Details of the Target

General Information of Target

Target ID LDTP17362
Target Name Magnesium transporter NIPA3 (NIPAL1)
Gene Name NIPAL1
Gene ID 152519
Synonyms
NIPA3; NPAL1; Magnesium transporter NIPA3; NIPA-like protein 1; Non-imprinted in Prader-Willi/Angelman syndrome region protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDERRLPGSAVGWLVCGGLSLLANAWGILSVGAKQKKWKPLEFLLCTLAATHMLNVAVP
IATYSVVQLRRQRPDFEWNEGLCKVFVSTFYTLTLATCFSVTSLSYHRMWMVCWPVNYRL
SNAKKQAVHTVMGIWMVSFILSALPAVGWHDTSERFYTHGCRFIVAEIGLGFGVCFLLLV
GGSVAMGVICTAIALFQTLAVQVGRQADRRAFTVPTIVVEDAQGKRRSSIDGSEPAKTSL
QTTGLVTTIVFIYDCLMGFPVLVVSFSSLRADASAPWMALCVLWCSVAQALLLPVFLWAC
DRYRADLKAVREKCMALMANDEESDDETSLEGGISPDLVLERSLDYGYGGDFVALDRMAK
YEISALEGGLPQLYPLRPLQEDKMQYLQVPPTRRFSHDDADVWAAVPLPAFLPRWGSGED
LAALAHLVLPAGPERRRASLLAFAEDAPPSRARRRSAESLLSLRPSALDSGPRGARDSPP
GSPRRRPGPGPRSASASLLPDAFALTAFECEPQALRRPPGPFPAAPAAPDGADPGEAPTP
PSSAQRSPGPRPSAHSHAGSLRPGLSASWGEPGGLRAAGGGGSTSSFLSSPSESSGYATL
HSDSLGSAS
Target Bioclass
Transporter and channel
Family
NIPA family
Subcellular location
Membrane
Function Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+).
Uniprot ID
Q6NVV3
Ensemble ID
ENST00000295461.10
HGNC ID
HGNC:27194

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C393(1.09)  LDD1513  [1]
PAL-AfBPP Probe
Click To Hide/Show 64 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C044
 Probe Info  		9.99  LDD1743  [2]
C048
 Probe Info  		5.50  LDD1746  [2]
C049
 Probe Info  		5.13  LDD1747  [2]
C067
 Probe Info  		9.32  LDD1763  [2]
C070
 Probe Info  		13.00  LDD1766  [2]
C071
 Probe Info  		9.99  LDD1767  [2]
C072
 Probe Info  		11.39  LDD1768  [2]
C141
 Probe Info  		28.84  LDD1823  [2]
C142
 Probe Info  		12.04  LDD1824  [2]
C143
 Probe Info  		33.36  LDD1825  [2]
C145
 Probe Info  		30.48  LDD1827  [2]
C147
 Probe Info  		21.56  LDD1829  [2]
C163
 Probe Info  		13.18  LDD1843  [2]
C165
 Probe Info  		12.30  LDD1845  [2]
C166
 Probe Info  		12.55  LDD1846  [2]
C169
 Probe Info  		20.39  LDD1849  [2]
C170
 Probe Info  		11.16  LDD1850  [2]
C173
 Probe Info  		10.48  LDD1853  [2]
C174
 Probe Info  		5.86  LDD1854  [2]
C187
 Probe Info  		25.11  LDD1865  [2]
C191
 Probe Info  		20.53  LDD1868  [2]
C193
 Probe Info  		16.91  LDD1869  [2]
C194
 Probe Info  		12.04  LDD1870  [2]
C196
 Probe Info  		11.71  LDD1872  [2]
C197
 Probe Info  		10.70  LDD1873  [2]
C198
 Probe Info  		15.24  LDD1874  [2]
C199
 Probe Info  		6.63  LDD1875  [2]
C215
 Probe Info  		9.32  LDD1889  [2]
C216
 Probe Info  		12.13  LDD1890  [2]
C217
 Probe Info  		10.63  LDD1891  [2]
C218
 Probe Info  		11.88  LDD1892  [2]
C219
 Probe Info  		12.73  LDD1893  [2]
C220
 Probe Info  		13.36  LDD1894  [2]
C229
 Probe Info  		18.64  LDD1902  [2]
C231
 Probe Info  		20.39  LDD1904  [2]
C233
 Probe Info  		27.10  LDD1906  [2]
C234
 Probe Info  		13.45  LDD1907  [2]
C235
 Probe Info  		22.32  LDD1908  [2]
C238
 Probe Info  		11.24  LDD1911  [2]
C239
 Probe Info  		13.64  LDD1912  [2]
C240
 Probe Info  		13.83  LDD1913  [2]
C242
 Probe Info  		5.43  LDD1915  [2]
C252
 Probe Info  		8.82  LDD1925  [2]
C255
 Probe Info  		6.02  LDD1928  [2]
C271
 Probe Info  		8.06  LDD1941  [2]
C272
 Probe Info  		7.84  LDD1942  [2]
C273
 Probe Info  		12.47  LDD1943  [2]
C274
 Probe Info  		6.77  LDD1944  [2]
C277
 Probe Info  		13.18  LDD1947  [2]
C328
 Probe Info  		6.68  LDD1992  [2]
C333
 Probe Info  		6.87  LDD1996  [2]
C376
 Probe Info  		10.56  LDD2036  [2]
C378
 Probe Info  		9.92  LDD2037  [2]
C380
 Probe Info  		9.19  LDD2039  [2]
C382
 Probe Info  		13.83  LDD2041  [2]
C399
 Probe Info  		13.09  LDD2058  [2]
C400
 Probe Info  		5.54  LDD2059  [2]
C403
 Probe Info  		14.42  LDD2061  [2]
C424
 Probe Info  		13.09  LDD2079  [2]
C426
 Probe Info  		15.35  LDD2081  [2]
C428
 Probe Info  		5.03  LDD2083  [2]
C429
 Probe Info  		12.38  LDD2084  [2]
C430
 Probe Info  		6.68  LDD2085  [2]
C433
 Probe Info  		9.58  LDD2088  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C393(1.09)  LDD1513  [1]
 LDCM0283  AC23 HEK-293T C393(1.03)  LDD1522  [1]
 LDCM0292  AC31 HEK-293T C393(0.98)  LDD1531  [1]
 LDCM0300  AC39 HEK-293T C393(1.16)  LDD1539  [1]
 LDCM0309  AC47 HEK-293T C393(1.27)  LDD1548  [1]
 LDCM0318  AC55 HEK-293T C393(0.94)  LDD1557  [1]
 LDCM0327  AC63 HEK-293T C393(0.85)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C393(1.03)  LDD1568  [1]
 LDCM0367  CL1 HEK-293T C393(1.08)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C393(1.34)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C393(0.76)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C393(1.00)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C393(1.15)  LDD1583  [1]
 LDCM0383  CL113 HEK-293T C393(1.01)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C393(0.82)  LDD1591  [1]
 LDCM0392  CL121 HEK-293T C393(1.00)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C393(1.35)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C393(0.94)  LDD1604  [1]
 LDCM0411  CL23 HEK-293T C393(1.16)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C393(1.20)  LDD1617  [1]
 LDCM0424  CL35 HEK-293T C393(0.97)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C393(0.88)  LDD1630  [1]
 LDCM0437  CL47 HEK-293T C393(0.97)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C393(0.74)  LDD1643  [1]
 LDCM0450  CL59 HEK-293T C393(1.03)  LDD1653  [1]
 LDCM0453  CL61 HEK-293T C393(0.89)  LDD1656  [1]
 LDCM0464  CL71 HEK-293T C393(1.38)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C393(0.86)  LDD1669  [1]
 LDCM0477  CL83 HEK-293T C393(1.08)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C393(1.13)  LDD1682  [1]
 LDCM0490  CL95 HEK-293T C393(0.86)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C393(0.99)  LDD1695  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587