Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name JN0003  Probe Info 
Probe concentration 200 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 17  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 15.7
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 13.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 12.1
 LDTP06142  Squalene monooxygenase (SQLE) 10.3
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 10.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 9.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 8.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 7.9
 LDTP04963  26S proteasome regulatory subunit 8 (PSMC5) 7.0
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 6.8
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 6.6
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 6.5
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 6.3
 LDTP06849  Prolyl endopeptidase-like (PREPL) 6.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 6.3
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 6.2
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 5.9
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 5.8
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 5.8
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 5.8
 LDTP02942  ADP-ribosylation factor 4 (ARF4) 5.6
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 5.5
 LDTP06638  Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) 5.3
 LDTP02743  Insulin-degrading enzyme (IDE) 5.2
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 5.0
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 4.8
 LDTP13787  RuvB-like 2 (RUVBL2) 4.8
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 4.7
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 4.6
 LDTP05192  ADP-ribosylation factor 1 (ARF1) 4.5
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 4.4
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 4.3
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 4.3
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 4.2
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 4.1
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 3.9
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) 3.9
 LDTP03682  DNA replication licensing factor MCM7 (MCM7) 3.8
 LDTP02569  Glucose-6-phosphate 1-dehydrogenase (G6PD) 3.7
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 3.7
 LDTP02223  Cathepsin B (CTSB) 3.5
 LDTP12610  Obg-like ATPase 1 (OLA1) 3.3
 LDTP12163  Calcyclin-binding protein (CACYBP) 3.1
Transporter and channel
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 12.1
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 10.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.3
 LDTP03405  Calnexin (CANX) 7.2
 LDTP11250  MICOS complex subunit MIC26 (APOO) 7.2
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.8
 LDTP00310  Syntenin-1 (SDCBP) 6.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 6.6
 LDTP01366  Flotillin-1 (FLOT1) 6.3
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 6.1
 LDTP14133  Transportin-3 (TNPO3) 6.1
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 6.0
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) 5.4
 LDTP04501  Importin subunit alpha-1 (KPNA2) 5.3
 LDTP09949  Transportin-1 (TNPO1) 4.1
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 4.1
 LDTP01574  Importin-7 (IPO7) 3.2
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 3.2
Other
Click to Show/Hide to Show 28 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) 11.8
 LDTP01522  Reticulon-3 (RTN3) 11.3
 LDTP12412  Reticulon-4 (RTN4) 9.8
 LDTP08224  Protein LYRIC (MTDH) 9.5
 LDTP16006  Optic atrophy 3 protein (OPA3) 9.3
 LDTP13908  AP-3 complex subunit mu-1 (AP3M1) 8.9
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 8.1
 LDTP04092  Crk-like protein (CRKL) 8.0
 LDTP10749  Exportin-6 (XPO6) 6.0
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 5.8
 LDTP13086  Syntaxin-18 (STX18) 5.8
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 5.4
 LDTP05922  Dynactin subunit 2 (DCTN2) 5.3
 LDTP08594  Negative elongation factor C/D (NELFCD) 5.1
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 4.4
 LDTP01259  Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) 4.4
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 4.4
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 4.1
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 4.1
 LDTP06181  Structural maintenance of chromosomes protein 1A (SMC1A) 4.1
 LDTP05375  Nucleobindin-1 (NUCB1) 4.0
 LDTP05160  Nucleobindin-2 (NUCB2) 3.8
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 3.7
 LDTP05277  Protein SET (SET) 3.7
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 3.5
 LDTP04917  Proteasome activator complex subunit 3 (PSME3) 3.2
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 3.2
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) 3.1

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.