Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C085  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 60 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 18.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 17.9
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 17.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 15.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 15.1
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 14.9
 LDTP03787  Choline kinase alpha (CHKA) 14.5
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 14.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 14.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 14.0
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 13.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 13.6
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 13.5
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 12.9
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 12.3
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 10.8
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 10.7
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 10.6
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 9.8
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 9.7
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 9.6
 LDTP01769  Dihydrofolate reductase (DHFR) 9.3
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 9.3
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 9.1
 LDTP07259  N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) 8.9
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 8.9
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 8.4
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 8.1
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 7.9
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 7.6
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 7.5
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 7.2
 LDTP10329  Ceramide synthase 2 (CERS2) 7.0
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 6.9
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 6.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 6.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 6.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 6.4
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 6.2
 LDTP05920  Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) 6.2
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 6.2
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 6.1
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 6.1
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 6.1
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 6.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 6.0
 LDTP03394  Ceramide synthase 1 (CERS1) 5.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.9
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 5.8
 LDTP02837  Beta-galactosidase (GLB1) 5.7
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 5.7
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 5.5
 LDTP12163  Calcyclin-binding protein (CACYBP) 5.4
 LDTP05905  Acid ceramidase (ASAH1) 5.3
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 5.2
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 5.1
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 5.1
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 5.0
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 4.9
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 4.9
Transporter and channel
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 22.9
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 21.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 19.2
 LDTP15481  Transmembrane protein 87A (TMEM87A) 17.6
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 16.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 15.0
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 12.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 12.6
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 12.4
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 11.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 10.4
 LDTP15967  Tetraspanin-10 (TSPAN10) 10.1
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 10.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 9.8
 LDTP01804  ATP synthase subunit a (MT-ATP6) 9.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 9.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 8.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 8.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 8.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 7.9
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 7.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 7.3
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 7.2
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 7.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 6.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 6.5
 LDTP20002  Transmembrane protein 160 (TMEM160) 6.1
 LDTP02215  Prosaposin (PSAP) 6.0
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 5.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 5.7
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 5.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 5.5
 LDTP15948  Transmembrane protein 126A (TMEM126A) 5.5
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 5.5
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05065  Y-box-binding protein 1 (YBX1) 4.9
Other
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 18.5
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 16.7
 LDTP11076  Apolipoprotein L2 (APOL2) 15.6
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 14.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 13.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 12.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 11.6
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 10.6
 LDTP00105  Protein unc-119 homolog B (UNC119B) 10.6
 LDTP05375  Nucleobindin-1 (NUCB1) 9.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 9.8
 LDTP07906  Mediator of RNA polymerase II transcription subunit 25 (MED25) 9.6
 LDTP13402  Dynactin subunit 4 (DCTN4) 9.4
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 8.4
 LDTP13630  Neudesin (NENF) 8.4
 LDTP18883  Protein CEBPZOS (CEBPZOS) 8.3
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 7.9
 LDTP10703  Leukocyte receptor cluster member 8 (LENG8) 7.4
 LDTP01075  Protein CutA (CUTA) 6.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 6.4
 LDTP05868  Protein unc-119 homolog A (UNC119) 6.1
 LDTP01652  Centrosomal protein 43 (CEP43) 6.0
 LDTP09920  Golgi apparatus protein 1 (GLG1) 5.8
 LDTP14458  Tetraspanin-6 (TSPAN6) 5.5
 LDTP08606  Nurim (NRM) 5.4
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 5.2
 LDTP05277  Protein SET (SET) 5.2
 LDTP00887  Calumenin (CALU) 5.1
 LDTP16080  Protein FAM114A2 (FAM114A2) 5.1
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 5.0
 LDTP02297  Vimentin (VIM) 5.0
 LDTP13086  Syntaxin-18 (STX18) 5.0
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587