Details of the Probe

General Information of Probe

Probe ID
LDPC0390
Probe Name
C149
Synonyms
Z4225967441
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 304.4
Lipid-water partition coefficient (xlogp) 2.3
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C17H28N4O
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-3-(1,2,5-trimethylpyrrolidin-3-yl)propanamide
Canonical SMILES
CC1CC(C(N1C)C)CCC(=O)NCCC2(N=N2)CCC#C
InChI
InChI=1S/C17H28N4O/c1-5-6-9-17(19-20-17)10-11-18-16(22)8-7-15-12-13(2)21(4)14(15)3/h1,13-15H,6-12H2,2-4H3,(H,18,22)
InChIKey
UZCAQCZPCWJMOT-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

37 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
5'-3' exonuclease PLD3 (PLD3) LDTP08476 7.84  LDD1830 
Acid ceramidase (ASAH1) LDTP05905 5.94  LDD1830 
Alpha-galactosidase A (GLA) LDTP02141 12.13  LDD1830 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 7.89  LDD1830 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 7.94  LDD1830 
Beta-galactosidase (GLB1) LDTP02837 6.77  LDD1830 
Beta-galactosidase-1-like protein 2 (GLB1L2) LDTP17633 5.24  LDD1830 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 9.13  LDD1830 
Bifunctional epoxide hydrolase 2 (EPHX2) LDTP03692 6.19  LDD1830 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 13.64  LDD1830 
Carboxypeptidase D (CPD) LDTP01372 9.78  LDD1830 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 6.77  LDD1830 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 6.68  LDD1830 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 20.82  LDD1830 
Epididymis-specific alpha-mannosidase (MAN2B2) LDTP13853 6.45  LDD1830 
Gamma-glutamyl hydrolase (GGH) LDTP09886 6.50  LDD1830 
Lactadherin (MFGE8) LDTP05561 5.50  LDD1830 
Legumain (LGMN) LDTP10888 10.06  LDD1830 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 16.34  LDD1830 
Lysosomal acid phosphatase (ACP2) LDTP02539 6.36  LDD1830 
Lysosomal alpha-glucosidase (GAA) LDTP02486 7.01  LDD1830 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 6.87  LDD1830 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 8.51  LDD1830 
Lysosomal protective protein (CTSA) LDTP02505 7.21  LDD1830 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.04  LDD1830 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 15.45  LDD1830 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 11.55  LDD1830 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 10.63  LDD1830 
Phospholipase A2 group XV (PLA2G15) LDTP09088 7.57  LDD1830 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 11.24  LDD1830 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 5.86  LDD1830 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 19.16  LDD1830 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 13.18  LDD1830 
Ribonuclease T2 (RNASET2) LDTP00316 13.64  LDD1830 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 6.45  LDD1830 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 8.51  LDD1830 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 17.63  LDD1830 
------------------------------------------------------------------------------------
⏷ Show the Full List of 37 Enzyme
21 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid-beta precursor protein (APP) LDTP02071 11.16  LDD1830 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 10.78  LDD1830 
Desmocollin-2 (DSC2) LDTP05356 6.02  LDD1830 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 5.10  LDD1830 
Integral membrane protein 2C (ITM2C) LDTP12451 6.02  LDD1830 
Low-density lipoprotein receptor (LDLR) LDTP01829 16.00  LDD1830 
Lysosome membrane protein 2 (SCARB2) LDTP06034 8.94  LDD1830 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 5.54  LDD1830 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 7.67  LDD1830 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 6.92  LDD1830 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 5.58  LDD1830 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 13.36  LDD1830 
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDTP05538 8.34  LDD1830 
Prosaposin (PSAP) LDTP02215 10.06  LDD1830 
Protein tweety homolog 3 (TTYH3) LDTP11615 9.06  LDD1830 
Slit homolog 2 protein (SLIT2) LDTP01427 5.46  LDD1830 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 10.48  LDD1830 
Sortilin (SORT1) LDTP10885 8.82  LDD1830 
Tetraspanin-3 (TSPAN3) LDTP16813 5.13  LDD1830 
Transferrin receptor protein 1 (TFRC) LDTP01969 10.34  LDD1830 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 5.13  LDD1830 
------------------------------------------------------------------------------------
⏷ Show the Full List of 21 Transporter and channel
1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adhesion G protein-coupled receptor E5 (ADGRE5) LDTP04221 6.96  LDD1830 
------------------------------------------------------------------------------------
2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 21.11  LDD1830 
Neogenin (NEO1) LDTP09907 12.21  LDD1830 
------------------------------------------------------------------------------------
22 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 16.22  LDD1830 
C-type mannose receptor 2 (MRC2) LDTP13114 9.85  LDD1830 
CD109 antigen (CD109) LDTP07760 6.32  LDD1830 
CD320 antigen (CD320) LDTP12352 9.92  LDD1830 
Collectin-12 (COLEC12) LDTP07031 11.55  LDD1830 
Desmocollin-3 (DSC3) LDTP06154 7.06  LDD1830 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 8.69  LDD1830 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 8.51  LDD1830 
Ferritin light chain (FTL) LDTP01973 5.24  LDD1830 
Galanin peptides (GAL) LDTP03175 8.34  LDD1830 
Galectin-3-binding protein (LGALS3BP) LDTP05558 7.94  LDD1830 
Ganglioside GM2 activator (GM2A) LDTP02927 6.68  LDD1830 
Golgi apparatus protein 1 (GLG1) LDTP09920 5.17  LDD1830 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 6.41  LDD1830 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 6.77  LDD1830 
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) LDTP10023 5.35  LDD1830 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 7.78  LDD1830 
Nicastrin (NCSTN) LDTP09787 5.74  LDD1830 
Protocadherin Fat 1 (FAT1) LDTP06134 7.41  LDD1830 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 19.97  LDD1830 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 16.00  LDD1830 
Trophoblast glycoprotein (TPBG) LDTP05960 5.31  LDD1830 
------------------------------------------------------------------------------------
⏷ Show the Full List of 22 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1830 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587