		99.73  LDD2016  [6]
C356
 Probe Info  		39.67  LDD2017  [6]
C357
 Probe Info  		18.13  LDD2018  [6]
C361
 Probe Info  		34.54  LDD2022  [6]
C362
 Probe Info  		99.73  LDD2023  [6]
C363
 Probe Info  		99.73  LDD2024  [6]
C364
 Probe Info  		99.73  LDD2025  [6]
C366
 Probe Info  		27.47  LDD2027  [6]
C367
 Probe Info  		20.68  LDD2028  [6]
C373
 Probe Info  		11.39  LDD2033  [6]
C376
 Probe Info  		14.52  LDD2036  [6]
C378
 Probe Info  		12.30  LDD2037  [6]
C380
 Probe Info  		7.36  LDD2039  [6]
C382
 Probe Info  		29.04  LDD2041  [6]
C383
 Probe Info  		29.45  LDD2042  [6]
C386
 Probe Info  		13.18  LDD2045  [6]
C388
 Probe Info  		99.73  LDD2047  [6]
C390
 Probe Info  		99.73  LDD2049  [6]
C391
 Probe Info  		99.73  LDD2050  [6]
C392
 Probe Info  		18.64  LDD2051  [6]
C393
 Probe Info  		17.88  LDD2052  [6]
C394
 Probe Info  		16.45  LDD2053  [6]
C396
 Probe Info  		26.17  LDD2055  [6]
C399
 Probe Info  		14.42  LDD2058  [6]
C403
 Probe Info  		69.07  LDD2061  [6]
C407
 Probe Info  		20.82  LDD2064  [6]
C413
 Probe Info  		34.30  LDD2069  [6]
C419
 Probe Info  		33.13  LDD2074  [6]
C420
 Probe Info  		42.81  LDD2075  [6]
C424
 Probe Info  		15.78  LDD2079  [6]
C426
 Probe Info  		50.56  LDD2081  [6]
C429
 Probe Info  		63.56  LDD2084  [6]
C430
 Probe Info  		5.98  LDD2085  [6]
C431
 Probe Info  		99.73  LDD2086  [6]
C433
 Probe Info  		8.69  LDD2088  [6]
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [7]
OEA-DA
 Probe Info  		20.00  LDD0046  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 1 (MT-CO1) Heme-copper respiratory oxidase family P00395
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Surfeit locus protein 1 (SURF1) SURF1 family Q15526

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570