Details of the Target

General Information of Target

Target ID LDTP07667
Target Name Transmembrane protein 205 (TMEM205)
Gene Name TMEM205
Gene ID 374882
Synonyms
Transmembrane protein 205
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEGGNLGGLIKMVHLLVLSGAWGMQMWVTFVSGFLLFRSLPRHTFGLVQSKLFPFYFHI
SMGCAFINLCILASQHAWAQLTFWEASQLYLLFLSLTLATVNARWLEPRTTAAMWALQTV
EKERGLGGEVPGSHQGPDPYRQLREKDPKYSALRQNFFRYHGLSSLCNLGCVLSNGLCLA
GLALEIRSL
Target Bioclass
Transporter and channel
Family
TMEM205 family
Subcellular location
Membrane
Function In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
Uniprot ID
Q6UW68
Ensemble ID
ENST00000354882.10
HGNC ID
HGNC:29631

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y140(11.11)  LDD0260  [1]
C-Sul
 Probe Info  		4.65  LDD0066  [2]
STPyne
 Probe Info  		K149(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y140(10.73)  LDD3495  [4]
m-APA
 Probe Info  		13.10  LDD0403  [5]
Jackson_1
 Probe Info  		20.00  LDD0120  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C171(0.00); C178(0.00); C167(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C171(0.00); C178(0.00); C167(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C171(0.00); C178(0.00); C167(0.00)  LDD0037  [8]
NHS
 Probe Info  		N.A.  LDD0010  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [7]
AOyne
 Probe Info  		10.00  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 86 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		53.08  LDD1725  [11]
C027
 Probe Info  		6.59  LDD1733  [11]
C040
 Probe Info  		10.13  LDD1740  [11]
C055
 Probe Info  		13.00  LDD1752  [11]
C056
 Probe Info  		17.51  LDD1753  [11]
C063
 Probe Info  		14.03  LDD1760  [11]
C070
 Probe Info  		63.56  LDD1766  [11]
C071
 Probe Info  		12.30  LDD1767  [11]
C072
 Probe Info  		7.21  LDD1768  [11]
C087
 Probe Info  		10.70  LDD1779  [11]
C091
 Probe Info  		14.62  LDD1782  [11]
C092
 Probe Info  		22.78  LDD1783  [11]
C094
 Probe Info  		48.17  LDD1785  [11]
C102
 Probe Info  		6.54  LDD1790  [11]
C106
 Probe Info  		16.00  LDD1793  [11]
C107
 Probe Info  		5.86  LDD1794  [11]
C112
 Probe Info  		30.06  LDD1799  [11]
C130
 Probe Info  		6.50  LDD1812  [11]
C131
 Probe Info  		7.16  LDD1813  [11]
C134
 Probe Info  		21.26  LDD1816  [11]
C138
 Probe Info  		5.74  LDD1820  [11]
C142
 Probe Info  		22.47  LDD1824  [11]
C153
 Probe Info  		15.56  LDD1834  [11]
C158
 Probe Info  		26.17  LDD1838  [11]
C161
 Probe Info  		17.88  LDD1841  [11]
C166
 Probe Info  		11.63  LDD1846  [11]
C169
 Probe Info  		28.25  LDD1849  [11]
C177
 Probe Info  		7.67  LDD1856  [11]
C187
 Probe Info  		99.73  LDD1865  [11]
C191
 Probe Info  		11.55  LDD1868  [11]
C199
 Probe Info  		7.52  LDD1875  [11]
C201
 Probe Info  		27.10  LDD1877  [11]
C215
 Probe Info  		99.73  LDD1889  [11]
C218
 Probe Info  		27.86  LDD1892  [11]
C220
 Probe Info  		17.63  LDD1894  [11]
C228
 Probe Info  		20.82  LDD1901  [11]
C229
 Probe Info  		9.45  LDD1902  [11]
C231
 Probe Info  		22.16  LDD1904  [11]
C232
 Probe Info  		58.08  LDD1905  [11]
C233
 Probe Info  		16.00  LDD1906  [11]
C234
 Probe Info  		7.94  LDD1907  [11]
C235
 Probe Info  		32.90  LDD1908  [11]
C243
 Probe Info  		12.47  LDD1916  [11]
C246
 Probe Info  		14.52  LDD1919  [11]
C264
 Probe Info  		16.91  LDD1935  [11]
C269
 Probe Info  		30.48  LDD1939  [11]
C273
 Probe Info  		5.17  LDD1943  [11]
C278
 Probe Info  		63.56  LDD1948  [11]
C285
 Probe Info  		20.68  LDD1955  [11]
C286
 Probe Info  		8.17  LDD1956  [11]
C287
 Probe Info  		12.64  LDD1957  [11]
C288
 Probe Info  		6.73  LDD1958  [11]
C289
 Probe Info  		48.84  LDD1959  [11]
C290
 Probe Info  		5.24  LDD1960  [11]
C293
 Probe Info  		16.34  LDD1963  [11]
C296
 Probe Info  		26.91  LDD1966  [11]
C299
 Probe Info  		6.15  LDD1968  [11]
C320
 Probe Info  		7.16  LDD1986  [11]
C338
 Probe Info  		12.04  LDD2001  [11]
C339
 Probe Info  		7.21  LDD2002  [11]
C346
 Probe Info  		17.03  LDD2007  [11]
C347
 Probe Info  		6.87  LDD2008  [11]
C349
 Probe Info  		8.51  LDD2010  [11]
C350
 Probe Info  		23.43  LDD2011  [11]
C361
 Probe Info  		18.38  LDD2022  [11]
C362
 Probe Info  		40.22  LDD2023  [11]
C364
 Probe Info  		19.43  LDD2025  [11]
C366
 Probe Info  		5.31  LDD2027  [11]
C373
 Probe Info  		19.29  LDD2033  [11]
C379
 Probe Info  		24.59  LDD2038  [11]
C382
 Probe Info  		10.20  LDD2041  [11]
C388
 Probe Info  		37.53  LDD2047  [11]
C390
 Probe Info  		22.63  LDD2049  [11]
C391
 Probe Info  		15.78  LDD2050  [11]
C403
 Probe Info  		22.63  LDD2061  [11]
C407
 Probe Info  		18.51  LDD2064  [11]
C420
 Probe Info  		17.15  LDD2075  [11]
C429
 Probe Info  		11.71  LDD2084  [11]
C430
 Probe Info  		7.73  LDD2085  [11]
C431
 Probe Info  		16.00  LDD2086  [11]
C433
 Probe Info  		34.78  LDD2088  [11]
FFF probe13
 Probe Info  		20.00  LDD0475  [12]
FFF probe2
 Probe Info  		18.61  LDD0463  [12]
FFF probe3
 Probe Info  		20.00  LDD0464  [12]
STS-1
 Probe Info  		N.A.  LDD0136  [13]
OEA-DA
 Probe Info  		7.41  LDD0046  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.10  LDD0403  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0070  Cisar_cp37 MDA-MB-231 20.00  LDD0120  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) Complex I NDUFA3 subunit family O95167
Serine/threonine-protein kinase VRK2 (VRK2) CK1 Ser/Thr protein kinase family Q86Y07
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Cardiac phospholamban (PLN) Phospholamban family P26678
Syntaxin-6 (STX6) Syntaxin family O43752
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6) ARL6IP6 family Q8N6S5
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Syntaxin-7 (STX7) Syntaxin family O15400
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Transmembrane protein 140 (TMEM140) . Q9NV12

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570