General Information of Experiment

Probe Name C328  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 99.7
 LDTP13367  Glutathione hydrolase 7 (GGT7) 30.5
 LDTP03900  ADP-ribosylation factor-like protein 1 (ARL1) 14.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 8.6
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 7.5
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 7.0
 LDTP03946  Glycine--tRNA ligase (GARS1) 6.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 5.9
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 5.8
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) 5.2
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.2
Transporter and channel
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 8.3
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 7.2
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 6.7
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 6.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 5.9
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 5.1
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09907  Neogenin (NEO1) 5.7
Other
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 12.0
 LDTP00417  Programmed cell death protein 5 (PDCD5) 9.2
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 9.0
 LDTP11076  Apolipoprotein L2 (APOL2) 6.5
 LDTP05160  Nucleobindin-2 (NUCB2) 5.2
 LDTP00105  Protein unc-119 homolog B (UNC119B) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587