Details of the Target

General Information of Target

Target ID LDTP05029
Target Name Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)
Gene Name FKBP1A
Gene ID 2280
Synonyms
FKBP1; FKBP12; Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; EC 5.2.1.8; 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
Target Type
Successful
Target Bioclass
Enzyme
Family
FKBP-type PPIase family, FKBP1 subfamily
Subcellular location
Cytoplasm, cytosol
Function
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
TTD ID
T76059
Uniprot ID
P62942
DrugMap ID
TTMW94E
Ensemble ID
ENST00000381719.8
HGNC ID
HGNC:3711
ChEMBL ID
CHEMBL1902

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y27(5.62)  LDD0260  [1]
TH214
 Probe Info  		Y27(13.90)  LDD0258  [1]
TH216
 Probe Info  		Y27(14.04)  LDD0259  [1]
ONAyne
 Probe Info  		K36(4.85); K53(4.41)  LDD0274  [2]
STPyne
 Probe Info  		K48(7.82); K53(9.21)  LDD0277  [2]
DBIA
 Probe Info  		C23(1.13)  LDD3397  [3]
BTD
 Probe Info  		C23(2.77)  LDD1700  [4]
HHS-482
 Probe Info  		Y27(1.44); Y83(0.96)  LDD0285  [5]
HHS-475
 Probe Info  		Y27(0.77); Y83(0.94); Y81(1.00)  LDD0264  [6]
HHS-465
 Probe Info  		Y27(9.10); Y81(5.81); Y83(4.78)  LDD2237  [7]
5E-2FA
 Probe Info  		H26(0.00); H88(0.00); H95(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		K35(0.00); K36(0.00); K53(0.00)  LDD0199  [9]
m-APA
 Probe Info  		H26(0.00); H88(0.00)  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
Ox-W18
 Probe Info  		N.A.  LDD2175  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 49 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C010
 Probe Info  		5.24  LDD1719  [15]
C011
 Probe Info  		5.24  LDD1720  [15]
C022
 Probe Info  		7.84  LDD1728  [15]
C041
 Probe Info  		12.30  LDD1741  [15]
C055
 Probe Info  		12.73  LDD1752  [15]
C069
 Probe Info  		5.90  LDD1765  [15]
C106
 Probe Info  		45.89  LDD1793  [15]
C108
 Probe Info  		11.16  LDD1795  [15]
C111
 Probe Info  		10.41  LDD1798  [15]
C141
 Probe Info  		9.38  LDD1823  [15]
C146
 Probe Info  		5.31  LDD1828  [15]
C147
 Probe Info  		91.77  LDD1829  [15]
C159
 Probe Info  		11.71  LDD1839  [15]
C161
 Probe Info  		13.36  LDD1841  [15]
C166
 Probe Info  		9.32  LDD1846  [15]
C194
 Probe Info  		27.28  LDD1870  [15]
C217
 Probe Info  		11.31  LDD1891  [15]
C220
 Probe Info  		13.27  LDD1894  [15]
C229
 Probe Info  		12.91  LDD1902  [15]
C231
 Probe Info  		12.55  LDD1904  [15]
C233
 Probe Info  		9.78  LDD1906  [15]
C234
 Probe Info  		6.59  LDD1907  [15]
C240
 Probe Info  		13.00  LDD1913  [15]
C246
 Probe Info  		14.83  LDD1919  [15]
C265
 Probe Info  		18.13  LDD1936  [15]
C277
 Probe Info  		9.51  LDD1947  [15]
C280
 Probe Info  		9.71  LDD1950  [15]
C288
 Probe Info  		6.50  LDD1958  [15]
C290
 Probe Info  		8.11  LDD1960  [15]
C293
 Probe Info  		25.99  LDD1963  [15]
C297
 Probe Info  		12.04  LDD1967  [15]
C299
 Probe Info  		6.15  LDD1968  [15]
C307
 Probe Info  		5.70  LDD1975  [15]
C342
 Probe Info  		99.73  LDD2004  [15]
C344
 Probe Info  		8.17  LDD2006  [15]
C351
 Probe Info  		6.19  LDD2012  [15]
C354
 Probe Info  		9.25  LDD2015  [15]
C357
 Probe Info  		6.41  LDD2018  [15]
C376
 Probe Info  		8.22  LDD2036  [15]
C380
 Probe Info  		5.06  LDD2039  [15]
C419
 Probe Info  		11.24  LDD2074  [15]
C431
 Probe Info  		77.71  LDD2086  [15]
FFF probe12
 Probe Info  		6.91  LDD0473  [16]
FFF probe13
 Probe Info  		20.00  LDD0475  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe15
 Probe Info  		16.58  LDD0478  [16]
CR-1
 Probe Info  		3.54  LDD0429  [17]
Alk-rapa
 Probe Info  		I92(0.00); P89(0.00); P94(0.00); Y81(0.00)  LDD0407  [18]
OEA-DA
 Probe Info  		18.07  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C23(0.35)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C23(0.51)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C23(1.40)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C23(1.56)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C23(1.09)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C23(0.45)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C23(0.68)  LDD2131  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C23(0.57)  LDD2113  [4]
 LDCM0498  BS-3668 MDA-MB-231 C23(0.46)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0168  Crenolanib NCI-H1703 3.54  LDD0429  [17]
 LDCM0625  F8 Ramos C23(3.32)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C23(0.28)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C23(0.02)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C23(0.45)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C23(0.53)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C23(0.77)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C23(0.33)  LDD2194  [20]
 LDCM0586  Fragment28 Ramos C23(0.72)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C23(0.92)  LDD2199  [20]
 LDCM0590  Fragment32 Ramos C23(0.42)  LDD2201  [20]
 LDCM0566  Fragment4 Ramos C23(0.53)  LDD2184  [20]
 LDCM0614  Fragment56 Ramos C23(0.41)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C23(0.49)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C23(0.19)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y27(0.77); Y83(0.94); Y81(1.00)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y27(0.73); Y83(0.91); Y81(1.58)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y27(0.65); Y81(0.81); Y83(1.15)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y27(0.92); Y81(1.05); Y83(1.11)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y27(0.89); Y83(1.00); Y81(1.31)  LDD0268  [6]
 LDCM0123  JWB131 DM93 Y27(1.44); Y83(0.96)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y27(0.56); Y83(0.65)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y27(1.16); Y83(1.44)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y27(3.56); Y83(4.15)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y27(2.21); Y83(1.34)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y27(1.57); Y83(1.74)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y27(0.40)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y27(0.81); Y83(0.81)  LDD0292  [5]
 LDCM0022  KB02 HEK-293T C23(1.03)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C23(0.98)  LDD1497  [21]
 LDCM0024  KB05 PF-382 C23(1.13)  LDD3397  [3]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C23(1.32)  LDD2102  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C23(1.38)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C23(1.42)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C23(1.52)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C23(2.33)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C23(0.63)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C23(0.75)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C23(0.74)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C23(1.18)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C23(0.40)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C23(0.89)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C23(0.42)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C23(0.26)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C23(1.23)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C23(0.56)  LDD2108  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C23(0.32)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C23(1.26)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C23(0.50)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C23(0.44)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C23(0.89)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C23(1.03)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C23(1.48)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C23(0.91)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C23(0.73)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C23(0.86)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C23(0.87)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C23(1.00)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C23(0.92)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C23(1.29)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C23(1.04)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C23(1.20)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C23(0.57)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C23(0.60)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C23(1.45)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C23(1.27)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C23(1.10)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C23(2.77)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C23(0.99)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C23(0.42)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C23(1.02)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C23(3.07)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C23(0.20)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C23(1.38)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C23(1.53)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C23(0.44)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C23(1.12)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C23(0.76)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C23(0.71)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C23(1.70)  LDD2153  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase mTOR (MTOR) PI3/PI4-kinase family P42345
Activin receptor type-1B (ACVR1B) TKL Ser/Thr protein kinase family P36896
TGF-beta receptor type-1 (TGFBR1) TKL Ser/Thr protein kinase family P36897
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Ryanodine receptor 2 (RYR2) Ryanodine receptor family Q92736
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 7 (SMAD7) Dwarfin/SMAD family O15105
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-hemoglobin-stabilizing protein (AHSP) AHSP family Q9NZD4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pimecrolimus Small molecular drug DB00337
Tacrolimus Small molecular drug DB00864
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gpi-1485 Small molecular drug D0N0AR
Ap1903 . D0K8TO
Sdz-281-240 . D0O5OF
Investigative
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4-hydroxy-2-butanone Small molecular drug D04NBE
4-hydroxybutan-2-one Small molecular drug DB04094
Dorsomorphin Small molecular drug DB08597
Fkb-001 Small molecular drug D0X2LN
Heptyl Glucoside Small molecular drug DB03338
Heptyl-beta-d-glucopyranoside Small molecular drug D06IBV
L-709,587 Small molecular drug D04OSU
L-709587 Small molecular drug DB03621
Methyl Methylsulfinylmethyl Sulfide Small molecular drug D08GFY
Myristic Acid Small molecular drug D08OBF
Myristic Acid Small molecular drug DB08231
Rapamycin Immunosuppressant Drug Small molecular drug D0Q5YP
(21s)-1aza-44-dimethyl-619-dioxa-23720-tetraoxobicyclo[19.4.0] Pentacosane . DB08520
(3r)-4-(P-toluenesulfonyl)-14-thiazane-3-carboxylicacid-l-leucine . DB04012
(3r)-4-(P-toluenesulfonyl)-14-thiazane-3-carboxylicacid-l-phenylalanine Ethyl Ester . DB01712
{3-[3-(34-dimethoxy-phenyl)-1-(1-{1-[2-(345-trimethoxy-phenyl)-butyryl]-piperidin-2yl}-vinyloxy)-propyl]-phenoxy}-acetic Acid . DB01723
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gpi-1046 Small molecular drug D04PGB

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Crenolanib-Derived Probes Suitable for Cell- and Tissue-Based Protein Profiling and Single-Cell Imaging. Chembiochem. 2019 Jul 15;20(14):1783-1788. doi: 10.1002/cbic.201900067. Epub 2019 Jul 3.
18 A Binding Site Hotspot Map of the FKBP12-Rapamycin-FRB Ternary Complex by Photoaffinity Labeling and Mass Spectrometry-Based Proteomics. J Am Chem Soc. 2019 Jul 31;141(30):11759-11764. doi: 10.1021/jacs.9b03764. Epub 2019 Jul 18.
Mass spectrometry data entry: PXD014319
19 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402