Details of the Target

General Information of Target

Target ID LDTP13807
Target Name PRELI domain-containing protein 1, mitochondrial (PRELID1)
Gene Name PRELID1
Gene ID 27166
Synonyms
PRELI; PRELI domain-containing protein 1, mitochondrial; 25 kDa protein of relevant evolutionary and lymphoid interest; Px19-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVT
RSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVD
LTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQI
DNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSH
GSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYA
MCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDND
RVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLT
MLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSL
ESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPFQTSQSTGTEPFFKQKSLLLK
QKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPVCEGVSKLEESSKATPAEMDLAHN
SQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEHMDYHFALELQ
KSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPRPEGMQTLESFFKPLTH
Target Bioclass
Other
Subcellular location
Mitochondrion
Function
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.
Uniprot ID
Q9Y255
Ensemble ID
ENST00000303204.9
HGNC ID
HGNC:30255

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MDST8 SNV: p.V86M .
MFE319 SNV: p.Q144H .
NCIH358 SNV: p.A196G .
OVK18 SNV: p.E172G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C112(1.06)  LDD0814  [1]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C010
 Probe Info  		5.24  LDD1719  [2]
C063
 Probe Info  		28.25  LDD1760  [2]
C106
 Probe Info  		21.71  LDD1793  [2]
C134
 Probe Info  		35.02  LDD1816  [2]
C135
 Probe Info  		9.78  LDD1817  [2]
C139
 Probe Info  		14.32  LDD1821  [2]
C140
 Probe Info  		14.72  LDD1822  [2]
C191
 Probe Info  		18.25  LDD1868  [2]
C193
 Probe Info  		5.50  LDD1869  [2]
C213
 Probe Info  		16.34  LDD1887  [2]
C285
 Probe Info  		27.28  LDD1955  [2]
C431
 Probe Info  		29.04  LDD2086  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C112(1.06)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C112(1.24)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C112(1.06)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C112(1.08)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C112(0.98)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C112(1.24)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C112(1.41)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C112(1.01)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C112(0.96)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C112(0.96)  LDD0823  [1]
 LDCM0227  AC110 HEK-293T C112(1.27)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C112(1.13)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C112(1.01)  LDD0827  [1]
 LDCM0296  AC35 HEK-293T C112(1.20)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C112(0.99)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C112(0.96)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C112(0.65)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C112(1.15)  LDD0898  [1]
 LDCM0302  AC40 HEK-293T C112(0.97)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C112(1.03)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C112(1.11)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C112(1.15)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C112(1.22)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C112(0.80)  LDD0905  [1]
 LDCM0320  AC57 HEK-293T C112(0.82)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C112(1.10)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C112(0.98)  LDD0920  [1]
 LDCM0324  AC60 HEK-293T C112(0.87)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C112(0.93)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C112(1.17)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C112(0.97)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C112(0.88)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C112(0.93)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C112(0.96)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C112(0.89)  LDD0929  [1]
 LDCM0349  AC83 HEK-293T C112(1.11)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C112(0.92)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C112(1.04)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C112(0.91)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C112(0.82)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C112(0.68)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C112(0.98)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C112(0.93)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C112(0.77)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C112(0.66)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C112(0.80)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C112(0.78)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C112(0.79)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C112(0.73)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C112(0.85)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C112(1.00)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C112(1.23)  LDD0964  [1]
 LDCM0387  CL117 HEK-293T C112(1.04)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C112(1.11)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C112(0.96)  LDD0987  [1]
 LDCM0391  CL120 HEK-293T C112(0.86)  LDD0989  [1]
 LDCM0396  CL125 HEK-293T C112(1.06)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C112(0.74)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C112(1.06)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C112(1.01)  LDD0997  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587