Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C426  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 72 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 99.7
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 98.4
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 86.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 85.6
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 74.5
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 74.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 60.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 56.9
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 55.7
 LDTP04689  Adenosine kinase (ADK) 54.9
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 52.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 49.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 41.1
 LDTP01273  Acyl-protein thioesterase 1 (LYPLA1) 39.9
 LDTP02359  Heme oxygenase 1 (HMOX1) 34.1
 LDTP03842  Squalene synthase (FDFT1) 34.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 30.1
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 29.0
 LDTP11127  ADP-dependent glucokinase (ADPGK) 28.6
 LDTP10329  Ceramide synthase 2 (CERS2) 28.1
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 27.7
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 26.4
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 25.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 24.6
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 24.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 24.1
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 22.8
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 22.0
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 22.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 21.6
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 20.8
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 20.8
 LDTP04618  Ubiquitin carboxyl-terminal hydrolase 14 (USP14) 19.8
 LDTP06322  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3) 19.7
 LDTP05905  Acid ceramidase (ASAH1) 19.2
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 18.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 17.9
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 17.9
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 17.6
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 17.6
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 17.4
 LDTP11012  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1) 17.0
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 17.0
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 16.7
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 16.6
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 16.4
 LDTP09845  Geranylgeranyl transferase type-2 subunit alpha (RABGGTA) 15.6
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 15.6
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 15.6
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 14.8
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 14.5
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 14.2
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 14.2
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 14.1
 LDTP07931  Heme A synthase COX15 (COX15) 14.0
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 14.0
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 13.9
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 13.9
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 13.8
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 13.8
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 13.5
 LDTP04144  Cytochrome b-c1 complex subunit Rieske, mitochondrial (UQCRFS1) 13.5
 LDTP03145  Catechol O-methyltransferase (COMT) 13.4
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 13.4
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 13.4
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 13.2
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 13.2
 LDTP04183  Lanosterol synthase (LSS) 13.1
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 12.8
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 12.8
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) 12.7
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 12.6
Transporter and channel
Click to Show/Hide to Show 60 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 99.7
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 87.4
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 81.0
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 71.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 61.4
 LDTP03546  Translocator protein (TSPO) 60.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 54.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 49.9
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 46.5
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 44.6
 LDTP15948  Transmembrane protein 126A (TMEM126A) 41.9
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 35.8
 LDTP12383  Protein GPR108 (GPR108) 35.3
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 34.5
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 32.0
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 31.8
 LDTP07531  Sideroflexin-4 (SFXN4) 28.4
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 27.9
 LDTP07236  Protein GPR107 (GPR107) 27.5
 LDTP07063  Hippocampus abundant transcript-like protein 1 (MFSD14B) 26.9
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 26.9
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 25.1
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 24.4
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 22.9
 LDTP01217  Metaxin-2 (MTX2) 22.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 22.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 22.2
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 20.7
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 20.1
 LDTP05900  Metaxin-1 (MTX1) 18.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 18.3
 LDTP11615  Protein tweety homolog 3 (TTYH3) 18.3
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 17.9
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 17.6
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 17.5
 LDTP15648  BRI3-binding protein (BRI3BP) 17.1
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 16.9
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 15.7
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 15.3
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 14.9
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 14.9
 LDTP11213  Nucleoporin NDC1 (NDC1) 14.8
 LDTP10343  Vacuole membrane protein 1 (VMP1) 14.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 14.7
 LDTP09180  Zinc transporter 7 (SLC30A7) 14.7
 LDTP00592  Surfeit locus protein 4 (SURF4) 14.2
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 14.1
 LDTP11245  Derlin-1 (DERL1) 14.0
 LDTP02215  Prosaposin (PSAP) 14.0
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 14.0
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 13.8
 LDTP00970  Gasdermin-E (GSDME) 13.5
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 13.5
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 13.5
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 13.2
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 12.9
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 12.7
 LDTP06198  Major facilitator superfamily domain-containing protein 10 (MFSD10) 12.6
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 12.6
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 14.8
Other
Click to Show/Hide to Show 35 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 99.7
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 50.6
 LDTP00105  Protein unc-119 homolog B (UNC119B) 50.2
 LDTP02736  Myosin light chain 6B (MYL6B) 49.2
 LDTP01522  Reticulon-3 (RTN3) 48.8
 LDTP11076  Apolipoprotein L2 (APOL2) 48.2
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 43.1
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 41.4
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 40.8
 LDTP10056  Protein FAM162A (FAM162A) 33.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 29.0
 LDTP12412  Reticulon-4 (RTN4) 27.3
 LDTP14458  Tetraspanin-6 (TSPAN6) 23.3
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 22.9
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 22.3
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 22.0
 LDTP19963  TraB domain-containing protein (TRABD) 21.7
 LDTP14939  Membralin (TMEM259) 21.4
 LDTP05160  Nucleobindin-2 (NUCB2) 20.5
 LDTP16080  Protein FAM114A2 (FAM114A2) 20.1
 LDTP01155  Ankyrin repeat domain-containing protein 17 (ANKRD17) 19.7
 LDTP18272  Transmembrane protein 209 (TMEM209) 19.6
 LDTP05277  Protein SET (SET) 19.0
 LDTP13086  Syntaxin-18 (STX18) 18.8
 LDTP08594  Negative elongation factor C/D (NELFCD) 17.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 17.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 16.8
 LDTP01075  Protein CutA (CUTA) 16.1
 LDTP15345  Zinc finger CCCH domain-containing protein 7A (ZC3H7A) 16.1
 LDTP04703  Tumor protein D52 (TPD52) 15.7
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 15.0
 LDTP00859  Synaptogyrin-2 (SYNGR2) 15.0
 LDTP13630  Neudesin (NENF) 13.8
 LDTP15623  Neuferricin (CYB5D2) 13.0
 LDTP17003  Matrix-remodeling-associated protein 7 (MXRA7) 12.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587