Details of the Target

General Information of Target

Target ID LDTP06134
Target Name Protocadherin Fat 1 (FAT1)
Gene Name FAT1
Gene ID 2195
Synonyms
CDHF7; FAT; Protocadherin Fat 1; Cadherin family member 7; Cadherin-related tumor suppressor homolog; Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMG
VYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIV
KALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSM
AKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLL
QQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLI
SILEPVKRQQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGT
TVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ
LVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYIN
ITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPL
DRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSE
IIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSG
QVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEV
EVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTS
EPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS
RKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKP
DRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEY
DILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI
SVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILT
QVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPL
SLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAP
WFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIK
TAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETV
SIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGT
NMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADAD
KDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAE
YAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE
GNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFT
QDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFD
REQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI
RYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGG
NPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITD
GDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNP
PVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTG
LISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARIS
EHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPF
YSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGD
SGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFC
TVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSE
SVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQL
PKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRL
KLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVE
NLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKR
DNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAIL
STTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD
GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITY
TLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVND
NAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGI
IQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVS
EDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE
YYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMAD
DADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPR
VNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTI
VTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI
YPPAILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQMDNLFSVSSTGGKLI
AHKKLDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYW
RNFQRALRNILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVT
DIEEIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVC
LCKEGRCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYV
KYRLTENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVS
VQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQG
TRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASN
PCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRG
LYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGA
LCENTHGSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLVVVFV
LCRKMISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSI
PSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHRKAVAVCSVAPNLPPPPPSNSPSDS
DSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNG
YHWDTSDWMPSVPLPDIQEFPNYEVIDEQTPLYSADPNAIDTDYYPGGYDIESDFPPPPE
DFPAADELPPLPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQRFNLNQYLPNFYPLDMSE
PQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYASTASCSDVSACCEVESEVM
MSDYESGDDGHFEEVTIPPLDSQQHTEV
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus; Cell membrane
Function [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
TTD ID
T96242
Uniprot ID
Q14517
DrugMap ID
TTGUJYV
Ensemble ID
ENST00000441802.7
HGNC ID
HGNC:3595

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K3396(1.06); K4219(3.87)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K978(0.71); K369(1.01); K2562(1.59); K3783(1.60)  LDD3494  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C4512(1.21); C3738(0.98); C3743(0.98); C3826(0.94)  LDD0078  [5]
CY4
 Probe Info  		E111(0.00); K113(0.00); R110(0.00)  LDD0247  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		C4342(0.00); C4512(0.00)  LDD0147  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
W1
 Probe Info  		N.A.  LDD0236  [10]
TPP-AC
 Probe Info  		N.A.  LDD0427  [11]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C149
 Probe Info  		7.41  LDD1830  [12]
C170
 Probe Info  		11.71  LDD1850  [12]
C208
 Probe Info  		12.21  LDD1883  [12]
C211
 Probe Info  		9.13  LDD1885  [12]
C213
 Probe Info  		15.45  LDD1887  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C4115(1.18); C3023(1.15); C3738(0.70); C3743(0.88)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C4115(1.28); C3023(1.28); C3738(1.10); C3743(1.14)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C4115(0.74); C3023(1.01); C3738(0.87); C3743(0.97)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C4115(0.72); C3023(0.94); C3738(0.82); C3743(0.97)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C4115(0.71); C3023(0.86); C3738(0.87); C3743(1.05)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C4115(1.34); C3023(1.06); C3738(0.94); C3743(1.01)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C4115(0.92); C3023(0.97); C3738(0.88); C3743(1.00)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C4115(1.23); C3023(1.03); C3738(0.91); C3743(0.84)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C4115(1.24); C3023(1.06); C3738(0.98); C3743(1.05)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C4115(1.09); C3023(0.57); C3738(1.00); C3743(1.13)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C4115(0.53); C3023(0.59); C3738(0.81); C3743(0.85)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C4115(0.85); C3023(0.56); C3738(0.83); C3743(0.94)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C4115(1.06); C3023(1.23); C3738(1.11); C3743(1.13)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C4115(0.82); C3023(0.54); C3738(0.90); C3743(0.92)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C4115(0.86); C3023(0.56); C3738(0.76); C3743(0.77)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C4115(0.86); C3023(0.54); C3738(1.02); C3743(1.02)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C4115(1.02); C3738(0.87); C3743(0.87); C3780(1.06)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C4115(1.37); C3738(1.13); C3743(1.13); C3780(1.20)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C4115(1.37); C3738(1.14); C3743(1.14); C3780(0.95)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C4115(1.42); C3738(1.25); C3743(1.25); C3780(1.53)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C4115(1.25); C3738(1.15); C3743(1.15); C3780(1.25)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C4115(1.54); C3738(1.10); C3743(1.10); C3780(1.22)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C4115(1.27); C3738(1.09); C3743(1.09); C3780(1.08)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C4115(0.88); C3023(1.25); C3738(0.96); C3743(0.99)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C4115(0.86); C3738(1.16); C3743(1.16); C3780(1.17)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C4115(1.42); C3738(1.08); C3743(1.08); C3780(1.54)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C4115(1.86); C3738(1.05); C3743(1.05); C3780(1.25)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C4115(1.11); C3738(1.11); C3743(1.11); C3780(1.38)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C4115(1.34); C3738(1.16); C3743(1.16); C3780(1.52)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C4115(1.17); C3738(1.17); C3743(1.17); C3780(1.21)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C4115(1.30); C3738(1.39); C3743(1.39); C3780(1.36)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C4115(1.38); C3738(1.24); C3743(1.24); C3780(1.19)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C4115(1.39); C3023(0.92); C3738(1.22); C3743(1.17)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C4115(1.90); C3023(0.90); C3738(0.83); C3743(0.80)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C4115(1.93); C3023(0.99); C3738(1.00); C3743(1.01)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C4115(1.63); C3023(1.11); C3738(0.92); C3743(0.86)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C4115(1.47); C3023(0.99); C3738(0.86); C3743(0.84)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C4115(1.81); C3023(1.05); C3738(1.04); C3743(1.01)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C4115(1.61); C3023(0.99); C3738(1.11); C3743(1.02)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C4115(1.76); C3023(0.92); C3738(0.90); C3743(0.92)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C4115(0.99); C3023(0.94); C3738(0.98); C3743(0.96)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C4115(1.13); C3023(0.98); C3738(1.05); C3743(1.06)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C4115(1.90); C3023(0.93); C3738(1.00); C3743(0.93)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C4115(1.48); C3023(1.07); C3738(0.91); C3743(0.93)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C4115(1.01); C3023(1.02); C3738(1.07); C3743(1.04)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C4115(1.62); C3023(1.05); C3738(0.96); C3743(1.01)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C4115(2.23); C3023(1.04); C3738(0.90); C3743(0.92)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C4115(1.21); C3023(0.94); C3738(0.85); C3743(0.84)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C4115(0.86); C3023(1.03); C3738(0.92); C3743(0.92)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C3787(1.07); C3794(1.07); C3743(1.10); C3816(1.11)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C3738(0.99); C3743(1.02); C3787(1.03); C3794(1.03)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C3816(0.94); C4087(0.95); C4093(0.95); C3738(0.99)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C3816(0.93); C4104(1.04); C4087(1.05); C4093(1.05)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C3816(1.17); C3976(1.20); C3780(1.23); C3743(1.29)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C4087(0.95); C4093(0.95); C3780(0.99); C3738(1.01)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C3738(0.92); C3780(0.96); C3818(1.01); C3782(1.01)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C3738(0.92); C3816(0.95); C4104(0.96); C3743(0.96)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C3816(0.94); C3743(0.98); C3023(0.98); C3818(1.00)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C4115(0.89); C4113(0.97); C3816(1.04); C3743(1.09)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C4087(1.10); C4093(1.10); C3743(1.21); C3816(1.21)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C4115(1.22); C3023(1.60); C3738(1.02); C3743(1.03)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C4115(1.20); C3023(1.44); C3738(1.21); C3743(1.14)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C4115(0.88); C3023(1.21); C3738(1.13); C3743(1.09)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C4115(1.10); C3023(0.84); C3738(1.05); C3743(1.01)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C4093(0.75); C3976(0.98); C4113(1.01); C4342(1.01)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C4093(0.85); C4104(0.95); C574(0.96); C4113(0.97)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C4093(0.75); C4342(0.99); C574(1.00); C94(1.06)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C3738(0.67); C3816(0.85); C3743(0.85); C3818(0.85)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C574(0.94); C3976(1.04); C4093(1.04); C94(1.05)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C4093(0.94); C3794(0.96); C94(1.01); C574(1.04)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C94(0.90); C4342(0.95); C574(0.97); C3976(1.12)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C4093(0.83); C4342(0.92); C574(0.99); C94(1.02)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C4093(0.84); C94(0.98); C4342(0.99); C574(1.02)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C4113(0.47); C4104(0.82); C3743(0.85); C3826(0.96)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C3780(0.96); C4113(0.97); C3816(0.97); C3743(0.99)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C3780(0.93); C3826(1.04); C3743(1.06); C3976(1.07)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C4113(0.62); C4104(0.81); C3787(0.99); C3794(0.99)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C4113(0.94); C3780(0.97); C3743(1.02); C3023(1.04)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C3738(0.68); C3818(0.78); C3816(0.81); C3787(0.81)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C4113(0.62); C3976(0.87); C3780(0.96); C3743(1.03)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C3976(0.96); C3780(0.99); C3743(1.02); C3023(1.08)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C4113(0.92); C3976(0.97); C3743(1.03); C3738(1.21)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C4113(0.79); C3780(1.06); C3743(1.11); C3782(1.18)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C4113(0.67); C3743(0.96); C3780(1.04); C4104(1.06)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C4115(0.70); C3787(0.80); C3794(0.80); C4104(0.84)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C3826(0.83); C94(0.88); C3787(0.92); C3794(0.92)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C94(0.85); C3826(0.87); C3976(0.96); C3023(0.99)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C3976(0.86); C3826(0.91); C3780(0.92); C94(0.97)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C3826(0.88); C3780(0.97); C3782(1.00); C3818(1.06)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C3738(0.70); C3787(0.79); C4342(0.84); C3818(0.86)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C3826(1.02); C3780(1.04); C3023(1.05); C3743(1.10)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C3826(0.95); C3976(0.98); C4113(1.01); C94(1.01)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C3780(1.01); C3826(1.03); C3738(1.04); C3743(1.04)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C3826(0.95); C3780(0.95); C3787(0.97); C3794(0.97)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C3826(0.91); C3743(1.00); C3976(1.01); C3738(1.01)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C3826(0.98); C3738(1.06); C3743(1.09); C3023(1.15)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C574(0.76); C3787(0.86); C3794(0.86); C3738(0.86)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C4113(0.71); C3738(0.94); C3743(0.94); C3023(0.99)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C4113(0.76); C3780(0.88); C3782(0.94); C3816(1.00)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C4113(0.76); C3738(1.07); C3743(1.07); C3787(1.07)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C3738(0.67); C3787(0.78); C4342(0.86); C3794(0.87)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C4113(0.79); C3787(1.04); C3794(1.04); C3976(1.05)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C94(0.79); C4113(0.84); C3787(0.87); C3794(0.87)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C4113(0.76); C3787(0.88); C3794(0.88); C3023(0.92)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C3787(0.93); C3794(0.93); C3976(0.95); C4113(0.96)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C3787(0.89); C3794(0.89); C3023(0.99); C3976(1.05)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C4113(0.72); C4512(0.93); C3976(0.94); C3738(1.07)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C4113(0.52); C3976(1.04); C3738(1.12); C3743(1.12)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C3976(0.67); C3816(0.93); C3794(1.01); C3023(1.01)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C3976(0.74); C3816(0.78); C3023(0.92); C3794(0.93)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C3976(0.66); C4113(0.79); C3023(0.84); C3794(0.98)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C3780(0.89); C4113(0.90); C3782(0.94); C4512(0.98)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C3976(0.70); C3023(0.82); C3816(0.94); C4115(1.01)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C3976(0.75); C4113(0.82); C3023(0.89); C3816(0.96)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C3976(0.70); C3023(0.86); C3816(0.98); C3818(1.12)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C3976(0.65); C4113(0.83); C574(0.94); C3023(0.94)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C3816(0.88); C3023(0.89); C4113(0.92); C3976(0.95)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C3976(0.56); C3816(0.78); C3818(0.90); C3787(0.90)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C3976(0.53); C3816(0.74); C3818(0.87); C4113(0.88)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C3976(0.54); C3816(0.76); C4113(0.77); C3787(0.83)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C4087(0.84); C4093(0.84); C4512(0.85); C3826(0.88)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C4512(0.78); C4087(0.87); C4093(0.87); C3826(0.89)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C4512(0.90); C4342(0.91); C3782(0.94); C3780(0.94)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C3738(0.86); C3976(0.86); C4512(0.95); C94(1.01)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C4512(0.89); C3738(0.92); C3826(0.92); C4104(0.94)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C3738(0.75); C4087(0.78); C4093(0.78); C3826(0.89)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C3738(0.90); C4087(0.90); C4093(0.90); C3976(0.90)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C4512(0.87); C4087(0.91); C4093(0.91); C4104(0.98)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C4087(0.93); C4093(0.93); C4512(1.00); C3826(1.18)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C3738(0.84); C3826(0.92); C4087(0.96); C4093(0.96)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C4512(0.80); C3738(0.93); C4087(0.93); C4093(0.93)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C3738(0.77); C3743(0.87); C4104(0.90); C4087(0.93)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C3738(0.78); C4512(0.87); C3743(0.95); C4104(1.03)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C3976(0.89); C3780(0.90); C3782(0.90); C3738(0.93)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C3738(0.77); C3743(0.93); C4087(0.96); C4093(0.96)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C3787(0.72); C3794(0.72); C4087(0.75); C4093(0.75)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C4512(0.84); C3738(0.92); C4087(0.92); C4093(0.92)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C3976(0.89); C4087(1.14); C4093(1.14); C3816(1.15)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C3976(0.69); C4115(1.01); C3787(1.04); C3794(1.04)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C3976(0.71); C4512(0.94); C4115(0.98); C3023(1.07)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C3976(0.60); C4512(0.83); C3023(1.07); C4087(1.08)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C3976(0.63); C3023(1.00); C4512(1.02); C4087(1.04)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C3976(0.60); C3816(1.02); C4115(1.04); C3023(1.09)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C3976(0.63); C4512(1.00); C3738(1.11); C4087(1.13)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C4087(0.57); C4093(0.57); C3976(0.62); C4115(0.95)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C4512(0.74); C3976(0.92); C3816(1.02); C4087(1.09)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C3976(0.77); C4512(0.94); C3816(1.06); C4087(1.10)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C3976(0.66); C3787(1.04); C3794(1.04); C4087(1.07)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C4512(0.75); C3816(1.03); C4115(1.08); C3976(1.12)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C3976(0.49); C94(1.03); C3787(1.05); C3794(1.05)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C4512(0.76); C3976(0.97); C3816(1.03); C3023(1.12)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C3976(0.49); C3738(1.18); C3816(1.20); C3743(1.22)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C4087(0.60); C4093(0.60); C3976(0.79); C3780(0.81)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C4087(0.56); C4093(0.56); C3976(0.69); C3780(0.74)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C4115(0.98); C3023(1.17); C3738(1.07); C3743(1.02)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C4512(0.89); C3780(0.94); C4104(0.95); C3738(0.95)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C4113(1.04); C4512(1.04); C3738(1.06); C3780(1.07)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C4512(1.21); C3738(0.98); C3743(0.98); C3826(0.94)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HCT 116 C4512(0.79); C4342(0.91); C3780(1.02); C3818(1.02)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C3780(0.85); C3782(0.96); C3023(0.97); C4342(1.03)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C3738(0.78); C3787(0.82); C4342(0.89); C3794(0.92)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C4512(0.82); C574(1.03); C4113(1.06); C3976(1.07)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C4113(0.86); C4342(0.92); C4512(0.99); C574(0.99)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C3976(0.85); C4512(0.87); C4342(0.91); C3826(0.95)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C4512(0.76); C4115(0.98); C4104(0.98); C4342(0.99)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C4342(0.95); C4093(1.04); C574(1.12); C3826(1.24)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C4093(0.74); C574(1.04); C4342(1.05); C3826(1.22)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C4093(1.02); C4342(1.10); C3826(1.12); C574(1.14)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C4093(0.92); C4342(1.06); C574(1.16); C3826(1.19)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C574(0.98); C4342(1.00); C4093(1.06); C94(1.22)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C3023(0.90); C3782(0.92); C3780(1.01); C3818(1.07)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C4093(0.91); C574(1.02); C4342(1.13); C3826(1.21)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C4093(0.70); C574(1.10); C4342(1.12); C3976(1.12)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C4113(0.89); C4342(0.92); C4104(0.95); C4115(1.01)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C4113(0.69); C3743(0.91); C4104(0.97); C3780(0.98)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C4113(0.78); C4512(0.97); C4342(0.98); C3780(1.08)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C4113(0.95); C4342(1.16); C3780(1.17); C4104(1.20)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C4113(0.72); C3743(0.90); C3738(0.98); C4104(0.99)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C3780(1.17); C4342(1.26); C3826(1.27); C3782(1.30)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C3826(0.92); C3780(1.00); C3782(1.03); C4342(1.06)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C3826(0.89); C3780(0.98); C3782(1.01); C3738(1.03)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C3780(1.00); C3782(1.03); C3818(1.07); C3023(1.08)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C3826(0.87); C3780(0.98); C3743(0.98); C3738(0.99)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C4512(0.86); C4113(0.92); C3826(1.01); C4342(1.07)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C3780(0.94); C3738(0.98); C3743(0.98); C4512(1.01)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C4512(0.87); C4113(1.01); C4342(1.05); C3976(1.19)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C4113(0.86); C574(1.05); C4512(1.10); C3023(1.17)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C3976(0.80); C3023(0.90); C94(0.93); C4342(0.99)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C3976(0.75); C3023(0.82); C574(0.88); C4113(0.89)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C3976(0.51); C4113(0.79); C3023(0.94); C94(0.97)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C3976(0.83); C3023(0.93); C3816(1.02); C574(1.05)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C3780(0.94); C3816(0.95); C3818(1.00); C3782(1.09)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C3780(0.77); C3818(0.86); C4342(0.93); C3782(0.95)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C3780(0.77); C3816(0.89); C3782(1.02); C4115(1.02)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C4113(1.00); C4342(1.04); C3976(1.05); C3826(1.08)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C4342(0.85); C4113(0.95); C3826(1.14); C4512(1.14)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C4113(0.94); C3743(0.97); C3787(0.97); C3738(0.99)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C3976(0.95); C4342(1.00); C3743(1.09); C3738(1.11)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C4512(0.91); C4342(0.96); C3780(0.98); C3818(1.00)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C3738(1.02); C3743(1.04); C3976(1.09); C3826(1.10)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C4342(1.04); C3738(1.08); C3743(1.15); C4512(1.16)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C3976(1.13); C4113(1.40); C3743(1.41); C3738(1.42)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C3738(0.95); C3743(0.95); C3826(0.96); C3976(1.00)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C4115(1.04); C3743(1.06); C3738(1.06); C4104(1.10)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C4115(1.26); C3738(1.37); C3743(1.37); C3780(1.44)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C4115(1.34); C3738(1.22); C3743(1.11); C3780(1.27)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C4115(1.39); C3738(1.25); C3743(1.29); C3780(1.36)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C4115(1.34); C3738(1.38); C3743(1.43); C3780(1.55)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C4115(1.21); C3738(1.04); C3743(1.04); C3780(1.12)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C4115(1.84); C3023(1.14); C3738(1.17); C3743(1.03)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C4115(1.03); C3738(0.98); C3743(1.05); C3780(1.24)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C4115(1.13); C3023(1.02); C3738(1.31); C3743(1.18)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C4115(1.43); C3023(1.13); C3738(1.14); C3743(1.10)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C4115(4.30); C3023(1.10); C3738(1.17); C3743(1.17)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C4115(1.99); C3023(0.96); C3738(1.49); C3743(1.32)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C4115(1.39); C3023(1.03); C3738(1.27); C3743(1.14)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C4115(1.59); C3023(1.01); C3738(1.41); C3743(1.25)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C4115(2.06); C3023(0.96); C3738(1.19); C3743(1.11)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C4115(2.09); C3023(1.09); C3738(1.70); C3743(1.42)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C4115(1.54); C3023(0.82); C3738(1.53); C3743(1.35)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C4115(1.45); C3023(1.12); C3738(1.12); C3743(1.27)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C4115(1.77); C3023(1.21); C3738(1.32); C3743(1.26)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C4115(1.87); C3023(1.13); C3738(1.29); C3743(1.25)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C4115(1.51); C3023(1.13); C3738(1.22); C3743(1.36)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C4115(1.24); C3023(1.16); C3738(1.26); C3743(1.19)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C4115(2.08); C3023(0.72); C3738(1.45); C3743(1.23)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C4115(1.56); C3023(1.11); C3738(1.17); C3743(1.11)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C4115(1.21); C3023(0.80); C3738(1.19); C3743(1.10)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C4115(1.27); C3023(0.93); C3738(1.06); C3743(0.99)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C4115(1.30); C3023(1.14); C3738(0.99); C3743(1.01)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C4115(1.44); C3023(1.14); C3738(1.08); C3743(1.00)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C4115(1.08); C3023(0.92); C3738(0.98); C3743(0.99)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C4115(1.09); C3023(0.81); C3738(0.93); C3743(0.90)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C4115(1.70); C3023(0.83); C3738(0.99); C3743(0.96)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C4115(0.96); C3023(1.03); C3738(1.01); C3743(0.98)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C4115(1.13); C3023(0.97); C3738(1.12); C3743(1.05)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C4115(1.05); C3023(1.00); C3738(1.04); C3743(0.94)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C4115(1.18); C3023(0.94); C3738(1.10); C3743(1.03)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C4115(1.10); C3023(1.06); C3738(1.25); C3743(1.20)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C4115(1.22); C3023(0.97); C3738(0.90); C3743(0.91)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C4115(1.35); C3023(0.94); C3738(1.01); C3743(0.99)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C4115(1.52); C3023(1.04); C3738(1.33); C3743(1.16)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C4115(1.17); C3023(0.99); C3738(1.17); C3743(1.13)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C4115(1.08); C3023(1.23); C3738(0.89); C3743(0.89)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C4115(0.95); C3023(1.27); C3738(1.18); C3743(1.18)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C4115(1.17); C3023(1.07); C3738(1.27); C3743(1.27)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C4115(2.82); C3023(1.25); C3738(1.34); C3743(1.34)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C4115(0.97); C3023(1.23); C3738(1.06); C3743(1.06)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C4115(1.17); C3023(1.31); C3738(1.57); C3743(1.57)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C4115(0.98); C3023(1.16); C3738(1.11); C3743(1.11)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C4115(1.79); C3023(1.21); C3738(1.26); C3743(1.26)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C4115(1.36); C3023(1.30); C3738(1.19); C3743(1.19)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C4115(1.67); C3023(1.09); C3738(1.39); C3743(1.26)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C4115(0.95); C3023(1.16); C3738(1.03); C3743(1.03)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C4115(1.07); C3023(1.20); C3738(1.20); C3743(1.20)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C4115(1.22); C3023(1.19); C3738(0.93); C3743(0.93)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C4115(1.01); C3023(1.36); C3738(1.27); C3743(1.27)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C4115(1.35); C3023(1.21); C3738(1.02); C3743(1.02)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C4115(1.20); C3023(0.85); C3738(1.08); C3743(1.21)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C4115(0.83); C3023(0.93); C3738(0.84); C3743(1.04)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C4115(1.18); C3023(0.87); C3738(1.00); C3743(1.27)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C4115(1.27); C3023(0.89); C3738(0.94); C3743(1.22)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C4115(1.04); C3023(0.96); C3738(1.07); C3743(1.09)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C4115(1.21); C3023(1.11); C3738(0.90); C3743(1.49)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C4115(1.19); C3023(0.94); C3738(1.00); C3743(1.53)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C4115(1.88); C3023(0.90); C3738(1.19); C3743(1.67)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C4115(1.19); C3023(0.86); C3738(1.15); C3743(1.37)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C4115(1.14); C3023(0.80); C3738(0.97); C3743(1.30)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C4115(1.02); C3023(0.78); C3738(0.90); C3743(1.20)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C4115(1.07); C3023(0.76); C3738(0.90); C3743(1.13)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C4115(1.58); C3023(1.04); C3738(1.12); C3743(1.58)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C4115(1.13); C3023(0.78); C3738(0.94); C3743(1.35)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C4115(1.19); C3023(0.97); C3738(0.99); C3743(1.66)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C4115(1.84); C3023(0.97); C3738(1.42); C3743(1.25)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C4115(0.81); C3023(0.70); C3738(0.87); C3743(1.23)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C4115(1.06); C3023(1.19); C3738(1.00); C3743(1.05)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C4115(1.09); C3023(1.38); C3738(1.07); C3743(1.07)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C4115(1.22); C3023(1.39); C3738(1.07); C3743(1.15)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C4115(1.38); C3023(1.35); C3738(0.94); C3743(1.08)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C4115(1.03); C3023(1.31); C3738(0.98); C3743(1.01)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C4115(1.09); C3023(1.20); C3738(0.94); C3743(1.02)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C4115(1.20); C3023(1.20); C3738(0.90); C3743(0.91)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C4115(0.99); C3023(1.18); C3738(0.79); C3743(0.94)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C4115(1.43); C3023(1.35); C3738(0.89); C3743(1.01)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C3023(0.91); C4342(0.94); C4512(1.09); C1016(1.13)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C3782(1.53); C3818(0.89)  LDD1702  [14]
 LDCM0468  Fragment33 HCT 116 C4115(1.25); C3023(1.11); C3738(1.31); C3743(1.31)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C4115(2.73); C3023(0.61); C3738(1.43); C3743(1.24)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C4512(1.10); C2411(1.08); C3023(1.06); C3826(0.85)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C4512(0.98); C2411(0.95); C3023(1.01); C3826(0.99)  LDD1497  [13]
 LDCM0024  KB05 HMCB C94(2.24)  LDD3312  [15]
 LDCM0021  THZ1 HCT 116 C3738(1.19); C3743(1.19); C4512(1.09); C3787(1.15)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein enabled homolog (ENAH) Ena/VASP family Q8N8S7
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840