Details of the Probe

General Information of Probe

Probe ID
LDPC0390
Probe Name
C149
Synonyms
Z4225967441
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 304.4
Lipid-water partition coefficient (xlogp) 2.3
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C17H28N4O
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-3-(1,2,5-trimethylpyrrolidin-3-yl)propanamide
Canonical SMILES
CC1CC(C(N1C)C)CCC(=O)NCCC2(N=N2)CCC#C
InChI
InChI=1S/C17H28N4O/c1-5-6-9-17(19-20-17)10-11-18-16(22)8-7-15-12-13(2)21(4)14(15)3/h1,13-15H,6-12H2,2-4H3,(H,18,22)
InChIKey
UZCAQCZPCWJMOT-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

74 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
5'-3' exonuclease PLD3 (PLD3) LDTP08476 7.84  LDD1830 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 7.84  LDD1830 
Acid ceramidase (ASAH1) LDTP05905 5.94  LDD1830 
Acid ceramidase (ASAH1) LDTP05905 5.94  LDD1830 
Alpha-galactosidase A (GLA) LDTP02141 12.13  LDD1830 
Alpha-galactosidase A (GLA) LDTP02141 12.13  LDD1830 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 7.89  LDD1830 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 7.89  LDD1830 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 7.94  LDD1830 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 7.94  LDD1830 
Beta-galactosidase (GLB1) LDTP02837 6.77  LDD1830 
Beta-galactosidase (GLB1) LDTP02837 6.77  LDD1830 
Beta-galactosidase-1-like protein 2 (GLB1L2) LDTP17633 5.24  LDD1830 
Beta-galactosidase-1-like protein 2 (GLB1L2) LDTP17633 5.24  LDD1830 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 9.13  LDD1830 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 9.13  LDD1830 
Bifunctional epoxide hydrolase 2 (EPHX2) LDTP03692 6.19  LDD1830 
Bifunctional epoxide hydrolase 2 (EPHX2) LDTP03692 6.19  LDD1830 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 13.64  LDD1830 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 13.64  LDD1830 
Carboxypeptidase D (CPD) LDTP01372 9.78  LDD1830 
Carboxypeptidase D (CPD) LDTP01372 9.78  LDD1830 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 6.77  LDD1830 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 6.77  LDD1830 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 6.68  LDD1830 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 6.68  LDD1830 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 20.82  LDD1830 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 20.82  LDD1830 
Epididymis-specific alpha-mannosidase (MAN2B2) LDTP13853 6.45  LDD1830 
Epididymis-specific alpha-mannosidase (MAN2B2) LDTP13853 6.45  LDD1830 
Gamma-glutamyl hydrolase (GGH) LDTP09886 6.50  LDD1830 
Gamma-glutamyl hydrolase (GGH) LDTP09886 6.50  LDD1830 
Lactadherin (MFGE8) LDTP05561 5.50  LDD1830 
Lactadherin (MFGE8) LDTP05561 5.50  LDD1830 
Legumain (LGMN) LDTP10888 10.06  LDD1830 
Legumain (LGMN) LDTP10888 10.06  LDD1830 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 16.34  LDD1830 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 16.34  LDD1830 
Lysosomal acid phosphatase (ACP2) LDTP02539 6.36  LDD1830 
Lysosomal acid phosphatase (ACP2) LDTP02539 6.36  LDD1830 
Lysosomal alpha-glucosidase (GAA) LDTP02486 7.01  LDD1830 
Lysosomal alpha-glucosidase (GAA) LDTP02486 7.01  LDD1830 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 6.87  LDD1830 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 6.87  LDD1830 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 8.51  LDD1830 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 8.51  LDD1830 
Lysosomal protective protein (CTSA) LDTP02505 7.21  LDD1830 
Lysosomal protective protein (CTSA) LDTP02505 7.21  LDD1830 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.04  LDD1830 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.04  LDD1830 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 15.45  LDD1830 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 15.45  LDD1830 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 11.55  LDD1830 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 11.55  LDD1830 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 10.63  LDD1830 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 10.63  LDD1830 
Phospholipase A2 group XV (PLA2G15) LDTP09088 7.57  LDD1830 
Phospholipase A2 group XV (PLA2G15) LDTP09088 7.57  LDD1830 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 11.24  LDD1830 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 11.24  LDD1830 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 5.86  LDD1830 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 5.86  LDD1830 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 19.16  LDD1830 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 19.16  LDD1830 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 13.18  LDD1830 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 13.18  LDD1830 
Ribonuclease T2 (RNASET2) LDTP00316 13.64  LDD1830 
Ribonuclease T2 (RNASET2) LDTP00316 13.64  LDD1830 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 6.45  LDD1830 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 6.45  LDD1830 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 8.51  LDD1830 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 8.51  LDD1830 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 17.63  LDD1830 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 17.63  LDD1830 
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⏷ Show the Full List of 74 Enzyme
42 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid-beta precursor protein (APP) LDTP02071 11.16  LDD1830 
Amyloid-beta precursor protein (APP) LDTP02071 11.16  LDD1830 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 10.78  LDD1830 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 10.78  LDD1830 
Desmocollin-2 (DSC2) LDTP05356 6.02  LDD1830 
Desmocollin-2 (DSC2) LDTP05356 6.02  LDD1830 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 5.10  LDD1830 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 5.10  LDD1830 
Integral membrane protein 2C (ITM2C) LDTP12451 6.02  LDD1830 
Integral membrane protein 2C (ITM2C) LDTP12451 6.02  LDD1830 
Low-density lipoprotein receptor (LDLR) LDTP01829 16.00  LDD1830 
Low-density lipoprotein receptor (LDLR) LDTP01829 16.00  LDD1830 
Lysosome membrane protein 2 (SCARB2) LDTP06034 8.94  LDD1830 
Lysosome membrane protein 2 (SCARB2) LDTP06034 8.94  LDD1830 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 5.54  LDD1830 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 5.54  LDD1830 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 7.67  LDD1830 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 7.67  LDD1830 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 6.92  LDD1830 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 6.92  LDD1830 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 5.58  LDD1830 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 5.58  LDD1830 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 13.36  LDD1830 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 13.36  LDD1830 
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDTP05538 8.34  LDD1830 
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDTP05538 8.34  LDD1830 
Prosaposin (PSAP) LDTP02215 10.06  LDD1830 
Prosaposin (PSAP) LDTP02215 10.06  LDD1830 
Protein tweety homolog 3 (TTYH3) LDTP11615 9.06  LDD1830 
Protein tweety homolog 3 (TTYH3) LDTP11615 9.06  LDD1830 
Slit homolog 2 protein (SLIT2) LDTP01427 5.46  LDD1830 
Slit homolog 2 protein (SLIT2) LDTP01427 5.46  LDD1830 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 10.48  LDD1830 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 10.48  LDD1830 
Sortilin (SORT1) LDTP10885 8.82  LDD1830 
Sortilin (SORT1) LDTP10885 8.82  LDD1830 
Tetraspanin-3 (TSPAN3) LDTP16813 5.13  LDD1830 
Tetraspanin-3 (TSPAN3) LDTP16813 5.13  LDD1830 
Transferrin receptor protein 1 (TFRC) LDTP01969 10.34  LDD1830 
Transferrin receptor protein 1 (TFRC) LDTP01969 10.34  LDD1830 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 5.13  LDD1830 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 5.13  LDD1830 
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⏷ Show the Full List of 42 Transporter and channel
2 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adhesion G protein-coupled receptor E5 (ADGRE5) LDTP04221 6.96  LDD1830 
Adhesion G protein-coupled receptor E5 (ADGRE5) LDTP04221 6.96  LDD1830 
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4 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 21.11  LDD1830 
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 21.11  LDD1830 
Neogenin (NEO1) LDTP09907 12.21  LDD1830 
Neogenin (NEO1) LDTP09907 12.21  LDD1830 
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44 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 16.22  LDD1830 
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 16.22  LDD1830 
C-type mannose receptor 2 (MRC2) LDTP13114 9.85  LDD1830 
C-type mannose receptor 2 (MRC2) LDTP13114 9.85  LDD1830 
CD109 antigen (CD109) LDTP07760 6.32  LDD1830 
CD109 antigen (CD109) LDTP07760 6.32  LDD1830 
CD320 antigen (CD320) LDTP12352 9.92  LDD1830 
CD320 antigen (CD320) LDTP12352 9.92  LDD1830 
Collectin-12 (COLEC12) LDTP07031 11.55  LDD1830 
Collectin-12 (COLEC12) LDTP07031 11.55  LDD1830 
Desmocollin-3 (DSC3) LDTP06154 7.06  LDD1830 
Desmocollin-3 (DSC3) LDTP06154 7.06  LDD1830 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 8.69  LDD1830 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 8.69  LDD1830 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 8.51  LDD1830 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 8.51  LDD1830 
Ferritin light chain (FTL) LDTP01973 5.24  LDD1830 
Ferritin light chain (FTL) LDTP01973 5.24  LDD1830 
Galanin peptides (GAL) LDTP03175 8.34  LDD1830 
Galanin peptides (GAL) LDTP03175 8.34  LDD1830 
Galectin-3-binding protein (LGALS3BP) LDTP05558 7.94  LDD1830 
Galectin-3-binding protein (LGALS3BP) LDTP05558 7.94  LDD1830 
Ganglioside GM2 activator (GM2A) LDTP02927 6.68  LDD1830 
Ganglioside GM2 activator (GM2A) LDTP02927 6.68  LDD1830 
Golgi apparatus protein 1 (GLG1) LDTP09920 5.17  LDD1830 
Golgi apparatus protein 1 (GLG1) LDTP09920 5.17  LDD1830 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 6.41  LDD1830 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 6.41  LDD1830 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 6.77  LDD1830 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 6.77  LDD1830 
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) LDTP10023 5.35  LDD1830 
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) LDTP10023 5.35  LDD1830 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 7.78  LDD1830 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 7.78  LDD1830 
Nicastrin (NCSTN) LDTP09787 5.74  LDD1830 
Nicastrin (NCSTN) LDTP09787 5.74  LDD1830 
Protocadherin Fat 1 (FAT1) LDTP06134 7.41  LDD1830 
Protocadherin Fat 1 (FAT1) LDTP06134 7.41  LDD1830 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 19.97  LDD1830 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 19.97  LDD1830 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 16.00  LDD1830 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 16.00  LDD1830 
Trophoblast glycoprotein (TPBG) LDTP05960 5.31  LDD1830 
Trophoblast glycoprotein (TPBG) LDTP05960 5.31  LDD1830 
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⏷ Show the Full List of 44 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1830 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587