Details of the Target

General Information of Target

Target ID LDTP05178
Target Name Small ribosomal subunit protein bS6m (MRPS6)
Gene Name MRPS6
Gene ID 64968
Synonyms
C21orf101; RPMS6; Small ribosomal subunit protein bS6m; 28S ribosomal protein S6, mitochondrial; MRP-S6; S6mt
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRYELALILKAMQRPETAATLKRTIEALMDRGAIVRDLENLGERALPYRISAHSQQHNR
GGYFLVDFYAPTAAVESMVEHLSRDIDVIRGNIVKHPLTQELKECEGIVPVPLAEKLYST
KKRKK
Target Bioclass
Other
Family
Bacterial ribosomal protein bS6 family
Subcellular location
Mitochondrion
Uniprot ID
P82932
Ensemble ID
ENST00000399312.3
HGNC ID
HGNC:14051

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.56  LDD0402  [1]
STPyne
 Probe Info  		K116(6.95); K23(10.00); K95(10.00)  LDD0277  [2]
BTD
 Probe Info  		C105(1.15)  LDD2092  [3]
AHL-Pu-1
 Probe Info  		C105(2.62)  LDD0170  [4]
Acrolein
 Probe Info  		H58(0.00); H96(0.00)  LDD0221  [5]
DBIA
 Probe Info  		C105(0.98)  LDD0078  [6]
5E-2FA
 Probe Info  		H96(0.00); H54(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0025  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
NAIA_5
 Probe Info  		N.A.  LDD2224  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Crotonaldehyde
 Probe Info  		H54(0.00); H58(0.00)  LDD0219  [5]
AOyne
 Probe Info  		13.90  LDD0443  [17]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		43.71  LDD1753  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C105(1.19)  LDD2112  [3]
 LDCM0025  4SU-RNA DM93 C105(2.62)  LDD0170  [4]
 LDCM0214  AC1 HEK-293T C105(1.10)  LDD1507  [19]
 LDCM0215  AC10 HCT 116 C105(0.99)  LDD0532  [6]
 LDCM0226  AC11 HCT 116 C105(0.92)  LDD0543  [6]
 LDCM0230  AC113 PaTu 8988t C105(0.96)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C105(1.17)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C105(0.87)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C105(0.86)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C105(0.80)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C105(1.06)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C105(0.76)  LDD1115  [6]
 LDCM0237  AC12 HCT 116 C105(0.95)  LDD0554  [6]
 LDCM0238  AC120 PaTu 8988t C105(0.76)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C105(0.77)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C105(1.05)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C105(0.74)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C105(0.81)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C105(0.88)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C105(1.01)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C105(0.76)  LDD1124  [6]
 LDCM0246  AC128 HCT 116 C105(1.10)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C105(1.22)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C105(1.09)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C105(1.28)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C105(1.32)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C105(1.36)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C105(1.28)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C105(1.10)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C105(1.21)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C105(1.06)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C105(0.98)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C105(1.24)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C105(1.00)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C105(1.12)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C105(1.05)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C105(1.11)  LDD0579  [6]
 LDCM0263  AC143 PaTu 8988t C105(0.56)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C105(0.38)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C105(0.34)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C105(0.72)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C105(0.33)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C105(0.44)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C105(0.31)  LDD1148  [6]
 LDCM0270  AC15 HCT 116 C105(0.96)  LDD0587  [6]
 LDCM0271  AC150 PaTu 8988t C105(0.34)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C105(0.41)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C105(0.35)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C105(0.32)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C105(0.49)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C105(0.33)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C105(0.41)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C105(0.41)  LDD2169  [6]
 LDCM0276  AC17 HCT 116 C105(0.89)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C105(0.86)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C105(0.88)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C105(1.02)  LDD1518  [19]
 LDCM0280  AC20 HCT 116 C105(0.92)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C105(0.84)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C105(0.90)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C105(0.84)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C105(1.04)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C105(0.96)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C105(0.91)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C105(0.94)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C105(0.91)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C105(1.01)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C105(1.06)  LDD1529  [19]
 LDCM0291  AC30 HCT 116 C105(0.98)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C105(0.97)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C105(0.89)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C105(0.93)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C105(0.95)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C105(1.10)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C105(1.13)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C105(1.21)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C105(1.10)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C105(1.09)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C105(1.09)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C105(1.03)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C105(1.07)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C105(1.04)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C105(1.09)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C105(1.20)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C105(1.21)  LDD1546  [19]
 LDCM0308  AC46 HCT 116 C105(1.07)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C105(0.99)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C105(1.13)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C105(1.21)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C105(1.10)  LDD1551  [19]
 LDCM0313  AC50 HCT 116 C105(1.10)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C105(1.14)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C105(0.98)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C105(1.10)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C105(1.05)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C105(1.26)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C105(1.38)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C105(1.08)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C105(0.72)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C105(0.67)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C105(0.95)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C105(0.68)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C105(1.31)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C105(0.87)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C105(0.58)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C105(0.77)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C105(0.86)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C105(1.01)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C105(0.97)  LDD0648  [6]
 LDCM0334  AC7 HCT 116 C105(0.97)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C105(0.92)  LDD0662  [6]
 LDCM0349  AC83 HCT 116 C105(0.90)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C105(0.94)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C105(0.93)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C105(0.89)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C105(0.97)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C105(1.06)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C105(0.90)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C105(0.86)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C105(0.86)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C105(0.81)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C105(0.87)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C105(0.80)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C105(0.99)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C105(0.69)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C105(0.81)  LDD0681  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C105(0.60)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C105(1.09)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C105(0.94)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C105(1.04)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.20  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C105(0.98)  LDD0078  [6]
 LDCM0630  CCW28-3 231MFP C105(2.00)  LDD2214  [20]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C105(20.00)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C105(1.04)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C105(1.06)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C105(0.97)  LDD1573  [19]
 LDCM0370  CL101 HCT 116 C105(0.88)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C105(1.11)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C105(1.09)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C105(1.01)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C105(0.81)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C105(0.89)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C105(0.84)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C105(0.95)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C105(0.83)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C105(1.24)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C105(0.89)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C105(0.93)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C105(1.10)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C105(0.94)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C105(1.08)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C105(1.00)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C105(0.98)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C105(1.01)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C105(1.00)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C105(1.05)  LDD1593  [19]
 LDCM0390  CL12 HCT 116 C105(1.19)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C105(1.06)  LDD1595  [19]
 LDCM0392  CL121 HCT 116 C105(1.02)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C105(1.08)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C105(1.11)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C105(1.18)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C105(1.03)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C105(0.69)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C105(0.64)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C105(0.62)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C105(1.06)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C105(1.08)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C105(1.19)  LDD0719  [6]
 LDCM0403  CL16 PaTu 8988t C105(1.05)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C105(0.89)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C105(1.04)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C105(1.23)  LDD1285  [6]
 LDCM0407  CL2 HCT 116 C105(0.97)  LDD0724  [6]
 LDCM0408  CL20 PaTu 8988t C105(1.07)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C105(1.31)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C105(1.06)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C105(1.05)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C105(1.10)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C105(0.99)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C105(0.94)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C105(1.05)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C105(1.11)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C105(1.14)  LDD1296  [6]
 LDCM0418  CL3 HCT 116 C105(0.94)  LDD0735  [6]
 LDCM0419  CL30 PaTu 8988t C105(1.05)  LDD1298  [6]
 LDCM0420  CL31 PaTu 8988t C105(1.04)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C105(1.06)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C105(1.10)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C105(1.01)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C105(1.13)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C105(0.52)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C105(0.92)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C105(1.01)  LDD1307  [6]
 LDCM0429  CL4 HCT 116 C105(1.51)  LDD0746  [6]
 LDCM0430  CL40 PaTu 8988t C105(0.98)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C105(0.95)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C105(1.01)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C105(1.00)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C105(1.16)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C105(0.90)  LDD1314  [6]
 LDCM0436  CL46 PaTu 8988t C105(0.98)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C105(1.07)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C105(1.00)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C105(1.04)  LDD1318  [6]
 LDCM0440  CL5 HCT 116 C105(1.04)  LDD0757  [6]
 LDCM0441  CL50 PaTu 8988t C105(0.91)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C105(1.06)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C105(0.95)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C105(1.10)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C105(0.89)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C105(0.86)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C105(0.89)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C105(0.96)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C105(0.95)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C105(0.94)  LDD1329  [6]
 LDCM0451  CL6 HCT 116 C105(0.89)  LDD0768  [6]
 LDCM0452  CL60 PaTu 8988t C105(1.04)  LDD1331  [6]
 LDCM0453  CL61 HCT 116 C105(0.90)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C105(0.90)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C105(0.83)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C105(1.08)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C105(0.99)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C105(0.86)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C105(0.95)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C105(0.82)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C105(1.02)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C105(0.95)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C105(0.90)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C105(0.82)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C105(1.09)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C105(1.03)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C105(0.92)  LDD0784  [6]
 LDCM0469  CL76 HEK-293T C105(0.98)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C105(1.10)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C105(1.01)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C105(0.99)  LDD1675  [19]
 LDCM0473  CL8 HCT 116 C105(0.99)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C105(1.08)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C105(1.21)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C105(1.06)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C105(1.11)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C105(1.02)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C105(1.05)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C105(1.03)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C105(1.03)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C105(1.08)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C105(1.18)  LDD1686  [19]
 LDCM0484  CL9 HCT 116 C105(1.15)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C105(1.04)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C105(1.07)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C105(1.07)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C105(1.18)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C105(1.17)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C105(1.95)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C105(1.09)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C105(0.88)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C105(1.03)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C105(1.04)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C105(1.08)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C105(1.50)  LDD1702  [3]
 LDCM0625  F8 Ramos C105(1.62)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C105(1.17)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C105(0.09)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C105(1.14)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C105(0.97)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C105(1.06)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C105(1.13)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C105(0.97)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C105(1.33)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C105(1.13)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C105(0.62)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C105(1.08)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C105(0.82)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C105(1.02)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C105(0.87)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C105(1.96)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C105(0.98)  LDD2184  [21]
 LDCM0427  Fragment51 PaTu 8988t C105(0.98)  LDD1306  [6]
 LDCM0610  Fragment52 Ramos C105(1.07)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C105(0.97)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C105(1.52)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C105(0.85)  LDD2188  [21]
 LDCM0015  HNE MDA-MB-231 C105(1.25)  LDD0346  [21]
 LDCM0107  IAA HeLa H58(0.00); H96(0.00)  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C105(0.97)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C105(0.98)  LDD1497  [19]
 LDCM0024  KB05 COLO792 C105(2.07)  LDD3310  [22]
 LDCM0109  NEM HeLa H54(0.00); H96(0.00); H58(0.00)  LDD0223  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C105(1.15)  LDD2092  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C105(1.00)  LDD2094  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C105(1.02)  LDD2098  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C105(1.23)  LDD2108  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C105(0.72)  LDD2114  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C105(1.04)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C105(1.10)  LDD2118  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C105(0.75)  LDD2127  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C105(1.23)  LDD2135  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C105(0.94)  LDD2141  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C105(1.56)  LDD2206  [23]
 LDCM0131  RA190 MM1.R C105(1.63)  LDD0304  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 5B (STAT5B) Transcription factor STAT family P51692

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.