Details of the Target

General Information of Target

Target ID LDTP13922
Target Name Tudor and KH domain-containing protein (TDRKH)
Gene Name TDRKH
Gene ID 11022
Synonyms
TDRD2; Tudor and KH domain-containing protein; Tudor domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLQQPGPRPGRQQPSGDRDACRLHPQGRPPALPTMIPAASSTPPGDALFPSVAPQDFWRS
QVTGYSGSVTRHLSHRANNFKRHPKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRE
LLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDR
CTSRFGRRRPFILVLAIGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFS
ADSADNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQL
RVIYLFTAVTLSVTTVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSL
PSHTATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHD
SYLAIPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPR
SSGILKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQP
LSVGRLCSTICNMPKALRTLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAY
QKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRN
LYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFL
AQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIYEIPPSDAADEEHRPLLL
NV
Target Bioclass
Other
Family
Tdrkh family
Subcellular location
Cytoplasm
Function
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Uniprot ID
Q9Y2W6
Ensemble ID
ENST00000368822.5
HGNC ID
HGNC:11713

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBPP2
 Probe Info  		2.54  LDD0318  [2]
STPyne
 Probe Info  		K112(10.00)  LDD0277  [3]
DA-P3
 Probe Info  		13.97  LDD0179  [4]
AHL-Pu-1
 Probe Info  		C109(2.09)  LDD0171  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
DBIA
 Probe Info  		C109(1.15)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C419(0.00); C160(0.00); C109(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C445(0.00); C160(0.00); C419(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C160(0.00); C419(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
Compound 10
 Probe Info  		C109(0.00); C160(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		C109(0.00); C160(0.00)  LDD2213  [12]
IPM
 Probe Info  		N.A.  LDD0005  [11]
Phosphinate-6
 Probe Info  		C160(0.00); C109(0.00); C540(0.00)  LDD0018  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		14.80  LDD0443  [16]
NAIA_5
 Probe Info  		C419(0.00); C445(0.00); C397(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C002
 Probe Info  		4.96  LDD1712  [17]
C004
 Probe Info  		12.55  LDD1714  [17]
C027
 Probe Info  		5.39  LDD1733  [17]
C049
 Probe Info  		6.73  LDD1747  [17]
C196
 Probe Info  		10.20  LDD1872  [17]
C208
 Probe Info  		5.17  LDD1883  [17]
C210
 Probe Info  		62.68  LDD1884  [17]
C213
 Probe Info  		14.42  LDD1887  [17]
C218
 Probe Info  		12.13  LDD1892  [17]
C228
 Probe Info  		21.11  LDD1901  [17]
C231
 Probe Info  		12.47  LDD1904  [17]
C232
 Probe Info  		48.17  LDD1905  [17]
C249
 Probe Info  		14.03  LDD1922  [17]
C277
 Probe Info  		7.94  LDD1947  [17]
C285
 Probe Info  		27.47  LDD1955  [17]
C287
 Probe Info  		10.93  LDD1957  [17]
C288
 Probe Info  		7.94  LDD1958  [17]
C289
 Probe Info  		54.19  LDD1959  [17]
C290
 Probe Info  		4.99  LDD1960  [17]
C296
 Probe Info  		14.62  LDD1966  [17]
C302
 Probe Info  		10.27  LDD1971  [17]
C310
 Probe Info  		10.78  LDD1977  [17]
C313
 Probe Info  		12.13  LDD1980  [17]
C314
 Probe Info  		11.79  LDD1981  [17]
C322
 Probe Info  		5.66  LDD1988  [17]
C346
 Probe Info  		18.38  LDD2007  [17]
C362
 Probe Info  		46.53  LDD2023  [17]
C363
 Probe Info  		23.92  LDD2024  [17]
C364
 Probe Info  		29.86  LDD2025  [17]
C366
 Probe Info  		5.94  LDD2027  [17]
C367
 Probe Info  		7.01  LDD2028  [17]
C382
 Probe Info  		9.51  LDD2041  [17]
C407
 Probe Info  		15.67  LDD2064  [17]
FFF probe11
 Probe Info  		20.00  LDD0471  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
FFF probe2
 Probe Info  		18.13  LDD0463  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C109(2.09)  LDD0171  [5]
 LDCM0214  AC1 PaTu 8988t C109(1.23)  LDD1093  [7]
 LDCM0215  AC10 PaTu 8988t C109(1.36)  LDD1094  [7]
 LDCM0216  AC100 HEK-293T C419(1.00)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C419(0.86)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C419(0.89)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C419(0.89)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C419(0.77)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C419(0.94)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C419(0.94)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C419(1.11)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C419(1.01)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C419(0.98)  LDD0823  [7]
 LDCM0226  AC11 PaTu 8988t C109(1.48)  LDD1105  [7]
 LDCM0227  AC110 HEK-293T C419(0.98)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C419(1.14)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C419(1.08)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C419(0.98)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C419(0.97)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C419(0.86)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C419(0.92)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C419(0.85)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C419(0.82)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C419(0.83)  LDD0834  [7]
 LDCM0237  AC12 PaTu 8988t C109(1.40)  LDD1116  [7]
 LDCM0238  AC120 HEK-293T C419(0.79)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C419(0.75)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C419(0.79)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C419(0.95)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C419(0.85)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C419(0.83)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C419(0.92)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C419(1.05)  LDD0843  [7]
 LDCM0246  AC128 HEK-293T C419(0.92)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C419(0.75)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C419(0.85)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C419(1.07)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C419(1.27)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C419(0.86)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C419(1.16)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C419(1.14)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C419(1.09)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C419(0.87)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C419(0.95)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C419(0.96)  LDD0856  [7]
 LDCM0259  AC14 PaTu 8988t C109(1.26)  LDD1138  [7]
 LDCM0260  AC140 HEK-293T C419(1.01)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C419(1.10)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C419(0.90)  LDD0860  [7]
 LDCM0263  AC143 PaTu 8988t C419(0.92)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C419(0.64)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C419(0.64)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C419(0.81)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C419(0.74)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C419(0.70)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C419(0.69)  LDD1148  [7]
 LDCM0270  AC15 PaTu 8988t C109(1.20)  LDD1149  [7]
 LDCM0271  AC150 PaTu 8988t C419(0.69)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C419(0.89)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C419(0.79)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C419(0.91)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C419(0.71)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C419(0.62)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C419(1.03)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C419(0.65)  LDD2169  [7]
 LDCM0276  AC17 PaTu 8988t C109(1.21); C419(0.84)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C109(1.57); C419(0.67)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C109(1.22); C419(0.74)  LDD1157  [7]
 LDCM0279  AC2 PaTu 8988t C109(0.82)  LDD1158  [7]
 LDCM0280  AC20 PaTu 8988t C109(1.32); C419(1.03)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C109(1.51); C419(0.86)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C109(1.66); C419(0.86)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C109(1.85); C419(0.76)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C109(1.34); C419(0.85)  LDD1163  [7]
 LDCM0285  AC25 PaTu 8988t C109(0.81)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C109(0.98)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C109(1.23)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C109(1.13)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C109(1.17)  LDD1168  [7]
 LDCM0290  AC3 PaTu 8988t C109(1.08)  LDD1169  [7]
 LDCM0291  AC30 PaTu 8988t C109(1.04)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C109(0.83)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C109(1.01)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C109(1.08)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C109(1.23)  LDD1174  [7]
 LDCM0296  AC35 PaTu 8988t C109(1.20); C419(0.97)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C109(1.52); C419(0.98)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C109(1.44); C419(0.85)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C109(1.37); C419(0.99)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C109(1.65); C419(0.80)  LDD1179  [7]
 LDCM0301  AC4 PaTu 8988t C109(0.88)  LDD1180  [7]
 LDCM0302  AC40 PaTu 8988t C109(1.88); C419(0.93)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C109(1.38); C419(0.80)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C109(1.57); C419(0.80)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C109(1.39); C419(0.97)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C109(1.73); C419(0.85)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C109(1.56); C419(0.91)  LDD1186  [7]
 LDCM0308  AC46 PaTu 8988t C109(1.34)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C109(1.24)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C109(1.30)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C109(1.98)  LDD1190  [7]
 LDCM0312  AC5 PaTu 8988t C109(1.15)  LDD1191  [7]
 LDCM0313  AC50 PaTu 8988t C109(2.25)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C109(6.02)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C109(1.66)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C109(3.22)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C109(2.30)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C109(1.38)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C109(1.71)  LDD1198  [7]
 LDCM0320  AC57 PaTu 8988t C109(1.28)  LDD1199  [7]
 LDCM0321  AC58 PaTu 8988t C109(1.18)  LDD1200  [7]
 LDCM0322  AC59 PaTu 8988t C109(1.15)  LDD1201  [7]
 LDCM0323  AC6 PaTu 8988t C109(1.07)  LDD1202  [7]
 LDCM0324  AC60 PaTu 8988t C109(1.28)  LDD1203  [7]
 LDCM0325  AC61 PaTu 8988t C109(1.08)  LDD1204  [7]
 LDCM0326  AC62 PaTu 8988t C109(1.14)  LDD1205  [7]
 LDCM0327  AC63 PaTu 8988t C109(1.20)  LDD1206  [7]
 LDCM0328  AC64 PaTu 8988t C109(1.01)  LDD1207  [7]
 LDCM0329  AC65 PaTu 8988t C109(0.93)  LDD1208  [7]
 LDCM0330  AC66 PaTu 8988t C109(1.04)  LDD1209  [7]
 LDCM0331  AC67 PaTu 8988t C109(0.98)  LDD1210  [7]
 LDCM0332  AC68 PaTu 8988t C109(0.90); C419(1.04)  LDD1211  [7]
 LDCM0333  AC69 PaTu 8988t C109(1.11); C419(0.99)  LDD1212  [7]
 LDCM0334  AC7 PaTu 8988t C109(1.09)  LDD1213  [7]
 LDCM0335  AC70 PaTu 8988t C109(1.01); C419(0.87)  LDD1214  [7]
 LDCM0336  AC71 PaTu 8988t C109(0.86); C419(0.94)  LDD1215  [7]
 LDCM0337  AC72 PaTu 8988t C109(0.89); C419(1.14)  LDD1216  [7]
 LDCM0338  AC73 PaTu 8988t C109(0.95); C419(1.04)  LDD1217  [7]
 LDCM0339  AC74 PaTu 8988t C109(0.93); C419(1.07)  LDD1218  [7]
 LDCM0340  AC75 PaTu 8988t C109(1.10); C419(1.05)  LDD1219  [7]
 LDCM0341  AC76 PaTu 8988t C109(0.97); C419(1.03)  LDD1220  [7]
 LDCM0342  AC77 PaTu 8988t C109(0.92); C419(1.09)  LDD1221  [7]
 LDCM0343  AC78 PaTu 8988t C109(1.03); C419(0.81)  LDD1222  [7]
 LDCM0344  AC79 PaTu 8988t C109(0.99); C419(0.84)  LDD1223  [7]
 LDCM0345  AC8 PaTu 8988t C109(0.91)  LDD1224  [7]
 LDCM0346  AC80 PaTu 8988t C109(1.02); C419(1.00)  LDD1225  [7]
 LDCM0347  AC81 PaTu 8988t C109(1.10); C419(0.93)  LDD1226  [7]
 LDCM0348  AC82 PaTu 8988t C109(1.01); C419(0.87)  LDD1227  [7]
 LDCM0349  AC83 PaTu 8988t C109(0.89)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C109(0.90)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C109(0.82)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C109(0.89)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C109(0.73)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C109(0.89)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C109(0.87)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C109(0.90)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C109(0.86)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C109(0.89)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C109(0.76)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C109(0.89)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C109(0.91)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C109(0.84)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C109(0.93)  LDD1243  [7]
 LDCM0365  AC98 HEK-293T C419(0.86)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C419(0.92)  LDD0964  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C109(1.25)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C109(1.46)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C109(1.38)  LDD1154  [7]
 LDCM0156  Aniline NCI-H1299 12.81  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C109(1.15)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C109(0.81); C160(0.45)  LDD2227  [10]
 LDCM0367  CL1 PaTu 8988t C109(1.04)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C109(1.68)  LDD1247  [7]
 LDCM0369  CL100 PaTu 8988t C109(0.87)  LDD1248  [7]
 LDCM0370  CL101 PaTu 8988t C109(1.34)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C109(1.54)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C109(1.72)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C109(1.33)  LDD1252  [7]
 LDCM0374  CL105 PaTu 8988t C109(1.31); C419(0.81)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C109(1.22); C419(0.75)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C109(1.13); C419(0.67)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C109(1.32); C419(0.70)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C109(1.48); C419(0.64)  LDD1257  [7]
 LDCM0379  CL11 PaTu 8988t C109(1.00)  LDD1258  [7]
 LDCM0380  CL110 PaTu 8988t C109(1.73); C419(0.84)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C109(2.07); C419(0.82)  LDD1260  [7]
 LDCM0382  CL112 PaTu 8988t C109(1.27)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C109(0.89)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C109(1.29)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C109(1.01)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C109(0.88)  LDD1265  [7]
 LDCM0387  CL117 PaTu 8988t C109(1.38); C419(0.87)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C109(1.17); C419(1.04)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C109(1.47); C419(0.86)  LDD1268  [7]
 LDCM0390  CL12 PaTu 8988t C109(1.36)  LDD1269  [7]
 LDCM0391  CL120 PaTu 8988t C109(1.44); C419(0.70)  LDD1270  [7]
 LDCM0392  CL121 PaTu 8988t C109(1.39)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C109(1.84)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C109(1.95)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C109(2.03)  LDD1274  [7]
 LDCM0396  CL125 PaTu 8988t C109(1.15)  LDD1275  [7]
 LDCM0397  CL126 PaTu 8988t C109(1.03)  LDD1276  [7]
 LDCM0398  CL127 PaTu 8988t C109(1.20)  LDD1277  [7]
 LDCM0399  CL128 PaTu 8988t C109(1.11)  LDD1278  [7]
 LDCM0400  CL13 PaTu 8988t C109(2.32)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C109(2.46)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C109(1.96)  LDD1281  [7]
 LDCM0403  CL16 HEK-293T C419(0.89)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C419(0.99)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C419(0.92)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C419(1.05)  LDD1004  [7]
 LDCM0407  CL2 PaTu 8988t C109(1.07)  LDD1286  [7]
 LDCM0408  CL20 HEK-293T C419(1.05)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C419(1.02)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C419(0.97)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C419(1.27)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C419(0.99)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C419(0.93)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C419(1.03)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C419(1.02)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C419(1.04)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C419(1.16)  LDD1015  [7]
 LDCM0418  CL3 PaTu 8988t C109(1.04)  LDD1297  [7]
 LDCM0419  CL30 HEK-293T C419(1.04)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C419(0.83)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C419(0.95)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C419(0.96)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C419(1.00)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C419(0.83)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C419(0.92)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C419(0.99)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C419(0.89)  LDD1026  [7]
 LDCM0429  CL4 PaTu 8988t C109(1.18)  LDD1308  [7]
 LDCM0430  CL40 HEK-293T C419(0.92)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C419(0.91)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C419(0.92)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C419(0.91)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C419(0.96)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C419(0.94)  LDD1033  [7]
 LDCM0436  CL46 PaTu 8988t C109(1.10)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C109(1.07)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C109(1.05)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C109(1.13)  LDD1318  [7]
 LDCM0440  CL5 PaTu 8988t C109(1.79)  LDD1319  [7]
 LDCM0441  CL50 PaTu 8988t C109(1.24)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C109(1.33)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C109(1.17)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C109(1.34)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C109(1.08)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C109(1.12)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C109(0.64)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C109(1.86)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C109(1.33)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C109(1.70)  LDD1329  [7]
 LDCM0451  CL6 PaTu 8988t C109(1.76)  LDD1330  [7]
 LDCM0452  CL60 PaTu 8988t C109(1.42)  LDD1331  [7]
 LDCM0453  CL61 HEK-293T C419(0.86)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C419(0.84)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C419(0.80)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C419(0.77)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C419(1.26)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C419(0.82)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C419(0.99)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C419(1.01)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C419(1.13)  LDD1059  [7]
 LDCM0462  CL7 PaTu 8988t C109(1.83)  LDD1341  [7]
 LDCM0463  CL70 HEK-293T C419(1.30)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C419(0.93)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C419(0.82)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C419(1.15)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C419(0.81)  LDD1065  [7]
 LDCM0469  CL76 PaTu 8988t C109(0.97)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C109(1.45)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C109(1.38)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C109(1.60)  LDD1351  [7]
 LDCM0473  CL8 PaTu 8988t C109(1.84)  LDD1352  [7]
 LDCM0474  CL80 PaTu 8988t C109(1.27)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C109(1.42)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C109(1.35)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C109(1.39)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C109(1.30)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C109(1.36)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C109(1.52)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C109(1.44)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C109(1.67)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C109(1.25)  LDD1362  [7]
 LDCM0484  CL9 PaTu 8988t C109(1.64)  LDD1363  [7]
 LDCM0485  CL90 PaTu 8988t C109(2.01)  LDD1364  [7]
 LDCM0486  CL91 PaTu 8988t C109(0.74)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C109(0.81)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C109(0.74)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C109(0.76)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C109(3.60)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C109(0.79)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C109(0.83)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C109(1.04)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C109(0.87)  LDD1373  [7]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C109(8.27)  LDD0513  [19]
 LDCM0028  Dobutamine HEK-293T 5.69  LDD0180  [4]
 LDCM0027  Dopamine HEK-293T 13.97  LDD0179  [4]
 LDCM0495  E2913 HEK-293T C109(0.92); C419(0.98); C397(0.90)  LDD1698  [20]
 LDCM0468  Fragment33 HEK-293T C419(0.86)  LDD1066  [7]
 LDCM0427  Fragment51 HEK-293T C419(1.05)  LDD1025  [7]
 LDCM0022  KB02 HCT 116 C109(4.56)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C109(4.43)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C109(13.10)  LDD0082  [7]
 LDCM0029  Quercetin HEK-293T 5.25  LDD0181  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 90 homolog (ZFP90) Krueppel C2H2-type zinc-finger protein family Q8TF47
Zinc finger and BTB domain-containing protein 34 (ZBTB34) . Q8NCN2
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM25C (FAM25C) FAM25 family B3EWG5
LanC-like protein 2 (LANCL2) LanC-like protein family Q9NS86
U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25) . Q9BV90

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402