Details of the Target

General Information of Target

Target ID LDTP04634
Target Name Alpha-N-acetylglucosaminidase (NAGLU)
Gene Name NAGLU
Gene ID 4669
Synonyms
UFHSD1; Alpha-N-acetylglucosaminidase; EC 3.2.1.50; N-acetyl-alpha-glucosaminidase; NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKP
GLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGE
LTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYL
ALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTP
VLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELI
KEFGTDHIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQF
WGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGAL
EAVNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAA
RRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAW
RLLLTSAPSLATSPAFRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAY
ELLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYAN
KQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPR
GDTVDLAKKIFLKYYPRWVAGSW
Target Type
Successful
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 89 family
Subcellular location
Lysosome
Function Involved in the degradation of heparan sulfate.
TTD ID
T53103
Uniprot ID
P54802
DrugMap ID
TTDM6HZ
Ensemble ID
ENST00000225927.7
HGNC ID
HGNC:7632

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K728(2.13)  LDD0277  [1]
Probe 1
 Probe Info  		Y638(23.26)  LDD3495  [2]
FBPP2
 Probe Info  		2.07  LDD0054  [3]
DBIA
 Probe Info  		C97(0.93); C99(0.93)  LDD0078  [4]
PAL-AfBPP Probe
Click To Hide/Show 110 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		6.96  LDD1711  [5]
C004
 Probe Info  		9.45  LDD1714  [5]
C022
 Probe Info  		14.32  LDD1728  [5]
C027
 Probe Info  		7.21  LDD1733  [5]
C041
 Probe Info  		6.87  LDD1741  [5]
C045
 Probe Info  		8.46  LDD1744  [5]
C063
 Probe Info  		22.94  LDD1760  [5]
C070
 Probe Info  		16.80  LDD1766  [5]
C071
 Probe Info  		8.28  LDD1767  [5]
C087
 Probe Info  		10.56  LDD1779  [5]
C106
 Probe Info  		28.05  LDD1793  [5]
C107
 Probe Info  		7.41  LDD1794  [5]
C108
 Probe Info  		11.79  LDD1795  [5]
C112
 Probe Info  		29.65  LDD1799  [5]
C115
 Probe Info  		5.74  LDD1802  [5]
C130
 Probe Info  		7.01  LDD1812  [5]
C134
 Probe Info  		27.10  LDD1816  [5]
C135
 Probe Info  		9.78  LDD1817  [5]
C139
 Probe Info  		11.00  LDD1821  [5]
C140
 Probe Info  		11.71  LDD1822  [5]
C141
 Probe Info  		9.32  LDD1823  [5]
C143
 Probe Info  		12.73  LDD1825  [5]
C149
 Probe Info  		7.89  LDD1830  [5]
C153
 Probe Info  		17.27  LDD1834  [5]
C159
 Probe Info  		10.63  LDD1839  [5]
C160
 Probe Info  		9.32  LDD1840  [5]
C161
 Probe Info  		16.91  LDD1841  [5]
C163
 Probe Info  		7.11  LDD1843  [5]
C169
 Probe Info  		20.68  LDD1849  [5]
C170
 Probe Info  		32.67  LDD1850  [5]
C171
 Probe Info  		8.57  LDD1851  [5]
C177
 Probe Info  		8.88  LDD1856  [5]
C178
 Probe Info  		20.11  LDD1857  [5]
C186
 Probe Info  		17.03  LDD1864  [5]
C194
 Probe Info  		12.55  LDD1870  [5]
C197
 Probe Info  		9.78  LDD1873  [5]
C198
 Probe Info  		18.13  LDD1874  [5]
C201
 Probe Info  		43.41  LDD1877  [5]
C206
 Probe Info  		16.22  LDD1881  [5]
C208
 Probe Info  		11.39  LDD1883  [5]
C211
 Probe Info  		11.63  LDD1885  [5]
C213
 Probe Info  		17.39  LDD1887  [5]
C219
 Probe Info  		5.78  LDD1893  [5]
C220
 Probe Info  		16.80  LDD1894  [5]
C221
 Probe Info  		8.34  LDD1895  [5]
C223
 Probe Info  		9.32  LDD1897  [5]
C225
 Probe Info  		5.78  LDD1898  [5]
C229
 Probe Info  		15.56  LDD1902  [5]
C231
 Probe Info  		17.75  LDD1904  [5]
C232
 Probe Info  		76.64  LDD1905  [5]
C233
 Probe Info  		16.00  LDD1906  [5]
C235
 Probe Info  		19.29  LDD1908  [5]
C237
 Probe Info  		5.78  LDD1910  [5]
C249
 Probe Info  		15.89  LDD1922  [5]
C264
 Probe Info  		20.39  LDD1935  [5]
C265
 Probe Info  		14.42  LDD1936  [5]
C270
 Probe Info  		6.50  LDD1940  [5]
C277
 Probe Info  		7.78  LDD1947  [5]
C280
 Probe Info  		9.25  LDD1950  [5]
C281
 Probe Info  		7.01  LDD1951  [5]
C284
 Probe Info  		26.17  LDD1954  [5]
C287
 Probe Info  		10.27  LDD1957  [5]
C288
 Probe Info  		7.11  LDD1958  [5]
C293
 Probe Info  		16.00  LDD1963  [5]
C296
 Probe Info  		17.39  LDD1966  [5]
C302
 Probe Info  		8.06  LDD1971  [5]
C305
 Probe Info  		19.03  LDD1974  [5]
C310
 Probe Info  		15.03  LDD1977  [5]
C313
 Probe Info  		13.83  LDD1980  [5]
C314
 Probe Info  		26.91  LDD1981  [5]
C326
 Probe Info  		17.51  LDD1990  [5]
C343
 Probe Info  		12.47  LDD2005  [5]
C346
 Probe Info  		18.25  LDD2007  [5]
C348
 Probe Info  		22.16  LDD2009  [5]
C349
 Probe Info  		16.80  LDD2010  [5]
C350
 Probe Info  		58.89  LDD2011  [5]
C353
 Probe Info  		9.65  LDD2014  [5]
C354
 Probe Info  		10.06  LDD2015  [5]
C355
 Probe Info  		38.85  LDD2016  [5]
C356
 Probe Info  		11.08  LDD2017  [5]
C357
 Probe Info  		5.28  LDD2018  [5]
C362
 Probe Info  		49.52  LDD2023  [5]
C363
 Probe Info  		33.59  LDD2024  [5]
C364
 Probe Info  		27.67  LDD2025  [5]
C376
 Probe Info  		8.00  LDD2036  [5]
C378
 Probe Info  		6.59  LDD2037  [5]
C383
 Probe Info  		12.13  LDD2042  [5]
C386
 Probe Info  		6.54  LDD2045  [5]
C390
 Probe Info  		48.84  LDD2049  [5]
C399
 Probe Info  		9.65  LDD2058  [5]
C403
 Probe Info  		17.75  LDD2061  [5]
C413
 Probe Info  		18.51  LDD2069  [5]
C419
 Probe Info  		16.22  LDD2074  [5]
C420
 Probe Info  		23.10  LDD2075  [5]
C425
 Probe Info  		20.68  LDD2080  [5]
C426
 Probe Info  		13.18  LDD2081  [5]
C429
 Probe Info  		12.55  LDD2084  [5]
C431
 Probe Info  		19.43  LDD2086  [5]
C433
 Probe Info  		6.92  LDD2088  [5]
FFF probe11
 Probe Info  		20.00  LDD0471  [6]
FFF probe12
 Probe Info  		20.00  LDD0473  [6]
FFF probe13
 Probe Info  		20.00  LDD0475  [6]
FFF probe14
 Probe Info  		20.00  LDD0477  [6]
FFF probe15
 Probe Info  		16.18  LDD0478  [6]
FFF probe3
 Probe Info  		20.00  LDD0464  [6]
FFF probe6
 Probe Info  		7.10  LDD0467  [6]
FFF probe9
 Probe Info  		20.00  LDD0470  [6]
JN0003
 Probe Info  		20.00  LDD0469  [6]
LD-F
 Probe Info  		E601(0.00); A605(0.00)  LDD0015  [7]
OEA-DA
 Probe Info  		20.00  LDD0046  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C97(0.93); C99(0.93)  LDD0078  [4]
 LDCM0185  Compound 17 HEK-293T 6.27  LDD0512  [6]
 LDCM0191  Compound 21 HEK-293T 11.56  LDD0508  [6]
 LDCM0190  Compound 34 HEK-293T 9.30  LDD0510  [6]
 LDCM0192  Compound 35 HEK-293T 9.09  LDD0509  [6]
 LDCM0193  Compound 36 HEK-293T 9.52  LDD0511  [6]
 LDCM0008  Tranylcypromine SH-SY5Y 2.07  LDD0054  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-acetyl-d-glucosamine Small molecular drug D05ZYM
N-acetylglucosamine Small molecular drug DB00141
Human Calcitonin . DB06773
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abo-101 Gene therapy DG1CX7

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
8 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570