Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C082  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 79 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 31.8
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 31.6
 LDTP01803  Adenosine deaminase (ADA) 19.6
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 18.8
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 17.4
 LDTP00697  Cytochrome b5 type B (CYB5B) 17.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 16.6
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 16.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 15.1
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 14.0
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 12.7
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 12.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 12.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 12.3
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 12.0
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 11.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 11.3
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 11.1
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 10.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.6
 LDTP13751  Exonuclease 1 (EXO1) 10.1
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 10.1
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 9.7
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 9.6
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 9.6
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 9.4
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 9.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 9.3
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 9.2
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 9.1
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 9.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 9.0
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 8.8
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 8.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 8.4
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 8.4
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 8.1
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 7.8
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 7.7
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 7.7
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 7.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 7.3
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.2
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 7.2
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 7.1
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 7.1
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 6.9
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 6.8
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 6.5
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 6.5
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 6.5
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 6.2
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 6.2
 LDTP10329  Ceramide synthase 2 (CERS2) 6.1
 LDTP02837  Beta-galactosidase (GLB1) 5.9
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 5.9
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 5.9
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 5.9
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 5.7
 LDTP03394  Ceramide synthase 1 (CERS1) 5.7
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 5.7
 LDTP11127  ADP-dependent glucokinase (ADPGK) 5.6
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 5.6
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 5.6
 LDTP06657  2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) 5.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 5.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.5
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 5.4
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 5.3
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 5.3
 LDTP05905  Acid ceramidase (ASAH1) 5.2
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 5.2
 LDTP13367  Glutathione hydrolase 7 (GGT7) 5.2
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 5.1
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 5.1
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 5.1
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 5.0
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 5.0
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 5.0
Transporter and channel
Click to Show/Hide to Show 59 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 31.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 29.2
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 26.9
 LDTP15481  Transmembrane protein 87A (TMEM87A) 25.1
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 22.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 22.3
 LDTP08881  Transmembrane protein 199 (TMEM199) 20.0
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 19.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 16.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 16.2
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 16.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 15.7
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 15.0
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 14.6
 LDTP03546  Translocator protein (TSPO) 13.9
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 13.2
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 12.1
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 11.6
 LDTP15967  Tetraspanin-10 (TSPAN10) 11.4
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 10.6
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 10.4
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 9.4
 LDTP15948  Transmembrane protein 126A (TMEM126A) 9.4
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 9.3
 LDTP20002  Transmembrane protein 160 (TMEM160) 9.0
 LDTP01804  ATP synthase subunit a (MT-ATP6) 8.9
 LDTP16813  Tetraspanin-3 (TSPAN3) 8.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 8.1
 LDTP15648  BRI3-binding protein (BRI3BP) 7.7
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 7.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 7.6
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 7.4
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 7.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 7.0
 LDTP02215  Prosaposin (PSAP) 7.0
 LDTP11245  Derlin-1 (DERL1) 7.0
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 6.9
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 6.8
 LDTP16201  B-cell receptor-associated protein 29 (BCAP29) 6.7
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 6.5
 LDTP05900  Metaxin-1 (MTX1) 6.3
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 6.3
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 6.1
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 5.9
 LDTP16190  Protein FAM8A1 (FAM8A1) 5.9
 LDTP10065  Transmembrane protein 230 (TMEM230) 5.8
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 5.7
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 5.7
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 5.7
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 5.6
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 5.5
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 5.5
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 5.5
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 5.3
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 5.3
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 5.2
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 5.2
 LDTP03952  Reduced folate transporter (SLC19A1) 5.0
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 4.9
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 6.5
 LDTP05065  Y-box-binding protein 1 (YBX1) 5.0
Other
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 39.9
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 30.9
 LDTP05160  Nucleobindin-2 (NUCB2) 25.3
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 23.8
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 19.3
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 17.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 12.1
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 11.6
 LDTP14458  Tetraspanin-6 (TSPAN6) 10.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 10.6
 LDTP18883  Protein CEBPZOS (CEBPZOS) 10.5
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 10.2
 LDTP05375  Nucleobindin-1 (NUCB1) 10.1
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 9.7
 LDTP00105  Protein unc-119 homolog B (UNC119B) 9.3
 LDTP13630  Neudesin (NENF) 8.9
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 8.8
 LDTP13086  Syntaxin-18 (STX18) 8.8
 LDTP01522  Reticulon-3 (RTN3) 7.9
 LDTP10469  Engulfment and cell motility protein 2 (ELMO2) 7.7
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 7.7
 LDTP12412  Reticulon-4 (RTN4) 7.6
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 7.5
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 7.2
 LDTP16080  Protein FAM114A2 (FAM114A2) 7.1
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 7.0
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 7.0
 LDTP19963  TraB domain-containing protein (TRABD) 6.9
 LDTP08606  Nurim (NRM) 6.7
 LDTP10056  Protein FAM162A (FAM162A) 6.5
 LDTP07906  Mediator of RNA polymerase II transcription subunit 25 (MED25) 6.4
 LDTP08224  Protein LYRIC (MTDH) 6.2
 LDTP06097  Reticulocalbin-2 (RCN2) 6.1
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 6.1
 LDTP01652  Centrosomal protein 43 (CEP43) 5.8
 LDTP16006  Optic atrophy 3 protein (OPA3) 5.8
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 5.7
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 5.6
 LDTP00121  Zinc finger SWIM domain-containing protein 8 (ZSWIM8) 5.5
 LDTP08000  Dymeclin (DYM) 5.2
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 5.0
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 5.0
 LDTP05868  Protein unc-119 homolog A (UNC119) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587