Details of the Target

General Information of Target

Target ID LDTP11162
Target Name Solute carrier family 25 member 33 (SLC25A33)
Gene Name SLC25A33
Gene ID 84275
Synonyms
Solute carrier family 25 member 33; Bone marrow stromal cell mitochondrial carrier protein; BMSC-MCP; HuBMSC-MCP; Protein PNC1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERSPGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQPAGPGAAGEALAVLTSFGR
RLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTL
YMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFT
FTRVELGEKPLRIIGVKVHPGQRKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLH
GVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAA
FLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYA
LVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDV
GKVLQASVLDDWFPLQGGQGQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAIL
VVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQE
LDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDS
SEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLI
AKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEV
FDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEV
LQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQT
SAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSG
QGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTH
VDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNR
GTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDL
AETDLSQGVARWYDLMDNKDKGSS
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism. Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production. Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation.
Uniprot ID
Q9BSK2
Ensemble ID
ENST00000302692.7
HGNC ID
HGNC:29681

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C20(0.75); C30(0.75)  LDD0531  [1]
TFBX
 Probe Info  		C246(0.00); C249(0.00); C111(0.00)  LDD0027  [2]
IPM
 Probe Info  		C246(0.00); C111(0.00)  LDD2156  [3]
AOyne
 Probe Info  		14.60  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 112 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		10.85  LDD1714  [5]
C006
 Probe Info  		5.43  LDD1715  [5]
C022
 Probe Info  		11.63  LDD1728  [5]
C044
 Probe Info  		5.03  LDD1743  [5]
C049
 Probe Info  		6.63  LDD1747  [5]
C053
 Probe Info  		6.28  LDD1751  [5]
C055
 Probe Info  		15.89  LDD1752  [5]
C056
 Probe Info  		41.93  LDD1753  [5]
C063
 Probe Info  		36.76  LDD1760  [5]
C070
 Probe Info  		46.85  LDD1766  [5]
C072
 Probe Info  		12.04  LDD1768  [5]
C082
 Probe Info  		7.41  LDD1774  [5]
C085
 Probe Info  		5.46  LDD1777  [5]
C087
 Probe Info  		39.67  LDD1779  [5]
C091
 Probe Info  		12.91  LDD1782  [5]
C092
 Probe Info  		18.64  LDD1783  [5]
C095
 Probe Info  		5.35  LDD1786  [5]
C106
 Probe Info  		36.50  LDD1793  [5]
C107
 Probe Info  		5.90  LDD1794  [5]
C108
 Probe Info  		10.06  LDD1795  [5]
C112
 Probe Info  		34.06  LDD1799  [5]
C129
 Probe Info  		15.78  LDD1811  [5]
C134
 Probe Info  		30.48  LDD1816  [5]
C135
 Probe Info  		10.70  LDD1817  [5]
C139
 Probe Info  		13.45  LDD1821  [5]
C140
 Probe Info  		8.00  LDD1822  [5]
C141
 Probe Info  		10.56  LDD1823  [5]
C143
 Probe Info  		47.18  LDD1825  [5]
C147
 Probe Info  		6.77  LDD1829  [5]
C153
 Probe Info  		47.50  LDD1834  [5]
C158
 Probe Info  		12.64  LDD1838  [5]
C159
 Probe Info  		10.34  LDD1839  [5]
C160
 Probe Info  		9.32  LDD1840  [5]
C161
 Probe Info  		24.93  LDD1841  [5]
C165
 Probe Info  		32.67  LDD1845  [5]
C177
 Probe Info  		8.82  LDD1856  [5]
C178
 Probe Info  		27.67  LDD1857  [5]
C183
 Probe Info  		6.68  LDD1861  [5]
C186
 Probe Info  		23.75  LDD1864  [5]
C187
 Probe Info  		15.78  LDD1865  [5]
C191
 Probe Info  		9.92  LDD1868  [5]
C201
 Probe Info  		99.73  LDD1877  [5]
C203
 Probe Info  		5.10  LDD1878  [5]
C204
 Probe Info  		7.89  LDD1879  [5]
C205
 Probe Info  		10.27  LDD1880  [5]
C206
 Probe Info  		88.03  LDD1881  [5]
C207
 Probe Info  		36.50  LDD1882  [5]
C210
 Probe Info  		99.73  LDD1884  [5]
C211
 Probe Info  		11.63  LDD1885  [5]
C213
 Probe Info  		33.59  LDD1887  [5]
C216
 Probe Info  		6.23  LDD1890  [5]
C218
 Probe Info  		23.59  LDD1892  [5]
C219
 Probe Info  		5.98  LDD1893  [5]
C220
 Probe Info  		31.34  LDD1894  [5]
C222
 Probe Info  		5.43  LDD1896  [5]
C225
 Probe Info  		7.84  LDD1898  [5]
C226
 Probe Info  		12.13  LDD1899  [5]
C228
 Probe Info  		99.73  LDD1901  [5]
C229
 Probe Info  		10.41  LDD1902  [5]
C231
 Probe Info  		37.01  LDD1904  [5]
C232
 Probe Info  		99.73  LDD1905  [5]
C233
 Probe Info  		12.82  LDD1906  [5]
C234
 Probe Info  		23.59  LDD1907  [5]
C235
 Probe Info  		32.90  LDD1908  [5]
C238
 Probe Info  		25.11  LDD1911  [5]
C243
 Probe Info  		11.39  LDD1916  [5]
C244
 Probe Info  		18.64  LDD1917  [5]
C246
 Probe Info  		23.43  LDD1919  [5]
C249
 Probe Info  		14.42  LDD1922  [5]
C251
 Probe Info  		32.90  LDD1924  [5]
C252
 Probe Info  		12.91  LDD1925  [5]
C264
 Probe Info  		37.27  LDD1935  [5]
C265
 Probe Info  		31.34  LDD1936  [5]
C266
 Probe Info  		10.78  LDD1937  [5]
C269
 Probe Info  		10.85  LDD1939  [5]
C270
 Probe Info  		13.74  LDD1940  [5]
C275
 Probe Info  		5.06  LDD1945  [5]
C277
 Probe Info  		8.63  LDD1947  [5]
C278
 Probe Info  		51.27  LDD1948  [5]
C282
 Probe Info  		20.11  LDD1952  [5]
C284
 Probe Info  		29.86  LDD1954  [5]
C285
 Probe Info  		21.71  LDD1955  [5]
C287
 Probe Info  		9.38  LDD1957  [5]
C289
 Probe Info  		35.02  LDD1959  [5]
C293
 Probe Info  		56.10  LDD1963  [5]
C296
 Probe Info  		40.22  LDD1966  [5]
C299
 Probe Info  		11.79  LDD1968  [5]
C305
 Probe Info  		15.24  LDD1974  [5]
C307
 Probe Info  		6.06  LDD1975  [5]
C310
 Probe Info  		20.11  LDD1977  [5]
C313
 Probe Info  		17.15  LDD1980  [5]
C314
 Probe Info  		16.68  LDD1981  [5]
C338
 Probe Info  		44.63  LDD2001  [5]
C339
 Probe Info  		12.73  LDD2002  [5]
C342
 Probe Info  		5.50  LDD2004  [5]
C343
 Probe Info  		31.34  LDD2005  [5]
C346
 Probe Info  		13.27  LDD2007  [5]
C355
 Probe Info  		25.81  LDD2016  [5]
C362
 Probe Info  		99.73  LDD2023  [5]
C363
 Probe Info  		54.57  LDD2024  [5]
C364
 Probe Info  		99.73  LDD2025  [5]
C366
 Probe Info  		19.70  LDD2027  [5]
C367
 Probe Info  		14.42  LDD2028  [5]
C383
 Probe Info  		24.25  LDD2042  [5]
C388
 Probe Info  		71.01  LDD2047  [5]
C397
 Probe Info  		16.91  LDD2056  [5]
C399
 Probe Info  		19.84  LDD2058  [5]
C400
 Probe Info  		5.54  LDD2059  [5]
C403
 Probe Info  		97.01  LDD2061  [5]
C407
 Probe Info  		36.00  LDD2064  [5]
FFF probe11
 Probe Info  		20.00  LDD0471  [6]
Alk-rapa
 Probe Info  		2.98  LDD0213  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C20(0.75); C30(0.75)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C111(0.93); C20(0.58); C30(0.58)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C111(0.94); C246(1.43); C249(1.43)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C111(0.97); C246(1.07); C249(1.07)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C111(1.16); C246(0.96); C249(0.96)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C111(1.06); C246(1.05); C249(1.05)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C111(1.06); C246(1.06); C249(1.06)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C111(0.96); C246(1.30); C249(1.30)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C111(0.97); C246(1.18); C249(1.18)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C111(1.09); C246(0.99); C249(0.99)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C111(1.01); C246(1.09); C249(1.09)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C111(1.12); C246(1.18); C249(1.18)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C111(0.81); C20(0.66); C30(0.66)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C111(1.04); C246(0.82); C249(0.82)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C111(1.03); C246(0.87); C249(0.87)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C111(1.02); C246(1.00); C249(1.00)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C111(0.78); C173(0.79); C20(1.20); C246(1.05)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C111(0.81); C173(0.84); C20(0.87); C246(0.82)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C111(0.81); C173(0.93); C20(0.84); C246(0.90)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C111(0.70); C173(0.79); C20(0.94); C246(0.69)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C111(0.76); C173(0.83); C20(0.87); C246(0.62)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C111(0.81); C173(0.97); C20(1.03); C246(0.69)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C111(0.74); C173(0.88); C20(0.98); C246(0.74)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C111(0.85); C20(0.69); C30(0.69)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C111(1.09); C173(0.75); C20(0.94); C246(0.83)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C111(1.18); C173(0.76); C20(1.06); C246(0.73)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C111(0.75); C173(0.73); C20(0.78); C246(0.95)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C111(1.25); C173(0.74); C20(1.07); C246(0.69)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C111(0.91); C173(0.88); C20(1.15); C246(0.67)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C111(0.88); C173(0.90); C20(1.09); C246(0.88)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C111(1.01); C173(0.75); C20(0.86); C246(0.87)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C111(0.79); C173(0.85); C20(0.88); C246(0.86)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C111(1.62)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C111(1.04)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C111(0.90)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C111(1.35)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C111(0.99)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C111(0.97)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C111(1.23)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C111(1.08)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C111(1.02)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C111(1.03)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C111(1.57)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C111(1.06)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C111(1.18); C20(0.63); C30(0.63)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C111(1.24)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C111(1.31)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C111(1.02)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C111(0.74)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C111(0.55)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C111(0.53)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C111(0.69)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C111(0.48)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C111(0.65)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C111(0.71)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C20(0.66); C30(0.66); C111(1.20)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C111(1.01)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C111(0.73)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C111(0.67)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C111(0.86)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C111(0.86)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C111(0.72)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C111(0.53)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C111(0.73)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C111(0.83)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C111(1.04)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C111(0.90)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C20(0.94); C30(0.94)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C111(1.12)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C111(1.04)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C111(1.10)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C111(1.18)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C111(0.91)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C20(0.52); C30(0.52); C246(1.34); C249(1.34)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C20(0.55); C30(0.55); C246(1.36); C249(1.36)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C20(0.75); C30(0.75); C246(1.11); C249(1.11)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C20(1.09); C30(1.09); C246(1.17); C249(1.17)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C20(0.53); C30(0.53); C246(1.00); C249(1.00)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C20(1.07); C30(1.07)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C20(0.66); C30(0.66); C246(0.96); C249(0.96)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C20(0.55); C30(0.55); C246(1.43); C249(1.43)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C20(0.58); C30(0.58); C246(1.31); C249(1.31)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C20(0.56); C30(0.56); C246(1.24); C249(1.24)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C20(0.73); C30(0.73); C246(1.07); C249(1.07)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C246(0.89); C249(0.89); C111(1.04)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C246(0.86); C249(0.86); C111(0.99)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C246(0.98); C249(0.98); C111(1.03)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C111(0.84); C246(0.85); C249(0.85)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C246(0.91); C249(0.91); C111(0.99)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C20(0.82); C30(0.82)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C246(0.97); C249(0.97); C111(1.08)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C111(0.86); C246(0.95); C249(0.95)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C246(0.85); C249(0.85); C111(0.85)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C111(0.67); C246(0.88); C249(0.88)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C246(0.94); C249(0.94); C111(1.06)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C246(0.98); C249(0.98); C111(1.00)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C111(0.88)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C111(0.85)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C111(1.00)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C111(1.03)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C20(0.92); C30(0.92)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C111(1.08)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C111(1.03)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C111(0.97)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C111(1.07)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C111(1.14)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C111(0.84)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C111(1.20)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C111(0.89)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C111(1.26)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C111(0.81)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C20(0.66); C30(0.66); C111(0.93)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C111(0.83)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C111(0.88)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C111(0.78)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C111(0.84)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C111(0.82)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C111(0.79)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C111(1.17)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C111(0.79)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C111(1.56)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C111(1.81)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C20(0.84); C30(0.84); C111(0.91)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C111(1.00)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C111(1.54)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C111(0.97)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C111(0.90)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C111(1.38)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C111(1.12)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C111(1.25)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C111(1.64)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C111(1.22)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C111(1.18)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C20(0.64); C30(0.64); C111(1.00)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C111(1.03)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C111(1.42)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C111(1.06)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C111(0.96)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C111(0.84)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C111(0.69)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C111(0.94)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C111(1.17)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C111(0.98)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C111(0.84)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C111(0.88)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C111(0.84)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C111(0.80)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C111(0.77)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C111(0.62)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C111(0.88)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C111(0.70)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C111(0.59)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C111(0.88); C246(0.92); C249(0.92)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C111(0.97); C246(1.02); C249(1.02)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C111(0.88); C20(0.88); C30(0.88)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C111(0.72); C20(0.73); C30(0.73)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C20(0.64); C30(0.64); C111(1.10)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C246(0.96); C249(0.96); C20(1.90); C30(1.90)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C246(0.99); C249(0.99); C20(1.21); C30(1.21)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C20(0.85); C30(0.85)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C20(0.55); C30(0.55); C111(1.36)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C20(0.67); C30(0.67); C111(1.31)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C20(0.80); C30(0.80); C111(1.03)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C20(0.77); C30(0.77); C111(1.06)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C111(0.99)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C111(1.41)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C111(1.12)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C111(0.97)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C111(1.21)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C246(1.12); C249(1.12); C20(1.13); C30(1.13)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C111(1.05)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C111(1.00)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C20(0.80); C30(0.80); C246(1.15); C249(1.15)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C20(0.50); C30(0.50); C246(1.36); C249(1.36)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C20(0.78); C30(0.78); C246(1.17); C249(1.17)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C20(0.56); C30(0.56); C246(1.24); C249(1.24)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C20(1.04); C30(1.04); C246(1.09); C249(1.09)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C111(0.85); C246(0.89); C249(0.89)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C111(0.75); C246(0.86); C249(0.86)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C111(0.69); C246(0.95); C249(0.95)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C246(0.83); C249(0.83); C20(1.31); C30(1.31)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C111(0.80); C246(0.88); C249(0.88)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C111(0.94)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C111(1.01)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C111(1.02)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C111(0.87)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C111(0.80)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C111(1.12)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C111(0.88)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C111(0.89)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C246(0.99); C249(0.99); C20(1.00); C30(1.00)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C246(0.96); C249(0.96); C20(1.37); C30(1.37)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C246(0.90); C249(0.90); C20(1.08); C30(1.08)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C111(0.76)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C111(0.74)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C111(0.67)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C111(1.03)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C246(0.97); C249(0.97); C20(1.43); C30(1.43)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C111(0.77)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C111(0.76)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C111(0.86)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C111(0.66)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C111(0.65)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C111(0.55)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C111(0.83)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C111(0.72)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C111(0.57)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C111(0.84)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C20(1.34); C246(0.87); C249(0.87); C30(1.34)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C111(1.10)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C111(0.89); C173(1.13)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C111(0.75); C173(0.95)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C111(0.92); C173(0.74)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C111(1.28); C173(1.00)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C111(0.72); C173(1.10)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C111(2.54); C173(0.91)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C111(1.03); C173(1.01)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C111(0.91); C173(0.82)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C20(1.21); C246(0.89); C249(0.89); C30(1.21)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C111(0.83); C173(0.91)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C111(1.65); C173(0.78)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C111(1.89); C173(0.83)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C111(1.02); C173(0.87)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C111(0.78); C173(1.01)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C111(0.80); C173(1.11)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C111(0.71); C173(0.61); C246(0.96); C249(0.96)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C111(0.89); C173(1.29); C246(0.89); C249(0.89)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C111(0.75); C173(1.18); C246(1.11); C249(1.11)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C111(0.83); C173(0.68); C246(0.72); C249(0.72)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C20(1.12); C246(0.99); C249(0.99); C30(1.12)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C111(0.82); C173(1.33); C246(0.96); C249(0.96)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C111(0.75); C173(2.02); C246(0.86); C249(0.86)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C111(0.90); C173(0.90); C246(1.08); C249(1.08)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C111(1.36); C173(0.69); C246(1.05); C249(1.05)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C111(0.75); C173(0.90); C246(0.99); C249(0.99)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C111(0.99); C173(1.12); C246(1.11); C249(1.11)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C111(1.09); C173(1.15); C246(1.12); C249(1.12)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C111(1.00); C173(0.93); C246(0.84); C249(0.84)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C111(0.81); C173(1.13); C246(0.87); C249(0.87)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C111(0.86); C173(1.55); C246(0.89); C249(0.89)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C20(1.18); C246(1.33); C249(1.33); C30(1.18)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C111(0.75); C173(0.79); C246(0.85); C249(0.85)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C111(0.72); C173(1.32); C246(1.06); C249(1.06)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C111(0.73); C173(0.74); C246(0.96); C249(0.96)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C111(0.78); C173(0.76); C246(0.97); C249(0.97)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C111(0.65); C173(0.72); C246(0.84); C249(0.84)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C111(0.94); C173(0.83); C246(0.89); C249(0.89)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C111(0.79); C173(0.96); C246(0.87); C249(0.87)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C111(1.04); C173(1.84); C246(0.87); C249(0.87)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C111(1.47); C173(1.08); C246(0.63); C249(0.63)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C111(0.71); C173(0.55); C246(0.63); C249(0.63)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C20(1.18); C246(0.81); C249(0.81); C30(1.18)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C111(1.03); C173(0.74); C246(0.73); C249(0.73)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C111(1.02); C173(0.84); C246(0.78); C249(0.78)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C111(0.87); C173(0.56); C246(0.64); C249(0.64)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C111(0.99); C173(0.97); C246(0.63); C249(0.63)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C111(1.12); C173(0.70); C246(0.80); C249(0.80)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C111(1.37); C20(0.64); C30(0.64)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C111(1.07); C20(1.20); C30(1.20)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C111(0.81); C20(0.69); C30(0.69)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C111(1.17); C20(0.65); C30(0.65)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C20(1.39); C246(1.16); C249(1.16); C30(1.39)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C111(0.92); C20(0.65); C30(0.65)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C111(1.32); C20(0.74); C30(0.74)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C111(1.26); C20(0.67); C30(0.67)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C111(1.30); C20(0.69); C30(0.69)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C111(1.10); C20(0.78); C30(0.78)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C111(1.05); C20(0.65); C30(0.65)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C111(1.02); C20(0.81); C30(0.81)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C111(1.25); C20(0.73); C30(0.73)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C111(1.36); C20(0.70); C30(0.70)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C111(1.15); C20(0.82); C30(0.82)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C20(1.21); C246(0.79); C249(0.79); C30(1.21)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C111(1.23); C20(1.10); C30(1.10)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C20(0.94); C30(0.94)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C20(1.23); C30(1.23)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C20(0.89); C30(0.89)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C20(1.14); C30(1.14)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C20(0.88); C30(0.88)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C20(0.93); C30(0.93)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C20(1.06); C30(1.06)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C20(1.08); C30(1.08)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C20(0.86); C30(0.86)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C20(1.00)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C111(0.75); C173(0.81); C246(0.65); C249(0.65)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C111(1.34); C173(0.78)  LDD0744  [1]
 LDCM0022  KB02 A2780 C111(1.93)  LDD2254  [9]
 LDCM0023  KB03 A2780 C111(3.84)  LDD2671  [9]
 LDCM0024  KB05 HMCB C111(3.18)  LDD3312  [9]
 LDCM0090  Rapamycin JHH-7 2.98  LDD0213  [7]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840