Details of the Target

General Information of Target

Target ID	LDTP12470
Target Name	GTP-binding protein SAR1a (SAR1A)
Gene Name	SAR1A
Gene ID	56681
Synonyms	SAR1; SARA; SARA1; GTP-binding protein SAR1a; COPII-associated small GTPase
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPGKLRSDAGLESDTAMKKGETLRKQTEEKEKKEKPKSDKTEEIAEEEETVFPKAKQVKK KAEPSEVDMNSPKSKKAKKKEEPSQNDISPKTKSLRKKKEPIEKKVVSSKTKKVTKNEEP SEEEIDAPKPKKMKKEKEMNGETREKSPKLKNGFPHPEPDCNPSEAASEESNSEIEQEIP VEQKEGAFSNFPISEETIKLLKGRGVTFLFPIQAKTFHHVYSGKDLIAQARTGTGKTFSF AIPLIEKLHGELQDRKRGRAPQVLVLAPTRELANQVSKDFSDITKKLSVACFYGGTPYGG QFERMRNGIDILVGTPGRIKDHIQNGKLDLTKLKHVVLDEVDQMLDMGFADQVEEILSVA YKKDSEDNPQTLLFSATCPHWVFNVAKKYMKSTYEQVDLIGKKTQKTAITVEHLAIKCHW TQRAAVIGDVIRVYSGHQGRTIIFCETKKEAQELSQNSAIKQDAQSLHGDIPQKQREITL KGFRNGSFGVLVATNVAARGLDIPEVDLVIQSSPPKDVESYIHRSGRTGRAGRTGVCICF YQHKEEYQLVQVEQKAGIKFKRIGVPSATEIIKASSKDAIRLLDSVPPTAISHFKQSAEK LIEEKGAVEALAAALAHISGATSVDQRSLINSNVGFVTMILQCSIEMPNISYAWKELKEQ LGEEIDSKVKGMVFLKGKLGVCFDVPTASVTEIQEKWHDSRRWQLSVATEQPELEGPREG YGGFRGQREGSRGFRGQRDGNRRFRGQREGSRGPRGQRSGGGNKSNRSQNKGQKRSFSKA FGQ
Target Bioclass	Enzyme
Family	Small GTPase superfamily, SAR1 family
Subcellular location	Endoplasmic reticulum
Function	Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).
Uniprot ID	Q9NR31
Ensemble ID	ENST00000373238.5
HGNC ID	HGNC:10534
ChEMBL ID	CHEMBL4295960

Target Site Mutations in Different Cell Lines

Cell line	Mutation details			Probe for labeling this protein in this cell
AGS	SNV: p.R171H			.
NCIH1793	SNV: p.G20V			DBIA Probe Info

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 24 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
TH211 Probe Info	Y89(5.60)	LDD0257	[1]
ONAyne Probe Info	N.A.	LDD0273	[2]
IPM Probe Info	C178(0.00); C102(0.00)	LDD0241	[3]
Probe 1 Probe Info	Y154(15.51); Y186(21.77)	LDD3495	[4]
JZ128-DTB Probe Info	N.A.	LDD0462	[5]
BTD Probe Info	C178(1.03)	LDD2130	[6]
HHS-475 Probe Info	Y89(0.90); Y154(1.18)	LDD0264	[7]
HHS-465 Probe Info	Y154(10.00)	LDD2237	[8]
DBIA Probe Info	C102(0.52)	LDD0531	[9]
5E-2FA Probe Info	N.A.	LDD2235	[10]
ATP probe Probe Info	K46(0.00); K146(0.00); K182(0.00)	LDD0199	[11]
m-APA Probe Info	H105(0.00); H43(0.00)	LDD2231	[10]
4-Iodoacetamidophenylacetylene Probe Info	C178(0.00); C102(0.00)	LDD0038	[12]
IA-alkyne Probe Info	C178(0.00); C102(0.00)	LDD0032	[13]
IPIAA_H Probe Info	N.A.	LDD0030	[14]
IPIAA_L Probe Info	N.A.	LDD0031	[14]
Lodoacetamide azide Probe Info	C178(0.00); C102(0.00)	LDD0037	[12]
NAIA_4 Probe Info	N.A.	LDD2226	[15]
NHS Probe Info	N.A.	LDD0010	[16]
SF Probe Info	Y154(0.00); K146(0.00)	LDD0028	[17]
STPyne Probe Info	N.A.	LDD0009	[16]
Phosphinate-6 Probe Info	N.A.	LDD0018	[18]
NAIA_5 Probe Info	C178(0.00); C102(0.00)	LDD2223	[15]
HHS-482 Probe Info	Y89(1.22)	LDD2239	[8]

PAL-AfBPP Probe

Click To Hide/Show 32 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C040 Probe Info	11.79	LDD1740	[19]
C055 Probe Info	13.09	LDD1752	[19]
C056 Probe Info	22.01	LDD1753	[19]
C091 Probe Info	14.52	LDD1782	[19]
C092 Probe Info	23.59	LDD1783	[19]
C094 Probe Info	30.70	LDD1785	[19]
C106 Probe Info	16.34	LDD1793	[19]
C112 Probe Info	18.51	LDD1799	[19]
C134 Probe Info	22.78	LDD1816	[19]
C161 Probe Info	9.85	LDD1841	[19]
C186 Probe Info	8.63	LDD1864	[19]
C218 Probe Info	10.93	LDD1892	[19]
C220 Probe Info	13.09	LDD1894	[19]
C228 Probe Info	22.78	LDD1901	[19]
C231 Probe Info	16.45	LDD1904	[19]
C235 Probe Info	26.35	LDD1908	[19]
C246 Probe Info	12.30	LDD1919	[19]
C289 Probe Info	44.63	LDD1959	[19]
C293 Probe Info	19.29	LDD1963	[19]
C310 Probe Info	9.92	LDD1977	[19]
C350 Probe Info	22.16	LDD2011	[19]
C362 Probe Info	28.64	LDD2023	[19]
C366 Probe Info	5.21	LDD2027	[19]
C388 Probe Info	63.12	LDD2047	[19]
FFF probe11 Probe Info	10.09	LDD0471	[20]
FFF probe13 Probe Info	12.40	LDD0475	[20]
FFF probe14 Probe Info	20.00	LDD0477	[20]
FFF probe2 Probe Info	14.66	LDD0463	[20]
FFF probe3 Probe Info	7.05	LDD0465	[20]
JN0003 Probe Info	20.00	LDD0469	[20]
A-DA Probe Info	2.27	LDD0143	[21]
OEA-DA Probe Info	6.32	LDD0046	[22]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0537	2-Cyano-N,N-dimethylacetamide	MDA-MB-231	C178(1.03)	LDD2130	[6]
LDCM0214	AC1	HCT 116	C102(0.52)	LDD0531	[9]
LDCM0215	AC10	HCT 116	C102(0.82)	LDD0532	[9]
LDCM0216	AC100	PaTu 8988t	C178(1.91); C102(1.14)	LDD1095	[9]
LDCM0217	AC101	PaTu 8988t	C178(0.84); C102(1.17)	LDD1096	[9]
LDCM0218	AC102	PaTu 8988t	C178(0.75); C102(1.10)	LDD1097	[9]
LDCM0219	AC103	PaTu 8988t	C178(0.81); C102(0.77)	LDD1098	[9]
LDCM0220	AC104	PaTu 8988t	C178(1.08); C102(1.14)	LDD1099	[9]
LDCM0221	AC105	PaTu 8988t	C178(0.82); C102(0.94)	LDD1100	[9]
LDCM0222	AC106	PaTu 8988t	C178(0.99); C102(0.90)	LDD1101	[9]
LDCM0223	AC107	PaTu 8988t	C178(1.02); C102(1.09)	LDD1102	[9]
LDCM0224	AC108	PaTu 8988t	C178(1.12); C102(0.90)	LDD1103	[9]
LDCM0225	AC109	PaTu 8988t	C178(1.28); C102(0.91)	LDD1104	[9]
LDCM0226	AC11	HCT 116	C102(0.64)	LDD0543	[9]
LDCM0227	AC110	PaTu 8988t	C178(0.94); C102(0.91)	LDD1106	[9]
LDCM0228	AC111	PaTu 8988t	C178(0.87); C102(0.96)	LDD1107	[9]
LDCM0229	AC112	PaTu 8988t	C178(0.90); C102(0.92)	LDD1108	[9]
LDCM0230	AC113	HCT 116	C102(0.98)	LDD0547	[9]
LDCM0231	AC114	HCT 116	C102(0.81)	LDD0548	[9]
LDCM0232	AC115	HCT 116	C102(0.67)	LDD0549	[9]
LDCM0233	AC116	HCT 116	C102(0.67)	LDD0550	[9]
LDCM0234	AC117	HCT 116	C102(0.98)	LDD0551	[9]
LDCM0235	AC118	HCT 116	C102(0.96)	LDD0552	[9]
LDCM0236	AC119	HCT 116	C102(0.81)	LDD0553	[9]
LDCM0237	AC12	HCT 116	C102(0.82)	LDD0554	[9]
LDCM0238	AC120	HCT 116	C102(0.57)	LDD0555	[9]
LDCM0239	AC121	HCT 116	C102(1.00)	LDD0556	[9]
LDCM0240	AC122	HCT 116	C102(0.72)	LDD0557	[9]
LDCM0241	AC123	HCT 116	C102(0.78)	LDD0558	[9]
LDCM0242	AC124	HCT 116	C102(1.04)	LDD0559	[9]
LDCM0243	AC125	HCT 116	C102(1.19)	LDD0560	[9]
LDCM0244	AC126	HCT 116	C102(0.69)	LDD0561	[9]
LDCM0245	AC127	HCT 116	C102(0.71)	LDD0562	[9]
LDCM0246	AC128	HCT 116	C102(0.99)	LDD0563	[9]
LDCM0247	AC129	HCT 116	C102(2.09)	LDD0564	[9]
LDCM0249	AC130	HCT 116	C102(1.07)	LDD0566	[9]
LDCM0250	AC131	HCT 116	C102(1.26)	LDD0567	[9]
LDCM0251	AC132	HCT 116	C102(1.93)	LDD0568	[9]
LDCM0252	AC133	HCT 116	C102(1.19)	LDD0569	[9]
LDCM0253	AC134	HCT 116	C102(1.38)	LDD0570	[9]
LDCM0254	AC135	HCT 116	C102(1.20)	LDD0571	[9]
LDCM0255	AC136	HCT 116	C102(0.91)	LDD0572	[9]
LDCM0256	AC137	HCT 116	C102(1.06)	LDD0573	[9]
LDCM0257	AC138	HCT 116	C102(1.25)	LDD0574	[9]
LDCM0258	AC139	HCT 116	C102(1.33)	LDD0575	[9]
LDCM0259	AC14	HCT 116	C102(0.68)	LDD0576	[9]
LDCM0260	AC140	HCT 116	C102(1.18)	LDD0577	[9]
LDCM0261	AC141	HCT 116	C102(1.18)	LDD0578	[9]
LDCM0262	AC142	HCT 116	C102(1.30)	LDD0579	[9]
LDCM0263	AC143	HCT 116	C178(1.01); C102(0.90)	LDD0580	[9]
LDCM0264	AC144	HCT 116	C178(0.65); C102(0.78)	LDD0581	[9]
LDCM0265	AC145	HCT 116	C178(0.67); C102(0.92)	LDD0582	[9]
LDCM0266	AC146	HCT 116	C178(0.60); C102(0.61)	LDD0583	[9]
LDCM0267	AC147	HCT 116	C178(0.59); C102(0.71)	LDD0584	[9]
LDCM0268	AC148	HCT 116	C178(0.60); C102(0.66)	LDD0585	[9]
LDCM0269	AC149	HCT 116	C178(0.54); C102(0.71)	LDD0586	[9]
LDCM0270	AC15	HCT 116	C102(0.73)	LDD0587	[9]
LDCM0271	AC150	HCT 116	C178(0.76); C102(0.78)	LDD0588	[9]
LDCM0272	AC151	HCT 116	C178(0.84); C102(0.93)	LDD0589	[9]
LDCM0273	AC152	HCT 116	C102(0.58); C178(0.69)	LDD0590	[9]
LDCM0274	AC153	HCT 116	C178(0.57); C102(0.62)	LDD0591	[9]
LDCM0621	AC154	HCT 116	C178(0.70); C102(0.67)	LDD2158	[9]
LDCM0622	AC155	HCT 116	C178(0.60); C102(0.72)	LDD2159	[9]
LDCM0623	AC156	HCT 116	C178(0.80); C102(0.92)	LDD2160	[9]
LDCM0624	AC157	HCT 116	C178(0.69); C102(1.06)	LDD2161	[9]
LDCM0276	AC17	HCT 116	C102(0.82)	LDD0593	[9]
LDCM0277	AC18	HCT 116	C102(0.83)	LDD0594	[9]
LDCM0278	AC19	HCT 116	C102(0.76)	LDD0595	[9]
LDCM0279	AC2	HCT 116	C102(0.81)	LDD0596	[9]
LDCM0280	AC20	HCT 116	C102(0.79)	LDD0597	[9]
LDCM0281	AC21	HCT 116	C102(0.78)	LDD0598	[9]
LDCM0282	AC22	HCT 116	C102(0.94)	LDD0599	[9]
LDCM0283	AC23	HCT 116	C102(0.59)	LDD0600	[9]
LDCM0284	AC24	HCT 116	C102(0.80)	LDD0601	[9]
LDCM0285	AC25	HCT 116	C102(0.89); C178(1.03)	LDD0602	[9]
LDCM0286	AC26	HCT 116	C102(0.75); C178(1.10)	LDD0603	[9]
LDCM0287	AC27	HCT 116	C102(0.98); C178(1.19)	LDD0604	[9]
LDCM0288	AC28	HCT 116	C102(0.76); C178(1.08)	LDD0605	[9]
LDCM0289	AC29	HCT 116	C102(1.05); C178(1.08)	LDD0606	[9]
LDCM0290	AC3	HCT 116	C102(0.86)	LDD0607	[9]
LDCM0291	AC30	HCT 116	C102(0.98); C178(1.05)	LDD0608	[9]
LDCM0292	AC31	HCT 116	C102(0.81); C178(1.03)	LDD0609	[9]
LDCM0293	AC32	HCT 116	C102(0.82); C178(1.16)	LDD0610	[9]
LDCM0294	AC33	HCT 116	C102(0.88); C178(1.15)	LDD0611	[9]
LDCM0295	AC34	HCT 116	C102(0.80); C178(1.00)	LDD0612	[9]
LDCM0296	AC35	HCT 116	C102(1.21)	LDD0613	[9]
LDCM0297	AC36	HCT 116	C102(1.14)	LDD0614	[9]
LDCM0298	AC37	HCT 116	C102(1.12)	LDD0615	[9]
LDCM0299	AC38	HCT 116	C102(1.07)	LDD0616	[9]
LDCM0300	AC39	HCT 116	C102(0.99)	LDD0617	[9]
LDCM0301	AC4	HCT 116	C102(0.67)	LDD0618	[9]
LDCM0302	AC40	HCT 116	C102(1.12)	LDD0619	[9]
LDCM0303	AC41	HCT 116	C102(0.94)	LDD0620	[9]
LDCM0304	AC42	HCT 116	C102(0.98)	LDD0621	[9]
LDCM0305	AC43	HCT 116	C102(0.99)	LDD0622	[9]
LDCM0306	AC44	HCT 116	C102(1.03)	LDD0623	[9]
LDCM0307	AC45	HCT 116	C102(0.95)	LDD0624	[9]
LDCM0308	AC46	HCT 116	C178(0.84)	LDD0625	[9]
LDCM0309	AC47	HCT 116	C178(0.83)	LDD0626	[9]
LDCM0310	AC48	HCT 116	C178(0.83)	LDD0627	[9]
LDCM0311	AC49	HCT 116	C178(0.80)	LDD0628	[9]
LDCM0312	AC5	HCT 116	C102(0.72)	LDD0629	[9]
LDCM0313	AC50	HCT 116	C178(0.79)	LDD0630	[9]
LDCM0314	AC51	HCT 116	C178(0.85)	LDD0631	[9]
LDCM0315	AC52	HCT 116	C178(0.78)	LDD0632	[9]
LDCM0316	AC53	HCT 116	C178(0.88)	LDD0633	[9]
LDCM0317	AC54	HCT 116	C178(0.89)	LDD0634	[9]
LDCM0318	AC55	HCT 116	C178(0.97)	LDD0635	[9]
LDCM0319	AC56	HCT 116	C178(0.81)	LDD0636	[9]
LDCM0320	AC57	PaTu 8988t	C178(1.17); C102(0.84)	LDD1199	[9]
LDCM0321	AC58	PaTu 8988t	C178(1.03); C102(0.96)	LDD1200	[9]
LDCM0322	AC59	PaTu 8988t	C178(1.09); C102(1.16)	LDD1201	[9]
LDCM0323	AC6	HCT 116	C102(0.79)	LDD0640	[9]
LDCM0324	AC60	PaTu 8988t	C178(1.12); C102(1.29)	LDD1203	[9]
LDCM0325	AC61	PaTu 8988t	C178(1.14); C102(1.32)	LDD1204	[9]
LDCM0326	AC62	PaTu 8988t	C178(0.97); C102(1.02)	LDD1205	[9]
LDCM0327	AC63	PaTu 8988t	C178(1.17); C102(0.91)	LDD1206	[9]
LDCM0328	AC64	PaTu 8988t	C178(1.21); C102(0.98)	LDD1207	[9]
LDCM0329	AC65	PaTu 8988t	C178(1.73); C102(1.06)	LDD1208	[9]
LDCM0330	AC66	PaTu 8988t	C178(1.19); C102(1.02)	LDD1209	[9]
LDCM0331	AC67	PaTu 8988t	C178(1.60); C102(1.13)	LDD1210	[9]
LDCM0332	AC68	HCT 116	C102(0.76)	LDD0649	[9]
LDCM0333	AC69	HCT 116	C102(0.68)	LDD0650	[9]
LDCM0334	AC7	HCT 116	C102(0.86)	LDD0651	[9]
LDCM0335	AC70	HCT 116	C102(0.59)	LDD0652	[9]
LDCM0336	AC71	HCT 116	C102(0.76)	LDD0653	[9]
LDCM0337	AC72	HCT 116	C102(0.81)	LDD0654	[9]
LDCM0338	AC73	HCT 116	C102(0.70)	LDD0655	[9]
LDCM0339	AC74	HCT 116	C102(0.62)	LDD0656	[9]
LDCM0340	AC75	HCT 116	C102(0.74)	LDD0657	[9]
LDCM0341	AC76	HCT 116	C102(0.80)	LDD0658	[9]
LDCM0342	AC77	HCT 116	C102(0.77)	LDD0659	[9]
LDCM0343	AC78	HCT 116	C102(0.70)	LDD0660	[9]
LDCM0344	AC79	HCT 116	C102(0.88)	LDD0661	[9]
LDCM0345	AC8	HCT 116	C102(0.65)	LDD0662	[9]
LDCM0346	AC80	HCT 116	C102(0.76)	LDD0663	[9]
LDCM0347	AC81	HCT 116	C102(0.58)	LDD0664	[9]
LDCM0348	AC82	HCT 116	C102(0.70)	LDD0665	[9]
LDCM0349	AC83	HCT 116	C178(0.64)	LDD0666	[9]
LDCM0350	AC84	HCT 116	C178(0.63)	LDD0667	[9]
LDCM0351	AC85	HCT 116	C178(0.60)	LDD0668	[9]
LDCM0352	AC86	HCT 116	C178(0.82)	LDD0669	[9]
LDCM0353	AC87	HCT 116	C178(0.72)	LDD0670	[9]
LDCM0354	AC88	HCT 116	C178(0.76)	LDD0671	[9]
LDCM0355	AC89	HCT 116	C178(0.64)	LDD0672	[9]
LDCM0357	AC90	HCT 116	C178(1.26)	LDD0674	[9]
LDCM0358	AC91	HCT 116	C178(0.59)	LDD0675	[9]
LDCM0359	AC92	HCT 116	C178(0.64)	LDD0676	[9]
LDCM0360	AC93	HCT 116	C178(0.64)	LDD0677	[9]
LDCM0361	AC94	HCT 116	C178(0.67)	LDD0678	[9]
LDCM0362	AC95	HCT 116	C178(0.43)	LDD0679	[9]
LDCM0363	AC96	HCT 116	C178(0.60)	LDD0680	[9]
LDCM0364	AC97	HCT 116	C178(0.59)	LDD0681	[9]
LDCM0365	AC98	PaTu 8988t	C178(1.25); C102(0.89)	LDD1244	[9]
LDCM0366	AC99	PaTu 8988t	C178(0.80); C102(1.04)	LDD1245	[9]
LDCM0248	AKOS034007472	HCT 116	C102(1.28)	LDD0565	[9]
LDCM0356	AKOS034007680	HCT 116	C102(0.79)	LDD0673	[9]
LDCM0275	AKOS034007705	HCT 116	C102(0.53)	LDD0592	[9]
LDCM0083	Avasimibe	A-549	2.27	LDD0143	[21]
LDCM0632	CL-Sc	Hep-G2	C178(2.22); C178(1.26); C178(1.00); C102(0.60)	LDD2227	[15]
LDCM0367	CL1	HEK-293T	C178(1.13); C102(1.14)	LDD1571	[23]
LDCM0368	CL10	HEK-293T	C178(0.56); C102(0.80)	LDD1572	[23]
LDCM0369	CL100	HCT 116	C102(0.59)	LDD0686	[9]
LDCM0370	CL101	HCT 116	C102(0.83)	LDD0687	[9]
LDCM0371	CL102	HCT 116	C102(1.08)	LDD0688	[9]
LDCM0372	CL103	HCT 116	C102(1.03)	LDD0689	[9]
LDCM0373	CL104	HCT 116	C102(0.90)	LDD0690	[9]
LDCM0374	CL105	HCT 116	C102(0.59)	LDD0691	[9]
LDCM0375	CL106	HCT 116	C102(0.53)	LDD0692	[9]
LDCM0376	CL107	HCT 116	C102(0.59)	LDD0693	[9]
LDCM0377	CL108	HCT 116	C102(0.53)	LDD0694	[9]
LDCM0378	CL109	HCT 116	C102(0.67)	LDD0695	[9]
LDCM0379	CL11	HEK-293T	C178(0.43); C102(0.90)	LDD1583	[23]
LDCM0380	CL110	HCT 116	C102(0.62)	LDD0697	[9]
LDCM0381	CL111	HCT 116	C102(0.79)	LDD0698	[9]
LDCM0382	CL112	HCT 116	C102(0.84); C178(1.02)	LDD0699	[9]
LDCM0383	CL113	HCT 116	C102(0.78); C178(0.98)	LDD0700	[9]
LDCM0384	CL114	HCT 116	C102(0.94); C178(1.03)	LDD0701	[9]
LDCM0385	CL115	HCT 116	C102(0.87); C178(1.06)	LDD0702	[9]
LDCM0386	CL116	HCT 116	C102(0.93); C178(1.05)	LDD0703	[9]
LDCM0387	CL117	HCT 116	C102(0.88)	LDD0704	[9]
LDCM0388	CL118	HCT 116	C102(0.93)	LDD0705	[9]
LDCM0389	CL119	HCT 116	C102(0.94)	LDD0706	[9]
LDCM0390	CL12	HEK-293T	C178(0.59); C102(0.98)	LDD1594	[23]
LDCM0391	CL120	HCT 116	C102(0.95)	LDD0708	[9]
LDCM0392	CL121	HCT 116	C178(0.91)	LDD0709	[9]
LDCM0393	CL122	HCT 116	C178(0.97)	LDD0710	[9]
LDCM0394	CL123	HCT 116	C178(0.86)	LDD0711	[9]
LDCM0395	CL124	HCT 116	C178(0.85)	LDD0712	[9]
LDCM0396	CL125	PaTu 8988t	C178(1.19); C102(0.88)	LDD1275	[9]
LDCM0397	CL126	PaTu 8988t	C178(1.39); C102(0.97)	LDD1276	[9]
LDCM0398	CL127	PaTu 8988t	C178(1.31); C102(1.15)	LDD1277	[9]
LDCM0399	CL128	PaTu 8988t	C178(1.28); C102(1.00)	LDD1278	[9]
LDCM0400	CL13	HEK-293T	C178(1.26); C102(1.09)	LDD1604	[23]
LDCM0401	CL14	HEK-293T	C178(1.22); C102(1.16)	LDD1605	[23]
LDCM0402	CL15	HEK-293T	C178(1.17); C102(0.97)	LDD1606	[23]
LDCM0403	CL16	PaTu 8988t	C102(0.79)	LDD1282	[9]
LDCM0404	CL17	PaTu 8988t	C102(0.79)	LDD1283	[9]
LDCM0405	CL18	PaTu 8988t	C102(0.71)	LDD1284	[9]
LDCM0406	CL19	PaTu 8988t	C102(0.75)	LDD1285	[9]
LDCM0407	CL2	HEK-293T	C178(1.10); C102(0.93)	LDD1611	[23]
LDCM0408	CL20	PaTu 8988t	C102(0.73)	LDD1287	[9]
LDCM0409	CL21	PaTu 8988t	C102(0.67)	LDD1288	[9]
LDCM0410	CL22	PaTu 8988t	C102(0.79)	LDD1289	[9]
LDCM0411	CL23	PaTu 8988t	C102(1.00)	LDD1290	[9]
LDCM0412	CL24	PaTu 8988t	C102(0.81)	LDD1291	[9]
LDCM0413	CL25	PaTu 8988t	C102(0.72)	LDD1292	[9]
LDCM0414	CL26	PaTu 8988t	C102(0.73)	LDD1293	[9]
LDCM0415	CL27	PaTu 8988t	C102(0.75)	LDD1294	[9]
LDCM0416	CL28	PaTu 8988t	C102(0.82)	LDD1295	[9]
LDCM0417	CL29	PaTu 8988t	C102(1.05)	LDD1296	[9]
LDCM0418	CL3	HEK-293T	C178(1.07); C102(1.09)	LDD1622	[23]
LDCM0419	CL30	PaTu 8988t	C102(0.67)	LDD1298	[9]
LDCM0420	CL31	HCT 116	C102(0.97)	LDD0737	[9]
LDCM0421	CL32	HCT 116	C102(0.54)	LDD0738	[9]
LDCM0422	CL33	HCT 116	C102(0.64)	LDD0739	[9]
LDCM0423	CL34	HCT 116	C102(0.76)	LDD0740	[9]
LDCM0424	CL35	HCT 116	C102(0.90)	LDD0741	[9]
LDCM0425	CL36	HCT 116	C102(1.02)	LDD0742	[9]
LDCM0426	CL37	HCT 116	C102(0.97)	LDD0743	[9]
LDCM0428	CL39	HCT 116	C102(0.76)	LDD0745	[9]
LDCM0429	CL4	HEK-293T	C178(1.04); C102(1.13)	LDD1633	[23]
LDCM0430	CL40	HCT 116	C102(0.88)	LDD0747	[9]
LDCM0431	CL41	HCT 116	C102(0.96)	LDD0748	[9]
LDCM0432	CL42	HCT 116	C102(0.84)	LDD0749	[9]
LDCM0433	CL43	HCT 116	C102(0.80)	LDD0750	[9]
LDCM0434	CL44	HCT 116	C102(0.72)	LDD0751	[9]
LDCM0435	CL45	HCT 116	C102(0.64)	LDD0752	[9]
LDCM0436	CL46	HCT 116	C178(0.94)	LDD0753	[9]
LDCM0437	CL47	HCT 116	C178(1.09)	LDD0754	[9]
LDCM0438	CL48	HCT 116	C178(0.98)	LDD0755	[9]
LDCM0439	CL49	HCT 116	C178(0.97)	LDD0756	[9]
LDCM0440	CL5	HEK-293T	C178(0.97); C102(1.02)	LDD1644	[23]
LDCM0441	CL50	HCT 116	C178(0.97)	LDD0758	[9]
LDCM0442	CL51	HCT 116	C178(0.93)	LDD0759	[9]
LDCM0443	CL52	HCT 116	C178(1.03)	LDD0760	[9]
LDCM0444	CL53	HCT 116	C178(1.07)	LDD0761	[9]
LDCM0445	CL54	HCT 116	C178(0.85)	LDD0762	[9]
LDCM0446	CL55	HCT 116	C178(1.06)	LDD0763	[9]
LDCM0447	CL56	HCT 116	C178(0.89)	LDD0764	[9]
LDCM0448	CL57	HCT 116	C178(0.97)	LDD0765	[9]
LDCM0449	CL58	HCT 116	C178(0.93)	LDD0766	[9]
LDCM0450	CL59	HCT 116	C178(1.01)	LDD0767	[9]
LDCM0451	CL6	HEK-293T	C178(0.93); C102(1.02)	LDD1654	[23]
LDCM0452	CL60	HCT 116	C178(1.04)	LDD0769	[9]
LDCM0453	CL61	HCT 116	C102(0.99)	LDD0770	[9]
LDCM0454	CL62	HCT 116	C102(0.75)	LDD0771	[9]
LDCM0455	CL63	HCT 116	C102(0.71)	LDD0772	[9]
LDCM0456	CL64	HCT 116	C102(0.74)	LDD0773	[9]
LDCM0457	CL65	HCT 116	C102(0.83)	LDD0774	[9]
LDCM0458	CL66	HCT 116	C102(0.55)	LDD0775	[9]
LDCM0459	CL67	HCT 116	C102(0.56)	LDD0776	[9]
LDCM0460	CL68	HCT 116	C102(0.65)	LDD0777	[9]
LDCM0461	CL69	HCT 116	C102(0.73)	LDD0778	[9]
LDCM0462	CL7	HEK-293T	C178(0.96); C102(1.04)	LDD1665	[23]
LDCM0463	CL70	HCT 116	C102(0.60)	LDD0780	[9]
LDCM0464	CL71	HCT 116	C102(0.67)	LDD0781	[9]
LDCM0465	CL72	HCT 116	C102(0.80)	LDD0782	[9]
LDCM0466	CL73	HCT 116	C102(0.87)	LDD0783	[9]
LDCM0467	CL74	HCT 116	C102(0.86)	LDD0784	[9]
LDCM0469	CL76	HCT 116	C178(0.86); C102(0.63)	LDD0786	[9]
LDCM0470	CL77	HCT 116	C178(0.01); C102(1.50)	LDD0787	[9]
LDCM0471	CL78	HCT 116	C178(0.62); C102(0.70)	LDD0788	[9]
LDCM0472	CL79	HCT 116	C178(5.50); C102(0.64)	LDD0789	[9]
LDCM0473	CL8	HEK-293T	C178(0.78); C102(0.83)	LDD1676	[23]
LDCM0474	CL80	HCT 116	C178(0.63); C102(0.60)	LDD0791	[9]
LDCM0475	CL81	HCT 116	C178(0.78); C102(0.77)	LDD0792	[9]
LDCM0476	CL82	HCT 116	C178(1.04); C102(0.58)	LDD0793	[9]
LDCM0477	CL83	HCT 116	C178(1.12); C102(0.63)	LDD0794	[9]
LDCM0478	CL84	HCT 116	C178(0.82); C102(0.68)	LDD0795	[9]
LDCM0479	CL85	HCT 116	C178(0.76); C102(0.71)	LDD0796	[9]
LDCM0480	CL86	HCT 116	C178(0.81); C102(0.72)	LDD0797	[9]
LDCM0481	CL87	HCT 116	C178(1.03); C102(0.69)	LDD0798	[9]
LDCM0482	CL88	HCT 116	C178(0.92); C102(0.58)	LDD0799	[9]
LDCM0483	CL89	HCT 116	C178(1.22); C102(0.53)	LDD0800	[9]
LDCM0484	CL9	HEK-293T	C178(0.67); C102(1.02)	LDD1687	[23]
LDCM0485	CL90	HCT 116	C178(0.84); C102(0.94)	LDD0802	[9]
LDCM0486	CL91	HCT 116	C102(0.81)	LDD0803	[9]
LDCM0487	CL92	HCT 116	C102(0.71)	LDD0804	[9]
LDCM0488	CL93	HCT 116	C102(0.73)	LDD0805	[9]
LDCM0489	CL94	HCT 116	C102(0.56)	LDD0806	[9]
LDCM0490	CL95	HCT 116	C102(0.58)	LDD0807	[9]
LDCM0491	CL96	HCT 116	C102(0.71)	LDD0808	[9]
LDCM0492	CL97	HCT 116	C102(0.59)	LDD0809	[9]
LDCM0493	CL98	HCT 116	C102(0.55)	LDD0810	[9]
LDCM0494	CL99	HCT 116	C102(0.55)	LDD0811	[9]
LDCM0495	E2913	HEK-293T	C178(1.14); C102(1.17)	LDD1698	[23]
LDCM0625	F8	Ramos	C178(1.26); C102(0.68)	LDD2187	[24]
LDCM0572	Fragment10	Ramos	C178(0.60); C102(0.41)	LDD2189	[24]
LDCM0573	Fragment11	Ramos	C178(0.13); C102(0.77)	LDD2190	[24]
LDCM0574	Fragment12	Ramos	C178(0.65); C102(0.35)	LDD2191	[24]
LDCM0575	Fragment13	Ramos	C178(0.83); C102(0.84)	LDD2192	[24]
LDCM0576	Fragment14	Ramos	C178(0.85); C102(1.00)	LDD2193	[24]
LDCM0579	Fragment20	Ramos	C178(0.68); C102(0.36)	LDD2194	[24]
LDCM0580	Fragment21	Ramos	C178(0.53); C102(0.60)	LDD2195	[24]
LDCM0582	Fragment23	Ramos	C178(0.46); C102(0.53)	LDD2196	[24]
LDCM0578	Fragment27	Ramos	C178(0.66); C102(0.80)	LDD2197	[24]
LDCM0586	Fragment28	Ramos	C178(0.68); C102(0.64)	LDD2198	[24]
LDCM0588	Fragment30	Ramos	C178(0.90); C102(0.59)	LDD2199	[24]
LDCM0589	Fragment31	Ramos	C178(0.84); C102(0.56)	LDD2200	[24]
LDCM0590	Fragment32	Ramos	C178(0.59); C102(0.37)	LDD2201	[24]
LDCM0468	Fragment33	HCT 116	C102(0.75)	LDD0785	[9]
LDCM0596	Fragment38	Ramos	C178(0.92); C102(2.32)	LDD2203	[24]
LDCM0566	Fragment4	Ramos	C178(0.81); C102(0.49)	LDD2184	[24]
LDCM0427	Fragment51	HCT 116	C102(0.81)	LDD0744	[9]
LDCM0610	Fragment52	Ramos	C178(0.51); C102(0.77)	LDD2204	[24]
LDCM0614	Fragment56	Ramos	C178(0.48); C102(0.73)	LDD2205	[24]
LDCM0569	Fragment7	Ramos	C178(0.55); C102(0.70)	LDD2186	[24]
LDCM0571	Fragment9	Ramos	C178(0.63); C102(0.41)	LDD2188	[24]
LDCM0116	HHS-0101	DM93	Y89(0.90); Y154(1.18)	LDD0264	[7]
LDCM0117	HHS-0201	DM93	Y154(0.83); Y89(1.04)	LDD0265	[7]
LDCM0118	HHS-0301	DM93	Y89(0.68); Y154(1.01)	LDD0266	[7]
LDCM0119	HHS-0401	DM93	Y154(0.93); Y89(1.00)	LDD0267	[7]
LDCM0120	HHS-0701	DM93	Y154(0.99); Y89(1.05)	LDD0268	[7]
LDCM0015	HNE	MDA-MB-231	C178(1.15)	LDD0346	[24]
LDCM0179	JZ128	PC-3	N.A.	LDD0462	[5]
LDCM0022	KB02	HEK-293T	C178(1.04); C102(1.03)	LDD1492	[23]
LDCM0023	KB03	HEK-293T	C178(0.98); C102(1.07)	LDD1497	[23]
LDCM0024	KB05	COLO792	C59(1.55)	LDD3310	[25]
LDCM0556	Nucleophilic fragment 8a	MDA-MB-231	C178(1.04)	LDD2150	[6]
LDCM0627	NUDT7-COV-1	HEK-293T	C102(0.26)	LDD2206	[26]
LDCM0628	OTUB2-COV-1	HEK-293T	C102(1.49); C178(0.97)	LDD2207	[26]
LDCM0131	RA190	MM1.R	C178(1.76)	LDD0304	[27]
LDCM0084	Ro 48-8071	A-549	2.13	LDD0145	[21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 10 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG8)	ALG6/ALG8 glucosyltransferase family	Q9BVK2
N-acetyltransferase 8 (NAT8)	Camello family	Q9UHE5
Vesicle transport protein GOT1B (GOLT1B)	GOT1 family	Q9Y3E0
Heme oxygenase 2 (HMOX2)	Heme oxygenase family	P30519
Mitochondrial Rho GTPase 2 (RHOT2)	Mitochondrial Rho GTPase family	Q8IXI1
Phospholipid phosphatase 4 (PLPP4)	PA-phosphatase related phosphoesterase family	Q5VZY2
GTPase IMAP family member 1 (GIMAP1)	AIG1/Toc34/Toc159-like paraseptin GTPase family	Q8WWP7
UbiA prenyltransferase domain-containing protein 1 (UBIAD1)	UbiA prenyltransferase family	Q9Y5Z9
Vitamin K epoxide reductase complex subunit 1 (VKORC1)	VKOR family	Q9BQB6
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5)	.	Q9NX47

Transporter and channel

Click To Hide/Show 24 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Sodium-coupled neutral amino acid transporter 7 (SLC38A7)	Amino acid/polyamine transporter 2 family	Q9NVC3
Bcl-2-like protein 2 (BCL2L2)	Bcl-2 family	Q92843
Proton-coupled zinc antiporter SLC30A8 (SLC30A8)	Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	Q8IWU4
Gap junction beta-2 protein (GJB2)	Connexin family	P29033
Glycophorin-A (GYPA)	Glycophorin A family	P02724
LHFPL tetraspan subfamily member 5 protein (LHFPL5)	LHFP family	Q8TAF8
Aquaporin-1 (AQP1)	MIP/aquaporin (TC 1.A.8) family	P29972
Aquaporin-10 (AQP10)	MIP/aquaporin (TC 1.A.8) family	Q96PS8
Aquaporin-3 (AQP3)	MIP/aquaporin (TC 1.A.8) family	Q92482
Lens fiber major intrinsic protein (MIP)	MIP/aquaporin (TC 1.A.8) family	P30301
CMP-sialic acid transporter (SLC35A1)	Nucleotide-sugar transporter family	P78382
Cardiac phospholamban (PLN)	Phospholamban family	P26678
Small integral membrane protein 1 (SMIM1)	SMIM1 family	B2RUZ4
Vesicle-associated membrane protein 3 (VAMP3)	Synaptobrevin family	Q15836
CD81 antigen (CD81)	Tetraspanin (TM4SF) family	P60033
Leukocyte surface antigen CD53 (CD53)	Tetraspanin (TM4SF) family	P19397
Uroplakin-1b (UPK1B)	Tetraspanin (TM4SF) family	O75841
Transmembrane protein 218 (TMEM218)	TMEM218 family	A2RU14
Sigma intracellular receptor 2 (TMEM97)	TMEM97/sigma-2 receptor family	Q5BJF2
Translocating chain-associated membrane protein 1-like 1 (TRAM1L1)	TRAM family	Q8N609
Proteolipid protein 2 (PLP2)	.	Q04941
Transmembrane protein 187 (TMEM187)	.	Q14656
Transmembrane protein 60 (TMEM60)	.	Q9H2L4
Voltage-gated monoatomic cation channel TMEM109 (TMEM109)	.	Q9BVC6

GPCR

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Adhesion G protein-coupled receptor E2 (ADGRE2)				G-protein coupled receptor 2 family	Q9UHX3
Metabotropic glutamate receptor 2 (GRM2)				G-protein coupled receptor 3 family	Q14416

Other

Click To Hide/Show 28 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Ataxin-1 (ATXN1)	ATXN1 family	P54253
Ergosterol biosynthetic protein 28 homolog (ERG28)	ERG28 family	Q9UKR5
Protein FAM3C (FAM3C)	FAM3 family	Q92520
Protein jagunal homolog 1 (JAGN1)	Jagunal family	Q8N5M9
Plasmolipin (PLLP)	MAL family	Q9Y342
Nurim (NRM)	Nurim family	Q8IXM6
ORM1-like protein 1 (ORMDL1)	ORM family	Q9P0S3
Claudin domain-containing protein 2 (CLDND2)	PMP-22/EMP/MP20 family	Q8NHS1
Epithelial membrane protein 3 (EMP3)	PMP-22/EMP/MP20 family	P54852
Stress-associated endoplasmic reticulum protein 1 (SERP1)	RAMP4 family	Q9Y6X1
Regulator of microtubule dynamics protein 2 (RMDN2)	RMDN family	Q96LZ7
Synaptosomal-associated protein 47 (SNAP47)	SVAP1 family	Q5SQN1
Vesicle-associated membrane protein 4 (VAMP4)	Synaptobrevin family	O75379
Vesicle-associated membrane protein 5 (VAMP5)	Synaptobrevin family	O95183
Vesicle-trafficking protein SEC22a (SEC22A)	Synaptobrevin family	Q96IW7
Syntaxin-7 (STX7)	Syntaxin family	O15400
Syntaxin-8 (STX8)	Syntaxin family	Q9UNK0
Transmembrane protein 243 (TMEM243)	TMEM243 family	Q9BU79
Protein unc-50 homolog (UNC50)	Unc-50 family	Q53HI1
Alpha-tocopherol transfer protein (TTPA)	.	P49638
Asialoglycoprotein receptor 1 (ASGR1)	.	P07306
Motile sperm domain-containing protein 3 (MOSPD3)	.	O75425
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC)	.	Q8N912
TPA-induced transmembrane protein (TTMP)	.	Q5BVD1
Transmembrane protein 107 (TMEM107)	.	Q6UX40
Transmembrane protein 254 (TMEM254)	.	Q8TBM7
Transmembrane protein 267 (TMEM267)	.	Q0VDI3
Transmembrane protein 42 (TMEM42)	.	Q69YG0

References

1	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
3	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5	A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
7	Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8	Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
11	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
13	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14	SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25. Mass spectrometry data entry: PXD029500 , PXD031647
15	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
16	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17	Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022. Mass spectrometry data entry: PXD039931
18	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
19	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
20	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Prof. Feng Zhu

Prof. Feng Ni