Details of the Probe

General Information of Probe

Probe ID
LDPC0279
Probe Name
C010
Synonyms
Z3433407733
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 327.3
Lipid-water partition coefficient (xlogp) 2.7
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C15H16F3N3O2
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-2-[2-methyl-4-(trifluoromethyl)furan-3-yl]acetamide
Canonical SMILES
CC1=C(C(=CO1)C(F)(F)F)CC(=O)NCCC2(N=N2)CCC#C
InChI
InChI=1S/C15H16F3N3O2/c1-3-4-5-14(20-21-14)6-7-19-13(22)8-11-10(2)23-9-12(11)15(16,17)18/h1,9H,4-8H2,2H3,(H,19,22)
InChIKey
YEZFODDUSPMELF-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

45 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Acid ceramidase (ASAH1) LDTP05905 5.17  LDD1719 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 5.35  LDD1719 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 5.39  LDD1719 
Beta-galactosidase (GLB1) LDTP02837 14.83  LDD1719 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 6.63  LDD1719 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 6.19  LDD1719 
Ceramide synthase 2 (CERS2) LDTP10329 7.67  LDD1719 
Cytochrome b5 type B (CYB5B) LDTP00697 7.84  LDD1719 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 8.06  LDD1719 
Delta(24)-sterol reductase (DHCR24) LDTP06375 5.66  LDD1719 
Dihydrofolate reductase (DHFR) LDTP01769 6.36  LDD1719 
DNA polymerase epsilon subunit 2 (POLE2) LDTP04737 7.16  LDD1719 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 8.00  LDD1719 
Exonuclease 1 (EXO1) LDTP13751 5.82  LDD1719 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 5.94  LDD1719 
Heme oxygenase 1 (HMOX1) LDTP02359 9.45  LDD1719 
Heme oxygenase 2 (HMOX2) LDTP03540 11.16  LDD1719 
Histone-lysine N-methyltransferase SMYD3 (SMYD3) LDTP12020 15.89  LDD1719 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 6.23  LDD1719 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 5.39  LDD1719 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 6.73  LDD1719 
Lysosomal acid phosphatase (ACP2) LDTP02539 6.06  LDD1719 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 10.56  LDD1719 
Lysosomal protective protein (CTSA) LDTP02505 7.84  LDD1719 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 5.13  LDD1719 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 10.06  LDD1719 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 7.94  LDD1719 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 5.24  LDD1719 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 7.73  LDD1719 
Peroxisomal ATPase PEX1 (PEX1) LDTP00910 5.28  LDD1719 
Phospholipase A2 group XV (PLA2G15) LDTP09088 13.74  LDD1719 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 7.41  LDD1719 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 12.55  LDD1719 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 6.32  LDD1719 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 8.00  LDD1719 
Protein O-GlcNAcase (OGA) LDTP00988 6.36  LDD1719 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 5.28  LDD1719 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 7.21  LDD1719 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 6.59  LDD1719 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 7.84  LDD1719 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 11.47  LDD1719 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 5.24  LDD1719 
Soluble calcium-activated nucleotidase 1 (CANT1) LDTP09620 5.10  LDD1719 
Thioredoxin domain-containing protein 12 (TXNDC12) LDTP01707 5.54  LDD1719 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 14.32  LDD1719 
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⏷ Show the Full List of 45 Enzyme
32 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 10.78  LDD1719 
BRI3-binding protein (BRI3BP) LDTP15648 5.82  LDD1719 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 5.90  LDD1719 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 8.57  LDD1719 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 16.80  LDD1719 
H(+)/Cl(-) exchange transporter 7 (CLCN7) LDTP04463 6.02  LDD1719 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 5.46  LDD1719 
Lysosome membrane protein 2 (SCARB2) LDTP06034 14.42  LDD1719 
Metaxin-1 (MTX1) LDTP05900 5.24  LDD1719 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 5.31  LDD1719 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 8.00  LDD1719 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 7.41  LDD1719 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 5.74  LDD1719 
Mpv17-like protein 2 (MPV17L2) LDTP14952 6.32  LDD1719 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 5.24  LDD1719 
Nucleoporin NDC1 (NDC1) LDTP11213 5.54  LDD1719 
Protein GPR107 (GPR107) LDTP07236 9.19  LDD1719 
Protein GPR108 (GPR108) LDTP12383 6.96  LDD1719 
Protein tweety homolog 3 (TTYH3) LDTP11615 5.62  LDD1719 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 13.93  LDD1719 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 14.03  LDD1719 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 9.58  LDD1719 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 5.43  LDD1719 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 6.06  LDD1719 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 8.28  LDD1719 
Surfeit locus protein 4 (SURF4) LDTP00592 6.41  LDD1719 
Tetraspanin-3 (TSPAN3) LDTP16813 9.06  LDD1719 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 12.64  LDD1719 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 8.57  LDD1719 
Transmembrane protein 199 (TMEM199) LDTP08881 5.35  LDD1719 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 8.00  LDD1719 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 8.51  LDD1719 
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⏷ Show the Full List of 32 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Forkhead-associated domain-containing protein 1 (FHAD1) LDTP16717 19.16  LDD1719 
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29 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Apolipoprotein L2 (APOL2) LDTP11076 15.89  LDD1719 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 12.13  LDD1719 
Capping protein-inhibiting regulator of actin dynamics (CRACD) LDTP07839 5.28  LDD1719 
Centrosomal protein 43 (CEP43) LDTP01652 9.25  LDD1719 
Clustered mitochondria protein homolog (CLUH) LDTP14486 8.22  LDD1719 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 9.06  LDD1719 
Dynactin subunit 4 (DCTN4) LDTP13402 5.10  LDD1719 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 6.82  LDD1719 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 5.50  LDD1719 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 16.11  LDD1719 
FHF complex subunit HOOK-interacting protein 2B (FHIP2B) LDTP17580 5.28  LDD1719 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 7.01  LDD1719 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 9.06  LDD1719 
Large proline-rich protein BAG6 (BAG6) LDTP04094 8.28  LDD1719 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 12.55  LDD1719 
Mediator of RNA polymerase II transcription subunit 24 (MED24) LDTP01225 7.52  LDD1719 
Mediator of RNA polymerase II transcription subunit 25 (MED25) LDTP07906 5.70  LDD1719 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 6.32  LDD1719 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 18.77  LDD1719 
Neudesin (NENF) LDTP13630 7.52  LDD1719 
Nucleobindin-1 (NUCB1) LDTP05375 6.92  LDD1719 
Nucleobindin-2 (NUCB2) LDTP05160 18.00  LDD1719 
PRELI domain-containing protein 1, mitochondrial (PRELID1) LDTP13807 5.24  LDD1719 
Protein FAM114A2 (FAM114A2) LDTP16080 6.41  LDD1719 
Rap guanine nucleotide exchange factor 2 (RAPGEF2) LDTP14058 6.59  LDD1719 
Reticulon-3 (RTN3) LDTP01522 7.46  LDD1719 
Syntaxin-18 (STX18) LDTP13086 5.58  LDD1719 
Tetraspanin-6 (TSPAN6) LDTP14458 6.92  LDD1719 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 5.86  LDD1719 
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⏷ Show the Full List of 29 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1719 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587