General Information of Target

Target ID LDTP08790
Target Name Mitochondrial cardiolipin hydrolase (PLD6)
Gene Name PLD6
Gene ID 201164
Synonyms
Mitochondrial cardiolipin hydrolase; EC 3.1.4.-; Choline phosphatase 6; Mitochondrial phospholipase; MitoPLD; Phosphatidylcholine-hydrolyzing phospholipase D6; Phospholipase D6; PLD6; Protein zucchini homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGRLSWQVAAAAAVGLALTLEALPWVLRWLRSRRRRPRREALFFPSQVTCTEALLRAPGA
ELAELPEGCPCGLPHGESALSRLLRALLAARASLDLCLFAFSSPQLGRAVQLLHQRGVRV
RVVTDCDYMALNGSQIGLLRKAGIQVRHDQDPGYMHHKFAIVDKRVLITGSLNWTTQAIQ
NNRENVLITEDDEYVRLFLEEFERIWEQFNPTKYTFFPPKKSHGSCAPPVSRAGGRLLSW
HRTCGTSSESQT
Target Bioclass
Enzyme
Family
Phospholipase D family, MitoPLD/Zucchini subfamily
Subcellular location
Mitochondrion outer membrane
Function
Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid. Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission. Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology. Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis. Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation. Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation. The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA). MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs. Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner.
Uniprot ID
Q8N2A8
Ensemble ID
ENST00000321560.4
HGNC ID
HGNC:30447

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info 
C69(1.62)  LDD2214  [1]
DBIA
 Probe Info 
C69(1.29); C71(1.29)  LDD0531  [2]
NAIA_4
 Probe Info 
N.A.  LDD2226  [3]
IPM
 Probe Info 
N.A.  LDD2156  [4]
PAL-AfBPP Probe
Click To Hide/Show 71 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info 
7.11  LDD1714  [5]
C017
 Probe Info 
16.00  LDD1725  [5]
C026
 Probe Info 
5.31  LDD1732  [5]
C040
 Probe Info 
9.78  LDD1740  [5]
C041
 Probe Info 
6.77  LDD1741  [5]
C055
 Probe Info 
56.49  LDD1752  [5]
C056
 Probe Info 
29.65  LDD1753  [5]
C063
 Probe Info 
10.48  LDD1760  [5]
C070
 Probe Info 
13.83  LDD1766  [5]
C072
 Probe Info 
10.85  LDD1768  [5]
C082
 Probe Info 
4.96  LDD1774  [5]
C091
 Probe Info 
20.53  LDD1782  [5]
C092
 Probe Info 
18.77  LDD1783  [5]
C094
 Probe Info 
28.44  LDD1785  [5]
C107
 Probe Info 
7.26  LDD1794  [5]
C108
 Probe Info 
11.63  LDD1795  [5]
C112
 Probe Info 
19.70  LDD1799  [5]
C130
 Probe Info 
8.46  LDD1812  [5]
C134
 Probe Info 
31.78  LDD1816  [5]
C135
 Probe Info 
32.67  LDD1817  [5]
C138
 Probe Info 
4.96  LDD1820  [5]
C139
 Probe Info 
24.76  LDD1821  [5]
C140
 Probe Info 
19.70  LDD1822  [5]
C158
 Probe Info 
10.34  LDD1838  [5]
C159
 Probe Info 
19.43  LDD1839  [5]
C160
 Probe Info 
23.43  LDD1840  [5]
C161
 Probe Info 
24.25  LDD1841  [5]
C163
 Probe Info 
5.90  LDD1843  [5]
C169
 Probe Info 
20.11  LDD1849  [5]
C183
 Probe Info 
8.46  LDD1861  [5]
C186
 Probe Info 
14.32  LDD1864  [5]
C194
 Probe Info 
12.21  LDD1870  [5]
C196
 Probe Info 
36.25  LDD1872  [5]
C198
 Probe Info 
18.13  LDD1874  [5]
C201
 Probe Info 
38.32  LDD1877  [5]
C206
 Probe Info 
38.85  LDD1881  [5]
C207
 Probe Info 
22.16  LDD1882  [5]
C216
 Probe Info 
6.28  LDD1890  [5]
C218
 Probe Info 
25.99  LDD1892  [5]
C219
 Probe Info 
16.80  LDD1893  [5]
C220
 Probe Info 
37.27  LDD1894  [5]
C231
 Probe Info 
21.86  LDD1904  [5]
C233
 Probe Info 
11.88  LDD1906  [5]
C234
 Probe Info 
8.00  LDD1907  [5]
C235
 Probe Info 
19.56  LDD1908  [5]
C238
 Probe Info 
16.91  LDD1911  [5]
C243
 Probe Info 
15.14  LDD1916  [5]
C244
 Probe Info 
15.67  LDD1917  [5]
C245
 Probe Info 
5.82  LDD1918  [5]
C246
 Probe Info 
14.22  LDD1919  [5]
C249
 Probe Info 
11.96  LDD1922  [5]
C264
 Probe Info 
18.90  LDD1935  [5]
C265
 Probe Info 
15.35  LDD1936  [5]
C269
 Probe Info 
6.15  LDD1939  [5]
C270
 Probe Info 
13.74  LDD1940  [5]
C285
 Probe Info 
38.59  LDD1955  [5]
C286
 Probe Info 
6.54  LDD1956  [5]
C287
 Probe Info 
22.78  LDD1957  [5]
C288
 Probe Info 
10.70  LDD1958  [5]
C289
 Probe Info 
37.27  LDD1959  [5]
C290
 Probe Info 
11.47  LDD1960  [5]
C299
 Probe Info 
17.03  LDD1968  [5]
C301
 Probe Info 
6.82  LDD1970  [5]
C304
 Probe Info 
7.11  LDD1973  [5]
C305
 Probe Info 
14.83  LDD1974  [5]
C314
 Probe Info 
11.88  LDD1981  [5]
C349
 Probe Info 
11.08  LDD2010  [5]
C353
 Probe Info 
7.67  LDD2014  [5]
C392
 Probe Info 
7.78  LDD2051  [5]
C424
 Probe Info 
15.78  LDD2079  [5]
C426
 Probe Info 
24.59  LDD2081  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C69(1.29); C71(1.29)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C244(0.98); C69(0.90); C71(0.90)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C69(0.88); C71(0.88)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C69(0.88); C71(0.88)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C69(1.28); C71(1.28)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C69(1.13); C71(1.13)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C69(1.23); C71(1.23)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C69(1.05); C71(1.05)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C69(1.24); C71(1.24)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C69(1.18); C71(1.18)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C69(0.98); C71(0.98)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C69(0.91); C71(0.91)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C244(1.30); C69(0.91); C71(0.91)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C69(0.85); C71(0.85)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C69(0.98); C71(0.98)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C69(0.84); C71(0.84)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C244(1.03); C69(1.05); C71(1.05)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C244(0.93); C69(0.94); C71(0.94)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C244(1.02); C69(0.89); C71(0.89)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C244(1.02); C69(0.92); C71(0.92)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C244(1.04); C69(0.98); C71(0.98)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C244(1.17); C69(1.03); C71(1.03)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C244(0.99); C69(1.12); C71(1.12)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C244(1.20); C69(0.84); C71(0.84)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C244(0.95); C69(0.99); C71(0.99)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C244(1.12); C69(0.93); C71(0.93)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C244(0.97); C69(1.00); C71(1.00)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C244(1.25); C69(1.03); C71(1.03)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C244(1.02); C69(0.88); C71(0.88)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C244(0.91); C69(0.90); C71(0.90)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C244(1.02); C69(0.87); C71(0.87)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C244(1.03); C69(0.87); C71(0.87)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C69(1.20); C71(1.20)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C69(0.87); C71(0.87)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C69(0.97); C71(0.97)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C69(1.06); C71(1.06)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C69(1.01); C71(1.01)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C69(1.02); C71(1.02)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C69(1.14); C71(1.14)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C69(1.13); C71(1.13)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C69(1.11); C71(1.11)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C69(1.17); C71(1.17)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C69(1.39); C71(1.39)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C69(1.24); C71(1.24)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C244(1.35); C69(0.97); C71(0.97)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C69(1.49); C71(1.49)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C69(1.27); C71(1.27)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C69(1.12); C71(1.12)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C69(1.12); C71(1.12); C244(1.48)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C69(0.92); C71(0.94); C244(1.92)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C244(0.88); C71(0.94); C69(0.99)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C71(0.97); C69(1.02); C244(1.04)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C71(0.85); C69(0.89); C244(1.41)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C69(0.92); C71(1.10); C244(1.66)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C69(0.98); C244(1.03); C71(1.06)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C69(1.04); C71(1.04); C244(2.15)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C244(1.09); C71(1.23); C69(1.25)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C71(1.21); C244(1.24); C69(1.26)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C71(0.95); C69(1.04); C244(1.43)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C71(1.06); C69(1.20); C244(1.94)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C244(1.44); C69(0.99); C71(0.93)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C244(1.45); C69(1.06); C71(1.01)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C244(1.32); C69(1.10); C71(1.00)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C244(1.13); C69(1.20); C71(1.08)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C244(0.69); C69(0.88); C71(0.88)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C244(0.65); C69(1.31); C71(1.31)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C244(0.52); C69(0.89); C71(0.89)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C69(1.15); C71(1.15)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C244(0.76); C69(0.95); C71(0.95)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C244(0.66); C69(0.91); C71(0.91)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C244(0.64); C69(0.87); C71(0.87)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C244(0.53); C69(0.93); C71(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C244(0.52); C69(0.92); C71(0.92)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C69(0.99); C71(0.99)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C69(1.09); C71(1.09)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C69(1.09); C71(1.09)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C69(1.35); C71(1.35)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C69(1.23); C71(1.23)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C69(1.22); C71(1.22)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C69(1.21); C71(1.21)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C69(1.29); C71(1.29)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C69(1.38); C71(1.38)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C69(1.14); C71(1.14)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C69(1.38); C71(1.38)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C69(0.90); C71(0.90)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C69(0.88); C71(0.88)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C69(0.97); C71(0.97)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C69(0.85); C71(0.85)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C69(1.00); C71(1.00)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C69(1.32); C71(1.32)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C69(1.07); C71(1.07)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C69(1.08); C71(1.08)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C69(0.90); C71(0.90)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C69(1.12); C71(1.12)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C69(1.08); C71(1.08)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C69(1.17); C71(1.17)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C69(1.21); C71(1.21)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C69(0.89); C71(0.89)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C69(1.00); C71(1.00)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C69(1.08); C71(1.08)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C69(1.32); C71(1.32)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C69(1.18); C71(1.18)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C69(1.14); C71(1.14)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C69(0.97); C71(0.97)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C69(0.80); C71(0.80)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C69(1.18); C71(1.18)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C69(0.87); C71(0.87)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C69(1.00); C71(1.00)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C69(0.87); C71(0.87)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C69(1.02); C71(1.02)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C69(1.13); C71(1.13)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C69(1.10); C71(1.10); C244(2.25)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C69(1.19); C71(1.19)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C69(0.90); C71(0.90)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C69(1.02); C71(1.02)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C69(1.08); C71(1.08)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C69(1.04); C71(1.04)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C69(0.94); C71(0.94)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C69(0.97); C71(0.97)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C69(0.99); C71(0.99)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C69(0.99); C71(0.99)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C69(0.82); C71(0.82)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C69(0.94); C71(0.94); C244(1.18)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C69(0.82); C71(0.82)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C69(0.75); C71(0.75)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C69(0.69); C71(0.69)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C69(0.80); C71(0.80)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C69(0.79); C71(0.79)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C69(0.90); C71(0.90)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C69(0.85); C71(0.85)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C69(0.89); C71(0.89)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C69(1.06); C71(1.06)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C69(0.75); C71(0.75)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C69(1.06); C71(1.06); C244(1.22)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C69(1.19); C71(1.19)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C69(0.83); C71(0.83)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C69(0.85); C71(0.85)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C69(1.49); C71(1.49); C244(1.65)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C244(1.21); C69(1.35); C71(1.35)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C244(1.11); C69(1.38); C71(1.38)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C244(0.97); C69(1.17); C71(1.17)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C244(0.89); C69(1.22); C71(1.22)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C244(0.96); C69(1.13); C71(1.13)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C244(0.93); C69(1.24); C71(1.24)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C69(0.97); C71(0.97); C244(1.27)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C69(1.33); C71(1.33); C244(1.61)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C244(0.87); C69(1.24); C71(1.24)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C244(0.93); C69(1.31); C71(1.31)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C244(0.90); C69(1.12); C71(1.12)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C244(1.06); C69(1.14); C71(1.14)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C244(0.82); C69(1.21); C71(1.21)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C244(1.38); C69(1.42); C71(1.42)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C69(1.72); C71(1.72)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C69(0.85); C71(0.85)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C244(0.85); C69(0.87); C71(0.87)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C69(0.92); C71(0.92); C244(1.12)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C69(1.32); C71(1.32); C244(1.46)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C69(1.08); C71(1.08)  LDD2171  [2]
 LDCM0630  CCW28-3 231MFP C69(1.62)  LDD2214  [1]
 LDCM0367  CL1 HCT 116 C244(1.04); C69(1.19); C71(1.19)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C244(0.92); C69(1.14); C71(1.14)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C69(1.31); C71(1.31)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C244(1.17); C69(1.19); C71(1.19)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C244(0.78); C69(0.95); C71(0.95)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C69(1.04); C71(1.04); C244(1.30)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C69(1.01); C71(1.01); C244(1.06)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C244(0.62); C69(0.96); C71(0.96)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C244(0.55); C69(1.13); C71(1.13)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C244(0.73); C69(1.01); C71(1.01)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C244(0.74); C69(1.18); C71(1.18)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C244(0.73); C69(1.07); C71(1.07)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C69(1.03); C71(1.03); C244(1.16)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C244(0.60); C69(1.43); C71(1.43)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C244(0.59); C69(1.22); C71(1.22)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C69(1.08); C71(1.08)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C69(1.30); C71(1.30)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C69(1.94); C71(1.94)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C69(1.35); C71(1.35)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C69(1.24); C71(1.24)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C69(1.23); C71(1.23)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C69(1.01); C71(1.01)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C69(1.10); C71(1.10)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C69(1.06); C71(1.06); C244(1.13)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C69(0.93); C71(0.93)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C69(1.00); C71(1.00)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C69(1.60); C71(1.60)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C69(1.46); C71(1.46)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C69(1.10); C71(1.10)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C69(1.06); C71(1.06)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C69(1.45); C71(1.45)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C69(1.04); C71(1.04)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C69(0.91); C71(0.91)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C69(0.95); C71(0.95); C244(1.01)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C244(0.98); C69(1.03); C71(1.03)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C244(1.03); C69(1.20); C71(1.20)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C69(0.95); C71(0.95); C244(1.20)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C244(1.12); C69(1.27); C71(1.27)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C69(1.11); C71(1.11); C244(1.51)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C244(1.05); C69(1.10); C71(1.10)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C244(0.81); C69(1.03); C71(1.03)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C244(0.94); C69(1.29); C71(1.29)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C244(1.01); C69(2.41); C71(2.41)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C244(1.00); C69(1.57); C71(1.57)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C69(1.33); C71(1.33); C244(1.65)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C244(1.19); C69(1.38); C71(1.38)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C244(1.12); C69(1.40); C71(1.40)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C244(1.09); C69(1.17); C71(1.17)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C244(1.03); C69(1.16); C71(1.16)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C244(1.25); C69(1.08); C71(1.08)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C244(1.32); C69(1.19); C71(1.19)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C244(0.85); C69(1.07); C71(1.07)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C244(1.38); C69(1.06); C71(1.06)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C69(1.06); C71(1.06)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C69(0.93); C71(0.93)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C69(1.13); C71(1.13)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C69(1.21); C71(1.21)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C69(1.08); C71(1.08)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C69(1.15); C71(1.15)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C69(1.10); C71(1.10)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C69(1.08); C71(1.08)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C244(1.06); C69(1.64); C71(1.64)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C69(1.41); C71(1.41)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C69(1.00); C71(1.00)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C69(1.09); C71(1.09)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C69(1.09); C71(1.09)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C69(0.97); C71(0.97)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C69(1.19); C71(1.19)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C244(1.01); C69(0.88); C71(0.88)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C244(0.96); C69(0.93); C71(0.93)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C244(0.75); C69(0.75); C71(0.75)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C244(0.62); C69(0.83); C71(0.83)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C244(1.02); C69(1.02); C71(1.02)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C244(0.92); C69(0.92); C71(0.92)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C244(1.18); C69(0.75); C71(0.75)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C244(1.18); C69(0.80); C71(0.80)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C244(1.02); C69(1.07); C71(1.07)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C244(0.96); C69(0.89); C71(0.89)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C244(0.87); C69(0.92); C71(0.92)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C244(0.68); C69(0.98); C71(0.98)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C244(0.83); C69(0.89); C71(0.89)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C244(0.93); C69(0.88); C71(0.88)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C244(0.89); C69(0.92); C71(0.92)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C244(1.20); C69(1.04); C71(1.04)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C244(0.87); C69(0.92); C71(0.92)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C244(1.60); C69(0.92); C71(0.92)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C244(1.28); C69(0.95); C71(0.95)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C244(1.26); C69(1.15); C71(1.15)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C244(1.09); C69(1.39); C71(1.39)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C244(1.29); C69(1.10); C71(1.10)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C244(1.47); C69(1.44); C71(1.44)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C244(1.02); C69(1.20); C71(1.20)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C244(1.81); C69(1.36); C71(1.36)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C244(1.45); C69(1.34); C71(1.34)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C244(0.91); C69(0.92); C71(0.92)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C244(1.36); C69(1.15); C71(1.15)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C244(1.48); C69(1.15); C71(1.15)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C244(1.66); C69(1.12); C71(1.12)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C244(0.90); C69(1.32); C71(1.32)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C244(2.39); C69(1.09); C71(1.09)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C244(1.35); C69(0.99); C71(0.99)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C244(0.97); C69(1.26); C71(1.26)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C244(1.31); C69(1.05); C71(1.05)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C244(1.37); C69(1.11); C71(1.11)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C244(2.20); C69(1.21); C71(1.21)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C244(1.00); C69(0.90); C71(0.90)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C244(1.17); C69(1.00); C71(1.00)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C244(1.12); C69(1.14); C71(1.14)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C244(1.09); C69(1.23); C71(1.23)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C244(1.12); C69(1.70); C71(1.70)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C244(2.19); C69(1.19); C71(1.19)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C244(1.22); C69(0.95); C71(0.95)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C244(1.20); C69(1.11); C71(1.11)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C244(1.47); C69(1.26); C71(1.26)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C244(1.17); C69(1.48); C71(1.48)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C244(0.95); C69(1.11); C71(1.11)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C244(0.96); C69(1.72); C71(1.72)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C69(1.07); C71(1.07)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C69(1.25); C71(1.25)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C69(0.99); C71(0.99)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C69(1.23); C71(1.23)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C69(1.46); C71(1.46)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C69(1.45); C71(1.45)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C69(1.67); C71(1.67)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C69(1.33); C71(1.33)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C69(1.34); C71(1.34)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C126(1.18); C50(0.95)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C244(1.63); C69(1.08); C71(1.08)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C69(1.70); C71(1.70)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C50(1.05)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C50(1.04)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C50(1.06)  LDD1502  [6]
 LDCM0021  THZ1 HCT 116 C69(1.08); C71(1.08)  LDD2173  [2]

References

1 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402