Details of the Target

General Information of Target

Target ID LDTP02254
Target Name ATP-dependent translocase ABCB1 (ABCB1)
Gene Name ABCB1
Gene ID 5243
Synonyms
MDR1; PGY1; ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; EC 7.6.2.2; P-glycoprotein 1; Phospholipid transporter ABCB1; EC 7.6.2.1; CD antigen CD243
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA
IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
LAQKGIYFSMVSVQAGTKRQ
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
Subcellular location
Cell membrane
Function
Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
TTD ID
T25258
Uniprot ID
P08183
DrugMap ID
TT3OT40
Ensemble ID
ENST00000265724.8
HGNC ID
HGNC:40
ChEMBL ID
CHEMBL4302

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.K645E DBIA    Probe Info 
A549 SNV: p.Y1267C .
CAL72 SNV: p.I461M .
CORL88 SNV: p.A229D .
DU145 SNV: p.G124V .
EFO27 SNV: p.R489H .
HCT116 SNV: p.D603H .
HCT15 SNV: p.A999T DBIA    Probe Info 
HT115 SNV: p.S228P; p.V253A DBIA    Probe Info 
JHH7 SNV: p.H166R .
JURLMK1 SNV: p.T558M .
KYSE150 SNV: p.G269R .
LNCaP clone FGC SNV: p.A727T .
MDST8 SNV: p.V417M DBIA    Probe Info 
MEWO SNV: p.S733L .
MFE296 Deletion: p.A529PfsTer27 .
NCIH1155 SNV: p.T1036I DBIA    Probe Info 
NCIH1792 SNV: p.G341W .
NCIH1993 SNV: p.R489P .
NCIH2291 Deletion: p.G939EfsTer10 .
NCIH661 SNV: p.H61N .
NCIN87 SNV: p.K915R .
NUGC3 SNV: p.Q347H .
OAW42 SNV: p.A869T .
RVH421 SNV: p.S374G .
SKMEL28 SNV: p.A1217T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		4.40  LDD0318  [1]
YN-4
 Probe Info  		100.00  LDD0445  [2]
IPM
 Probe Info  		C431(0.00); C1074(0.00); C1227(0.00)  LDD0241  [3]
OPA-S-S-alkyne
 Probe Info  		K748(1.52)  LDD3494  [4]
DBIA
 Probe Info  		C431(2.05)  LDD3318  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		C1125(0.00); C1074(0.00)  LDD0163  [7]
PAL-AfBPP Probe
Click To Hide/Show 104 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.16  LDD1714  [8]
C022
 Probe Info  		10.70  LDD1728  [8]
C027
 Probe Info  		7.62  LDD1733  [8]
C040
 Probe Info  		7.21  LDD1740  [8]
C056
 Probe Info  		16.22  LDD1753  [8]
C063
 Probe Info  		14.52  LDD1760  [8]
C070
 Probe Info  		17.15  LDD1766  [8]
C071
 Probe Info  		11.16  LDD1767  [8]
C072
 Probe Info  		13.83  LDD1768  [8]
C082
 Probe Info  		11.08  LDD1774  [8]
C085
 Probe Info  		13.45  LDD1777  [8]
C087
 Probe Info  		10.34  LDD1779  [8]
C091
 Probe Info  		12.64  LDD1782  [8]
C092
 Probe Info  		19.97  LDD1783  [8]
C094
 Probe Info  		24.93  LDD1785  [8]
C107
 Probe Info  		7.62  LDD1794  [8]
C108
 Probe Info  		9.92  LDD1795  [8]
C112
 Probe Info  		25.99  LDD1799  [8]
C117
 Probe Info  		6.45  LDD1804  [8]
C130
 Probe Info  		7.94  LDD1812  [8]
C143
 Probe Info  		14.62  LDD1825  [8]
C145
 Probe Info  		9.00  LDD1827  [8]
C147
 Probe Info  		6.73  LDD1829  [8]
C149
 Probe Info  		7.94  LDD1830  [8]
C152
 Probe Info  		9.65  LDD1833  [8]
C159
 Probe Info  		10.20  LDD1839  [8]
C160
 Probe Info  		8.69  LDD1840  [8]
C161
 Probe Info  		13.18  LDD1841  [8]
C166
 Probe Info  		8.75  LDD1846  [8]
C177
 Probe Info  		10.85  LDD1856  [8]
C178
 Probe Info  		17.27  LDD1857  [8]
C183
 Probe Info  		6.59  LDD1861  [8]
C187
 Probe Info  		33.13  LDD1865  [8]
C191
 Probe Info  		17.51  LDD1868  [8]
C193
 Probe Info  		11.96  LDD1869  [8]
C194
 Probe Info  		8.46  LDD1870  [8]
C198
 Probe Info  		10.63  LDD1874  [8]
C199
 Probe Info  		8.57  LDD1875  [8]
C211
 Probe Info  		8.75  LDD1885  [8]
C218
 Probe Info  		11.96  LDD1892  [8]
C219
 Probe Info  		7.01  LDD1893  [8]
C220
 Probe Info  		11.79  LDD1894  [8]
C222
 Probe Info  		9.06  LDD1896  [8]
C225
 Probe Info  		6.45  LDD1898  [8]
C226
 Probe Info  		7.67  LDD1899  [8]
C228
 Probe Info  		15.24  LDD1901  [8]
C234
 Probe Info  		8.88  LDD1907  [8]
C238
 Probe Info  		11.31  LDD1911  [8]
C243
 Probe Info  		14.03  LDD1916  [8]
C245
 Probe Info  		5.43  LDD1918  [8]
C246
 Probe Info  		14.32  LDD1919  [8]
C249
 Probe Info  		12.91  LDD1922  [8]
C252
 Probe Info  		12.73  LDD1925  [8]
C266
 Probe Info  		7.67  LDD1937  [8]
C269
 Probe Info  		7.73  LDD1939  [8]
C270
 Probe Info  		6.19  LDD1940  [8]
C272
 Probe Info  		5.13  LDD1942  [8]
C273
 Probe Info  		5.31  LDD1943  [8]
C288
 Probe Info  		7.11  LDD1958  [8]
C290
 Probe Info  		5.70  LDD1960  [8]
C297
 Probe Info  		5.28  LDD1967  [8]
C299
 Probe Info  		7.89  LDD1968  [8]
C313
 Probe Info  		12.21  LDD1980  [8]
C320
 Probe Info  		7.11  LDD1986  [8]
C326
 Probe Info  		11.08  LDD1990  [8]
C327
 Probe Info  		6.96  LDD1991  [8]
C333
 Probe Info  		5.94  LDD1996  [8]
C338
 Probe Info  		10.48  LDD2001  [8]
C339
 Probe Info  		9.13  LDD2002  [8]
C346
 Probe Info  		15.67  LDD2007  [8]
C348
 Probe Info  		14.52  LDD2009  [8]
C349
 Probe Info  		10.13  LDD2010  [8]
C353
 Probe Info  		8.51  LDD2014  [8]
C354
 Probe Info  		9.38  LDD2015  [8]
C355
 Probe Info  		23.75  LDD2016  [8]
C356
 Probe Info  		8.94  LDD2017  [8]
C357
 Probe Info  		5.21  LDD2018  [8]
C361
 Probe Info  		32.67  LDD2022  [8]
C378
 Probe Info  		6.73  LDD2037  [8]
C382
 Probe Info  		11.31  LDD2041  [8]
C390
 Probe Info  		34.06  LDD2049  [8]
C391
 Probe Info  		17.51  LDD2050  [8]
C396
 Probe Info  		8.40  LDD2055  [8]
C399
 Probe Info  		6.73  LDD2058  [8]
C413
 Probe Info  		12.55  LDD2069  [8]
C420
 Probe Info  		21.86  LDD2075  [8]
C426
 Probe Info  		22.01  LDD2081  [8]
C429
 Probe Info  		15.89  LDD2084  [8]
C430
 Probe Info  		6.59  LDD2085  [8]
C431
 Probe Info  		20.39  LDD2086  [8]
C432
 Probe Info  		8.06  LDD2087  [8]
C433
 Probe Info  		9.92  LDD2088  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe14
 Probe Info  		20.00  LDD0477  [9]
FFF probe15
 Probe Info  		20.00  LDD0478  [9]
FFF probe2
 Probe Info  		20.00  LDD0479  [9]
JN0003
 Probe Info  		20.00  LDD0484  [9]
STS-1
 Probe Info  		N.A.  LDD0137  [10]
HM-1
 Probe Info  		1.66  LDD0438  [11]
HM-2
 Probe Info  		2.20  LDD0436  [11]
A-DA
 Probe Info  		3.60  LDD0331  [12]
AEA-DA
 Probe Info  		4.20  LDD0334  [12]
OEA-DA
 Probe Info  		20.00  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C431(0.99)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C1074(1.01)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C431(0.87)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C1074(0.87); C431(0.95)  LDD1510  [13]
 LDCM0246  AC128 HEK-293T C431(1.47)  LDD0844  [14]
 LDCM0247  AC129 HEK-293T C431(1.43)  LDD0845  [14]
 LDCM0249  AC130 HEK-293T C431(1.22)  LDD0847  [14]
 LDCM0250  AC131 HEK-293T C431(0.93)  LDD0848  [14]
 LDCM0251  AC132 HEK-293T C431(1.02)  LDD0849  [14]
 LDCM0252  AC133 HEK-293T C431(1.06)  LDD0850  [14]
 LDCM0253  AC134 HEK-293T C431(1.06)  LDD0851  [14]
 LDCM0254  AC135 HEK-293T C431(1.11)  LDD0852  [14]
 LDCM0255  AC136 HEK-293T C431(1.17)  LDD0853  [14]
 LDCM0256  AC137 HEK-293T C431(1.36)  LDD0854  [14]
 LDCM0257  AC138 HEK-293T C431(1.22)  LDD0855  [14]
 LDCM0258  AC139 HEK-293T C431(1.25)  LDD0856  [14]
 LDCM0259  AC14 HEK-293T C1074(1.14)  LDD1512  [13]
 LDCM0260  AC140 HEK-293T C431(1.29)  LDD0858  [14]
 LDCM0261  AC141 HEK-293T C431(1.15)  LDD0859  [14]
 LDCM0262  AC142 HEK-293T C431(1.00)  LDD0860  [14]
 LDCM0270  AC15 HEK-293T C1074(1.07)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C431(1.39)  LDD0874  [14]
 LDCM0277  AC18 HEK-293T C431(1.47)  LDD0875  [14]
 LDCM0278  AC19 HEK-293T C431(1.35)  LDD0876  [14]
 LDCM0279  AC2 HEK-293T C1074(0.92)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C431(1.57)  LDD0878  [14]
 LDCM0281  AC21 HEK-293T C431(1.48)  LDD0879  [14]
 LDCM0282  AC22 HEK-293T C431(1.73)  LDD0880  [14]
 LDCM0283  AC23 HEK-293T C431(1.56)  LDD0881  [14]
 LDCM0284  AC24 HEK-293T C431(1.29)  LDD0882  [14]
 LDCM0285  AC25 HEK-293T C431(1.08)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C1074(0.94)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C431(0.96)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C1074(1.05); C431(0.94)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C1074(1.04)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C431(0.93)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C1074(0.99)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C1074(1.15)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C1074(1.01)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C431(1.00)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C1074(1.04)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C431(0.89)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C1074(0.85); C431(0.95)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C1074(0.98)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C1074(1.10)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C1074(1.15)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C1074(0.81); C431(1.00)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C1074(1.02)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C431(1.10)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C1074(1.14)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C431(1.01)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C1074(0.98); C431(1.00)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C1074(1.01)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C1074(0.93)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C1074(1.08)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C1074(1.09)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C431(0.89)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C1074(1.10)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C1074(0.93)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C431(0.85)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C1074(0.98); C431(1.02)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C1074(1.08)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C1074(0.92)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C1074(0.99)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C1074(1.05)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C431(0.56)  LDD0918  [14]
 LDCM0321  AC58 HEK-293T C431(0.73)  LDD0919  [14]
 LDCM0322  AC59 HEK-293T C431(0.75)  LDD0920  [14]
 LDCM0323  AC6 HEK-293T C1074(0.95)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C431(2.25)  LDD0922  [14]
 LDCM0325  AC61 HEK-293T C431(2.00)  LDD0923  [14]
 LDCM0326  AC62 HEK-293T C431(1.70)  LDD0924  [14]
 LDCM0327  AC63 HEK-293T C431(1.39)  LDD0925  [14]
 LDCM0328  AC64 HEK-293T C431(1.13)  LDD0926  [14]
 LDCM0329  AC65 HEK-293T C431(1.77)  LDD0927  [14]
 LDCM0330  AC66 HEK-293T C431(1.18)  LDD0928  [14]
 LDCM0331  AC67 HEK-293T C431(1.41)  LDD0929  [14]
 LDCM0334  AC7 HEK-293T C1074(0.99)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C1074(0.98)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C1074(1.11)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C431(1.08)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C1074(1.00)  LDD1514  [13]
 LDCM0367  CL1 HEK-293T C1074(1.20)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C1074(1.01)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C1074(0.94); C431(0.98)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C1074(1.04)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C1074(0.99)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C1074(0.90)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C1074(0.96); C431(1.05)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C431(1.56)  LDD0972  [14]
 LDCM0375  CL106 HEK-293T C431(1.21)  LDD0973  [14]
 LDCM0376  CL107 HEK-293T C431(1.05)  LDD0974  [14]
 LDCM0377  CL108 HEK-293T C431(1.20)  LDD0975  [14]
 LDCM0378  CL109 HEK-293T C431(1.09)  LDD0976  [14]
 LDCM0379  CL11 HEK-293T C1074(2.26)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C431(1.71)  LDD0978  [14]
 LDCM0381  CL111 HEK-293T C431(1.66)  LDD0979  [14]
 LDCM0382  CL112 HEK-293T C1074(0.97); C431(1.07)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C1074(1.00)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C1074(1.00)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C1074(1.06)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C1074(0.96); C431(0.95)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C1074(1.01)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C1074(0.95)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C1074(1.02)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C1074(1.46)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C1074(0.96); C431(0.94)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C1074(0.98)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C1074(0.95)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C1074(1.09)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C1074(0.96); C431(1.17)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C431(0.90)  LDD0994  [14]
 LDCM0397  CL126 HEK-293T C431(1.26)  LDD0995  [14]
 LDCM0398  CL127 HEK-293T C431(0.69)  LDD0996  [14]
 LDCM0399  CL128 HEK-293T C431(0.89)  LDD0997  [14]
 LDCM0400  CL13 HEK-293T C1074(1.24)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C1074(0.98)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C1074(1.32)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C1074(1.02); C431(1.11)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C431(1.10)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C1074(1.17)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C431(0.97)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C1074(0.97)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C1074(1.24); C431(1.08)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C1074(1.80)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C1074(0.88)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C1074(1.54)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C1074(1.45)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C1074(1.10)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C1074(1.09)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C1074(0.93)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C1074(0.96); C431(1.05)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C431(0.79)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C1074(1.04)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C1074(1.03)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C431(1.07)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C1074(1.25); C431(1.00)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C1074(1.45)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C1074(0.89)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C1074(1.45)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C1074(1.45)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C1074(0.90)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C1074(0.94)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C1074(1.20); C431(1.04)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C1074(0.98); C431(1.05)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C431(0.89)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C1074(1.02)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C431(0.85)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C1074(1.13); C431(1.07)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C1074(1.24)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C431(1.20)  LDD1034  [14]
 LDCM0437  CL47 HEK-293T C431(1.09)  LDD1035  [14]
 LDCM0438  CL48 HEK-293T C431(1.48)  LDD1036  [14]
 LDCM0439  CL49 HEK-293T C431(1.03)  LDD1037  [14]
 LDCM0440  CL5 HEK-293T C431(1.18)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C431(0.97)  LDD1039  [14]
 LDCM0442  CL51 HEK-293T C431(1.51)  LDD1040  [14]
 LDCM0443  CL52 HEK-293T C431(1.08)  LDD1041  [14]
 LDCM0444  CL53 HEK-293T C431(0.96)  LDD1042  [14]
 LDCM0445  CL54 HEK-293T C431(0.89)  LDD1043  [14]
 LDCM0446  CL55 HEK-293T C431(1.47)  LDD1044  [14]
 LDCM0447  CL56 HEK-293T C431(1.28)  LDD1045  [14]
 LDCM0448  CL57 HEK-293T C431(1.13)  LDD1046  [14]
 LDCM0449  CL58 HEK-293T C431(1.37)  LDD1047  [14]
 LDCM0450  CL59 HEK-293T C431(1.32)  LDD1048  [14]
 LDCM0451  CL6 HEK-293T C1074(1.22)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C431(1.12)  LDD1050  [14]
 LDCM0453  CL61 HEK-293T C1074(0.96)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C1074(0.97)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C1074(1.06)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C1074(1.14); C431(0.95)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C431(0.94)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C1074(1.12)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C431(0.99)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C1074(1.12); C431(1.16)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C1074(1.42)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C431(1.06)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C1074(0.97)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C1074(1.45)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C1074(1.33)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C1074(1.10)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C1074(0.91)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C431(1.09)  LDD1067  [14]
 LDCM0470  CL77 HEK-293T C431(1.24)  LDD1068  [14]
 LDCM0471  CL78 HEK-293T C431(1.19)  LDD1069  [14]
 LDCM0472  CL79 HEK-293T C431(1.27)  LDD1070  [14]
 LDCM0473  CL8 HEK-293T C1074(2.00); C431(1.29)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C431(1.20)  LDD1072  [14]
 LDCM0475  CL81 HEK-293T C431(1.12)  LDD1073  [14]
 LDCM0476  CL82 HEK-293T C431(0.92)  LDD1074  [14]
 LDCM0477  CL83 HEK-293T C431(0.91)  LDD1075  [14]
 LDCM0478  CL84 HEK-293T C431(1.25)  LDD1076  [14]
 LDCM0479  CL85 HEK-293T C431(1.14)  LDD1077  [14]
 LDCM0480  CL86 HEK-293T C431(1.51)  LDD1078  [14]
 LDCM0481  CL87 HEK-293T C431(1.01)  LDD1079  [14]
 LDCM0482  CL88 HEK-293T C431(1.20)  LDD1080  [14]
 LDCM0483  CL89 HEK-293T C431(1.14)  LDD1081  [14]
 LDCM0484  CL9 HEK-293T C1074(1.46)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C431(1.46)  LDD1083  [14]
 LDCM0486  CL91 HEK-293T C431(0.92)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C1074(1.13); C431(1.07)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C1074(1.29)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C1074(1.06)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C1074(1.68)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C1074(1.20)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C1074(1.06)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C1074(0.97)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C1074(0.98)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C1074(1.08)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C1074(1.04)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C1074(0.96)  LDD1631  [13]
 LDCM0173  HM30181 Hep-G2 2.20  LDD0436  [11]
 LDCM0022  KB02 769-P C431(1.47)  LDD2246  [5]
 LDCM0023  KB03 769-P C431(1.43)  LDD2663  [5]
 LDCM0024  KB05 MELHO C431(2.05)  LDD3318  [5]
 LDCM0137  SR-4995 HEK-293T 3.60  LDD0331  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RING2 (RNF2) . Q99496
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysosomal-associated transmembrane protein 4B (LAPTM4B) LAPTM4/LAPTM5 transporter family Q86VI4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 486 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Inotuzumab Ozogamicin Antibody DB05889
Polatuzumab Vedotin Antibody DB12240
Belantamab Mafodotin Antibody drug conjugate DB15719
Loncastuximab Tesirine Antibody drug conjugate DB16222
Trastuzumab Emtansine Antibody drug conjugate DB05773
Somatotropin BiotechDrug DB00052
Cyclosporine Protein/peptide DB00091
Abemaciclib Small molecular drug DB12001
Acebutolol Small molecular drug DB01193
Acenocoumarol Small molecular drug DB01418
Acetaminophen Small molecular drug DB00316
Acetylsalicylic Acid Small molecular drug DB00945
Afatinib Small molecular drug DB08916
Albendazole Small molecular drug DB00518
Alectinib Small molecular drug DB11363
Alfentanil Small molecular drug DB00802
Alfuzosin Small molecular drug DB00346
Aliskiren Small molecular drug DB09026
Alitretinoin Small molecular drug DB00523
Alpelisib Small molecular drug DB12015
Ambrisentan Small molecular drug DB06403
Amiodarone Small molecular drug DB01118
Amisulpride Small molecular drug DB06288
Amitriptyline Small molecular drug DB00321
Amlodipine Small molecular drug DB00381
Amodiaquine Small molecular drug DB00613
Amprenavir Small molecular drug DB00701
Amsacrine Small molecular drug DB00276
Anastrozole Small molecular drug DB01217
Apalutamide Small molecular drug DB11901
Apixaban Small molecular drug DB06605
Apremilast Small molecular drug DB05676
Arsenic Trioxide Small molecular drug DB01169
Artesunate Small molecular drug DB09274
Asciminib Small molecular drug DB12597
Astemizole Small molecular drug DB00637
Asunaprevir Small molecular drug DB11586
Atazanavir Small molecular drug DB01072
Atorvastatin Small molecular drug DB01076
Atovaquone Small molecular drug DB01117
Avanafil Small molecular drug DB06237
Avatrombopag Small molecular drug DB11995
Axitinib Small molecular drug DB06626
Azathioprine Small molecular drug DB00993
Azelastine Small molecular drug DB00972
Azilsartan Medoxomil Small molecular drug DB08822
Azithromycin Small molecular drug DB00207
Baloxavir Marboxil Small molecular drug DB13997
Baricitinib Small molecular drug DB11817
Beclomethasone Dipropionate Small molecular drug DB00394
Benzocaine Small molecular drug DB01086
Bepridil Small molecular drug DB01244
Berotralstat Small molecular drug DB15982
Betamethasone Small molecular drug DB00443
Betrixaban Small molecular drug DB12364
Bicalutamide Small molecular drug DB01128
Bisoprolol Small molecular drug DB00612
Boceprevir Small molecular drug DB08873
Bortezomib Small molecular drug DB00188
Bosutinib Small molecular drug DB06616
Bromocriptine Small molecular drug DB01200
Budesonide Small molecular drug DB01222
Buprenorphine Small molecular drug DB00921
Buspirone Small molecular drug DB00490
Cabazitaxel Small molecular drug DB06772
Cabergoline Small molecular drug DB00248
Cabotegravir Small molecular drug DB11751
Canagliflozin Small molecular drug DB08907
Candesartan Cilexetil Small molecular drug DB00796
Cannabidiol Small molecular drug DB09061
Capmatinib Small molecular drug DB11791
Captopril Small molecular drug DB01197
Carbamazepine Small molecular drug DB00564
Carfilzomib Small molecular drug DB08889
Cariprazine Small molecular drug DB06016
Carvedilol Small molecular drug DB01136
Caspofungin Small molecular drug DB00520
Ceftriaxone Small molecular drug DB01212
Celecoxib Small molecular drug DB00482
Ceritinib Small molecular drug DB09063
Cerivastatin Small molecular drug DB00439
Cetirizine Small molecular drug DB00341
Chloroquine Small molecular drug DB00608
Chlorpromazine Small molecular drug DB00477
Chlorprothixene Small molecular drug DB01239
Cholesterol Small molecular drug DB04540
Cholic Acid Small molecular drug DB02659
Cilazapril Small molecular drug DB01340
Cimetidine Small molecular drug DB00501
Ciprofloxacin Small molecular drug DB00537
Citalopram Small molecular drug DB00215
Clarithromycin Small molecular drug DB01211
Clindamycin Small molecular drug DB01190
Clofazimine Small molecular drug DB00845
Clomifene Small molecular drug DB00882
Clomipramine Small molecular drug DB01242
Clopidogrel Small molecular drug DB00758
Clotrimazole Small molecular drug DB00257
Clozapine Small molecular drug DB00363
Cobicistat Small molecular drug DB09065
Cobimetinib Small molecular drug DB05239
Colchicine Small molecular drug DB01394
Conivaptan Small molecular drug DB00872
Conjugated Estrogens Small molecular drug DB00286
Cortisone Acetate Small molecular drug DB01380
Crizotinib Small molecular drug DB08865
Curcumin Small molecular drug DB11672
Dabigatran Etexilate Small molecular drug DB06695
Dabrafenib Small molecular drug DB08912
Daclatasvir Small molecular drug DB09102
Dacomitinib Small molecular drug DB11963
Dactinomycin Small molecular drug DB00970
Dapagliflozin Small molecular drug DB06292
Darunavir Small molecular drug DB01264
Dasabuvir Small molecular drug DB09183
Dasatinib Small molecular drug DB01254
Daunorubicin Small molecular drug DB00694
Debrisoquine Small molecular drug DB04840
Desipramine Small molecular drug DB01151
Desloratadine Small molecular drug DB00967
Dexamethasone Small molecular drug DB01234
Dexibuprofen Small molecular drug DB09213
Diclofenac Small molecular drug DB00586
Diethylstilbestrol Small molecular drug DB00255
Digitoxin Small molecular drug DB01396
Digoxin Small molecular drug DB00390
Dihydroergotamine Small molecular drug DB00320
Diltiazem Small molecular drug DB00343
Dipyridamole Small molecular drug DB00975
Docetaxel Small molecular drug DB01248
Dolutegravir Small molecular drug DB08930
Domperidone Small molecular drug DB01184
Doxazosin Small molecular drug DB00590
Doxepin Small molecular drug DB01142
Doxorubicin Small molecular drug DB00997
Dronabinol Small molecular drug DB00470
Dronedarone Small molecular drug DB04855
Duloxetine Small molecular drug DB00476
Duvelisib Small molecular drug DB11952
Edoxaban Small molecular drug DB09075
Elagolix Small molecular drug DB11979
Eletriptan Small molecular drug DB00216
Eliglustat Small molecular drug DB09039
Empagliflozin Small molecular drug DB09038
Enalapril Small molecular drug DB00584
Entrectinib Small molecular drug DB11986
Enzalutamide Small molecular drug DB08899
Epinastine Small molecular drug DB00751
Ergometrine Small molecular drug DB01253
Ergotamine Small molecular drug DB00696
Erlotinib Small molecular drug DB00530
Ertugliflozin Small molecular drug DB11827
Erythromycin Small molecular drug DB00199
Escitalopram Small molecular drug DB01175
Esomeprazole Small molecular drug DB00736
Estradiol Small molecular drug DB00783
Estradiol Acetate Small molecular drug DB13952
Estradiol Cypionate Small molecular drug DB13954
Estradiol Valerate Small molecular drug DB13956
Estramustine Small molecular drug DB01196
Estriol Small molecular drug DB04573
Estrone Small molecular drug DB00655
Ethinylestradiol Small molecular drug DB00977
Etoposide Small molecular drug DB00773
Etravirine Small molecular drug DB06414
Everolimus Small molecular drug DB01590
Ezetimibe Small molecular drug DB00973
Favipiravir Small molecular drug DB12466
Fedratinib Small molecular drug DB12500
Felodipine Small molecular drug DB01023
Fentanyl Small molecular drug DB00813
Fesoterodine Small molecular drug DB06702
Fexofenadine Small molecular drug DB00950
Fidaxomicin Small molecular drug DB08874
Fingolimod Small molecular drug DB08868
Flecainide Small molecular drug DB01195
Flibanserin Small molecular drug DB04908
Fluconazole Small molecular drug DB00196
Fluoxetine Small molecular drug DB00472
Flupentixol Small molecular drug DB00875
Fluphenazine Small molecular drug DB00623
Fluticasone Small molecular drug DB13867
Fluticasone Furoate Small molecular drug DB08906
Fluticasone Propionate Small molecular drug DB00588
Fluvoxamine Small molecular drug DB00176
Fostemsavir Small molecular drug DB11796
Galantamine Small molecular drug DB00674
Gefitinib Small molecular drug DB00317
Gemcitabine Small molecular drug DB00441
Gilteritinib Small molecular drug DB12141
Glasdegib Small molecular drug DB11978
Glecaprevir Small molecular drug DB13879
Glyburide Small molecular drug DB01016
Grepafloxacin Small molecular drug DB00365
Haloperidol Small molecular drug DB00502
Hydrocortisone Small molecular drug DB00741
Hydroxychloroquine Small molecular drug DB01611
Hydroxyzine Small molecular drug DB00557
Ibrexafungerp Small molecular drug DB12471
Ibuprofen Small molecular drug DB01050
Idelalisib Small molecular drug DB09054
Imatinib Small molecular drug DB00619
Imipramine Small molecular drug DB00458
Indacaterol Small molecular drug DB05039
Indinavir Small molecular drug DB00224
Indomethacin Small molecular drug DB00328
Infigratinib Small molecular drug DB11886
Irinotecan Small molecular drug DB00762
Isavuconazole Small molecular drug DB11633
Istradefylline Small molecular drug DB11757
Itraconazole Small molecular drug DB01167
Ivacaftor Small molecular drug DB08820
Ivosidenib Small molecular drug DB14568
Ixabepilone Small molecular drug DB04845
Ketoconazole Small molecular drug DB01026
Lamivudine Small molecular drug DB00709
Lamotrigine Small molecular drug DB00555
Lansoprazole Small molecular drug DB00448
Lapatinib Small molecular drug DB01259
Lasmiditan Small molecular drug DB11732
Ledipasvir Small molecular drug DB09027
Lenalidomide Small molecular drug DB00480
Lenvatinib Small molecular drug DB09078
Letrozole Small molecular drug DB01006
Levamlodipine Small molecular drug DB09237
Levetiracetam Small molecular drug DB01202
Levofloxacin Small molecular drug DB01137
Levomilnacipran Small molecular drug DB08918
Levothyroxine Small molecular drug DB00451
Lidocaine Small molecular drug DB00281
Linagliptin Small molecular drug DB08882
Liothyronine Small molecular drug DB00279
Liotrix Small molecular drug DB01583
Lomitapide Small molecular drug DB08827
Lonafarnib Small molecular drug DB06448
Loperamide Small molecular drug DB00836
Lopinavir Small molecular drug DB01601
Loratadine Small molecular drug DB00455
Losartan Small molecular drug DB00678
Lovastatin Small molecular drug DB00227
Lumacaftor Small molecular drug DB09280
Maribavir Small molecular drug DB06234
Medroxyprogesterone Acetate Small molecular drug DB00603
Medrysone Small molecular drug DB00253
Mefloquine Small molecular drug DB00358
Megestrol Acetate Small molecular drug DB00351
Meperidine Small molecular drug DB00454
Methadone Small molecular drug DB00333
Methotrexate Small molecular drug DB00563
Methylprednisolone Small molecular drug DB00959
Metoclopramide Small molecular drug DB01233
Metronidazole Small molecular drug DB00916
Miconazole Small molecular drug DB01110
Mifepristone Small molecular drug DB00834
Miltefosine Small molecular drug DB09031
Mirabegron Small molecular drug DB08893
Mitotane Small molecular drug DB00648
Mitoxantrone Small molecular drug DB01204
Mobocertinib Small molecular drug DB16390
Morphine Small molecular drug DB00295
Mycophenolate Mofetil Small molecular drug DB00688
Nadolol Small molecular drug DB01203
Naloxone Small molecular drug DB01183
Naproxen Small molecular drug DB00788
Nefazodone Small molecular drug DB01149
Nelfinavir Small molecular drug DB00220
Neratinib Small molecular drug DB11828
Netupitant Small molecular drug DB09048
Nicardipine Small molecular drug DB00622
Nifedipine Small molecular drug DB01115
Nilotinib Small molecular drug DB04868
Nintedanib Small molecular drug DB09079
Niraparib Small molecular drug DB11793
Nisoldipine Small molecular drug DB00401
Nitrendipine Small molecular drug DB01054
Nitrofurantoin Small molecular drug DB00698
Nizatidine Small molecular drug DB00585
Norethisterone Small molecular drug DB00717
Norgestimate Small molecular drug DB00957
Nortriptyline Small molecular drug DB00540
Odevixibat Small molecular drug DB16261
Olanzapine Small molecular drug DB00334
Olaparib Small molecular drug DB09074
Olopatadine Small molecular drug DB00768
Omadacycline Small molecular drug DB12455
Ombitasvir Small molecular drug DB09296
Omeprazole Small molecular drug DB00338
Osimertinib Small molecular drug DB09330
Paclitaxel Small molecular drug DB01229
Pacritinib Small molecular drug DB11697
Palbociclib Small molecular drug DB09073
Paliperidone Small molecular drug DB01267
Pantoprazole Small molecular drug DB00213
Paritaprevir Small molecular drug DB09297
Paroxetine Small molecular drug DB00715
Pazopanib Small molecular drug DB06589
Pentazocine Small molecular drug DB00652
Phenobarbital Small molecular drug DB01174
Phenytoin Small molecular drug DB00252
Pibrentasvir Small molecular drug DB13878
Pimozide Small molecular drug DB01100
Pitavastatin Small molecular drug DB08860
Pomalidomide Small molecular drug DB08910
Ponatinib Small molecular drug DB08901
Posaconazole Small molecular drug DB01263
Pravastatin Small molecular drug DB00175
Prazosin Small molecular drug DB00457
Prednisolone Small molecular drug DB00860
Prednisone Small molecular drug DB00635
Primaquine Small molecular drug DB01087
Progesterone Small molecular drug DB00396
Promethazine Small molecular drug DB01069
Propafenone Small molecular drug DB01182
Propofol Small molecular drug DB00818
Propranolol Small molecular drug DB00571
Protriptyline Small molecular drug DB00344
Prucalopride Small molecular drug DB06480
Quetiapine Small molecular drug DB01224
Quinidine Small molecular drug DB00908
Quinine Small molecular drug DB00468
Raloxifene Small molecular drug DB00481
Ranitidine Small molecular drug DB00863
Ranolazine Small molecular drug DB00243
Reboxetine Small molecular drug DB00234
Regorafenib Small molecular drug DB08896
Relugolix Small molecular drug DB11853
Remdesivir Small molecular drug DB14761
Reserpine Small molecular drug DB00206
Rifabutin Small molecular drug DB00615
Rifampicin Small molecular drug DB01045
Rifamycin Small molecular drug DB11753
Rilpivirine Small molecular drug DB08864
Rimegepant Small molecular drug DB12457
Riociguat Small molecular drug DB08931
Risperidone Small molecular drug DB00734
Ritonavir Small molecular drug DB00503
Rivaroxaban Small molecular drug DB06228
Rolapitant Small molecular drug DB09291
Romidepsin Small molecular drug DB06176
Roxithromycin Small molecular drug DB00778
Rucaparib Small molecular drug DB12332
Sapropterin Small molecular drug DB00360
Saquinavir Small molecular drug DB01232
Selegiline Small molecular drug DB01037
Selexipag Small molecular drug DB11362
Selumetinib Small molecular drug DB11689
Sertraline Small molecular drug DB01104
Sildenafil Small molecular drug DB00203
Silodosin Small molecular drug DB06207
Simeprevir Small molecular drug DB06290
Simvastatin Small molecular drug DB00641
Sirolimus Small molecular drug DB00877
Sitagliptin Small molecular drug DB01261
Sofosbuvir Small molecular drug DB08934
Sorafenib Small molecular drug DB00398
Sotagliflozin Small molecular drug DB12713
Sotorasib Small molecular drug DB15569
Sparfloxacin Small molecular drug DB01208
Spironolactone Small molecular drug DB00421
Stiripentol Small molecular drug DB09118
Streptozocin Small molecular drug DB00428
Sulpiride Small molecular drug DB00391
Sumatriptan Small molecular drug DB00669
Sunitinib Small molecular drug DB01268
Suvorexant Small molecular drug DB09034
Tacrine Small molecular drug DB00382
Tacrolimus Small molecular drug DB00864
Talazoparib Small molecular drug DB11760
Tamoxifen Small molecular drug DB00675
Taurocholic Acid Small molecular drug DB04348
Tazemetostat Small molecular drug DB12887
Tegaserod Small molecular drug DB01079
Telaprevir Small molecular drug DB05521
Telmisartan Small molecular drug DB00966
Telotristat Ethyl Small molecular drug DB12095
Temsirolimus Small molecular drug DB06287
Tenofovir Alafenamide Small molecular drug DB09299
Tenofovir Disoproxil Small molecular drug DB00300
Tepotinib Small molecular drug DB15133
Terazosin Small molecular drug DB01162
Terfenadine Small molecular drug DB00342
Testosterone Propionate Small molecular drug DB01420
Testosterone Undecanoate Small molecular drug DB13946
Tezacaftor Small molecular drug DB11712
Ticagrelor Small molecular drug DB08816
Timolol Small molecular drug DB00373
Tipranavir Small molecular drug DB00932
Tivozanib Small molecular drug DB11800
Tolvaptan Small molecular drug DB06212
Topiramate Small molecular drug DB00273
Topotecan Small molecular drug DB01030
Toremifene Small molecular drug DB00539
Trazodone Small molecular drug DB00656
Trifluoperazine Small molecular drug DB00831
Triflupromazine Small molecular drug DB00508
Trimethoprim Small molecular drug DB00440
Trimipramine Small molecular drug DB00726
Troleandomycin Small molecular drug DB13179
Ubrogepant Small molecular drug DB15328
Umeclidinium Small molecular drug DB09076
Vandetanib Small molecular drug DB05294
Vardenafil Small molecular drug DB00862
Vecuronium Small molecular drug DB01339
Velpatasvir Small molecular drug DB11613
Vemurafenib Small molecular drug DB08881
Venetoclax Small molecular drug DB11581
Venlafaxine Small molecular drug DB00285
Verapamil Small molecular drug DB00661
Vericiguat Small molecular drug DB15456
Vibegron Small molecular drug DB14895
Vildagliptin Small molecular drug DB04876
Vinblastine Small molecular drug DB00570
Vincristine Small molecular drug DB00541
Vismodegib Small molecular drug DB08828
Voclosporin Small molecular drug DB11693
Vorapaxar Small molecular drug DB09030
Voxilaprevir Small molecular drug DB12026
Zidovudine Small molecular drug DB00495
Zimelidine Small molecular drug DB04832
Ziprasidone Small molecular drug DB00246
Zolmitriptan Small molecular drug DB00315
Zonisamide Small molecular drug DB00909
Abrocitinib . DB14973
Adagrasib . DB15568
Atogepant . DB16098
Avacopan . DB15011
Avapritinib . DB15233
Belumosudil . DB16703
Belzutifan . DB15463
Betamethasone Phosphate . DB14669
Chloramphenicol Succinate . DB07565
Copanlisib . DB12483
Darolutamide . DB12941
Deucravacitinib . DB16650
Dexamethasone Acetate . DB14649
Diosmin . DB08995
Elbasvir . DB11574
Elexacaftor . DB15444
Enasidenib . DB13874
Enfortumab Vedotin . DB13007
Erdafitinib . DB12147
Estradiol Benzoate . DB13953
Estradiol Dienanthate . DB13955
Filgotinib . DB14845
Futibatinib . DB15149
Grazoprevir . DB11575
Hydrocortisone Acetate . DB14539
Hydrocortisone Butyrate . DB14540
Hydrocortisone Cypionate . DB14541
Hydrocortisone Phosphate . DB14542
Hydrocortisone Probutate . DB14543
Hydrocortisone Valerate . DB14544
Larotrectinib . DB14723
Lefamulin . DB12825
Lemborexant . DB11951
Letermovir . DB12070
Levoketoconazole . DB05667
Lonapegsomatropin . DB16220
Lusutrombopag . DB13125
Methylene Blue . DB09241
Mirvetuximab Soravtansine . DB12489
Mitapivat . DB16236
Nirmatrelvir . DB16691
Olutasidenib . DB16267
Opicapone . DB11632
Ozanimod . DB12612
Pemigatinib . DB15102
Polyethylene Glycol 400 . DB11077
Pralsetinib . DB15822
Prednisolone Acetate . DB15566
Prednisolone Phosphate . DB14631
Ripretinib . DB14840
Selpercatinib . DB15685
Somatostatin . DB09099
Testosterone Cypionate . DB13943
Testosterone Enanthate . DB13944
Tisotumab Vedotin . DB16732
Tocofersolan . DB11635
Trastuzumab Deruxtecan . DB14962
Trilaciclib . DB15442
Tucatinib . DB11652
Ubidecarenone . DB09270
Umbralisib . DB14989
Upadacitinib . DB15091
Vinflunine . DB11641
Zanubrutinib . DB15035
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cbt-1 . D06XVF
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
W-198 Small molecular drug D0GS2W
Edp-322 . D09LSY
Investigative
Click To Hide/Show 55 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4,3'',5''-trimethoxy-[1,1':2',1'-terphenyl Small molecular drug D0AW4W
6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol Small molecular drug D05XGZ
Aldosterone Small molecular drug DB04630
Annamycin Small molecular drug DB06420
Atp Small molecular drug DB00171
Camptothecin Small molecular drug DB04690
Candesartan Small molecular drug DB13919
Colforsin Small molecular drug DB02587
Dexniguldipine Small molecular drug DB14068
Elacridar Small molecular drug DB04881
Emopamil Small molecular drug DB14064
Genistein Small molecular drug DB01645
Grapiprant Small molecular drug DB12836
Lobeglitazone Small molecular drug DB09198
Lomerizine Small molecular drug DB14065
Mibefradil Small molecular drug DB01388
Naringenin Small molecular drug DB03467
Niguldipine Small molecular drug DB09239
Odanacatib Small molecular drug DB06670
Piperine Small molecular drug DB12582
Platelet Activating Factor Small molecular drug DB02261
Quercetin Small molecular drug DB04216
Quinacrine Small molecular drug DB01103
Sphingosine Small molecular drug DB03203
Staurosporine Small molecular drug DB02010
Tenofovir Small molecular drug DB14126
Tesmilifene Small molecular drug DB04905
Tetrandrine Small molecular drug DB14066
Tipifarnib Small molecular drug DB04960
Trismethoxyresveratrol Small molecular drug D0O9NE
Voacamine Small molecular drug DB04877
Xr-9456 Small molecular drug D04GYT
Xr-9504 Small molecular drug D09HIM
Xr-9544 Small molecular drug D0A4TF
Xr-9577 Small molecular drug D0S8CE
Zosuquidar Small molecular drug DB06191
[1,1':2',1'-terphenyl-4,3'',5''-triol Small molecular drug D03PLP
Azvudine . DB16407
Concanamycin A . DB14062
Curcumin Sulfate . DB14635
Desmethylsertraline . DB14071
Dexverapamil . DB14063
Dofequidar . DB14067
Dovitinib . DB05928
Estriol Tripropionate . DB14641
Fm-vp4 . DB05449
Hm-30181 . DB14070
Hycanthone . DB14061
Hydrocortisone Aceponate . DB14538
Lenacapavir . DB15673
Loxicodegol . DB14146
Medical Cannabis . DB14009
Reversin 121 . DB14072
Rhodamine 6g . DB03825
Stanolone Acetate . DB13951
Discontinued
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biricodar Small molecular drug D02VJY
Elacridar Small molecular drug D09FGX
Ly335979 Small molecular drug D06DCL
Ont-093 Small molecular drug D0SR4G
Stanolone Small molecular drug DB02901
Tariquidar Small molecular drug D04RLX

References

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Mass spectrometry data entry: PXD018580
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
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4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
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12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402
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