Details of the Target

General Information of Target

Target ID LDTP04093
Target Name Translation initiation factor IF-2, mitochondrial (MTIF2)
Gene Name MTIF2
Gene ID 4528
Synonyms
Translation initiation factor IF-2, mitochondrial; IF-2(Mt); IF-2Mt; IF2(mt)
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTG
AALSQYRLLVTKKEEGPWKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTDYVYEALLNT
DIDIDSLEADSHLDEVWIKEVITKAGMKLKWSKLKQDKVRKNKDAVRRPQADPALLTPRS
PVVTIMGHVDHGKTTLLDKFRKTQVAAVETGGITQHIGAFLVSLPSGEKITFLDTPGHAA
FSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQHAKDAQVPIILAVNKCDKAEADPEKV
KKELLAYDVVCEDYGGDVQAVPVSALTGDNLMALAEATVALAEMLELKADPNGPVEGTVI
ESFTDKGRGLVTTAIIQRGTLRKGSVLVAGKCWAKVRLMFDENGKTIDEAYPSMPVGITG
WRDLPSAGEEILEVESEPRAREVVDWRKYEQEQEKGQEDLKIIEEKRKEHKEAHQKAREK
YGHLLWKKRSILRFLERKEQIPLKPKEKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDA
SHECELELVHFGVGDVSANDVNLAETFDGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIY
RLVEDLQEELSSRLPCAVEEHPVGEASILATFSVTEGKKKVPVAGCRVQKGQLEKQKKFK
LTRNGHVIWKGSLTSLKHHKDDISIVKTGMDCGLSLDEDNMEFQVGDRIVCYEEKQIQAK
TSWDPGF
Target Bioclass
Enzyme
Family
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, IF-2 subfamily
Subcellular location
Mitochondrion
Function
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Uniprot ID
P46199
Ensemble ID
ENST00000263629.9
HGNC ID
HGNC:7441

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K199(1.23); K680(5.00)  LDD0277  [1]
BTD
 Probe Info  		C646(1.20)  LDD1699  [2]
Probe 1
 Probe Info  		Y449(21.89)  LDD3495  [3]
m-APA
 Probe Info  		11.48  LDD0403  [4]
IPM
 Probe Info  		C646(2.28)  LDD1701  [2]
DBIA
 Probe Info  		C646(1.07)  LDD0547  [5]
ATP probe
 Probe Info  		K715(0.00); K720(0.00)  LDD0199  [6]
IA-alkyne
 Probe Info  		C290(0.00); C711(0.00)  LDD0162  [7]
TFBX
 Probe Info  		C290(0.00); C646(0.00)  LDD0148  [8]
Phosphinate-6
 Probe Info  		C616(0.00); C290(0.00)  LDD0018  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
NAIA_5
 Probe Info  		C290(0.00); C646(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		9.78  LDD1868  [12]
C290
 Probe Info  		8.57  LDD1960  [12]
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C646(0.96); C290(1.63)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C646(0.92)  LDD2112  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C290(0.87)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C646(1.12)  LDD2152  [2]
 LDCM0214  AC1 HEK-293T C646(0.95); C616(1.12); C711(0.93)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C646(1.08); C616(1.05)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C646(1.33); C616(1.03)  LDD1509  [14]
 LDCM0230  AC113 HCT 116 C646(1.07)  LDD0547  [5]
 LDCM0231  AC114 PaTu 8988t C646(1.10)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C646(1.39)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C646(1.18)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C646(1.21)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C646(0.92)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C646(0.75)  LDD1115  [5]
 LDCM0237  AC12 HEK-293T C646(0.97); C616(0.98); C711(0.96)  LDD1510  [14]
 LDCM0238  AC120 PaTu 8988t C646(0.89)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C646(0.71)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C646(1.27)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C646(0.88)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C646(0.60)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C646(0.98)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C646(0.90)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C646(0.77)  LDD1124  [5]
 LDCM0246  AC128 HCT 116 C646(1.01)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C646(1.13)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C646(1.07)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C646(0.99)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C646(0.73)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C646(0.72)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C646(0.37)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C646(0.48)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C646(0.37)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C646(0.35)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C646(0.21)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C646(0.27)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C646(0.99); C616(0.99); C711(1.03)  LDD1512  [14]
 LDCM0260  AC140 HCT 116 C646(0.24)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C646(0.24)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C646(0.33)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C646(0.55)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C646(0.23)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C646(0.38)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C646(0.36)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C646(0.22)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C646(0.20)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C646(0.25)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C646(1.00); C616(0.89)  LDD1513  [14]
 LDCM0271  AC150 HCT 116 C646(0.51)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C646(0.43)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C646(0.19)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C646(0.16)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C646(0.32)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C646(0.34)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C646(0.84)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C646(0.61)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C646(0.92); C616(1.12); C711(0.96)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C646(1.08); C616(0.94)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C646(0.91); C616(0.89)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C646(1.03); C616(1.01)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C646(1.01); C616(1.00); C711(1.04)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C646(1.03); C616(0.97); C711(1.19)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C646(1.07); C616(1.05); C711(1.06)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C646(1.00); C616(1.03)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C646(1.03); C616(1.00); C711(0.96)  LDD1523  [14]
 LDCM0285  AC25 HCT 116 C646(0.55)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C646(0.38)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C646(0.32)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C646(0.34)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C646(0.37)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C646(1.10); C616(1.00)  LDD1529  [14]
 LDCM0291  AC30 HCT 116 C646(0.37)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C646(0.41)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C646(0.24)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C646(0.25)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C646(0.23)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C646(0.97); C616(1.04)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C646(0.98); C616(1.02); C711(0.98)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C646(1.12); C616(1.03); C711(1.48)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C646(1.00); C616(0.98); C711(1.13)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C646(1.05); C616(0.96)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C646(1.03); C616(1.03); C711(1.02)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C646(1.03); C616(1.00); C711(1.05)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C646(0.95); C616(1.00); C711(1.12)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C646(1.06); C616(0.91)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C646(1.09); C616(1.04)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C646(0.99); C616(1.03); C711(1.12)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C646(1.05); C616(0.98); C711(1.25)  LDD1546  [14]
 LDCM0308  AC46 PaTu 8988t C646(0.61)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C646(0.63)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C646(0.45)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C646(0.29)  LDD1190  [5]
 LDCM0312  AC5 HEK-293T C646(1.12); C616(1.01); C711(1.26)  LDD1551  [14]
 LDCM0313  AC50 PaTu 8988t C646(0.26)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C646(0.16)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C646(0.40)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C646(0.22)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C646(0.25)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C646(0.63)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C646(0.31)  LDD1198  [5]
 LDCM0320  AC57 HEK-293T C646(0.94); C616(1.09); C711(0.91)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C646(1.07); C616(0.96)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C646(0.94); C616(0.95)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C646(1.02); C616(1.05); C711(1.07)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C646(0.96); C616(1.03); C711(0.97)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C646(1.06); C616(1.00); C711(1.31)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C646(1.02); C616(0.98); C711(1.18)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C646(1.04); C616(1.05)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C646(1.09); C616(1.00); C711(1.04)  LDD1567  [14]
 LDCM0332  AC68 HCT 116 C646(0.80)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C646(0.69)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C646(1.05); C616(0.92)  LDD1568  [14]
 LDCM0335  AC70 HCT 116 C646(0.57)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C646(0.99)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C646(0.71)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C646(0.55)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C646(0.55)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C646(0.56)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C646(0.55)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C646(0.60)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C646(0.92)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C646(0.97)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C646(1.10); C616(0.96); C711(1.01)  LDD1569  [14]
 LDCM0346  AC80 HCT 116 C646(0.68)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C646(1.56)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C646(0.78)  LDD0665  [5]
 LDCM0349  AC83 PaTu 8988t C646(1.28)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C646(1.35)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C646(1.45)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C646(1.31)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C646(1.71)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C646(1.74)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C646(1.36)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C646(1.81)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C646(1.86)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C646(1.10)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C646(2.14)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C646(1.87)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C646(1.49)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C646(2.29)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C646(1.82)  LDD1243  [5]
 LDCM0545  Acetamide MDA-MB-231 C646(0.41)  LDD2138  [2]
 LDCM0248  AKOS034007472 HEK-293T C646(1.08); C616(1.01); C711(1.16)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C646(0.90); C616(0.97); C711(1.09)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C646(1.05); C616(1.02); C711(1.04)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 11.48  LDD0403  [4]
 LDCM0498  BS-3668 MDA-MB-231 C646(0.52)  LDD2091  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C290(1.03)  LDD2227  [11]
 LDCM0367  CL1 PaTu 8988t C646(1.02)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C646(0.32)  LDD1247  [5]
 LDCM0369  CL100 HEK-293T C646(0.98); C616(0.99); C711(1.03)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C646(1.08); C616(0.95)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C646(0.93); C616(0.86)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C646(0.98); C616(1.06)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C646(0.97); C616(0.99); C711(1.21)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C646(1.01); C616(0.93)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C646(0.99); C616(0.98)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C646(1.04); C616(0.96)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C646(1.01); C616(0.99); C711(0.74)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C646(1.05); C616(1.02)  LDD1582  [14]
 LDCM0379  CL11 PaTu 8988t C646(0.81)  LDD1258  [5]
 LDCM0380  CL110 HEK-293T C646(0.90); C616(0.92)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C646(1.00); C616(1.03)  LDD1585  [14]
 LDCM0382  CL112 HCT 116 C646(0.68)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C646(0.28)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C646(0.42)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C646(0.43)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C646(0.37)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C646(1.05); C616(0.95)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C646(0.91); C616(1.03)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C646(1.00); C616(0.97)  LDD1593  [14]
 LDCM0390  CL12 PaTu 8988t C646(0.79)  LDD1269  [5]
 LDCM0391  CL120 HEK-293T C646(1.04); C616(1.00); C711(0.94)  LDD1595  [14]
 LDCM0392  CL121 PaTu 8988t C646(0.57)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C646(0.48)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C646(0.37)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C646(0.29)  LDD1274  [5]
 LDCM0396  CL125 HEK-293T C646(1.07); C616(0.85)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C646(0.90); C616(0.98)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C646(0.99); C616(1.06)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C646(0.96); C616(0.98); C711(0.89)  LDD1603  [14]
 LDCM0400  CL13 PaTu 8988t C646(0.38)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C646(0.38)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C646(0.54)  LDD1281  [5]
 LDCM0403  CL16 HEK-293T C646(0.93); C616(0.99); C711(1.03)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C646(0.81); C616(0.77); C711(1.19)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C646(1.15); C616(0.96)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C646(1.10); C616(1.06)  LDD1610  [14]
 LDCM0407  CL2 PaTu 8988t C646(0.64)  LDD1286  [5]
 LDCM0408  CL20 HEK-293T C646(0.97); C616(0.85); C711(1.07)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C646(0.94); C616(1.06); C711(1.02)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C646(1.02); C616(0.67); C711(1.06)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C646(1.04); C616(0.53)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C646(1.01); C616(1.09); C711(0.95)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C646(1.02); C616(0.94)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C646(1.02); C616(1.00)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C646(1.00); C616(1.06)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C646(1.06); C616(1.04); C711(0.72)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C646(0.91); C616(0.88); C711(1.13)  LDD1621  [14]
 LDCM0418  CL3 PaTu 8988t C646(0.54)  LDD1297  [5]
 LDCM0419  CL30 HEK-293T C646(1.10); C616(1.01)  LDD1623  [14]
 LDCM0420  CL31 HCT 116 C646(0.50)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C646(0.52)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C646(0.41)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C646(0.26)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C646(0.20)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C646(0.27)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C646(0.21)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C646(0.28)  LDD0745  [5]
 LDCM0429  CL4 PaTu 8988t C646(0.69)  LDD1308  [5]
 LDCM0430  CL40 HCT 116 C646(0.25)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C646(0.30)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C646(0.24)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C646(0.24)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C646(0.29)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C646(0.25)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C646(1.11); C616(0.59); C711(1.06)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C646(1.11); C616(0.48)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C646(1.06); C616(1.17); C711(0.98)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C646(1.14); C616(1.00)  LDD1643  [14]
 LDCM0440  CL5 PaTu 8988t C646(0.32)  LDD1319  [5]
 LDCM0441  CL50 HEK-293T C646(0.92); C616(0.94)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C646(0.99); C616(0.99); C711(0.85)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C646(0.88); C616(0.84); C711(0.91)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C646(1.05); C616(0.78)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C646(1.26); C616(1.08)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C646(1.12); C616(0.84); C711(1.18)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C646(1.08); C616(0.94); C711(1.24)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C646(1.05); C616(0.63); C711(1.09)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C646(1.14); C616(0.49)  LDD1653  [14]
 LDCM0451  CL6 PaTu 8988t C646(0.35)  LDD1330  [5]
 LDCM0452  CL60 HEK-293T C646(1.10); C616(1.13); C711(1.02)  LDD1655  [14]
 LDCM0453  CL61 HCT 116 C646(0.94)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C646(0.82)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C646(0.62)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C646(0.49)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C646(0.88)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C646(0.36)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C646(0.49)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C646(0.54)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C646(1.14)  LDD0778  [5]
 LDCM0462  CL7 PaTu 8988t C646(0.29)  LDD1341  [5]
 LDCM0463  CL70 HCT 116 C646(0.70)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C646(0.57)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C646(0.89)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C646(0.58)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C646(0.54)  LDD0784  [5]
 LDCM0469  CL76 PaTu 8988t C646(0.73)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C646(0.54)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C646(0.38)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C646(0.43)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C646(0.46)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C646(0.50)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C646(0.37)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C646(0.47)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C646(0.39)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C646(0.70)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C646(0.48)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C646(0.35)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C646(0.47)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C646(0.37)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C646(0.54)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C646(0.33)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C646(0.31)  LDD1364  [5]
 LDCM0486  CL91 HEK-293T C646(1.03); C616(1.00)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C646(1.00); C616(0.92); C711(1.10)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C646(1.01); C616(0.98); C711(1.22)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C646(1.00); C616(0.78); C711(1.11)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C646(0.97); C616(0.57)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C646(1.00); C616(0.91); C711(0.88)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C646(1.05); C616(0.99)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C646(0.85); C616(1.09)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C646(1.02); C616(0.98)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C646(1.01); C616(1.03)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C646(1.10)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C646(0.69)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C646(0.24)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C646(0.97); C711(0.97); C616(1.08)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C646(0.99); C711(1.05); C616(1.03)  LDD1497  [14]
 LDCM0024  KB05 HMCB C711(2.38)  LDD3312  [15]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C646(0.91); C290(0.81)  LDD2099  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C646(0.78)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C646(1.02)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C646(0.97)  LDD2108  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C646(0.83); C290(0.82)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C646(1.13)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C290(1.28)  LDD2114  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C646(1.05); C290(0.76)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C290(0.60)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C646(1.08); C290(0.87)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C646(1.16)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C290(0.71)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C646(1.68); C290(1.05)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C646(1.00); C290(1.26)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C646(1.43)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C646(0.75)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C646(0.77); C290(1.40)  LDD2141  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C646(0.99)  LDD2146  [2]

References

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Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD044402
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840