Details of the Target

General Information of Target

Target ID LDTP15967
Target Name Tetraspanin-10 (TSPAN10)
Gene Name TSPAN10
Gene ID 83882
Synonyms
OCSP; Tetraspanin-10; Tspan-10; Oculospanin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMDSEAHEKRPPILTSSKQDISPHITNVGEMKHYLCGCCAAFNNVAITFPIQKVLFRQQL
YGIKTRDAILQLRRDGFRNLYRGILPPLMQKTTTLALMFGLYEDLSCLLHKHVSAPEFAT
SGVAAVLAGTTEAIFTPLERVQTLLQDHKHHDKFTNTYQAFKALKCHGIGEYYRGLVPIL
FRNGLSNVLFFGLRGPIKEHLPTATTHSAHLVNDFICGGLLGAMLGFLFFPINVVKTRIQ
SQIGGEFQSFPKVFQKIWLERDRKLINLFRGAHLNYHRSLISWGIINATYEFLLKVI
Target Bioclass
Transporter and channel
Family
Tetraspanin (TM4SF) family
Subcellular location
Membrane
Function
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates.
Uniprot ID
Q9H1Z9
HGNC ID
HGNC:29942

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C30(0.83)  LDD1492  [1]
PAL-AfBPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C082
 Probe Info  		11.39  LDD1774  [2]
C085
 Probe Info  		10.13  LDD1777  [2]
C087
 Probe Info  		16.11  LDD1779  [2]
C091
 Probe Info  		18.64  LDD1782  [2]
C092
 Probe Info  		25.11  LDD1783  [2]
C094
 Probe Info  		33.13  LDD1785  [2]
C106
 Probe Info  		49.18  LDD1793  [2]
C107
 Probe Info  		18.00  LDD1794  [2]
C108
 Probe Info  		18.64  LDD1795  [2]
C187
 Probe Info  		19.70  LDD1865  [2]
C191
 Probe Info  		14.03  LDD1868  [2]
C193
 Probe Info  		6.77  LDD1869  [2]
C218
 Probe Info  		13.93  LDD1892  [2]
C219
 Probe Info  		13.74  LDD1893  [2]
C220
 Probe Info  		27.28  LDD1894  [2]
C225
 Probe Info  		20.25  LDD1898  [2]
C226
 Probe Info  		14.03  LDD1899  [2]
C228
 Probe Info  		42.22  LDD1901  [2]
C264
 Probe Info  		27.28  LDD1935  [2]
C265
 Probe Info  		17.75  LDD1936  [2]
C270
 Probe Info  		8.22  LDD1940  [2]
C280
 Probe Info  		11.96  LDD1950  [2]
C282
 Probe Info  		20.82  LDD1952  [2]
C285
 Probe Info  		21.86  LDD1955  [2]
C287
 Probe Info  		17.27  LDD1957  [2]
C288
 Probe Info  		8.57  LDD1958  [2]
C289
 Probe Info  		30.91  LDD1959  [2]
C293
 Probe Info  		16.11  LDD1963  [2]
C296
 Probe Info  		13.36  LDD1966  [2]
C307
 Probe Info  		5.24  LDD1975  [2]
C310
 Probe Info  		14.32  LDD1977  [2]
C343
 Probe Info  		33.82  LDD2005  [2]
C346
 Probe Info  		13.36  LDD2007  [2]
C355
 Probe Info  		85.04  LDD2016  [2]
C356
 Probe Info  		31.34  LDD2017  [2]
C357
 Probe Info  		13.64  LDD2018  [2]
C361
 Probe Info  		19.97  LDD2022  [2]
C376
 Probe Info  		13.64  LDD2036  [2]
C378
 Probe Info  		7.94  LDD2037  [2]
C380
 Probe Info  		9.71  LDD2039  [2]
C382
 Probe Info  		12.55  LDD2041  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C30(0.83)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C30(0.93)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C30(1.02)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587