Details of the Target

General Information of Target

Target ID LDTP01743
Target Name NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10)
Gene Name NDUFB10
Gene ID 4716
Synonyms
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; Complex I-PDSW; CI-PDSW; NADH-ubiquinone oxidoreductase PDSW subunit
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPDSWDKDVYPEPPRRTPVQPNPIVYMMKAFDLIVDRPVTLVREFIERQHAKNRYYYYHR
QYRRVPDITECKEEDIMCMYEAEMQWKRDYKVDQEIINIMQDRLKACQQREGQNYQQNCI
KEVEQFTQVAKAYQDRYQDLGAYSSARKCLAKQRQRMLQERKAAKEAAAATS
Target Bioclass
Enzyme
Family
Complex I NDUFB10 subunit family
Subcellular location
Mitochondrion inner membrane
Function
Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
Uniprot ID
O96000
Ensemble ID
ENST00000268668.11
HGNC ID
HGNC:7696
ChEMBL ID
CHEMBL2363065

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1395 SNV: p.E47D .
HCT15 SNV: p.N114S .
HT115 SNV: p.M28I .
JURKAT SNV: p.D36E .
SBC5 SNV: p.R103G .
YSCCC SNV: p.E160D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.01  LDD0402  [1]
FBPP2
 Probe Info  		2.76  LDD0318  [2]
TH211
 Probe Info  		Y26(12.39)  LDD0260  [3]
TH216
 Probe Info  		Y26(5.19)  LDD0259  [3]
STPyne
 Probe Info  		K52(10.00); K91(8.33)  LDD0277  [4]
DBIA
 Probe Info  		C119(3.09)  LDD3310  [5]
BTD
 Probe Info  		C119(0.89)  LDD1700  [6]
IPM
 Probe Info  		C71(0.29)  LDD1701  [6]
Acrolein
 Probe Info  		N.A.  LDD0222  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
ENE
 Probe Info  		N.A.  LDD0006  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
1d-yne
 Probe Info  		N.A.  LDD0357  [14]
Crotonaldehyde
 Probe Info  		C119(0.00); H59(0.00)  LDD0219  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		14.20  LDD0443  [15]
NAIA_5
 Probe Info  		C119(0.00); C107(0.00); C71(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 52 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		54.57  LDD1740  [17]
C055
 Probe Info  		12.30  LDD1752  [17]
C056
 Probe Info  		27.28  LDD1753  [17]
C063
 Probe Info  		26.54  LDD1760  [17]
C070
 Probe Info  		8.46  LDD1766  [17]
C091
 Probe Info  		12.21  LDD1782  [17]
C092
 Probe Info  		99.73  LDD1783  [17]
C094
 Probe Info  		25.11  LDD1785  [17]
C106
 Probe Info  		18.90  LDD1793  [17]
C112
 Probe Info  		99.73  LDD1799  [17]
C134
 Probe Info  		22.63  LDD1816  [17]
C139
 Probe Info  		10.85  LDD1821  [17]
C159
 Probe Info  		8.17  LDD1839  [17]
C161
 Probe Info  		14.32  LDD1841  [17]
C169
 Probe Info  		33.13  LDD1849  [17]
C170
 Probe Info  		8.75  LDD1850  [17]
C178
 Probe Info  		16.56  LDD1857  [17]
C218
 Probe Info  		17.03  LDD1892  [17]
C220
 Probe Info  		16.11  LDD1894  [17]
C228
 Probe Info  		19.03  LDD1901  [17]
C231
 Probe Info  		13.27  LDD1904  [17]
C232
 Probe Info  		55.33  LDD1905  [17]
C235
 Probe Info  		17.15  LDD1908  [17]
C278
 Probe Info  		51.63  LDD1948  [17]
C282
 Probe Info  		14.42  LDD1952  [17]
C289
 Probe Info  		39.12  LDD1959  [17]
C293
 Probe Info  		20.11  LDD1963  [17]
C305
 Probe Info  		12.91  LDD1974  [17]
C326
 Probe Info  		7.41  LDD1990  [17]
C348
 Probe Info  		17.03  LDD2009  [17]
C349
 Probe Info  		19.56  LDD2010  [17]
C350
 Probe Info  		86.22  LDD2011  [17]
C353
 Probe Info  		15.56  LDD2014  [17]
C354
 Probe Info  		21.11  LDD2015  [17]
C382
 Probe Info  		56.49  LDD2041  [17]
C388
 Probe Info  		66.72  LDD2047  [17]
C390
 Probe Info  		35.26  LDD2049  [17]
C391
 Probe Info  		22.16  LDD2050  [17]
C403
 Probe Info  		48.17  LDD2061  [17]
C413
 Probe Info  		13.83  LDD2069  [17]
C419
 Probe Info  		12.04  LDD2074  [17]
C429
 Probe Info  		12.38  LDD2084  [17]
C431
 Probe Info  		16.91  LDD2086  [17]
C433
 Probe Info  		5.78  LDD2088  [17]
FFF probe11
 Probe Info  		20.00  LDD0471  [18]
FFF probe12
 Probe Info  		20.00  LDD0473  [18]
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe14
 Probe Info  		17.00  LDD0477  [18]
FFF probe2
 Probe Info  		13.75  LDD0463  [18]
FFF probe3
 Probe Info  		18.41  LDD0465  [18]
STS-2
 Probe Info  		N.A.  LDD0138  [19]
OEA-DA
 Probe Info  		8.79  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C119(0.57)  LDD2117  [6]
 LDCM0214  AC1 HEK-293T C71(0.93)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C71(0.89)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C71(0.98)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C119(1.03)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C119(0.87)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C71(0.89)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C71(0.90)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C71(0.95)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C71(1.22)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C71(0.92)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C119(0.93)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C71(0.91)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C119(0.83)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C71(0.92)  LDD1522  [21]
 LDCM0285  AC25 HEK-293T C71(0.88)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C71(0.97)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C71(0.91)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C119(0.94)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C71(1.03)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C71(0.97)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C119(1.03)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C71(0.90)  LDD1531  [21]
 LDCM0294  AC33 HEK-293T C71(0.98)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C71(0.94)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C71(1.01)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C119(1.15)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C71(0.93)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C119(0.79)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C71(0.88)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C119(1.21)  LDD1540  [21]
 LDCM0303  AC41 HEK-293T C71(0.90)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C71(0.88)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C71(0.96)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C119(1.19)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C71(1.09)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C119(0.98)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C71(0.89)  LDD1548  [21]
 LDCM0311  AC49 HEK-293T C71(0.81)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C71(0.80)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C71(0.91)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C71(0.93)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C119(1.11)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C71(1.02)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C119(0.77)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C71(0.88)  LDD1557  [21]
 LDCM0320  AC57 HEK-293T C71(0.91)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C71(0.95)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C71(0.93)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C119(1.15)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C119(0.94)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C71(0.91)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C119(1.11)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C71(0.91)  LDD1566  [21]
 LDCM0334  AC7 HEK-293T C71(0.93)  LDD1568  [21]
 LDCM0545  Acetamide MDA-MB-231 C107(0.25)  LDD2138  [6]
 LDCM0248  AKOS034007472 HEK-293T C71(0.93)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C71(0.91)  LDD1570  [21]
 LDCM0156  Aniline NCI-H1299 11.53  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C71(0.77)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C119(0.92)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C71(0.90)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C71(0.92)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C71(1.05)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C71(1.10)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C71(0.90)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C71(0.88)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C71(0.93)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C71(1.05)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C71(0.94)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C71(1.04)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C71(1.64)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C71(0.90)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C71(1.28)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C71(0.92)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C71(0.94)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C71(1.07)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C71(1.27)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C71(0.90)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C71(1.03)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C71(1.00)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C71(1.01)  LDD1593  [21]
 LDCM0391  CL120 HEK-293T C71(1.02)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C71(0.98)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C71(0.95)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C71(1.18)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C71(0.92)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C71(0.75)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C71(0.90)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C71(1.03)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C71(0.93)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C71(0.86)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C71(1.06)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C71(1.19)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C71(0.91)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C71(1.10)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C71(1.07)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C71(1.23)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C71(1.07)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C119(1.06)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C71(1.77)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C119(0.95)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C71(1.45)  LDD1615  [21]
 LDCM0413  CL25 HEK-293T C71(0.79)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C71(0.91)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C71(1.02)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C71(1.02)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C71(1.00)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C71(1.41)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C71(0.99)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C71(1.19)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C119(1.02)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C71(1.52)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C119(0.90)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C71(1.51)  LDD1628  [21]
 LDCM0426  CL37 HEK-293T C71(0.75)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C71(1.08)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C71(0.95)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C71(0.94)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C71(1.05)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C71(1.16)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C71(1.18)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C119(0.93)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C71(1.84)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C119(0.81)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C71(1.56)  LDD1641  [21]
 LDCM0439  CL49 HEK-293T C71(0.77)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C71(1.14)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C71(1.01)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C71(0.93)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C71(1.09)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C71(1.00)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C71(1.28)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C119(1.05)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C71(1.66)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C119(1.02)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C71(1.32)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C71(1.14)  LDD1654  [21]
 LDCM0453  CL61 HEK-293T C71(0.77)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C71(0.92)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C71(1.00)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C71(0.92)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C71(1.07)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C71(1.01)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C71(1.17)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C119(1.01)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C71(1.67)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C71(1.17)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C119(0.87)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C71(1.15)  LDD1667  [21]
 LDCM0466  CL73 HEK-293T C71(0.80)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C71(0.95)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C71(0.90)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C71(0.93)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C71(0.99)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C71(1.10)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C119(1.00)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C119(1.03)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C71(1.62)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C119(0.85)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C71(1.34)  LDD1680  [21]
 LDCM0479  CL85 HEK-293T C71(0.68)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C71(0.77)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C71(0.94)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C71(0.88)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C71(0.88)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C71(1.96)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C71(1.14)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C71(1.15)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C119(1.23)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C71(1.27)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C119(0.94)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C71(1.33)  LDD1693  [21]
 LDCM0492  CL97 HEK-293T C71(1.03)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C71(0.97)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C71(0.91)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C71(1.04)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C71(0.85)  LDD1702  [6]
 LDCM0625  F8 Ramos C119(1.39)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C119(0.71)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C119(0.98)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C119(0.99)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C119(0.64)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C119(1.01)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C119(1.17)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C119(0.57)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C119(0.63)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C119(0.64)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C119(0.71)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C119(0.64)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C119(0.78)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C119(0.84)  LDD2201  [22]
 LDCM0468  Fragment33 HEK-293T C71(1.07)  LDD1671  [21]
 LDCM0596  Fragment38 Ramos C119(0.47)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C119(1.60)  LDD2184  [22]
 LDCM0427  Fragment51 HEK-293T C71(0.94)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C119(0.98)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C119(0.81)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C119(1.50)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C119(1.68)  LDD2188  [22]
 LDCM0022  KB02 Ramos C119(1.63)  LDD2182  [22]
 LDCM0023  KB03 MDA-MB-231 C71(0.29)  LDD1701  [6]
 LDCM0024  KB05 COLO792 C119(3.09)  LDD3310  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C107(0.41)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C119(1.00)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C119(0.66)  LDD2107  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C107(0.76)  LDD2111  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C119(0.80)  LDD2115  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C107(0.59); C119(0.87)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C107(0.48)  LDD2123  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C119(0.62)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C107(0.46)  LDD2128  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C119(0.88)  LDD2134  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C119(0.96)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C119(0.58)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C119(0.89)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C107(0.36); C119(0.56)  LDD2140  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C119(1.35)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C119(1.24)  LDD2145  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C119(0.72)  LDD2148  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C119(1.35)  LDD2153  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Transmembrane protein 185A (TMEM185A) TMEM185 family Q8NFB2
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Lupus La protein (SSB) . P05455
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578