Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C149  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 20.8
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 19.2
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 17.6
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 16.3
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 15.5
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 13.6
 LDTP00316  Ribonuclease T2 (RNASET2) 13.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 13.2
 LDTP02141  Alpha-galactosidase A (GLA) 12.1
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 12.0
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 11.6
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 11.2
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 10.6
 LDTP10888  Legumain (LGMN) 10.1
 LDTP01372  Carboxypeptidase D (CPD) 9.8
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 9.1
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.5
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 8.5
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 7.9
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 7.9
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 7.8
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.6
 LDTP02505  Lysosomal protective protein (CTSA) 7.2
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 7.0
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 6.9
 LDTP02837  Beta-galactosidase (GLB1) 6.8
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 6.8
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 6.7
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 6.5
 LDTP13853  Epididymis-specific alpha-mannosidase (MAN2B2) 6.5
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 6.5
 LDTP02539  Lysosomal acid phosphatase (ACP2) 6.4
 LDTP03692  Bifunctional epoxide hydrolase 2 (EPHX2) 6.2
 LDTP05905  Acid ceramidase (ASAH1) 5.9
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 5.9
 LDTP05561  Lactadherin (MFGE8) 5.5
 LDTP17633  Beta-galactosidase-1-like protein 2 (GLB1L2) 5.2
Transporter and channel
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01829  Low-density lipoprotein receptor (LDLR) 16.0
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 13.4
 LDTP02071  Amyloid-beta precursor protein (APP) 11.2
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 10.8
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 10.5
 LDTP01969  Transferrin receptor protein 1 (TFRC) 10.3
 LDTP02215  Prosaposin (PSAP) 10.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 9.1
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 8.9
 LDTP10885  Sortilin (SORT1) 8.8
 LDTP05538  Prolow-density lipoprotein receptor-related protein 1 (LRP1) 8.3
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 7.7
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.9
 LDTP05356  Desmocollin-2 (DSC2) 6.0
 LDTP12451  Integral membrane protein 2C (ITM2C) 6.0
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 5.6
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 5.5
 LDTP01427  Slit homolog 2 protein (SLIT2) 5.5
 LDTP16813  Tetraspanin-3 (TSPAN3) 5.1
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 5.1
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 5.1
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04221  Adhesion G protein-coupled receptor E5 (ADGRE5) 7.0
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 21.1
 LDTP09907  Neogenin (NEO1) 12.2
Other
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07703  Seizure 6-like protein 2 (SEZ6L2) 20.0
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 16.2
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 16.0
 LDTP07031  Collectin-12 (COLEC12) 11.6
 LDTP12352  CD320 antigen (CD320) 9.9
 LDTP13114  C-type mannose receptor 2 (MRC2) 9.8
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 8.7
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 8.5
 LDTP03175  Galanin peptides (GAL) 8.3
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 7.9
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 7.8
 LDTP06134  Protocadherin Fat 1 (FAT1) 7.4
 LDTP06154  Desmocollin-3 (DSC3) 7.1
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 6.8
 LDTP02927  Ganglioside GM2 activator (GM2A) 6.7
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 6.4
 LDTP07760  CD109 antigen (CD109) 6.3
 LDTP09787  Nicastrin (NCSTN) 5.7
 LDTP10023  Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) 5.4
 LDTP05960  Trophoblast glycoprotein (TPBG) 5.3
 LDTP01973  Ferritin light chain (FTL) 5.2
 LDTP09920  Golgi apparatus protein 1 (GLG1) 5.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587