Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C424  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 59 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 45.6
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 41.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 41.6
 LDTP04542  Thimet oligopeptidase (THOP1) 39.1
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 32.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 29.4
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 25.1
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 24.3
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 22.6
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 21.7
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 21.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 18.6
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 17.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 17.1
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 16.0
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 15.8
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 15.3
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 15.1
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 15.1
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 15.0
 LDTP00988  Protein O-GlcNAcase (OGA) 14.5
 LDTP11127  ADP-dependent glucokinase (ADPGK) 14.3
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 13.4
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 13.2
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 11.8
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.6
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 11.5
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 11.4
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 10.9
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 10.3
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 10.2
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 10.1
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 9.7
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 9.4
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 9.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 9.1
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 8.9
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 8.6
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 8.3
 LDTP02359  Heme oxygenase 1 (HMOX1) 8.2
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 8.2
 LDTP13751  Exonuclease 1 (EXO1) 8.1
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 8.1
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 8.0
 LDTP01284  Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU) 7.9
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 7.9
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 7.9
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 7.9
 LDTP10329  Ceramide synthase 2 (CERS2) 7.8
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 7.7
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 7.7
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 7.6
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 7.6
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 7.5
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 7.5
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 7.4
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 7.4
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 7.4
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 7.4
Transporter and channel
Click to Show/Hide to Show 41 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 65.3
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 53.8
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 48.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 27.3
 LDTP08881  Transmembrane protein 199 (TMEM199) 26.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 24.9
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 20.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 18.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 18.8
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 18.1
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 17.0
 LDTP12383  Protein GPR108 (GPR108) 14.2
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 13.3
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 13.1
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 13.0
 LDTP07236  Protein GPR107 (GPR107) 13.0
 LDTP11041  Calcium uptake protein 1, mitochondrial (MICU1) 12.9
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 12.2
 LDTP00970  Gasdermin-E (GSDME) 11.9
 LDTP05900  Metaxin-1 (MTX1) 11.5
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 11.2
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 11.0
 LDTP10533  Sorting nexin-27 (SNX27) 10.3
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 9.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 9.7
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 9.5
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 9.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 9.4
 LDTP11213  Nucleoporin NDC1 (NDC1) 9.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 8.5
 LDTP15648  BRI3-binding protein (BRI3BP) 8.5
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 8.4
 LDTP07063  Hippocampus abundant transcript-like protein 1 (MFSD14B) 8.3
 LDTP15948  Transmembrane protein 126A (TMEM126A) 8.3
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 7.8
 LDTP10343  Vacuole membrane protein 1 (VMP1) 7.8
 LDTP07531  Sideroflexin-4 (SFXN4) 7.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 7.7
 LDTP02010  Annexin A1 (ANXA1) 7.6
 LDTP08673  Calcium uptake protein 2, mitochondrial (MICU2) 7.5
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 7.5
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10891  DnaJ homolog subfamily C member 2 (DNAJC2) 13.5
Cytokine and receptor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02775  Interferon gamma receptor 1 (IFNGR1) 11.4
Other
Click to Show/Hide to Show 39 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 64.0
 LDTP12412  Reticulon-4 (RTN4) 38.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 28.8
 LDTP11076  Apolipoprotein L2 (APOL2) 22.9
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 22.3
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 19.4
 LDTP01522  Reticulon-3 (RTN3) 19.2
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 19.0
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 17.9
 LDTP01652  Centrosomal protein 43 (CEP43) 16.4
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 16.2
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 15.8
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 14.7
 LDTP16080  Protein FAM114A2 (FAM114A2) 14.7
 LDTP18272  Transmembrane protein 209 (TMEM209) 14.6
 LDTP05868  Protein unc-119 homolog A (UNC119) 13.9
 LDTP01608  Proteasome assembly chaperone 1 (PSMG1) 13.7
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 13.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 13.3
 LDTP13086  Syntaxin-18 (STX18) 13.3
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 11.9
 LDTP01075  Protein CutA (CUTA) 11.8
 LDTP02205  Tubulin beta chain (TUBB) 11.7
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 11.6
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 11.4
 LDTP11233  Tubulin beta-6 chain (TUBB6) 11.1
 LDTP10056  Protein FAM162A (FAM162A) 11.0
 LDTP15623  Neuferricin (CYB5D2) 10.5
 LDTP05160  Nucleobindin-2 (NUCB2) 10.4
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 9.4
 LDTP06097  Reticulocalbin-2 (RCN2) 9.4
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 9.3
 LDTP10857  c-Myc-binding protein (MYCBP) 8.6
 LDTP19963  TraB domain-containing protein (TRABD) 8.5
 LDTP15345  Zinc finger CCCH domain-containing protein 7A (ZC3H7A) 8.2
 LDTP11239  Protein misato homolog 1 (MSTO1) 7.8
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 7.8
 LDTP00887  Calumenin (CALU) 7.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 7.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587