Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C139  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 95 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 73.5
 LDTP01769  Dihydrofolate reductase (DHFR) 54.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 42.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 41.4
 LDTP00325  Pirin (PIR) 35.3
 LDTP03842  Squalene synthase (FDFT1) 32.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 31.8
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 31.6
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 29.7
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 27.3
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 24.8
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 23.8
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 23.6
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 22.9
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 22.9
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 22.5
 LDTP02505  Lysosomal protective protein (CTSA) 22.2
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 21.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 21.4
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 19.3
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 19.2
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 19.2
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 19.0
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 18.6
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 18.3
 LDTP10101  Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) 18.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 18.0
 LDTP10780  Trimethylguanosine synthase (TGS1) 17.9
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 17.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 17.4
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 16.8
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 16.8
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 16.8
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 16.6
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 16.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 16.6
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 16.3
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 16.1
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 15.9
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 15.6
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 15.1
 LDTP11518  Histone-lysine N-methyltransferase NSD3 (NSD3) 15.1
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 15.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 14.5
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 14.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 14.4
 LDTP01803  Adenosine deaminase (ADA) 14.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 14.3
 LDTP10329  Ceramide synthase 2 (CERS2) 14.3
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 14.3
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 14.3
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 14.3
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 13.8
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 13.6
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 13.3
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 13.1
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 13.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 12.9
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 12.9
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 12.9
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 12.9
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 12.9
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 12.5
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 12.4
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 12.2
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 12.2
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 12.1
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 12.1
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 12.0
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 12.0
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 11.6
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 11.6
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 11.6
 LDTP05905  Acid ceramidase (ASAH1) 11.4
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 11.4
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 11.3
 LDTP12444  Xaa-Pro aminopeptidase 1 (XPNPEP1) 11.3
 LDTP03787  Choline kinase alpha (CHKA) 11.2
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 11.0
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 11.0
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 11.0
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 11.0
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 10.9
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 10.9
 LDTP03145  Catechol O-methyltransferase (COMT) 10.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 10.8
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 10.8
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 10.8
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 10.7
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 10.7
 LDTP03779  Copper-transporting ATPase 2 (ATP7B) 10.6
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) 10.6
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 10.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 10.3
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 10.3
Transporter and channel
Click to Show/Hide to Show 53 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 85.0
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 50.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 48.8
 LDTP12383  Protein GPR108 (GPR108) 45.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 45.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 38.1
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 37.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 37.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 36.8
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 34.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 30.7
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 27.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 26.0
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 25.6
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 24.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 23.4
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 22.3
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 21.6
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.5
 LDTP07236  Protein GPR107 (GPR107) 19.6
 LDTP02215  Prosaposin (PSAP) 18.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 18.4
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 17.5
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 17.4
 LDTP15948  Transmembrane protein 126A (TMEM126A) 16.8
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 16.3
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 16.1
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 15.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 15.1
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 14.9
 LDTP15648  BRI3-binding protein (BRI3BP) 14.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 14.0
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 13.5
 LDTP05900  Metaxin-1 (MTX1) 13.4
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 13.3
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 13.0
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 12.9
 LDTP15481  Transmembrane protein 87A (TMEM87A) 12.6
 LDTP02010  Annexin A1 (ANXA1) 12.6
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 12.6
 LDTP11615  Protein tweety homolog 3 (TTYH3) 12.3
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 11.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 11.3
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 11.2
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 11.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 11.2
 LDTP05662  Cell division cycle protein 20 homolog (CDC20) 10.9
 LDTP12451  Integral membrane protein 2C (ITM2C) 10.9
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 10.9
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 10.7
 LDTP04213  Phosphatidylinositol transfer protein beta isoform (PITPNB) 10.5
 LDTP16813  Tetraspanin-3 (TSPAN3) 10.4
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 10.3
Other
Click to Show/Hide to Show 61 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 38.6
 LDTP11076  Apolipoprotein L2 (APOL2) 34.1
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 28.8
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 26.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 24.4
 LDTP05160  Nucleobindin-2 (NUCB2) 23.6
 LDTP05375  Nucleobindin-1 (NUCB1) 22.9
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 22.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 21.6
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 21.0
 LDTP18569  PRELI domain containing protein 3B (PRELID3B) 19.4
 LDTP16088  Ribosome biogenesis protein SLX9 homolog (SLX9) 19.2
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 18.5
 LDTP05012  Small ribosomal subunit protein eS24 (RPS24) 18.0
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 16.9
 LDTP06305  WD repeat-containing protein 43 (WDR43) 16.8
 LDTP00105  Protein unc-119 homolog B (UNC119B) 16.4
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 15.7
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 15.0
 LDTP13807  PRELI domain-containing protein 1, mitochondrial (PRELID1) 14.3
 LDTP10056  Protein FAM162A (FAM162A) 14.3
 LDTP11143  Centromere protein K (CENPK) 14.2
 LDTP01522  Reticulon-3 (RTN3) 14.2
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 14.1
 LDTP06097  Reticulocalbin-2 (RCN2) 13.8
 LDTP18883  Protein CEBPZOS (CEBPZOS) 13.7
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 13.5
 LDTP01075  Protein CutA (CUTA) 13.2
 LDTP09773  Protein FAM3C (FAM3C) 13.2
 LDTP00859  Synaptogyrin-2 (SYNGR2) 13.2
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 12.4
 LDTP16080  Protein FAM114A2 (FAM114A2) 12.4
 LDTP13125  Protein UXT (UXT) 12.3
 LDTP15834  Integrator complex subunit 14 (INTS14) 12.1
 LDTP12412  Reticulon-4 (RTN4) 12.1
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 12.0
 LDTP01652  Centrosomal protein 43 (CEP43) 11.9
 LDTP00986  Syntaxin-10 (STX10) 11.8
 LDTP13630  Neudesin (NENF) 11.7
 LDTP01246  KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) 11.4
 LDTP03775  RNA-binding protein FUS (FUS) 11.4
 LDTP04946  Ubiquitin-fold modifier 1 (UFM1) 11.4
 LDTP07703  Seizure 6-like protein 2 (SEZ6L2) 11.2
 LDTP02297  Vimentin (VIM) 11.2
 LDTP05226  RNA-binding protein 3 (RBM3) 11.1
 LDTP09563  Stromal membrane-associated protein 2 (SMAP2) 11.1
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 11.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 11.0
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 10.9
 LDTP14458  Tetraspanin-6 (TSPAN6) 10.9
 LDTP08224  Protein LYRIC (MTDH) 10.9
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 10.8
 LDTP18272  Transmembrane protein 209 (TMEM209) 10.8
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 10.7
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 10.6
 LDTP09589  Charged multivesicular body protein 7 (CHMP7) 10.6
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 10.6
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 10.5
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 10.4
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 10.4
 LDTP19963  TraB domain-containing protein (TRABD) 10.3

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587