Details of the Probe

General Information of Probe

Probe ID
LDPC0648
Probe Name
C433
Synonyms
Z3462042539
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 329.35
Lipid-water partition coefficient (xlogp) 2.1
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C17H19N3O4
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-5-methoxy-2,3-dihydro-1,4-benzodioxine-7-carboxamide
Canonical SMILES
COC1=CC(=CC2=C1OCCO2)C(=O)NCCC3(N=N3)CCC#C
InChI
InChI=1S/C17H19N3O4/c1-3-4-5-17(19-20-17)6-7-18-16(21)12-10-13(22-2)15-14(11-12)23-8-9-24-15/h1,10-11H,4-9H2,2H3,(H,18,21)
InChIKey
RMIAWAMCUXMKJH-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

67 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
5'-3' exonuclease PLD3 (PLD3) LDTP08476 11.63  LDD2088 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 10.56  LDD2088 
Adenosine deaminase (ADA) LDTP01803 18.51  LDD2088 
Adenosine kinase (ADK) LDTP04689 5.66  LDD2088 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 8.22  LDD2088 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 6.92  LDD2088 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 8.69  LDD2088 
ATP-binding cassette sub-family C member 4 (ABCC4) LDTP00639 5.86  LDD2088 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 5.98  LDD2088 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 9.92  LDD2088 
Beta-galactosidase (GLB1) LDTP02837 6.82  LDD2088 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 6.59  LDD2088 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 8.46  LDD2088 
Catechol O-methyltransferase (COMT) LDTP03145 23.92  LDD2088 
Ceramide synthase 2 (CERS2) LDTP10329 5.86  LDD2088 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 5.98  LDD2088 
Cytochrome b5 type B (CYB5B) LDTP00697 8.40  LDD2088 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 7.62  LDD2088 
Delta(24)-sterol reductase (DHCR24) LDTP06375 9.38  LDD2088 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 11.00  LDD2088 
Deoxyhypusine hydroxylase (DOHH) LDTP11225 7.52  LDD2088 
Deoxyhypusine synthase (DHPS) LDTP04248 5.82  LDD2088 
DNA replication licensing factor MCM4 (MCM4) LDTP03680 12.55  LDD2088 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 6.68  LDD2088 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 7.73  LDD2088 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 16.11  LDD2088 
Epoxide hydrolase 1 (EPHX1) LDTP02175 12.82  LDD2088 
Exosome complex component MTR3 (EXOSC6) LDTP07054 27.86  LDD2088 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 10.70  LDD2088 
Ferrochelatase, mitochondrial (FECH) LDTP03198 22.47  LDD2088 
Heme oxygenase 1 (HMOX1) LDTP02359 11.16  LDD2088 
Heme oxygenase 2 (HMOX2) LDTP03540 17.75  LDD2088 
Holocytochrome c-type synthase (HCCS) LDTP04581 7.01  LDD2088 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 14.12  LDD2088 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 9.51  LDD2088 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 17.88  LDD2088 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 25.28  LDD2088 
Lysosomal protective protein (CTSA) LDTP02505 6.23  LDD2088 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 6.50  LDD2088 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 8.34  LDD2088 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 7.84  LDD2088 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 5.78  LDD2088 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 7.89  LDD2088 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 10.93  LDD2088 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 7.31  LDD2088 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 8.17  LDD2088 
Phospholipase A2 group XV (PLA2G15) LDTP09088 6.50  LDD2088 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 6.45  LDD2088 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 13.36  LDD2088 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 7.89  LDD2088 
Prostaglandin reductase 3 (PTGR3) LDTP15422 9.32  LDD2088 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 6.36  LDD2088 
Proteasome subunit beta type-7 (PSMB7) LDTP10862 6.41  LDD2088 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 9.71  LDD2088 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 8.11  LDD2088 
Retinal dehydrogenase 2 (ALDH1A2) LDTP01419 8.51  LDD2088 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 16.80  LDD2088 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 15.78  LDD2088 
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) LDTP06384 10.06  LDD2088 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 7.89  LDD2088 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 8.63  LDD2088 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 16.00  LDD2088 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 10.13  LDD2088 
Transcriptional regulator ATRX (ATRX) LDTP04090 5.62  LDD2088 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 7.41  LDD2088 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 11.39  LDD2088 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 16.00  LDD2088 
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⏷ Show the Full List of 67 Enzyme
39 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ATP synthase subunit a (MT-ATP6) LDTP01804 19.56  LDD2088 
Cation-dependent mannose-6-phosphate receptor (M6PR) LDTP03061 7.16  LDD2088 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 8.46  LDD2088 
Integral membrane protein 2C (ITM2C) LDTP12451 6.82  LDD2088 
Lysosome membrane protein 2 (SCARB2) LDTP06034 11.55  LDD2088 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 9.58  LDD2088 
Metaxin-1 (MTX1) LDTP05900 6.36  LDD2088 
MFS-type transporter SLC18B1 (SLC18B1) LDTP07462 25.81  LDD2088 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 25.99  LDD2088 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 8.51  LDD2088 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 32.67  LDD2088 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 15.56  LDD2088 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 5.62  LDD2088 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 9.13  LDD2088 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 9.51  LDD2088 
Mpv17-like protein 2 (MPV17L2) LDTP14952 14.03  LDD2088 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 6.23  LDD2088 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 61.39  LDD2088 
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDTP05538 6.63  LDD2088 
Prosaposin (PSAP) LDTP02215 13.93  LDD2088 
Protein GPR107 (GPR107) LDTP07236 39.40  LDD2088 
Protein GPR108 (GPR108) LDTP12383 11.63  LDD2088 
Protein Mpv17 (MPV17) LDTP03869 5.86  LDD2088 
Protein spinster homolog 1 (SPNS1) LDTP11844 6.06  LDD2088 
Proton-coupled amino acid transporter 1 (SLC36A1) LDTP08016 14.22  LDD2088 
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) LDTP09294 5.90  LDD2088 
Reduced folate transporter (SLC19A1) LDTP03952 8.57  LDD2088 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 22.16  LDD2088 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 6.11  LDD2088 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 19.97  LDD2088 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 7.21  LDD2088 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 6.82  LDD2088 
Translocator protein (TSPO) LDTP03546 5.82  LDD2088 
Transmembrane protein 160 (TMEM160) LDTP20002 8.69  LDD2088 
Transmembrane protein 199 (TMEM199) LDTP08881 13.18  LDD2088 
Transmembrane protein 205 (TMEM205) LDTP07667 34.78  LDD2088 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 25.99  LDD2088 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 14.52  LDD2088 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 15.24  LDD2088 
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⏷ Show the Full List of 39 Transporter and channel
48 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
A-kinase anchor protein 8 (AKAP8) LDTP00880 5.86  LDD2088 
Alpha-internexin (INA) LDTP06527 6.45  LDD2088 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 6.15  LDD2088 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 10.93  LDD2088 
Calumenin (CALU) LDTP00887 5.86  LDD2088 
Centrosomal protein 43 (CEP43) LDTP01652 9.38  LDD2088 
Clustered mitochondria protein homolog (CLUH) LDTP14486 13.64  LDD2088 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 6.59  LDD2088 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 8.69  LDD2088 
DDRGK domain-containing protein 1 (DDRGK1) LDTP10403 5.66  LDD2088 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 5.86  LDD2088 
Dynactin subunit 3 (DCTN3) LDTP01359 8.94  LDD2088 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 5.58  LDD2088 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 7.52  LDD2088 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 15.45  LDD2088 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 6.41  LDD2088 
Golgi apparatus protein 1 (GLG1) LDTP09920 6.15  LDD2088 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 9.25  LDD2088 
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) LDTP06255 5.94  LDD2088 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 5.98  LDD2088 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 5.90  LDD2088 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 9.13  LDD2088 
Large proline-rich protein BAG6 (BAG6) LDTP04094 18.00  LDD2088 
Large ribosomal subunit protein mL55 (MRPL55) LDTP15269 57.28  LDD2088 
Mdm2-binding protein (MTBP) LDTP15714 11.16  LDD2088 
Microtubule nucleation factor SSNA1 (SSNA1) LDTP00871 7.36  LDD2088 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 17.27  LDD2088 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 5.98  LDD2088 
Myomegalin (PDE4DIP) LDTP07221 6.36  LDD2088 
Neudesin (NENF) LDTP13630 7.57  LDD2088 
Neuferricin (CYB5D2) LDTP15623 42.52  LDD2088 
Nucleobindin-1 (NUCB1) LDTP05375 5.62  LDD2088 
Nucleobindin-2 (NUCB2) LDTP05160 10.78  LDD2088 
Nurim (NRM) LDTP08606 5.74  LDD2088 
Protein FAM114A2 (FAM114A2) LDTP16080 7.31  LDD2088 
Protein FAM89A (FAM89A) LDTP19867 6.41  LDD2088 
Protein unc-119 homolog B (UNC119B) LDTP00105 16.68  LDD2088 
Reticulocalbin-2 (RCN2) LDTP06097 14.42  LDD2088 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 6.96  LDD2088 
Testis-expressed protein 264 (TEX264) LDTP14259 5.86  LDD2088 
Tetraspanin-6 (TSPAN6) LDTP14458 7.41  LDD2088 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 6.15  LDD2088 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 6.32  LDD2088 
TraB domain-containing protein (TRABD) LDTP19963 8.82  LDD2088 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 7.01  LDD2088 
Vimentin (VIM) LDTP02297 7.94  LDD2088 
WD repeat and coiled-coil-containing protein (WDCP) LDTP11995 5.90  LDD2088 
YEATS domain-containing protein 4 (YEATS4) LDTP01638 8.57  LDD2088 
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⏷ Show the Full List of 48 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2088 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587