Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C357  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 81 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 28.1
 LDTP00697  Cytochrome b5 type B (CYB5B) 27.9
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 20.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 18.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 15.6
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 15.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 14.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 14.1
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 14.1
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 13.9
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 12.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 12.4
 LDTP03842  Squalene synthase (FDFT1) 11.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 11.1
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 11.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 10.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 10.0
 LDTP02837  Beta-galactosidase (GLB1) 9.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 9.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 9.5
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 9.2
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 9.2
 LDTP14189  UbiA prenyltransferase domain-containing protein 1 (UBIAD1) 9.2
 LDTP03394  Ceramide synthase 1 (CERS1) 8.9
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 8.8
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 8.8
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 8.8
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 8.7
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 8.4
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 8.3
 LDTP06617  Ceramide glucosyltransferase (UGCG) 8.3
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 8.2
 LDTP05905  Acid ceramidase (ASAH1) 8.1
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 8.1
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 8.1
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 8.1
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 8.0
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 7.8
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 7.8
 LDTP01515  NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) 7.6
 LDTP13409  Anaphase-promoting complex subunit 7 (ANAPC7) 7.5
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.0
 LDTP03145  Catechol O-methyltransferase (COMT) 7.0
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 7.0
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 6.9
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 6.8
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 6.7
 LDTP00988  Protein O-GlcNAcase (OGA) 6.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 6.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 6.5
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 6.5
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 6.4
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 6.4
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 6.4
 LDTP07109  ATP-binding cassette sub-family C member 10 (ABCC10) 6.2
 LDTP08933  Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) 6.2
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 6.2
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 6.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 6.1
 LDTP02539  Lysosomal acid phosphatase (ACP2) 6.1
 LDTP11318  ADP-ribose pyrophosphatase, mitochondrial (NUDT9) 5.9
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 5.9
 LDTP11127  ADP-dependent glucokinase (ADPGK) 5.8
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 5.8
 LDTP10530  Beta-1,3-galactosyltransferase 6 (B3GALT6) 5.7
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 5.7
 LDTP06142  Squalene monooxygenase (SQLE) 5.6
 LDTP12886  Glycerophosphodiester phosphodiesterase 1 (GDE1) 5.5
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 5.5
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 5.3
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 5.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 5.3
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 5.2
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 5.2
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 5.2
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 5.2
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 5.1
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 5.1
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 5.1
Transporter and channel
Click to Show/Hide to Show 53 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 66.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 54.9
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 28.2
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 28.1
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 24.8
 LDTP01804  ATP synthase subunit a (MT-ATP6) 23.4
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 20.4
 LDTP11615  Protein tweety homolog 3 (TTYH3) 18.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 18.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 16.8
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 15.9
 LDTP02215  Prosaposin (PSAP) 14.5
 LDTP05662  Cell division cycle protein 20 homolog (CDC20) 14.1
 LDTP15967  Tetraspanin-10 (TSPAN10) 13.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 13.0
 LDTP16813  Tetraspanin-3 (TSPAN3) 12.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 12.3
 LDTP20002  Transmembrane protein 160 (TMEM160) 11.2
 LDTP06633  Reticulon-1 (RTN1) 11.1
 LDTP08881  Transmembrane protein 199 (TMEM199) 9.8
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 9.4
 LDTP15948  Transmembrane protein 126A (TMEM126A) 9.3
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 8.3
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 8.2
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 7.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 7.8
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 7.8
 LDTP15648  BRI3-binding protein (BRI3BP) 7.7
 LDTP10036  BOS complex subunit NCLN (NCLN) 7.6
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 7.3
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 7.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 6.5
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 6.5
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 6.5
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 6.5
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 6.4
 LDTP11213  Nucleoporin NDC1 (NDC1) 6.4
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.2
 LDTP02071  Amyloid-beta precursor protein (APP) 6.0
 LDTP08673  Calcium uptake protein 2, mitochondrial (MICU2) 5.9
 LDTP11844  Protein spinster homolog 1 (SPNS1) 5.8
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 5.7
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.7
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 5.7
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 5.5
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 5.5
 LDTP15064  G-protein coupled receptor-associated protein LMBRD2 (LMBRD2) 5.5
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 5.4
 LDTP16190  Protein FAM8A1 (FAM8A1) 5.4
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 5.2
 LDTP01574  Importin-7 (IPO7) 5.1
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 5.1
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 5.1
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 10.6
Other
Click to Show/Hide to Show 40 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 27.1
 LDTP05160  Nucleobindin-2 (NUCB2) 23.1
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 19.7
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 18.6
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 18.1
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 14.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 14.7
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 14.4
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 12.4
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 12.3
 LDTP05375  Nucleobindin-1 (NUCB1) 10.9
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 10.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 9.7
 LDTP14458  Tetraspanin-6 (TSPAN6) 8.9
 LDTP01522  Reticulon-3 (RTN3) 8.8
 LDTP16080  Protein FAM114A2 (FAM114A2) 8.5
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 8.5
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 7.9
 LDTP08224  Protein LYRIC (MTDH) 7.7
 LDTP01652  Centrosomal protein 43 (CEP43) 7.5
 LDTP10056  Protein FAM162A (FAM162A) 7.4
 LDTP00105  Protein unc-119 homolog B (UNC119B) 7.2
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 7.1
 LDTP19963  TraB domain-containing protein (TRABD) 6.9
 LDTP00859  Synaptogyrin-2 (SYNGR2) 6.9
 LDTP02443  Calmodulin-3 (CALM3) 6.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 6.5
 LDTP12412  Reticulon-4 (RTN4) 6.1
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 6.0
 LDTP11143  Centromere protein K (CENPK) 5.9
 LDTP13086  Syntaxin-18 (STX18) 5.9
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 5.8
 LDTP16006  Optic atrophy 3 protein (OPA3) 5.6
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 5.5
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 5.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 5.4
 LDTP08594  Negative elongation factor C/D (NELFCD) 5.4
 LDTP09080  Reticulophagy regulator 2 (RETREG2) 5.2
 LDTP00986  Syntaxin-10 (STX10) 5.2
 LDTP01494  Protein YIF1A (YIF1A) 5.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587