Details of the Target

General Information of Target

Target ID LDTP02942
Target Name ADP-ribosylation factor 4 (ARF4)
Gene Name ARF4
Gene ID 378
Synonyms
ARF2; ADP-ribosylation factor 4
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN
ICFTVWDVGGQDRIRPLWKHYFQNTQGLIFVVDSNDRERIQEVADELQKMLLVDELRDAV
LLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Arf family
Subcellular location
Golgi apparatus
Function
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation.
Uniprot ID
P18085
Ensemble ID
ENST00000303436.11
HGNC ID
HGNC:655

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CHEMBL5175495
 Probe Info  		5.96  LDD0196  [2]
CY-1
 Probe Info  		8.13  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		10.55  LDD0242  [3]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [4]
STPyne
 Probe Info  		K127(8.15); K109(20.00); K142(20.00)  LDD2217  [5]
AZ-9
 Probe Info  		D26(1.02)  LDD2208  [6]
Probe 1
 Probe Info  		Y35(149.30); Y58(50.43)  LDD3495  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
HHS-482
 Probe Info  		Y35(0.86); Y58(1.10)  LDD0285  [10]
HHS-475
 Probe Info  		Y81(0.49); Y35(0.80); Y167(0.96); Y58(0.97)  LDD0264  [11]
HHS-465
 Probe Info  		Y35(7.78); Y58(7.97); Y81(6.70)  LDD2237  [12]
DBIA
 Probe Info  		C62(1.10)  LDD0078  [13]
5E-2FA
 Probe Info  		N.A.  LDD2235  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C62(0.00); C159(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C62(0.00); C159(0.00)  LDD0036  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C62(0.00); C159(0.00)  LDD0037  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		C62(0.00); 0.00  LDD2226  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
IPM
 Probe Info  		N.A.  LDD0005  [19]
NHS
 Probe Info  		N.A.  LDD0010  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
TER-AC
 Probe Info  		N.A.  LDD0426  [22]
TPP-AC
 Probe Info  		N.A.  LDD0427  [22]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C186
 Probe Info  		9.85  LDD1864  [23]
C220
 Probe Info  		15.45  LDD1894  [23]
C228
 Probe Info  		22.01  LDD1901  [23]
C265
 Probe Info  		20.11  LDD1936  [23]
FFF probe11
 Probe Info  		6.66  LDD0471  [24]
FFF probe12
 Probe Info  		5.33  LDD0473  [24]
FFF probe13
 Probe Info  		12.60  LDD0475  [24]
FFF probe2
 Probe Info  		7.93  LDD0463  [24]
FFF probe3
 Probe Info  		5.78  LDD0465  [24]
JN0003
 Probe Info  		20.00  LDD0469  [24]
STS-2
 Probe Info  		N.A.  LDD0138  [25]
Staurosporine capture compound
 Probe Info  		2.25  LDD0083  [26]
OEA-DA
 Probe Info  		4.23  LDD0046  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C62(0.82)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C62(1.04)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C62(1.30)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C62(1.14)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C62(1.06)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C62(1.69)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C62(1.15)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C62(1.26)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C62(1.74)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C62(1.15)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C62(1.28)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C62(1.24)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C62(1.20)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C62(1.26)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C62(1.22)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C62(1.16)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C159(0.91); C62(0.95)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C159(0.72); C62(0.96)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C159(0.54); C62(1.06)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C159(0.49); C62(0.99)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C159(0.70); C62(1.05)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C159(0.55); C62(0.98)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C159(0.63); C62(1.07)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C62(1.01)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C159(0.63); C62(0.96)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C159(0.57); C62(0.97)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C159(0.47); C62(1.01)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C159(0.56); C62(0.97)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C159(0.91); C62(0.92)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C159(0.58); C62(0.92)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C159(0.57); C62(0.92)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C159(0.57); C62(0.92)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C159(0.78); C62(1.38)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C159(1.46); C62(1.20)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C159(0.92); C62(1.46)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C159(1.21); C62(1.14)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C159(1.04); C62(1.46)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C159(0.77); C62(1.31)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C159(0.82); C62(1.59)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C159(0.74); C62(1.57)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C159(0.84); C62(1.48)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C159(0.82); C62(1.49)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C159(0.80); C62(1.82)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C159(0.82); C62(1.73)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C62(0.89)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C159(0.82); C62(1.79)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C159(0.81); C62(1.90)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C159(0.82); C62(1.47)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C62(0.98)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C62(1.29)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C62(1.77)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C62(1.15)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C62(1.79)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C62(2.03)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C62(1.99)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C62(1.09)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C62(1.16)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C62(1.01)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C62(1.52)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C62(3.07)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C62(1.28)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C62(1.05)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C62(0.78)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C62(1.12)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C62(1.15)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C62(1.39)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C62(1.29)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C62(1.10)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C62(1.21)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C62(1.49)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C62(1.18)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C62(1.07)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C62(1.25)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C62(0.99)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C62(1.33)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C62(1.12)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C62(1.21)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C62(1.49)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C62(0.99)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C62(1.39)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C62(1.24)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C62(1.46)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C62(1.11)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C62(1.19)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C62(0.77)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C62(0.58)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C62(0.59)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C62(0.72)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C62(0.60)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C62(0.86)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C62(0.59)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C62(0.80)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C62(0.87)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C62(0.88)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C62(0.70)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C62(0.59)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C62(1.26)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C62(1.41)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C62(1.09)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C62(2.29)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C62(0.88)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C62(1.98)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C62(0.91)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C62(1.02)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C62(1.63)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C62(1.49)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C62(1.79)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C62(2.45)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C62(1.63)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C62(1.72)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C62(1.59)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C62(1.15)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C62(1.76)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C62(1.82)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C62(1.96)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C62(1.63)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C62(1.95)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C62(2.06)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C62(1.81)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C62(2.47)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C62(0.91)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C62(0.91)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C62(1.04)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C62(1.13)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C62(0.79)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C62(1.06)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C62(1.15)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C62(0.93)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C62(1.05)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C62(0.91)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C62(1.06)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C62(1.00)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C62(1.05)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C62(1.13)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C62(0.95)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C62(0.91)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C62(1.00)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C62(2.32)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C62(2.40)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C62(1.34)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C62(1.43)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C62(1.18)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C62(1.50)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C62(1.63)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C62(1.49)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C62(2.69)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C62(1.87)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C62(1.32)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C62(1.30)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C62(1.39)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C62(1.55)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C62(1.79)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C62(2.27)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C62(1.06)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C62(1.07)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C62(1.17)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C62(1.17)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 11.87  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C62(1.10)  LDD0078  [13]
 LDCM0630  CCW28-3 231MFP C62(1.36); C159(1.28)  LDD2214  [28]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [20]
 LDCM0367  CL1 HCT 116 C62(1.15); C159(1.24)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C159(0.65); C62(1.31)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C62(0.93)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C62(1.04)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C62(0.85)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C62(0.91)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C62(0.98)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C62(1.09)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C62(1.65)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C62(1.49)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C62(1.41)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C62(1.32)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C62(1.02); C159(1.13)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C62(1.52)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C62(1.35)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C62(1.02)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C62(1.37)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C62(1.29)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C62(1.18)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C62(1.12)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C62(0.56)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C62(0.90)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C62(0.78)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C159(0.93); C62(1.13)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C62(0.73)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C62(1.09)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C62(1.25)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C62(1.28)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C62(1.74)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C62(1.48)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C62(1.56)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C62(1.20)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C62(1.79)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C159(1.03); C62(1.10)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C159(1.14); C62(1.34)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C159(0.71); C62(0.97)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C62(1.02)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C62(1.14)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C62(1.09)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C62(1.04)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C159(0.91); C62(1.15)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C62(1.92)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C62(2.04)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C62(2.24)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C62(1.12)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C62(1.70)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C62(1.52)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C62(1.04)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C62(1.28)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C62(1.35)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C62(1.39)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C159(1.08); C62(1.08)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C62(1.20)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C159(0.47); C62(1.67)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C159(0.38); C62(1.43)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C159(0.29); C62(1.76)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C159(0.34); C62(1.48)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C159(0.44); C62(1.93)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C159(0.61); C62(1.61)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C159(0.44); C62(1.73)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C159(0.47); C62(2.15)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C159(0.98); C62(1.00)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C159(0.52); C62(2.18)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C159(0.56); C62(1.25)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C159(0.44); C62(3.02)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C159(0.58); C62(1.65)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C159(0.71); C62(1.58)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C159(0.30); C62(2.49)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C62(1.01)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C62(1.03)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C62(0.94)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C62(1.15)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C159(0.95); C62(0.97)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C62(0.97)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C62(1.21)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C62(1.25)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C62(1.03)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C62(1.17)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C62(1.21)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C62(1.08)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C62(1.23)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C62(1.07)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C62(0.98)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C159(0.86); C62(1.19)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C62(0.93)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C62(1.25)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C62(1.09)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C62(1.16)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C62(1.12)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C62(1.14)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C62(1.57)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C62(1.13)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C62(1.27)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C62(1.44)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C159(0.86); C62(1.09)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C62(1.37)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C62(1.12)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C62(1.07)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C62(1.22)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C62(1.29)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C159(0.66); C62(1.56)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C159(0.92); C62(1.24)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C159(0.82); C62(1.02)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C159(0.68); C62(1.73)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C159(0.97); C62(1.04)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C159(0.70); C62(1.04)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C159(0.76); C62(0.99)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C159(0.66); C62(1.63)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C159(0.58); C62(1.45)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C159(0.65); C62(1.66)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C159(0.77); C62(1.17)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C159(0.95); C62(0.92)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C159(0.70); C62(1.52)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C159(0.58); C62(1.66)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C159(0.71); C62(2.29)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C159(1.08); C62(1.23)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C159(1.17); C62(0.96)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C62(1.08)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C62(0.97)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C62(0.91)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C62(0.90)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C62(0.92)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C62(0.99)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C62(1.05)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C62(1.05)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C62(0.88)  LDD0811  [13]
 LDCM0185  Compound 17 HEK-293T 5.60  LDD0512  [24]
 LDCM0634  CY-0357 Hep-G2 C62(2.97)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C62(0.88); C159(1.06)  LDD1698  [29]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0625  F8 Ramos C62(0.66)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C62(1.33)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C62(0.03)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C62(1.27)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C62(0.80)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C62(1.05)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C62(1.61)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C62(1.31)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C62(1.04)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C62(0.76)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C62(2.51)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C62(0.49)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C62(0.74)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C62(1.29)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C62(1.26)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C62(1.34)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C62(1.38)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C159(0.34); C62(1.84)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C62(0.89)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C62(0.51)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C62(1.28)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C62(3.55)  LDD2188  [30]
 LDCM0116  HHS-0101 DM93 Y81(0.49); Y35(0.80); Y167(0.96); Y58(0.97)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y81(0.65); Y35(0.80); Y58(0.84); Y167(2.41)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y35(0.78); Y58(0.89); Y81(1.31)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y35(0.84); Y58(0.90); Y81(1.04); Y167(2.03)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y35(1.11); Y167(1.30); Y81(2.44); Y58(3.05)  LDD0268  [11]
 LDCM0015  HNE MDA-MB-231 C62(1.00)  LDD0346  [30]
 LDCM0123  JWB131 DM93 Y35(0.86); Y58(1.10)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y35(0.72); Y58(1.04)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y35(1.05); Y58(0.87)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y35(3.18); Y58(3.37)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y35(2.08); Y58(2.44)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y35(1.55); Y58(1.29)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y35(1.07); Y58(0.74)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y35(1.06); Y58(1.40)  LDD0292  [10]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 HCT 116 C62(1.23)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C62(2.08)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C62(1.13)  LDD0082  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C159(1.11); C159(1.05); C62(0.85); C159(0.61)  LDD2206  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C159(0.90); C159(0.80); C62(0.78)  LDD2207  [31]
 LDCM0131  RA190 MM1.R C62(1.15)  LDD0304  [32]
 LDCM0019  Staurosporine Hep-G2 2.25  LDD0083  [26]
 LDCM0021  THZ1 HCT 116 C62(0.98)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) . Q96PM5
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-2 (SDCBP2) . Q9H190

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
5 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
27 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
28 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.