Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C366  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 92 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 61.4
 LDTP00697  Cytochrome b5 type B (CYB5B) 54.2
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 30.1
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 24.6
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 22.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 22.3
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 19.2
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 18.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 18.1
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 17.8
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 17.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 17.1
 LDTP10329  Ceramide synthase 2 (CERS2) 17.1
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 15.2
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 14.4
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 14.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 14.2
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 13.4
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 12.9
 LDTP02359  Heme oxygenase 1 (HMOX1) 12.4
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 11.8
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 11.2
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 10.3
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 9.9
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 9.9
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 9.6
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 9.5
 LDTP12303  ATP-binding cassette sub-family B member 6 (ABCB6) 9.0
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 8.9
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) 8.9
 LDTP13751  Exonuclease 1 (EXO1) 8.8
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 8.7
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 8.5
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 8.4
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 8.2
 LDTP06617  Ceramide glucosyltransferase (UGCG) 8.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 8.1
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 7.7
 LDTP03145  Catechol O-methyltransferase (COMT) 7.6
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 7.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 7.4
 LDTP13352  GTP:AMP phosphotransferase AK3, mitochondrial (AK3) 7.4
 LDTP08064  ATP-dependent RNA helicase DHX29 (DHX29) 7.3
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 7.3
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 7.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.2
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 7.1
 LDTP00344  Stearoyl-CoA desaturase (SCD) 7.0
 LDTP00831  NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) 7.0
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 6.9
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 6.8
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 6.8
 LDTP07620  Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) 6.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 6.8
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 6.7
 LDTP01502  NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) 6.6
 LDTP01769  Dihydrofolate reductase (DHFR) 6.5
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 6.5
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 6.4
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 6.3
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) 6.3
 LDTP11733  Ras-related protein Rab-1B (RAB1B) 6.2
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 6.2
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 6.1
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 6.1
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 5.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 5.9
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 5.8
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 5.7
 LDTP13986  Vesicle transport protein GOT1B (GOLT1B) 5.7
 LDTP12197  Ethanolamine kinase 1 (ETNK1) 5.7
 LDTP07756  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) 5.7
 LDTP00837  Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) 5.7
 LDTP09251  Atlastin-2 (ATL2) 5.6
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 5.6
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 5.5
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 5.5
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 5.5
 LDTP00267  DNA-directed RNA polymerase, mitochondrial (POLRMT) 5.5
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 5.5
 LDTP01329  Lathosterol oxidase (SC5D) 5.4
 LDTP02643  Uracil-DNA glycosylase (UNG) 5.4
 LDTP06657  2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) 5.3
 LDTP13367  Glutathione hydrolase 7 (GGT7) 5.3
 LDTP13720  Ubiquitin carboxyl-terminal hydrolase 24 (USP24) 5.3
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.3
 LDTP06988  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) 5.2
 LDTP06511  Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) 5.2
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 5.2
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 5.2
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 5.2
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 5.2
Transporter and channel
Click to Show/Hide to Show 85 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01804  ATP synthase subunit a (MT-ATP6) 99.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 70.5
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 54.2
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 34.3
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 28.8
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 27.5
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 24.9
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 22.9
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 22.2
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 21.7
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 21.7
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 20.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 20.7
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 19.7
 LDTP20002  Transmembrane protein 160 (TMEM160) 19.6
 LDTP12383  Protein GPR108 (GPR108) 18.9
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 18.8
 LDTP07236  Protein GPR107 (GPR107) 18.8
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 18.4
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 18.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 18.1
 LDTP11245  Derlin-1 (DERL1) 18.0
 LDTP08881  Transmembrane protein 199 (TMEM199) 17.9
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 17.1
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 17.1
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 16.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 16.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 15.5
 LDTP10065  Transmembrane protein 230 (TMEM230) 15.1
 LDTP15481  Transmembrane protein 87A (TMEM87A) 14.1
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 13.9
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 13.7
 LDTP10036  BOS complex subunit NCLN (NCLN) 13.3
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 13.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 12.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 11.2
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 10.6
 LDTP03546  Translocator protein (TSPO) 10.4
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 10.3
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 9.7
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 9.7
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 9.4
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 9.3
 LDTP15648  BRI3-binding protein (BRI3BP) 8.9
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 8.9
 LDTP05900  Metaxin-1 (MTX1) 8.9
 LDTP00872  Peroxisomal membrane protein PMP34 (SLC25A17) 8.8
 LDTP04787  Transmembrane protein 33 (TMEM33) 8.7
 LDTP07467  Rhomboid domain-containing protein 2 (RHBDD2) 8.5
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 8.5
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 8.5
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.3
 LDTP13416  Stomatin-like protein 2, mitochondrial (STOML2) 8.3
 LDTP10663  Importin-9 (IPO9) 8.2
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 8.1
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 8.1
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 7.8
 LDTP13320  Prenylated Rab acceptor protein 1 (RABAC1) 7.8
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 7.6
 LDTP11626  Protein YIPF3 (YIPF3) 7.5
 LDTP01060  PRA1 family protein 2 (PRAF2) 7.3
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 7.3
 LDTP07477  Transmembrane protein 214 (TMEM214) 7.3
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 7.3
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 7.1
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 7.1
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 7.1
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 7.0
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 6.8
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 6.7
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 6.5
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 6.4
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 6.3
 LDTP05662  Cell division cycle protein 20 homolog (CDC20) 6.3
 LDTP12979  Transmembrane protein 14C (TMEM14C) 6.1
 LDTP11116  45 kDa calcium-binding protein (SDF4) 6.1
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 6.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 6.0
 LDTP11844  Protein spinster homolog 1 (SPNS1) 6.0
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 5.9
 LDTP07439  Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) 5.7
 LDTP07531  Sideroflexin-4 (SFXN4) 5.6
 LDTP07667  Transmembrane protein 205 (TMEM205) 5.3
 LDTP04213  Phosphatidylinositol transfer protein beta isoform (PITPNB) 5.3
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 5.2
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 7.7
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 8.9
Other
Click to Show/Hide to Show 69 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 66.3
 LDTP01522  Reticulon-3 (RTN3) 52.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 50.6
 LDTP13086  Syntaxin-18 (STX18) 40.5
 LDTP05160  Nucleobindin-2 (NUCB2) 34.3
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 27.5
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 23.6
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 21.9
 LDTP10056  Protein FAM162A (FAM162A) 18.9
 LDTP05375  Nucleobindin-1 (NUCB1) 18.8
 LDTP16006  Optic atrophy 3 protein (OPA3) 18.5
 LDTP12412  Reticulon-4 (RTN4) 16.6
 LDTP08224  Protein LYRIC (MTDH) 15.7
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 15.3
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 12.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 12.6
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 12.6
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 12.6
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 12.5
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 12.2
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 12.2
 LDTP19963  TraB domain-containing protein (TRABD) 11.8
 LDTP16080  Protein FAM114A2 (FAM114A2) 11.6
 LDTP00986  Syntaxin-10 (STX10) 11.3
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 11.1
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 10.9
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 10.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 10.1
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 9.9
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 9.6
 LDTP01494  Protein YIF1A (YIF1A) 8.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 8.5
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 8.3
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 7.9
 LDTP15623  Neuferricin (CYB5D2) 7.8
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 7.8
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 7.7
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 7.6
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 7.4
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 7.4
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 7.1
 LDTP10442  Thioredoxin domain-containing protein 15 (TXNDC15) 7.0
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 6.9
 LDTP04557  Arfaptin-2 (ARFIP2) 6.6
 LDTP10403  DDRGK domain-containing protein 1 (DDRGK1) 6.6
 LDTP12379  Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) 6.5
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 6.4
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 6.3
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 6.3
 LDTP15112  Mitochondrial fission regulator 2 (MTFR2) 6.2
 LDTP00859  Synaptogyrin-2 (SYNGR2) 6.1
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 6.1
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 6.0
 LDTP13410  Anaphase-promoting complex subunit 5 (ANAPC5) 5.9
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 5.9
 LDTP08594  Negative elongation factor C/D (NELFCD) 5.9
 LDTP04947  DDB1- and CUL4-associated factor 7 (DCAF7) 5.9
 LDTP14792  Small ribosomal subunit protein uS9m (MRPS9) 5.9
 LDTP10200  60S ribosomal export protein NMD3 (NMD3) 5.8
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 5.7
 LDTP05960  Trophoblast glycoprotein (TPBG) 5.7
 LDTP10046  Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) 5.6
 LDTP12287  Ran guanine nucleotide release factor (RANGRF) 5.6
 LDTP01652  Centrosomal protein 43 (CEP43) 5.6
 LDTP14058  Rap guanine nucleotide exchange factor 2 (RAPGEF2) 5.5
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 5.5
 LDTP08606  Nurim (NRM) 5.4
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 5.4
 LDTP02887  Transmembrane protein 11, mitochondrial (TMEM11) 5.3

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587