Details of the Target

General Information of Target

Target ID LDTP07063
Target Name Hippocampus abundant transcript-like protein 1 (MFSD14B)
Gene Name MFSD14B
Gene ID 84641
Synonyms
HIATL1; Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain-containing 14B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVEPPPELEEKAASEPEAGAMPEKRAGAQAAGSTWLQGFGRPSVYHAAIVIFLEFFAWG
LLTTPMLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFT
CFPIPLMRISPWWYFAMISVSGVFSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLV
SSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSWGAQISWKQAD
PFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGIL
SIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFP
AISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVELTELGPKLNSNNV
PLQGAVIPGPPFLFGACIVLMSFLVALFIPEYSKASGVQKHSNSSSGSLTNTPERGSDED
IEPLLQDSSIWELSSFEEPGNQCTEL
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily
Subcellular location
Membrane
Uniprot ID
Q5SR56
Ensemble ID
ENST00000375344.8
HGNC ID
HGNC:23376

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.L326V .
HCT116 SNV: p.G387E .
HEC1 SNV: p.T147M .
IGROV1 SNV: p.T147M .
IM95 SNV: p.F399L; p.I400T .
Ishikawa (Heraklio) 02 ER SNV: p.A153G .
LS180 SNV: p.M403I .
SKMEL2 SNV: p.S466N .
TE4 SNV: p.V322I .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C070
 Probe Info  		8.82  LDD1766  [1]
C072
 Probe Info  		8.22  LDD1768  [1]
C424
 Probe Info  		8.28  LDD2079  [1]
C426
 Probe Info  		26.91  LDD2081  [1]
C428
 Probe Info  		5.31  LDD2083  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ5
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ7
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q7L5N7
N-acetyltransferase 8 (NAT8) Camello family Q9UHE5
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) Chondroitin N-acetylgalactosaminyltransferase family Q8N6G5
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Probable palmitoyltransferase ZDHHC24 (ZDHHC24) DHHC palmitoyltransferase family Q6UX98
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Flavin-containing monooxygenase 1 (FMO1) FMO family Q01740
Very-long-chain enoyl-CoA reductase (TECR) Steroid 5-alpha reductase family Q9NZ01
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Ubiquitin-conjugating enzyme family Q9Y385
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) . Q9NTJ5
Transporter and channel
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bax inhibitor 1 (TMBIM6) BI1 family P55061
Proline-rich transmembrane protein 2 (PRRT2) CD225/Dispanin family Q7Z6L0
Claudin-4 (CLDN4) Claudin family O14493
ER membrane protein complex subunit 6 (EMC6) EMC6 family Q9BV81
Mitochondrial outer membrane protein SLC25A46 (SLC25A46) Mitochondrial carrier (TC 2.A.29) family Q96AG3
B-lymphocyte antigen CD20 (MS4A1) MS4A family P11836
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Peroxisomal membrane protein PEX16 (PEX16) Peroxin-16 family Q9Y5Y5
Syntaxin-3 (STX3) Syntaxin family Q13277
Transmembrane protein 176A (TMEM176A) TMEM176 family Q96HP8
Transmembrane protein 208 (TMEM208) TMEM208 family Q9BTX3
Protein YIPF1 (YIPF1) YIP1 family Q9Y548
Protein YIPF2 (YIPF2) YIP1 family Q9BWQ6
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Adiponectin (ADIPOQ) . Q15848
Solute carrier family 66 member 2 (SLC66A2) . Q8N2U9
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metabotropic glutamate receptor 2 (GRM2) G-protein coupled receptor 3 family Q14416
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 3 (CMTM3) Chemokine-like factor family Q96MX0
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Other
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Beta-defensin 127 (DEFB127) Beta-defensin family Q9H1M4
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Protein kish-B (TMEM167B) KISH family Q9NRX6
Low-density lipoprotein receptor-related protein 10 (LRP10) LDLR family Q7Z4F1
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
ORM1-like protein 1 (ORMDL1) ORM family Q9P0S3
Stress-associated endoplasmic reticulum protein 1 (SERP1) RAMP4 family Q9Y6X1
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Transmembrane protein 19 (TMEM19) TMEM19 family Q96HH6
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Tumor protein p63-regulated gene 1 protein (TPRG1) TPRG1 family Q6ZUI0
Protein unc-50 homolog (UNC50) Unc-50 family Q53HI1
Vesicle transport protein USE1 (USE1) USE1 family Q9NZ43
Protein YIPF4 (YIPF4) YIP1 family Q9BSR8
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Complement factor H-related protein 5 (CFHR5) . Q9BXR6
DnaJ homolog subfamily C member 30, mitochondrial (DNAJC30) . Q96LL9
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
Thrombospondin type-1 domain-containing protein 7B (THSD7B) . Q9C0I4

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587