Details of the Target

General Information of Target

Target ID LDTP07467
Target Name Rhomboid domain-containing protein 2 (RHBDD2)
Gene Name RHBDD2
Gene ID 57414
Synonyms
RHBDL7; Rhomboid domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASGPGCRSWCLCPEVPSATFFTALLSLLVSGPRLFLLQQPLAPSGLTLKSEALRNWQV
YRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTVRHCFFTVIFAIFSAIIFLSFEAV
SSLSKLGEVEDARGFTPVAFAMLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQ
TSFLSNVCGLSIGLAYGLTYCYSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERR
AAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPA
SGLCYVQNHFGPNPTSSSVYPASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSR
VPMP
Target Bioclass
Transporter and channel
Family
Peptidase S54 family
Subcellular location
Golgi apparatus, cis-Golgi network membrane
Uniprot ID
Q6NTF9
Ensemble ID
ENST00000006777.11
HGNC ID
HGNC:23082

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
REH SNV: p.G173C .
TOV21G SNV: p.L194M .
VMRCRCW SNV: p.R9C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		7.84  LDD1733  [7]
C040
 Probe Info  		8.75  LDD1740  [7]
C091
 Probe Info  		16.80  LDD1782  [7]
C092
 Probe Info  		34.54  LDD1783  [7]
C094
 Probe Info  		45.25  LDD1785  [7]
C112
 Probe Info  		21.11  LDD1799  [7]
C134
 Probe Info  		23.92  LDD1816  [7]
C159
 Probe Info  		7.62  LDD1839  [7]
C161
 Probe Info  		10.56  LDD1841  [7]
C169
 Probe Info  		23.75  LDD1849  [7]
C201
 Probe Info  		25.28  LDD1877  [7]
C218
 Probe Info  		30.06  LDD1892  [7]
C219
 Probe Info  		8.11  LDD1893  [7]
C220
 Probe Info  		30.06  LDD1894  [7]
C231
 Probe Info  		19.97  LDD1904  [7]
C232
 Probe Info  		34.78  LDD1905  [7]
C235
 Probe Info  		30.27  LDD1908  [7]
C243
 Probe Info  		11.47  LDD1916  [7]
C246
 Probe Info  		19.70  LDD1919  [7]
C278
 Probe Info  		92.41  LDD1948  [7]
C282
 Probe Info  		14.12  LDD1952  [7]
C362
 Probe Info  		67.18  LDD2023  [7]
C363
 Probe Info  		16.91  LDD2024  [7]
C364
 Probe Info  		17.88  LDD2025  [7]
C366
 Probe Info  		8.51  LDD2027  [7]
C367
 Probe Info  		5.74  LDD2028  [7]
C388
 Probe Info  		44.02  LDD2047  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0628  OTUB2-COV-1 HEK-293T C8(0.70)  LDD2207  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) ATP-dependent AMP-binding enzyme family Q96CM8
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
Amine oxidase [flavin-containing] B (MAOB) Flavin monoamine oxidase family P27338
Dimethylaniline monooxygenase [N-oxide-forming] 4 (FMO4) FMO family P31512
Galactose-3-O-sulfotransferase 3 (GAL3ST3) Galactose-3-O-sulfotransferase family Q96A11
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Ubiquitin carboxyl-terminal hydrolase 30 (USP30) Peptidase C19 family Q70CQ3
N-acetylated-alpha-linked acidic dipeptidase 2 (NAALAD2) Peptidase M28 family Q9Y3Q0
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2) RSAD2 family Q8WXG1
Pre-rRNA-processing protein TSR1 homolog (TSR1) Bms1-like GTPase family Q2NL82
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 1 (BCL2L1) Bcl-2 family Q07817
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD) CybS family O14521
Reactive oxygen species modulator 1 (ROMO1) MGR2 family P60602
Mitochondrial ornithine transporter 2 (SLC25A2) Mitochondrial carrier (TC 2.A.29) family Q9BXI2
Mitochondrial pyruvate carrier 2 (MPC2) Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family O95563
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) Tim17/Tim22/Tim23 family O60830
LETM1 domain-containing protein 1 (LETMD1) . Q6P1Q0
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Glycine cleavage system H protein, mitochondrial (GCSH) GcvH family P23434
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Histone H2B type 1-B (H2BC3) Histone H2B family P33778
Histone H4-like protein type G (H4C7) Histone H4 family Q99525
Interferon alpha-inducible protein 27-like protein 1 (IFI27L1) IFI6/IFI27 family Q96BM0
Major facilitator superfamily domain-containing 14C pseudogene (MFSD14CP) Major facilitator superfamily Q5VZR4
MICOS complex subunit MIC13 (MICOS13) MICOS complex subunit Mic13 family Q5XKP0
Cytosolic iron-sulfur assembly component 2A (CIAO2A) MIP18 family Q9H5X1
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) NifU family Q9UMS0
Nurim (NRM) Nurim family Q8IXM6
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
Secretoglobin family 3A member 1 (SCGB3A1) Secretoglobin family Q96QR1
Serpin H1 (SERPINH1) Serpin family P50454
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
Tumor protein p63-regulated gene 1 protein (TPRG1) TPRG1 family Q6ZUI0
Collagen alpha-1(VIII) chain (COL8A1) . P27658
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
Interleukin-32 (IL32) . P24001
Multimerin-2 (MMRN2) . Q9H8L6
Protein GDF5-AS1, mitochondrial (GDF5-AS1) . Q5U4N7
Protein NCBP2AS2 (NCBP2AS2) . Q69YL0
RING finger protein 11 (RNF11) . Q9Y3C5
Syntaphilin (SNPH) . O15079
Testis-expressed protein 44 (TEX44) . Q53QW1
Thrombomodulin (THBD) . P07204

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.