Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C379  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 15.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 10.6
 LDTP12673  4'-phosphopantetheine phosphatase (PANK4) 9.9
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 8.0
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 6.7
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 6.0
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 5.5
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 5.2
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07667  Transmembrane protein 205 (TMEM205) 24.6
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 5.9
Other
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01075  Protein CutA (CUTA) 14.2
 LDTP05868  Protein unc-119 homolog A (UNC119) 7.4
 LDTP08000  Dymeclin (DYM) 6.5
 LDTP00105  Protein unc-119 homolog B (UNC119B) 5.2
 LDTP11076  Apolipoprotein L2 (APOL2) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587