Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0015
Competitor Name
HNE
Synonyms
4-Hydroxynonenal; 4-Hydroxy-2-nonenal; 75899-68-2; 4-HNE; 4-hydroxynon-2-enal; (E)-4-hydroxynon-2-enal; trans-4-Hydroxy-2-nonenal; 4-Hydroxy-2,3-nonenal; 128946-65-6; 29343-52-0; 2-Nonenal, 4-hydroxy-, (2E)-; (E)-4-hydroxy-2-nonenal; (2E)-4-Hydroxy-2-nonenal; 4-hydroxy-2E-nonenal; HNE; 2-NONENAL, 4-HYDROXY-; (+/-)4-HYDROXYNON-2-ENAL; (2E)-4-hydroxynon-2-enal; CHEMBL454280; K1CVM13F96; DTXSID4040395; CHEBI:58968; NCGC00161254-02; CCRIS 1781; CCRIS 9028; (E)-4-Hydroxynonenal; 4HNE; CHEBI:32585; UNII-K1CVM13F96; CCRIS 6927; 4-Hydroxynonenal?; 4-hydroxy-2-trans-nonenal; HNE [MI]; SCHEMBL3920; Trans-4-hydroxynonan-2-enal; BML1-C09; GTPL6274; DTXCID2020395; HMS3648N14; EX-A5735; (.+/-.)-4-Hydroxy-2E-nonenal; Tox21_113063; AC8369; BDBM50242402; HSCI1_000340; LMFA06000051; 4-HYDROXY-2-NONENAL, TRANS-; AKOS006274954; SMP2_000061; NCGC00161254-01; DA-48643; MS-22883; PD021010; CAS-75899-68-2; HY-113466; CS-0061995; NS00122691; C21642; M01859; Q229982; SR-01000946534; J-525023; SR-01000946534-1; BRD-A15914070-001-01-5
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 156.22
Lipid-water partition coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C9H16O2
IUPAC Name
(E)-4-hydroxynon-2-enal
Canonical SMILES
CCCCCC(C=CC=O)O
InChI
InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
InChIKey
JVJFIQYAHPMBBX-FNORWQNLSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
IA-alkyne
 Probe Info  		100 uM Human breast adenocarcinoma cell lysate (MDA-MB-231) [1]

Target(s) List of this Competitor

124 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
2-hydroxyacyl-CoA lyase 2 (ILVBL) LDTP00032 0.86  LDD0346 
26S proteasome non-ATPase regulatory subunit 9 (PSMD9) LDTP00225 0.93  LDD0346 
26S proteasome regulatory subunit 10B (PSMC6) LDTP04987 1.12; 1.01; 0.95  LDD0346 
26S proteasome regulatory subunit 4 (PSMC1) LDTP04962 0.95  LDD0346 
26S proteasome regulatory subunit 6B (PSMC4) LDTP04061 1.27; 1.17  LDD0346 
26S proteasome regulatory subunit 7 (PSMC2) LDTP03797 0.99; 1.02  LDD0346 
5-methylcytosine rRNA methyltransferase NSUN4 (NSUN4) LDTP10167 0.96  LDD0346 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 1.12  LDD0346 
Acyl-CoA (8-3)-desaturase (FADS1) LDTP00968 0.95  LDD0346 
Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9) LDTP16274 1.09; 1.28  LDD0346 
ADP-ribosylation factor 4 (ARF4) LDTP02942 1.00  LDD0346 
ADP-ribosylation factor 5 (ARF5) LDTP05193 0.98  LDD0346 
ADP-ribosylation factor 6 (ARF6) LDTP04986 0.75  LDD0346 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 1.02  LDD0346 
AMP deaminase 2 (AMPD2) LDTP05289 0.91  LDD0346 
Anaphase-promoting complex subunit 7 (ANAPC7) LDTP13409 1.02  LDD0346 
Arginine--tRNA ligase, cytoplasmic (RARS1) LDTP04601 2.50; 0.96  LDD0346 
ATP-binding cassette sub-family D member 3 (ABCD3) LDTP03424 1.27  LDD0346 
ATP-dependent 6-phosphofructokinase, liver type (PFKL) LDTP02925 0.94  LDD0346 
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) LDTP02261 0.91  LDD0346 
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) LDTP05314 0.78  LDD0346 
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) LDTP04358 1.18; 1.19  LDD0346 
Caspase-8 (CASP8) LDTP06211 0.99  LDD0346 
Catechol O-methyltransferase (COMT) LDTP03145 0.94; 1.00; 1.04 ...  LDD0346 
Cullin-4A (CUL4A) LDTP05949 1.35  LDD0346 
Cullin-associated NEDD8-dissociated protein 1 (CAND1) LDTP08296 0.95  LDD0346 
Cyclin-dependent kinase inhibitor 3 (CDKN3) LDTP06603 1.06  LDD0346 
Cytochrome c oxidase subunit NDUFA4 (NDUFA4) LDTP00293 1.21  LDD0346 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 1.39  LDD0346 
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) LDTP14805 1.08  LDD0346 
Delta(24)-sterol reductase (DHCR24) LDTP06375 0.99; 0.96  LDD0346 
Deoxycytidine kinase (DCK) LDTP03400 0.90  LDD0346 
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) LDTP12539 0.94  LDD0346 
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LDTP13087 1.17  LDD0346 
Dolichyl-phosphate beta-glucosyltransferase (ALG5) LDTP14214 0.93  LDD0346 
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) LDTP04103 0.86  LDD0346 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 1.16  LDD0346 
Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) LDTP02694 1.53; 0.88  LDD0346 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 2.49  LDD0346 
Elongation factor 2 (EEF2) LDTP02672 1.55  LDD0346 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 1.67; 0.95  LDD0346 
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) LDTP09063 1.02  LDD0346 
FAST kinase domain-containing protein 4 (TBRG4) LDTP10049 1.44  LDD0346 
Fatty acid CoA ligase Acsl3 (ACSL3) LDTP01634 1.12; 0.93  LDD0346 
Fatty acid synthase (FASN) LDTP04243 1.32; 1.32  LDD0346 
Glutamate--cysteine ligase regulatory subunit (GCLM) LDTP04186 1.25; 1.25  LDD0346 
Glutaminase kidney isoform, mitochondrial (GLS) LDTP01465 0.75  LDD0346 
Glutathione S-transferase kappa 1 (GSTK1) LDTP13900 1.05  LDD0346 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 0.97  LDD0346 
Glutathione S-transferase P (GSTP1) LDTP02333 1.96  LDD0346 
Glycogen [starch] synthase, muscle (GYS1) LDTP02696 0.97  LDD0346 
GTP-binding protein SAR1a (SAR1A) LDTP12470 1.15  LDD0346 
GTP-binding protein SAR1b (SAR1B) LDTP14231 1.07; 0.98  LDD0346 
GTPase Era, mitochondrial (ERAL1) LDTP01275 1.29  LDD0346 
GTPase NRas (NRAS) LDTP01825 0.80  LDD0346 
Heme oxygenase 2 (HMOX2) LDTP03540 1.30  LDD0346 
Hexokinase-2 (HK2) LDTP04531 0.96; 0.75  LDD0346 
Integrin-linked protein kinase (ILK) LDTP05859 1.14  LDD0346 
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3A) LDTP04345 1.07  LDD0346 
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (IDH3B) LDTP00885 1.06  LDD0346 
Ketosamine-3-kinase (FN3KRP) LDTP16025 1.64  LDD0346 
L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) LDTP12105 1.03  LDD0346 
Leucine--tRNA ligase, cytoplasmic (LARS1) LDTP13056 0.88  LDD0346 
Long-chain-fatty-acid--CoA ligase 4 (ACSL4) LDTP00982 1.94  LDD0346 
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) LDTP13533 1.02  LDD0346 
Lymphokine-activated killer T-cell-originated protein kinase (PBK) LDTP10500 1.18  LDD0346 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 0.94  LDD0346 
Methionine--tRNA ligase, cytoplasmic (MARS1) LDTP04730 0.75; 0.88  LDD0346 
Microsomal glutathione S-transferase 1 (MGST1) LDTP02506 1.10  LDD0346 
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) LDTP07651 1.42  LDD0346 
N-acylneuraminate cytidylyltransferase (CMAS) LDTP09228 0.82  LDD0346 
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) LDTP01561 1.00  LDD0346 
NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) LDTP01984 1.04  LDD0346 
Ornithine aminotransferase, mitochondrial (OAT) LDTP02021 0.98  LDD0346 
Pachytene checkpoint protein 2 homolog (TRIP13) LDTP06432 0.82  LDD0346 
Peptidyl-prolyl cis-trans isomerase D (PPID) LDTP05573 1.10  LDD0346 
Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) LDTP13989 1.28  LDD0346 
Peroxiredoxin-5, mitochondrial (PRDX5) LDTP03512 0.78  LDD0346 
Phosphatidate cytidylyltransferase, mitochondrial (TAMM41) LDTP10144 1.06  LDD0346 
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) LDTP06638 1.22  LDD0346 
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (FTSJ3) LDTP08629 0.99  LDD0346 
Probable arginine--tRNA ligase, mitochondrial (RARS2) LDTP07092 0.96  LDD0346 
Probable ATP-dependent RNA helicase DDX56 (DDX56) LDTP12814 1.02  LDD0346 
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) LDTP01647 0.87  LDD0346 
Proteasome subunit alpha type-4 (PSMA4) LDTP03333 1.02  LDD0346 
Putative methyltransferase C9orf114 (SPOUT1) LDTP07101 0.93  LDD0346 
Ras-related C3 botulinum toxin substrate 2 (RAC2) LDTP02768 1.00; 0.91  LDD0346 
Ras-related protein Rab-14 (RAB14) LDTP04901 1.02; 1.97  LDD0346 
Ras-related protein Rab-21 (RAB21) LDTP13512 0.97  LDD0346 
Ras-related protein Rab-2B (RAB2B) LDTP09569 1.10  LDD0346 
Ras-related protein Rab-34 (RAB34) LDTP11535 0.81  LDD0346 
Replication factor C subunit 2 (RFC2) LDTP03726 1.33  LDD0346 
Replication factor C subunit 5 (RFC5) LDTP03910 0.84  LDD0346 
Retinol dehydrogenase 11 (RDH11) LDTP09364 0.98  LDD0346 
Rho-related GTP-binding protein RhoC (RHOC) LDTP02248 0.90  LDD0346 
Rho-related GTP-binding protein RhoF (RHOF) LDTP12178 0.78; 1.06; 1.25  LDD0346 
Rho-related GTP-binding protein RhoG (RHOG) LDTP05195 0.93; 1.13  LDD0346 
Ribonucleoside-diphosphate reductase large subunit (RRM1) LDTP03259 1.55  LDD0346 
Ribosomal oxygenase 2 (RIOX2) LDTP08451 1.01  LDD0346 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 1.31  LDD0346 
Ribosomal RNA-processing protein 8 (RRP8) LDTP00693 0.87  LDD0346 
RNA-binding protein PNO1 (PNO1) LDTP12542 1.05; 0.87  LDD0346 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 0.92  LDD0346 
Serine--tRNA ligase, cytoplasmic (SARS1) LDTP04265 0.89  LDD0346 
Serine/threonine-protein kinase OSR1 (OXSR1) LDTP01664 1.11  LDD0346 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E) LDTP06546 0.82  LDD0346 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) LDTP05841 1.27  LDD0346 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) LDTP03522 1.08; 1.09  LDD0346 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 1.01; 0.98  LDD0346 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 1.34; 0.97  LDD0346 
Squalene synthase (FDFT1) LDTP03842 0.59  LDD0346 
Sulfide:quinone oxidoreductase, mitochondrial (SQOR) LDTP14278 1.11  LDD0346 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 0.88  LDD0346 
Tubulin alpha-4A chain (TUBA4A) LDTP05075 0.94; 0.79; 0.92  LDD0346 
Tudor-interacting repair regulator protein (NUDT16L1) LDTP11111 1.00  LDD0346 
Tyrosine-protein kinase CSK (CSK) LDTP03944 1.04  LDD0346 
Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) LDTP05070 1.02  LDD0346 
UDP-glucose 6-dehydrogenase (UGDH) LDTP01033 0.87  LDD0346 
Vacuolar protein sorting-associated protein 4B (VPS4B) LDTP01186 0.88  LDD0346 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 1.19; 1.12  LDD0346 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 1.10  LDD0346 
Vesicle-fusing ATPase (NSF) LDTP04096 1.02; 1.06  LDD0346 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 1.86  LDD0346 
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) LDTP06320 0.80  LDD0346 
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⏷ Show the Full List of 124 Enzyme
46 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Acyl-CoA-binding domain-containing protein 5 (ACBD5) LDTP07152 1.21  LDD0346 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 1.25; 0.93  LDD0346 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 1.09; 1.07  LDD0346 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 1.25  LDD0346 
Aladin (AAAS) LDTP12510 1.27  LDD0346 
ATP synthase subunit gamma, mitochondrial (ATP5F1C) LDTP03810 1.28  LDD0346 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 1.05  LDD0346 
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) LDTP01301 0.98  LDD0346 
Equilibrative nucleoside transporter 1 (SLC29A1) LDTP10985 1.26  LDD0346 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 2.34; 1.12  LDD0346 
Exportin-1 (XPO1) LDTP00501 1.00; 1.28  LDD0346 
Exportin-2 (CSE1L) LDTP04662 1.20; 1.11; 1.17 ...  LDD0346 
Exportin-7 (XPO7) LDTP13335 1.04  LDD0346 
Histone deacetylase complex subunit SAP18 (SAP18) LDTP00270 1.09  LDD0346 
Importin subunit alpha-1 (KPNA2) LDTP04501 1.03  LDD0346 
Importin subunit beta-1 (KPNB1) LDTP06242 1.23; 0.85  LDD0346 
Importin-5 (IPO5) LDTP00266 0.81  LDD0346 
Importin-7 (IPO7) LDTP01574 0.96; 0.93; 0.91  LDD0346 
Importin-9 (IPO9) LDTP10663 0.89  LDD0346 
Metaxin-1 (MTX1) LDTP05900 0.99  LDD0346 
MICOS complex subunit MIC10 (MICOS10) LDTP07191 1.83  LDD0346 
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) LDTP07472 1.14  LDD0346 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 0.91  LDD0346 
Nuclear pore complex protein Nup205 (NUP205) LDTP09825 0.88  LDD0346 
Nuclear pore complex protein Nup50 (NUP50) LDTP13498 0.77  LDD0346 
Nucleoporin NUP188 (NUP188) LDTP07064 0.96  LDD0346 
Nucleoporin NUP35 (NUP35) LDTP09204 0.97; 0.90  LDD0346 
Protein cornichon homolog 1 (CNIH1) LDTP01592 1.02  LDD0346 
Protein S100-A10 (S100A10) LDTP04885 0.99  LDD0346 
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) LDTP04932 1.13  LDD0346 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 1.11  LDD0346 
Ran GTPase-activating protein 1 (RANGAP1) LDTP04082 1.19  LDD0346 
Secretory carrier-associated membrane protein 4 (SCAMP4) LDTP09987 1.38  LDD0346 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 0.78  LDD0346 
Sodium-dependent multivitamin transporter (SLC5A6) LDTP13834 1.13  LDD0346 
Solute carrier family 25 member 3 (SLC25A3) LDTP05238 1.14  LDD0346 
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) LDTP10931 1.47  LDD0346 
Surfeit locus protein 4 (SURF4) LDTP00592 1.00  LDD0346 
T-complex protein 1 subunit delta (CCT4) LDTP04391 1.06  LDD0346 
Transmembrane protein 33 (TMEM33) LDTP04787 1.10; 0.90  LDD0346 
Transportin-1 (TNPO1) LDTP09949 1.24; 1.66; 0.88  LDD0346 
Transportin-3 (TNPO3) LDTP14133 1.00  LDD0346 
Tricarboxylate transport protein, mitochondrial (SLC25A1) LDTP04553 1.05  LDD0346 
V-type proton ATPase subunit G 1 (ATP6V1G1) LDTP01185 1.06  LDD0346 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 1.95; 0.99  LDD0346 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 1.06; 1.02  LDD0346 
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⏷ Show the Full List of 46 Transporter and channel
5 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
CDKN2A-interacting protein (CDKN2AIP) LDTP12792 1.13  LDD0346 
Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1) LDTP11746 0.90  LDD0346 
eIF5-mimic protein 2 (BZW1) LDTP07940 0.96  LDD0346 
GA-binding protein alpha chain (GABPA) LDTP05494 1.09  LDD0346 
SWI/SNF complex subunit SMARCC2 (SMARCC2) LDTP09311 0.99  LDD0346 
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86 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
A-kinase anchor protein 8-like (AKAP8L) LDTP13591 1.03  LDD0346 
Actin nucleation-promoting factor WASL (WASL) LDTP00263 0.86  LDD0346 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) LDTP05770 0.92  LDD0346 
Ataxin-10 (ATXN10) LDTP13091 1.40  LDD0346 
Ataxin-7-like protein 3B (ATXN7L3B) LDTP15730 0.74  LDD0346 
CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) LDTP10454 0.95  LDD0346 
Centromere/kinetochore protein zw10 homolog (ZW10) LDTP00720 1.34  LDD0346 
Cleavage stimulation factor subunit 2 (CSTF2) LDTP03665 0.99  LDD0346 
Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) LDTP12883 0.89  LDD0346 
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 1.33  LDD0346 
Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) LDTP14179 1.11  LDD0346 
Cytosolic iron-sulfur assembly component 2B (CIAO2B) LDTP13979 0.92  LDD0346 
DNA polymerase delta subunit 3 (POLD3) LDTP06300 1.03  LDD0346 
Dynactin subunit 4 (DCTN4) LDTP13402 0.99  LDD0346 
Dynein light chain 1, cytoplasmic (DYNLL1) LDTP05049 1.13  LDD0346 
Eukaryotic translation initiation factor 3 subunit K (EIF3K) LDTP13143 1.09; 1.19  LDD0346 
Eukaryotic translation initiation factor 3 subunit M (EIF3M) LDTP07947 0.94; 0.99  LDD0346 
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) LDTP05421 0.81; 1.07  LDD0346 
G patch domain-containing protein 4 (GPATCH4) LDTP17229 0.99  LDD0346 
Growth factor receptor-bound protein 2 (GRB2) LDTP05035 1.09  LDD0346 
Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) LDTP02059 0.98  LDD0346 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 0.95; 1.11  LDD0346 
Hsp70-binding protein 1 (HSPBP1) LDTP12914 0.93  LDD0346 
KH domain-containing RNA-binding protein QKI (QKI) LDTP10700 1.09  LDD0346 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 1.12; 0.81  LDD0346 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 0.96  LDD0346 
Large ribosomal subunit protein eL24 (RPL24) LDTP05186 1.03  LDD0346 
Large ribosomal subunit protein uL11m (MRPL11) LDTP13971 0.88  LDD0346 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 1.04; 1.06  LDD0346 
Large ribosomal subunit protein uL15 (RPL27A) LDTP04105 1.24  LDD0346 
Large ribosomal subunit protein uL16 (RPL10) LDTP03395 0.95; 1.00; 1.52  LDD0346 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 0.93; 1.12  LDD0346 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 1.17; 0.91  LDD0346 
Large ribosomal subunit protein uL5 (RPL11) LDTP05026 1.01  LDD0346 
Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) LDTP03997 1.00; 1.15; 1.07  LDD0346 
Melanoma-associated antigen B2 (MAGEB2) LDTP00648 1.22  LDD0346 
Myb-binding protein 1A (MYBBP1A) LDTP11079 1.08; 0.87; 1.53  LDD0346 
Nucleolar complex protein 2 homolog (NOC2L) LDTP14011 1.01  LDD0346 
Nucleolar protein 56 (NOP56) LDTP00313 1.08; 1.20  LDD0346 
Nucleolar protein 58 (NOP58) LDTP13925 1.18  LDD0346 
NudC domain-containing protein 1 (NUDCD1) LDTP10781 1.02  LDD0346 
OCIA domain-containing protein 2 (OCIAD2) LDTP17157 1.12  LDD0346 
Oxysterol-binding protein-related protein 10 (OSBPL10) LDTP11368 0.98  LDD0346 
Pre-mRNA-splicing factor 38B (PRPF38B) LDTP17266 0.97  LDD0346 
Pre-rRNA-processing protein TSR2 homolog (TSR2) LDTP09989 1.04  LDD0346 
Proteasome activator complex subunit 3 (PSME3) LDTP04917 1.12  LDD0346 
Protein flightless-1 homolog (FLII) LDTP05734 1.20  LDD0346 
Protein KRI1 homolog (KRI1) LDTP17765 0.96  LDD0346 
Protein pelota homolog (PELO) LDTP11138 1.16  LDD0346 
Protein S100-A11 (S100A11) LDTP03620 0.98  LDD0346 
Protein SAAL1 (SAAL1) LDTP18152 0.73  LDD0346 
Protein SDA1 homolog (SDAD1) LDTP12694 1.43  LDD0346 
Protein unc-45 homolog A (UNC45A) LDTP11890 1.11; 1.05; 1.05  LDD0346 
Rab3 GTPase-activating protein non-catalytic subunit (RAB3GAP2) LDTP11833 1.05  LDD0346 
Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) LDTP04504 1.10  LDD0346 
Ribosomal RNA processing protein 1 homolog B (RRP1B) LDTP06182 1.52  LDD0346 
rRNA-processing protein UTP23 homolog (UTP23) LDTP11135 0.90  LDD0346 
RRP12-like protein (RRP12) LDTP14980 1.12  LDD0346 
Sideroflexin-3 (SFXN3) LDTP11331 1.03; 0.91  LDD0346 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 0.97; 1.02; 0.90  LDD0346 
Small ribosomal subunit protein bS6m (MRPS6) LDTP05178 1.25  LDD0346 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 0.98; 0.93  LDD0346 
Small ribosomal subunit protein eS27 (RPS27) LDTP03987 0.90  LDD0346 
Small ribosomal subunit protein eS4, X isoform (RPS4X) LDTP04997 0.99  LDD0346 
Small ribosomal subunit protein eS6 (RPS6) LDTP05002 1.06; 0.93  LDD0346 
Small ribosomal subunit protein eS8 (RPS8) LDTP04964 1.03; 0.94; 1.36 ...  LDD0346 
Small ribosomal subunit protein uS10 (RPS20) LDTP04880 0.87  LDD0346 
Small ribosomal subunit protein uS12 (RPS23) LDTP04971 0.78  LDD0346 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 0.95; 1.18  LDD0346 
Small ribosomal subunit protein uS5 (RPS2) LDTP02809 0.95  LDD0346 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 1.31; 0.98; 0.98  LDD0346 
Small ribosomal subunit protein uS9 (RPS16) LDTP04966 1.03  LDD0346 
SPATS2-like protein (SPATS2L) LDTP16102 1.60  LDD0346 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 1.16  LDD0346 
Surfeit locus protein 6 (SURF6) LDTP14502 0.93  LDD0346 
Symplekin (SYMPK) LDTP09878 1.31  LDD0346 
Synembryn-A (RIC8A) LDTP12381 0.91  LDD0346 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 1.05  LDD0346 
T-complex protein 1 subunit eta (CCT7) LDTP10990 0.96; 1.04  LDD0346 
T-complex protein 1 subunit gamma (CCT3) LDTP04249 0.99  LDD0346 
TBC1 domain family member 13 (TBC1D13) LDTP16107 1.01  LDD0346 
TIP41-like protein (TIPRL) LDTP01285 0.96  LDD0346 
Transducin beta-like protein 2 (TBL2) LDTP16285 1.04  LDD0346 
tRNA-splicing endonuclease subunit Sen15 (TSEN15) LDTP09632 1.02  LDD0346 
Tubulin beta chain (TUBB) LDTP02205 0.98  LDD0346 
U4/U6.U5 tri-snRNP-associated protein 1 (SART1) LDTP00727 0.90  LDD0346 
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Full Information of The Labelling Profiles of This Competitor

IA-alkyne
 Probe Info 
Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method Isotope tag
Experimemt Name rdTOP-ABPP
Competitor Name HNE
Competitor Concentration 5 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)
Interaction Atlas ID  LDD0346  Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method Isotope tag
Experimemt Name rdTOP-ABPP
Competitor Name HNE
Competitor Concentration 10 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)
Interaction Atlas ID  LDD2179  Download The Altas
  
Experiment 3 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method Isotope tag
Experimemt Name rdTOP-ABPP
Competitor Name HNE
Competitor Concentration 50 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)
Interaction Atlas ID  LDD2180  Download The Altas
  
Experiment 4 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method Isotope tag
Experimemt Name rdTOP-ABPP
Competitor Name HNE
Competitor Concentration 100 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)
Interaction Atlas ID  LDD2181  Download The Altas

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578