Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C290  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 84 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 40.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 25.6
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 21.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 19.7
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 19.6
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 16.3
 LDTP12197  Ethanolamine kinase 1 (ETNK1) 15.7
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 15.7
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 15.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 15.0
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 14.3
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 14.2
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 13.3
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 13.0
 LDTP04032  Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) 12.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 12.0
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 12.0
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 11.9
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 11.7
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 11.5
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 11.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 11.1
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 10.6
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 10.3
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 10.3
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 10.3
 LDTP00988  Protein O-GlcNAcase (OGA) 10.1
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 10.1
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 9.8
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 9.6
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 9.4
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 9.2
 LDTP10329  Ceramide synthase 2 (CERS2) 9.1
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 9.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.9
 LDTP06849  Prolyl endopeptidase-like (PREPL) 8.9
 LDTP04093  Translation initiation factor IF-2, mitochondrial (MTIF2) 8.6
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 8.5
 LDTP13751  Exonuclease 1 (EXO1) 8.4
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 8.3
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 8.2
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 8.2
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 8.1
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 8.1
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 8.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 7.8
 LDTP04183  Lanosterol synthase (LSS) 7.7
 LDTP12233  Helicase MOV-10 (MOV10) 7.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 7.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 7.0
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 6.9
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 6.8
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 6.8
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 6.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 6.5
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 6.5
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 6.4
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 6.2
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 6.1
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 6.1
 LDTP01769  Dihydrofolate reductase (DHFR) 6.1
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 6.1
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 6.1
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 6.1
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 6.0
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 6.0
 LDTP11127  ADP-dependent glucokinase (ADPGK) 6.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 6.0
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 5.7
 LDTP07259  N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) 5.7
 LDTP05408  Antigen peptide transporter 1 (TAP1) 5.7
 LDTP08687  tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) 5.7
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 5.7
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 5.6
 LDTP04253  Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) 5.4
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 5.3
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.2
 LDTP05369  Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) 5.0
 LDTP03001  E3 ubiquitin-protein ligase TRIM21 (TRIM21) 5.0
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 5.0
 LDTP06986  Rab-like protein 3 (RABL3) 5.0
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 5.0
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 5.0
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 5.0
Transporter and channel
Click to Show/Hide to Show 61 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 24.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 23.3
 LDTP01804  ATP synthase subunit a (MT-ATP6) 21.3
 LDTP07236  Protein GPR107 (GPR107) 21.1
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 21.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 16.3
 LDTP20002  Transmembrane protein 160 (TMEM160) 15.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 15.0
 LDTP15948  Transmembrane protein 126A (TMEM126A) 14.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 13.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 12.1
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 12.0
 LDTP05900  Metaxin-1 (MTX1) 11.6
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 11.5
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 11.5
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 11.1
 LDTP15481  Transmembrane protein 87A (TMEM87A) 10.6
 LDTP03546  Translocator protein (TSPO) 10.2
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 9.8
 LDTP16163  Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (COX16) 9.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 9.2
 LDTP12383  Protein GPR108 (GPR108) 8.9
 LDTP08881  Transmembrane protein 199 (TMEM199) 8.8
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 8.1
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 8.0
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 7.6
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 7.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.5
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 7.4
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 7.4
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 7.3
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 7.1
 LDTP08673  Calcium uptake protein 2, mitochondrial (MICU2) 6.9
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 6.8
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 6.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 6.7
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 6.7
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 6.5
 LDTP15648  BRI3-binding protein (BRI3BP) 6.5
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 6.4
 LDTP11213  Nucleoporin NDC1 (NDC1) 6.1
 LDTP01160  Peroxisomal membrane protein 11A (PEX11A) 6.1
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 6.1
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 6.1
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 5.9
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 5.9
 LDTP11041  Calcium uptake protein 1, mitochondrial (MICU1) 5.8
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 5.7
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 5.5
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 5.4
 LDTP11245  Derlin-1 (DERL1) 5.3
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 5.3
 LDTP11812  Protein ARV1 (ARV1) 5.3
 LDTP11844  Protein spinster homolog 1 (SPNS1) 5.2
 LDTP07667  Transmembrane protein 205 (TMEM205) 5.2
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 5.2
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 5.1
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 5.1
 LDTP16813  Tetraspanin-3 (TSPAN3) 5.1
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 4.9
 LDTP11626  Protein YIPF3 (YIPF3) 4.9
Other
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 18.6
 LDTP16006  Optic atrophy 3 protein (OPA3) 17.0
 LDTP10381  Peroxisomal membrane protein 11C (PEX11G) 16.6
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 15.2
 LDTP00105  Protein unc-119 homolog B (UNC119B) 14.9
 LDTP08000  Dymeclin (DYM) 14.7
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 14.1
 LDTP08081  Hepatoma-derived growth factor-related protein 2 (HDGFL2) 11.6
 LDTP10184  HAUS augmin-like complex subunit 1 (HAUS1) 11.3
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 9.1
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 9.1
 LDTP01522  Reticulon-3 (RTN3) 8.6
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 8.6
 LDTP13214  UPF0449 protein C19orf25 (C19orf25) 8.6
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 8.5
 LDTP05375  Nucleobindin-1 (NUCB1) 8.0
 LDTP01075  Protein CutA (CUTA) 7.7
 LDTP16080  Protein FAM114A2 (FAM114A2) 7.7
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 7.7
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 7.3
 LDTP15714  Mdm2-binding protein (MTBP) 7.1
 LDTP12746  Gem-associated protein 8 (GEMIN8) 7.1
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 6.9
 LDTP11076  Apolipoprotein L2 (APOL2) 6.7
 LDTP11871  Cobalamin trafficking protein CblD (MMADHC) 6.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 6.2
 LDTP06948  Protein YIF1B (YIF1B) 6.2
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 6.1
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 6.0
 LDTP04483  Hepatoma-derived growth factor (HDGF) 5.9
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 5.9
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 5.8
 LDTP06097  Reticulocalbin-2 (RCN2) 5.8
 LDTP01652  Centrosomal protein 43 (CEP43) 5.5
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 5.5
 LDTP02345  Retinol-binding protein 1 (RBP1) 5.4
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 5.4
 LDTP09970  RNA-binding protein with multiple splicing (RBPMS) 5.1
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 5.1
 LDTP10116  Lipid droplet assembly factor 1 (LDAF1) 5.0
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 5.0
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 5.0
 LDTP15623  Neuferricin (CYB5D2) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587