Details of the Target

General Information of Target

Target ID LDTP01273
Target Name Acyl-protein thioesterase 1 (LYPLA1)
Gene Name LYPLA1
Gene ID 10434
Synonyms
APT1; LPL1; Acyl-protein thioesterase 1; APT-1; hAPT1; EC 3.1.2.-; Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I; Palmitoyl-protein hydrolase; EC 3.1.2.22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, AB hydrolase 2 family
Subcellular location
Cytoplasm
Function
Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.
Uniprot ID
O75608
Ensemble ID
ENST00000316963.8
HGNC ID
HGNC:6737
ChEMBL ID
CHEMBL1681631

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CFPAC1 SNV: p.G77V .
HCT116 SNV: p.W145C DBIA    Probe Info 
NCIH1944 SNV: p.M69V .
TOV21G SNV: p.A12D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.05  LDD0402  [1]
HDSF-alk
 Probe Info  		2.58  LDD0197  [2]
CHEMBL5175495
 Probe Info  		7.40  LDD0196  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
BTD
 Probe Info  		C53(0.83)  LDD2117  [6]
AHL-Pu-1
 Probe Info  		C173(2.71); C169(3.80)  LDD0170  [7]
DBIA
 Probe Info  		C169(0.42); C173(0.42)  LDD0563  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C144(0.00); C211(0.00); C53(0.00); C173(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		C169(0.00); C173(0.00)  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C144(0.00); C211(0.00); C53(0.00); C173(0.00)  LDD0037  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Ox-W18
 Probe Info  		N.A.  LDD2175  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
W1
 Probe Info  		N.A.  LDD0236  [5]
AOyne
 Probe Info  		9.30  LDD0443  [16]
NAIA_5
 Probe Info  		C144(0.00); C211(0.00); C173(0.00); C169(0.00)  LDD2223  [17]
TER-AC
 Probe Info  		N.A.  LDD0426  [18]
TPP-AC
 Probe Info  		N.A.  LDD0427  [18]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C426
 Probe Info  		39.95  LDD2081  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C53(0.83)  LDD2117  [6]
 LDCM0025  4SU-RNA DM93 C173(2.71); C169(3.80)  LDD0170  [7]
 LDCM0214  AC1 PaTu 8988t C169(0.20); C173(0.20)  LDD1093  [8]
 LDCM0215  AC10 HEK-293T C144(0.99)  LDD0813  [8]
 LDCM0216  AC100 PaTu 8988t C169(0.68); C173(0.68)  LDD1095  [8]
 LDCM0217  AC101 PaTu 8988t C169(0.99); C173(0.99)  LDD1096  [8]
 LDCM0218  AC102 PaTu 8988t C169(1.81); C173(1.81)  LDD1097  [8]
 LDCM0219  AC103 PaTu 8988t C169(0.57); C173(0.57)  LDD1098  [8]
 LDCM0220  AC104 PaTu 8988t C169(1.39); C173(1.39)  LDD1099  [8]
 LDCM0221  AC105 PaTu 8988t C169(1.29); C173(1.29)  LDD1100  [8]
 LDCM0222  AC106 PaTu 8988t C169(0.94); C173(0.94)  LDD1101  [8]
 LDCM0223  AC107 PaTu 8988t C169(1.47); C173(1.47)  LDD1102  [8]
 LDCM0224  AC108 PaTu 8988t C169(0.64); C173(0.64)  LDD1103  [8]
 LDCM0225  AC109 PaTu 8988t C169(0.73); C173(0.73)  LDD1104  [8]
 LDCM0226  AC11 HEK-293T C144(0.95)  LDD0824  [8]
 LDCM0227  AC110 PaTu 8988t C169(0.57); C173(0.57)  LDD1106  [8]
 LDCM0228  AC111 PaTu 8988t C169(0.89); C173(0.89)  LDD1107  [8]
 LDCM0229  AC112 PaTu 8988t C169(1.04); C173(1.04)  LDD1108  [8]
 LDCM0230  AC113 PaTu 8988t C169(1.13); C173(1.13)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C169(1.36); C173(1.36)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C169(0.82); C173(0.82)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C169(0.96); C173(0.96)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C169(0.95); C173(0.95)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C169(0.95); C173(0.95)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C169(0.97); C173(0.97)  LDD1115  [8]
 LDCM0237  AC12 HEK-293T C144(1.09)  LDD0835  [8]
 LDCM0238  AC120 PaTu 8988t C169(1.70); C173(1.70)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C169(1.41); C173(1.41)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C169(1.47); C173(1.47)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C169(1.38); C173(1.38)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C169(1.26); C173(1.26)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C169(0.80); C173(0.80)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C169(1.28); C173(1.28)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C169(1.57); C173(1.57)  LDD1124  [8]
 LDCM0246  AC128 HCT 116 C169(0.42); C173(0.42)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C169(1.07); C173(1.07)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C169(0.49); C173(0.49)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C169(1.90); C173(1.90)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C169(1.21); C173(1.21)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C169(0.55); C173(0.55)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C169(0.61); C173(0.61)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C169(0.64); C173(0.64)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C169(0.72); C173(0.72)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C169(1.06); C173(1.06)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C169(0.62); C173(0.62)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C169(0.77); C173(0.77)  LDD0575  [8]
 LDCM0259  AC14 HEK-293T C144(1.05)  LDD0857  [8]
 LDCM0260  AC140 HCT 116 C169(0.64); C173(0.64)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C169(0.77); C173(0.77)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C169(0.75); C173(0.75)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C169(0.80); C173(0.80)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C169(0.25); C173(0.25)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C169(0.49); C173(0.49)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C169(0.19); C173(0.19)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C169(0.23); C173(0.23)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C169(0.14); C173(0.14)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C169(0.18); C173(0.18)  LDD0586  [8]
 LDCM0270  AC15 HEK-293T C144(1.22)  LDD0868  [8]
 LDCM0271  AC150 HCT 116 C169(0.75); C173(0.75)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C169(0.75); C173(0.75)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C169(0.26); C173(0.26)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C169(0.13); C173(0.13)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C169(0.37); C173(0.37)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C169(0.46); C173(0.46)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C169(1.06); C173(1.06)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C169(1.43); C173(1.43)  LDD2161  [8]
 LDCM0276  AC17 HEK-293T C211(1.01); C144(0.87); C53(0.75); C173(0.93)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C211(0.94); C144(0.78); C53(1.18); C173(0.96)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C211(0.81); C144(0.63); C53(0.66); C173(0.78)  LDD1517  [20]
 LDCM0279  AC2 PaTu 8988t C169(0.28); C173(0.28)  LDD1158  [8]
 LDCM0280  AC20 HEK-293T C211(1.09); C53(0.67); C173(0.85); C169(1.00)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C211(0.94); C144(1.07); C53(0.92); C173(1.03)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C211(1.04); C144(0.91); C53(0.91); C173(0.97)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C211(1.09); C144(1.01); C53(0.82); C173(0.93)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C211(0.99); C53(0.90); C173(0.97)  LDD1523  [20]
 LDCM0285  AC25 PaTu 8988t C169(0.52); C173(0.52)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C169(0.14); C173(0.14)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C169(0.11); C173(0.11)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C169(0.09); C173(0.09)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C169(0.14); C173(0.14)  LDD1168  [8]
 LDCM0290  AC3 PaTu 8988t C169(0.34); C173(0.34)  LDD1169  [8]
 LDCM0291  AC30 PaTu 8988t C169(0.49); C173(0.49)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C169(0.42); C173(0.42)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C169(0.33); C173(0.33)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C169(0.16); C173(0.16)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C169(0.52); C173(0.52)  LDD1174  [8]
 LDCM0296  AC35 HCT 116 C169(1.63); C173(1.63)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C169(1.36); C173(1.36)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C169(1.18); C173(1.18)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C169(1.20); C173(1.20)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C169(0.91); C173(0.91)  LDD0617  [8]
 LDCM0301  AC4 PaTu 8988t C169(0.42); C173(0.42)  LDD1180  [8]
 LDCM0302  AC40 HCT 116 C169(0.97); C173(0.97)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C169(1.26); C173(1.26)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C169(0.96); C173(0.96)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C169(0.91); C173(0.91)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C169(1.18); C173(1.18)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C169(0.68); C173(0.68)  LDD0624  [8]
 LDCM0308  AC46 HEK-293T C144(0.80)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C144(0.86)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C144(0.90)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C144(0.90)  LDD0909  [8]
 LDCM0312  AC5 PaTu 8988t C169(0.28); C173(0.28)  LDD1191  [8]
 LDCM0313  AC50 HEK-293T C144(0.95)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C144(0.91)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C144(0.92)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C144(0.77)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C144(0.91)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C144(0.97)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C144(0.95)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C144(0.87)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C144(1.06)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C144(0.99)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C144(1.30)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C144(1.13)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C144(1.49)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C144(0.98)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C144(1.19)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C144(1.16)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C144(1.25)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C144(1.19)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C144(1.18)  LDD0929  [8]
 LDCM0334  AC7 HEK-293T C144(1.62)  LDD0932  [8]
 LDCM0345  AC8 HEK-293T C144(1.30)  LDD0943  [8]
 LDCM0349  AC83 PaTu 8988t C169(1.35); C173(1.35)  LDD1228  [8]
 LDCM0350  AC84 PaTu 8988t C169(1.47); C173(1.47)  LDD1229  [8]
 LDCM0351  AC85 PaTu 8988t C169(1.40); C173(1.40)  LDD1230  [8]
 LDCM0352  AC86 PaTu 8988t C169(1.43); C173(1.43)  LDD1231  [8]
 LDCM0353  AC87 PaTu 8988t C169(1.28); C173(1.28)  LDD1232  [8]
 LDCM0354  AC88 PaTu 8988t C169(1.15); C173(1.15)  LDD1233  [8]
 LDCM0355  AC89 PaTu 8988t C169(1.66); C173(1.66)  LDD1234  [8]
 LDCM0357  AC90 PaTu 8988t C169(1.06); C173(1.06)  LDD1236  [8]
 LDCM0358  AC91 PaTu 8988t C169(1.22); C173(1.22)  LDD1237  [8]
 LDCM0359  AC92 PaTu 8988t C169(1.63); C173(1.63)  LDD1238  [8]
 LDCM0360  AC93 PaTu 8988t C169(1.63); C173(1.63)  LDD1239  [8]
 LDCM0361  AC94 PaTu 8988t C169(1.59); C173(1.59)  LDD1240  [8]
 LDCM0362  AC95 PaTu 8988t C169(1.68); C173(1.68)  LDD1241  [8]
 LDCM0363  AC96 PaTu 8988t C169(1.51); C173(1.51)  LDD1242  [8]
 LDCM0364  AC97 PaTu 8988t C169(1.95); C173(1.95)  LDD1243  [8]
 LDCM0365  AC98 PaTu 8988t C169(0.74); C173(0.74)  LDD1244  [8]
 LDCM0366  AC99 PaTu 8988t C169(1.30); C173(1.30)  LDD1245  [8]
 LDCM0248  AKOS034007472 HEK-293T C144(1.12)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C144(1.29)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C144(1.18)  LDD0873  [8]
 LDCM0156  Aniline NCI-H1299 11.67  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C144(0.75)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C211(0.97); C144(1.04); C53(0.95); C173(0.82)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C211(1.06); C144(1.06); C53(0.69); C173(0.80)  LDD1572  [20]
 LDCM0369  CL100 PaTu 8988t C169(0.40); C173(0.40)  LDD1248  [8]
 LDCM0370  CL101 HEK-293T C144(1.59)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C144(1.49)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C144(1.30)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C144(1.18)  LDD0971  [8]
 LDCM0374  CL105 HEK-293T C211(0.93); C144(0.90); C53(0.90); C173(0.87)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C211(0.84); C144(1.10); C53(0.91); C173(0.90)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C211(1.16); C144(0.92); C53(0.75); C173(0.98)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C211(1.01); C144(0.76); C53(0.81); C173(0.98)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C211(0.92); C144(0.93); C53(0.87); C173(0.99)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C211(1.14); C144(1.17); C53(0.81); C173(0.87)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C211(0.87); C144(1.05); C53(0.47); C173(0.80)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C211(1.05); C144(0.92); C53(0.91); C173(0.88)  LDD1585  [20]
 LDCM0382  CL112 PaTu 8988t C169(0.43); C173(0.43)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C169(0.35); C173(0.35)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C169(0.21); C173(0.21)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C169(0.52); C173(0.52)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C169(0.13); C173(0.13)  LDD1265  [8]
 LDCM0387  CL117 HCT 116 C169(0.54); C173(0.54)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C169(1.02); C173(1.02)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C169(1.01); C173(1.01)  LDD0706  [8]
 LDCM0390  CL12 HEK-293T C211(1.00); C53(0.91); C173(0.93)  LDD1594  [20]
 LDCM0391  CL120 HCT 116 C169(1.07); C173(1.07)  LDD0708  [8]
 LDCM0392  CL121 HEK-293T C144(1.11)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C144(0.94)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C144(0.96)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C144(1.02)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C144(1.15)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C144(1.18)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C144(1.08)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C144(0.92)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C211(1.01); C144(1.18); C53(0.94); C173(0.91)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C211(0.97); C144(0.97); C53(0.82); C173(0.99)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C211(1.28); C144(1.01); C53(0.54); C173(1.05)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C144(1.23)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C144(1.34)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C144(0.96)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C144(1.04)  LDD1004  [8]
 LDCM0407  CL2 HEK-293T C211(0.88); C144(1.08); C53(0.87); C173(1.01)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C144(0.91)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C144(1.22)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C144(0.92)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C144(0.81)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C144(0.91)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C144(1.16)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C144(1.10)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C144(1.01)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C144(1.03)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C144(0.98)  LDD1015  [8]
 LDCM0418  CL3 HEK-293T C211(1.02); C144(1.03); C53(0.73); C173(0.96)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C144(1.00)  LDD1017  [8]
 LDCM0420  CL31 PaTu 8988t C169(0.96); C173(0.96)  LDD1299  [8]
 LDCM0421  CL32 PaTu 8988t C169(0.54); C173(0.54)  LDD1300  [8]
 LDCM0422  CL33 PaTu 8988t C169(0.82); C173(0.82)  LDD1301  [8]
 LDCM0423  CL34 PaTu 8988t C169(0.54); C173(0.54)  LDD1302  [8]
 LDCM0424  CL35 PaTu 8988t C169(0.59); C173(0.59)  LDD1303  [8]
 LDCM0425  CL36 PaTu 8988t C169(0.20); C173(0.20)  LDD1304  [8]
 LDCM0426  CL37 PaTu 8988t C169(0.56); C173(0.56)  LDD1305  [8]
 LDCM0428  CL39 PaTu 8988t C169(0.48); C173(0.48)  LDD1307  [8]
 LDCM0429  CL4 HEK-293T C211(0.82); C144(1.09); C53(1.14); C173(0.95)  LDD1633  [20]
 LDCM0430  CL40 PaTu 8988t C169(0.79); C173(0.79)  LDD1309  [8]
 LDCM0431  CL41 PaTu 8988t C169(0.78); C173(0.78)  LDD1310  [8]
 LDCM0432  CL42 PaTu 8988t C169(0.50); C173(0.50)  LDD1311  [8]
 LDCM0433  CL43 PaTu 8988t C169(0.46); C173(0.46)  LDD1312  [8]
 LDCM0434  CL44 PaTu 8988t C169(0.18); C173(0.18)  LDD1313  [8]
 LDCM0435  CL45 PaTu 8988t C169(0.40); C173(0.40)  LDD1314  [8]
 LDCM0436  CL46 HEK-293T C211(1.08); C144(0.97); C53(0.72); C173(0.88)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C211(1.07); C144(1.10); C53(0.75); C173(0.84)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C211(0.93); C53(0.72); C173(0.86)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C211(1.25); C144(1.08); C53(1.20); C173(0.93)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C211(0.93); C144(0.98); C53(0.73); C173(1.01)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C211(0.95); C144(1.00); C53(0.98); C173(0.97)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C211(1.06); C144(0.96); C53(0.94); C173(0.95)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C211(0.88); C144(0.81); C53(0.74); C173(0.79)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C211(0.88); C144(1.02); C53(0.63); C173(0.79)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C211(1.13); C144(0.79); C53(0.69); C173(0.93)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C211(1.17); C53(0.62); C173(0.91); C169(1.21)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C211(0.89); C144(1.16); C53(0.73); C173(0.87)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C211(1.09); C144(0.89); C53(0.69); C173(0.87)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C211(1.01); C144(0.95); C53(0.77); C173(0.84)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C211(0.79); C144(0.98); C53(0.78); C173(0.83)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C211(1.05); C53(0.68); C173(0.87)  LDD1655  [20]
 LDCM0453  CL61 HCT 116 C169(0.86); C173(0.86)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C169(0.87); C173(0.87)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C169(0.50); C173(0.50)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C169(0.48); C173(0.48)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C169(0.59); C173(0.59)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C169(0.31); C173(0.31)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C169(0.44); C173(0.44)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C169(0.30); C173(0.30)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C169(0.34); C173(0.34)  LDD0778  [8]
 LDCM0462  CL7 HEK-293T C211(0.97); C144(1.16); C53(0.87); C173(1.02)  LDD1665  [20]
 LDCM0463  CL70 HCT 116 C169(0.36); C173(0.36)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C169(0.55); C173(0.55)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C169(0.86); C173(0.86)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C169(0.93); C173(0.93)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C169(0.60); C173(0.60)  LDD0784  [8]
 LDCM0469  CL76 PaTu 8988t C169(0.98); C173(0.98)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C169(0.69); C173(0.69)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C169(0.44); C173(0.44)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C169(0.47); C173(0.47)  LDD1351  [8]
 LDCM0473  CL8 HEK-293T C211(0.77); C53(0.43); C173(0.58); C169(0.85)  LDD1676  [20]
 LDCM0474  CL80 PaTu 8988t C169(0.59); C173(0.59)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C169(0.55); C173(0.55)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C169(0.61); C173(0.61)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C169(0.16); C173(0.16)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C169(0.68); C173(0.68)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C169(0.74); C173(0.74)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C169(0.55); C173(0.55)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C169(0.24); C173(0.24)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C169(0.36); C173(0.36)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C169(0.82); C173(0.82)  LDD1362  [8]
 LDCM0484  CL9 HEK-293T C211(0.95); C144(1.08); C53(0.91); C173(1.00)  LDD1687  [20]
 LDCM0485  CL90 PaTu 8988t C169(0.46); C173(0.46)  LDD1364  [8]
 LDCM0486  CL91 PaTu 8988t C169(0.43); C173(0.43)  LDD1365  [8]
 LDCM0487  CL92 PaTu 8988t C169(0.34); C173(0.34)  LDD1366  [8]
 LDCM0488  CL93 PaTu 8988t C169(0.34); C173(0.34)  LDD1367  [8]
 LDCM0489  CL94 PaTu 8988t C169(0.31); C173(0.31)  LDD1368  [8]
 LDCM0490  CL95 PaTu 8988t C169(0.16); C173(0.16)  LDD1369  [8]
 LDCM0491  CL96 PaTu 8988t C169(0.24); C173(0.24)  LDD1370  [8]
 LDCM0492  CL97 PaTu 8988t C169(0.37); C173(0.37)  LDD1371  [8]
 LDCM0493  CL98 PaTu 8988t C169(0.12); C173(0.12)  LDD1372  [8]
 LDCM0494  CL99 PaTu 8988t C169(0.27); C173(0.27)  LDD1373  [8]
 LDCM0495  E2913 HEK-293T C211(1.36); C144(0.87); C53(0.73); C173(1.00)  LDD1698  [20]
 LDCM0625  F8 Ramos C144(0.62); C211(1.25)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C144(0.61); C211(0.75)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C211(0.64)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C144(0.60); C211(0.75)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C144(0.98); C211(1.01)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C144(0.77); C211(0.56)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C144(0.43)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C144(0.86); C211(0.78)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C144(0.83); C211(1.10)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C144(1.59); C211(0.82)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C144(1.14); C211(0.73)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C144(0.92); C211(1.50)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C144(1.48); C211(1.44)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C144(0.54); C211(0.67)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C169(0.55); C173(0.55)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C144(0.87); C211(1.32)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C144(0.81); C211(0.78)  LDD2184  [21]
 LDCM0427  Fragment51 PaTu 8988t C169(0.35); C173(0.35)  LDD1306  [8]
 LDCM0610  Fragment52 Ramos C144(0.98); C211(0.88)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C144(1.51); C211(1.06)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C144(0.49); C211(0.70)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C144(0.55); C211(0.65)  LDD2188  [21]
 LDCM0022  KB02 HEK-293T C211(1.13); C53(1.11); C173(1.07)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C211(1.10); C53(0.97); C173(0.97)  LDD1497  [20]
 LDCM0024  KB05 MOLM-13 C211(2.52)  LDD3333  [22]
 LDCM0109  NEM HeLa H28(0.00); H35(0.00)  LDD0223  [15]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C53(1.16)  LDD2123  [6]
 LDCM0131  RA190 MM1.R C144(1.74)  LDD0304  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Scm-like with four MBT domains protein 2 (SFMBT2) . Q5VUG0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.