Details of the Target

General Information of Target

Target ID LDTP05868
Target Name Protein unc-119 homolog A (UNC119)
Gene Name UNC119
Gene ID 9094
Synonyms
RG4; Protein unc-119 homolog A; Retinal protein 4; hRG4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVKKGGGGAGTATESAPGPSGQSVAPIPQPPAESESGSESEPDAGPGPRPGPLQRKQPI
GPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSERLPINRRD
LDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFG
FCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP
Target Bioclass
Other
Family
PDE6D/unc-119 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A.
Uniprot ID
Q13432
Ensemble ID
ENST00000301032.8
HGNC ID
HGNC:12565

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE319 SNV: p.C182Y .
MOLT4 SNV: p.V129I IA-alkyne    Probe Info 
NCIH1155 SNV: p.C190Y .
NCIH146 SNV: p.P79S .
NCIH2170 SNV: p.P51S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C77(0.94)  LDD0547  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C77(0.00); C190(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [3]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [4]
Lodoacetamide azide
 Probe Info  		C77(0.00); C190(0.00); C182(0.00)  LDD0037  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
NAIA_5
 Probe Info  		C77(0.00); C182(0.00)  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 57 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		13.74  LDD1728  [7]
C026
 Probe Info  		13.45  LDD1732  [7]
C055
 Probe Info  		22.16  LDD1752  [7]
C070
 Probe Info  		26.35  LDD1766  [7]
C071
 Probe Info  		10.13  LDD1767  [7]
C072
 Probe Info  		27.86  LDD1768  [7]
C082
 Probe Info  		4.99  LDD1774  [7]
C085
 Probe Info  		6.06  LDD1777  [7]
C091
 Probe Info  		32.45  LDD1782  [7]
C092
 Probe Info  		23.26  LDD1783  [7]
C094
 Probe Info  		36.76  LDD1785  [7]
C156
 Probe Info  		5.46  LDD1836  [7]
C159
 Probe Info  		14.83  LDD1839  [7]
C160
 Probe Info  		18.38  LDD1840  [7]
C161
 Probe Info  		18.77  LDD1841  [7]
C163
 Probe Info  		10.70  LDD1843  [7]
C166
 Probe Info  		11.31  LDD1846  [7]
C187
 Probe Info  		23.59  LDD1865  [7]
C215
 Probe Info  		22.32  LDD1889  [7]
C216
 Probe Info  		6.96  LDD1890  [7]
C218
 Probe Info  		86.82  LDD1892  [7]
C219
 Probe Info  		44.32  LDD1893  [7]
C220
 Probe Info  		44.63  LDD1894  [7]
C222
 Probe Info  		5.17  LDD1896  [7]
C225
 Probe Info  		12.04  LDD1898  [7]
C226
 Probe Info  		9.65  LDD1899  [7]
C228
 Probe Info  		35.75  LDD1901  [7]
C229
 Probe Info  		10.56  LDD1902  [7]
C233
 Probe Info  		15.45  LDD1906  [7]
C234
 Probe Info  		11.63  LDD1907  [7]
C235
 Probe Info  		21.71  LDD1908  [7]
C264
 Probe Info  		21.71  LDD1935  [7]
C270
 Probe Info  		8.06  LDD1940  [7]
C273
 Probe Info  		10.27  LDD1943  [7]
C322
 Probe Info  		11.39  LDD1988  [7]
C326
 Probe Info  		7.31  LDD1990  [7]
C348
 Probe Info  		21.26  LDD2009  [7]
C349
 Probe Info  		15.03  LDD2010  [7]
C350
 Probe Info  		30.70  LDD2011  [7]
C353
 Probe Info  		9.06  LDD2014  [7]
C355
 Probe Info  		22.16  LDD2016  [7]
C356
 Probe Info  		10.85  LDD2017  [7]
C360
 Probe Info  		4.96  LDD2021  [7]
C362
 Probe Info  		26.91  LDD2023  [7]
C363
 Probe Info  		20.11  LDD2024  [7]
C376
 Probe Info  		11.31  LDD2036  [7]
C378
 Probe Info  		8.57  LDD2037  [7]
C379
 Probe Info  		7.41  LDD2038  [7]
C380
 Probe Info  		11.08  LDD2039  [7]
C382
 Probe Info  		42.52  LDD2041  [7]
C399
 Probe Info  		11.08  LDD2058  [7]
C419
 Probe Info  		18.38  LDD2074  [7]
C422
 Probe Info  		29.86  LDD2077  [7]
C424
 Probe Info  		13.93  LDD2079  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [8]
FFF probe3
 Probe Info  		20.00  LDD0465  [8]
OEA-DA
 Probe Info  		20.00  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C77(1.19); C190(1.10)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C77(0.97); C190(0.96)  LDD1508  [10]
 LDCM0216  AC100 PaTu 8988t C77(0.59)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C77(0.88)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C77(0.61)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C77(0.64)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C77(0.77)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C77(0.69)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C77(0.49)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C77(0.89)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C77(0.49)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C77(0.52)  LDD1104  [1]
 LDCM0226  AC11 HEK-293T C77(0.99); C190(1.04)  LDD1509  [10]
 LDCM0227  AC110 PaTu 8988t C77(0.69)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C77(0.34)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C77(0.60)  LDD1108  [1]
 LDCM0230  AC113 HCT 116 C77(0.94)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C77(0.62)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C77(0.53)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C77(0.55)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C77(0.65)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C77(0.73)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C77(0.73)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C77(0.86)  LDD1510  [10]
 LDCM0238  AC120 HCT 116 C77(0.62)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C77(0.88)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C77(0.72)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C77(0.85)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C77(0.91)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C77(0.85)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C77(0.63)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C77(0.63)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C77(0.75)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C77(1.17)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C77(0.92)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C77(1.23)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C77(1.40)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C77(1.10)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C77(0.85)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C77(0.91)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C77(0.99)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C77(1.19)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C77(0.96)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C77(1.01)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C77(1.08)  LDD1512  [10]
 LDCM0260  AC140 HCT 116 C77(1.01)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C77(1.02)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C77(1.26)  LDD0579  [1]
 LDCM0263  AC143 PaTu 8988t C77(1.24)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C77(1.12)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C77(1.04)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C77(1.23)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C77(1.23)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C77(0.74)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C77(0.73)  LDD1148  [1]
 LDCM0270  AC15 HEK-293T C77(0.91); C190(1.00)  LDD1513  [10]
 LDCM0271  AC150 PaTu 8988t C77(0.66)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C77(0.48)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C77(0.61)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C77(0.49)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C77(0.54)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C77(0.53)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C77(0.86)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C77(0.54)  LDD2169  [1]
 LDCM0276  AC17 PaTu 8988t C77(0.58)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C77(0.41)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C77(0.53)  LDD1157  [1]
 LDCM0279  AC2 HEK-293T C77(1.18); C190(0.94)  LDD1518  [10]
 LDCM0280  AC20 PaTu 8988t C77(0.39)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C77(0.35)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C77(0.33)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C77(0.33)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C77(0.51)  LDD1163  [1]
 LDCM0285  AC25 HCT 116 C77(0.71)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C77(0.45)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C77(0.47)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C77(0.44)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C77(0.52)  LDD0606  [1]
 LDCM0290  AC3 HEK-293T C77(1.04); C190(1.09)  LDD1529  [10]
 LDCM0291  AC30 HCT 116 C77(0.44)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C77(0.44)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C77(0.31)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C77(0.48)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C77(0.31)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C77(1.44)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C77(1.18)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C77(1.13)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C77(1.27)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C77(1.10)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C77(1.18)  LDD1540  [10]
 LDCM0302  AC40 HCT 116 C77(0.77)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C77(1.07)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C77(0.87)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C77(0.92)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C77(0.85)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C77(0.82)  LDD0624  [1]
 LDCM0308  AC46 PaTu 8988t C77(0.81)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C77(0.76)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C77(0.76)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C77(0.75)  LDD1190  [1]
 LDCM0312  AC5 HEK-293T C77(0.99); C190(1.27)  LDD1551  [10]
 LDCM0313  AC50 PaTu 8988t C77(0.73)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C77(0.93)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C77(0.59)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C77(0.65)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C77(0.62)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C77(0.82)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C77(0.90)  LDD1198  [1]
 LDCM0320  AC57 HCT 116 C77(0.39)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C77(0.39)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C77(0.31)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C77(1.03)  LDD1562  [10]
 LDCM0324  AC60 HCT 116 C77(0.37)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C77(0.44)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C77(0.28)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C77(0.40)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C77(0.32)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C77(0.30)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C77(0.34)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C77(0.26)  LDD0648  [1]
 LDCM0332  AC68 PaTu 8988t C77(0.85)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C77(0.70)  LDD1212  [1]
 LDCM0334  AC7 HEK-293T C77(1.12); C190(0.96)  LDD1568  [10]
 LDCM0335  AC70 PaTu 8988t C77(0.59)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C77(0.91)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C77(0.88)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C77(0.88)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C77(0.68)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C77(0.60)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C77(0.73)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C77(0.74)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C77(0.72)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C77(0.59)  LDD1223  [1]
 LDCM0345  AC8 HEK-293T C77(1.03)  LDD1569  [10]
 LDCM0346  AC80 PaTu 8988t C77(0.66)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C77(0.58)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C77(0.48)  LDD1227  [1]
 LDCM0365  AC98 PaTu 8988t C77(0.76)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C77(0.59)  LDD1245  [1]
 LDCM0248  AKOS034007472 HEK-293T C77(0.93); C190(1.03)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C77(0.95); C190(0.97)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C77(0.90)  LDD1514  [10]
 LDCM0367  CL1 PaTu 8988t C77(0.94)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C77(0.42)  LDD1247  [1]
 LDCM0369  CL100 HEK-293T C77(0.98); C190(0.95)  LDD1573  [10]
 LDCM0371  CL102 HEK-293T C77(0.79); C190(1.07)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C77(0.91); C190(1.15)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C77(0.97); C190(0.99)  LDD1577  [10]
 LDCM0374  CL105 PaTu 8988t C77(0.69)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C77(0.59)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C77(0.64)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C77(0.62)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C77(0.51)  LDD1257  [1]
 LDCM0379  CL11 PaTu 8988t C77(0.71)  LDD1258  [1]
 LDCM0380  CL110 PaTu 8988t C77(0.46)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C77(0.31)  LDD1260  [1]
 LDCM0382  CL112 HCT 116 C77(0.85)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C77(0.37)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C77(0.53)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C77(0.47)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C77(0.64)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C77(0.81)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C77(0.93)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C77(0.84)  LDD0706  [1]
 LDCM0390  CL12 PaTu 8988t C77(0.64)  LDD1269  [1]
 LDCM0391  CL120 HCT 116 C77(1.07)  LDD0708  [1]
 LDCM0392  CL121 PaTu 8988t C77(0.92)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C77(0.87)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C77(0.64)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C77(0.83)  LDD1274  [1]
 LDCM0396  CL125 HCT 116 C77(0.76)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C77(0.62)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C77(0.50)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C77(0.33)  LDD0716  [1]
 LDCM0400  CL13 PaTu 8988t C77(0.44)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C77(0.48)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C77(0.59)  LDD1281  [1]
 LDCM0403  CL16 HEK-293T C77(1.12); C190(0.88)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C77(1.17); C190(1.05)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C77(0.92); C190(1.01)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C77(1.23); C190(1.17)  LDD1610  [10]
 LDCM0407  CL2 PaTu 8988t C77(0.84)  LDD1286  [1]
 LDCM0408  CL20 HEK-293T C77(1.03)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C77(0.99); C190(1.03)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C77(1.05)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C77(1.28); C190(1.08)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C77(1.15)  LDD1616  [10]
 LDCM0414  CL26 HEK-293T C77(0.79); C190(1.21)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C77(0.92); C190(1.37)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C77(1.07); C190(0.80)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C77(1.16); C190(0.89)  LDD1621  [10]
 LDCM0418  CL3 PaTu 8988t C77(0.65)  LDD1297  [1]
 LDCM0419  CL30 HEK-293T C77(1.07); C190(0.80)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C77(1.04); C190(1.06)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C77(0.99)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C77(0.92); C190(1.05)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C77(1.09)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C77(1.04); C190(1.06)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C77(1.13)  LDD1629  [10]
 LDCM0428  CL39 HEK-293T C77(0.92); C190(0.98)  LDD1632  [10]
 LDCM0429  CL4 PaTu 8988t C77(0.76)  LDD1308  [1]
 LDCM0430  CL40 HEK-293T C77(1.27); C190(0.73)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C77(1.11); C190(1.00)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C77(1.17); C190(0.96)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C77(1.19); C190(0.93)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C77(1.09)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C77(0.97); C190(1.13)  LDD1639  [10]
 LDCM0436  CL46 PaTu 8988t C77(0.83)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C77(0.73)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C77(0.71)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C77(0.73)  LDD1318  [1]
 LDCM0440  CL5 PaTu 8988t C77(0.60)  LDD1319  [1]
 LDCM0441  CL50 PaTu 8988t C77(0.60)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C77(0.67)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C77(0.62)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C77(0.58)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C77(0.70)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C77(0.67)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C77(0.37)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C77(0.58)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C77(0.60)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C77(0.59)  LDD1329  [1]
 LDCM0451  CL6 PaTu 8988t C77(0.51)  LDD1330  [1]
 LDCM0452  CL60 PaTu 8988t C77(0.62)  LDD1331  [1]
 LDCM0454  CL62 HEK-293T C77(0.95); C190(1.22)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C77(1.03); C190(1.03)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C77(1.03); C190(0.88)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C77(1.11); C190(1.06)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C77(1.22); C190(1.26)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C77(1.02); C190(0.92)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C77(0.92)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C77(0.99); C190(1.14)  LDD1664  [10]
 LDCM0462  CL7 PaTu 8988t C77(0.58)  LDD1341  [1]
 LDCM0463  CL70 HEK-293T C77(1.06)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C77(0.94); C190(1.16)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C77(1.21)  LDD1668  [10]
 LDCM0467  CL74 HEK-293T C77(0.93); C190(1.12)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C77(1.32); C190(1.00)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C77(1.04); C190(0.94)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C77(0.92); C190(1.18)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C77(1.16); C190(0.91)  LDD1675  [10]
 LDCM0473  CL8 PaTu 8988t C77(0.54)  LDD1352  [1]
 LDCM0474  CL80 HEK-293T C77(0.98)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C77(0.90); C190(1.14)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C77(0.97)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C77(1.03); C190(1.13)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C77(1.06)  LDD1681  [10]
 LDCM0480  CL86 HEK-293T C77(0.70); C190(1.35)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C77(1.06); C190(1.10)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C77(1.14); C190(0.89)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C77(1.12); C190(1.01)  LDD1686  [10]
 LDCM0484  CL9 PaTu 8988t C77(0.58)  LDD1363  [1]
 LDCM0485  CL90 HEK-293T C77(0.56); C190(0.87)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C77(1.10); C190(1.08)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C77(1.01)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C77(0.98); C190(1.10)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C77(1.12)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C77(1.10); C190(0.94)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C77(1.11)  LDD1694  [10]
 LDCM0493  CL98 HEK-293T C77(0.71); C190(0.93)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C77(0.95); C190(1.02)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C77(0.99); C190(0.61)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C77(1.04); C190(1.18)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C77(0.74); C190(1.07)  LDD1631  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C77(0.71); C190(0.92)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C77(0.87); C190(0.96)  LDD1497  [10]
 LDCM0024  KB05 OCI-Ly3 C77(2.68)  LDD3372  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC) PPP phosphatase family P48454
ADP-ribosylation factor-like protein 15 (ARL15) Arf family Q9NXU5
ADP-ribosylation factor-like protein 2 (ARL2) Arf family P36404
ADP-ribosylation factor-like protein 3 (ARL3) Arf family P36405
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) LRIF1 family Q5T3J3
Calcipressin-3 (RCAN3) RCAN family Q9UKA8
Transmembrane protein 200A (TMEM200A) TMEM200 family Q86VY9
Nephrocystin-3 (NPHP3) . Q7Z494
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) . Q96A56
Uncharacterized protein C16orf74 (C16orf74) . Q96GX8

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840