Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C342  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 40 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 99.7
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 42.8
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 34.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 27.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 26.2
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 21.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 20.7
 LDTP03842  Squalene synthase (FDFT1) 18.5
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 14.9
 LDTP10709  Pseudouridylate synthase 7 homolog (PUS7) 14.6
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 14.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 13.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 12.4
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 12.3
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.5
 LDTP10101  Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) 9.8
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 9.5
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 8.6
 LDTP12610  Obg-like ATPase 1 (OLA1) 7.9
 LDTP03374  Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2) 7.8
 LDTP00325  Pirin (PIR) 7.6
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 7.6
 LDTP01769  Dihydrofolate reductase (DHFR) 7.0
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 6.9
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 6.8
 LDTP00988  Protein O-GlcNAcase (OGA) 6.6
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 6.1
 LDTP02359  Heme oxygenase 1 (HMOX1) 6.1
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 6.0
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 6.0
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 6.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.9
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 5.8
 LDTP00697  Cytochrome b5 type B (CYB5B) 5.7
 LDTP03001  E3 ubiquitin-protein ligase TRIM21 (TRIM21) 5.5
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 5.4
 LDTP04183  Lanosterol synthase (LSS) 5.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 5.1
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 5.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 5.0
Transporter and channel
Click to Show/Hide to Show 23 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 12.1
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 11.1
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 10.2
 LDTP01804  ATP synthase subunit a (MT-ATP6) 9.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.6
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 8.4
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 8.3
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 7.7
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 7.4
 LDTP12383  Protein GPR108 (GPR108) 7.3
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.8
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 6.5
 LDTP03952  Reduced folate transporter (SLC19A1) 6.0
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 6.0
 LDTP15481  Transmembrane protein 87A (TMEM87A) 5.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 5.6
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 5.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 5.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 5.4
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.4
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 5.2
 LDTP07236  Protein GPR107 (GPR107) 5.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 4.9
Other
Click to Show/Hide to Show 19 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 11.1
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 9.9
 LDTP01451  UBX domain-containing protein 7 (UBXN7) 9.8
 LDTP00105  Protein unc-119 homolog B (UNC119B) 9.1
 LDTP01075  Protein CutA (CUTA) 8.9
 LDTP08000  Dymeclin (DYM) 8.5
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 7.9
 LDTP15714  Mdm2-binding protein (MTBP) 7.9
 LDTP13630  Neudesin (NENF) 7.5
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 6.9
 LDTP05160  Nucleobindin-2 (NUCB2) 6.8
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 6.5
 LDTP08874  Mitochondrial intermembrane space import and assembly protein 40 (CHCHD4) 6.3
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 6.3
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 5.8
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.4
 LDTP05375  Nucleobindin-1 (NUCB1) 5.3
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 5.1
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587